Clinical trials stopped by Covid-19

Benjamin Gregory Carlisle PhD

Charité – Universitätsmedizin Berlin, Germany
Berliner Institut für Gesundheitsforschung (BIG) / Berlin Institute of Health (BIH)
QUEST – Quality | Ethics | Open Science | Translation

The Covid-19 outbreak that became a global pandemic in 2020 has disrupted lives, families, industries and entire nations. This project is a weekly-updated "living paper" that aims to quantify some of the effects of Covid-19 on the enterprise of human research.

The following table contains all registry entries from ClinicalTrials.gov whose overall status changed to Terminated, Suspended or Withdrawn since 2019-12-01. Investigator-provided reasons that explicitly mention Covid-19 are highlighted in green. Click a row of the table for more details about the trial.

To date, 1884 clinical trials have been stopped for reasons that explicitly cite Covid-19.

These data and figures are available to be downloaded under a Creative Commons By-Attribution Non-Commercial license. This data set was last updated 2020-11-17.

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Covid-19 arm per-trial data set TSV
Comparator arm per-trial data set TSV
Drugs and biologics in stopped trials TSV
NCT ID Overall status Brief title Phase Study type Why stopped Enrollment
NCT02957604 Terminated Evolocumab Pregnancy Exposure Registry Observational [Patient Registry] Actual 140
NCT03089463 Suspended Foot Assessment in People With Diabetes: A Quantitative Diagnostic Approach Observational The study has not managed to recruit adequate number of participants. Anticipated 153
NCT01543750 Withdrawn 4-Aminopyridine in Episodic Ataxia Type 2 Phase 2 Interventional Actual 0
NCT01843569 Withdrawn In Vitro Maturation (IVM) of Human Oocytes N/A Interventional Institutional approval of study has expired. Actual 0
NCT02053727 Withdrawn Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir Background N/A Interventional The study team did not enroll any patients due to difficulty with recruitment. Actual 0
NCT02331355 Withdrawn Hand Transplantation: Functional and Quality of Life Outcomes Observational unable to find appropriate candidates Actual 0
NCT02474888 Terminated Pharmacokinetic Study of Rituximab Induction Regimen in ANCA-associated Vasculitis Observational failure of recruit Actual 28
NCT02597660 Withdrawn A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy Phase 2 Interventional PI decided not to enroll Actual 0
NCT02718677 Withdrawn Patient-reported Outcomes in Subjects Treated With ReFacto AF Routine Prophylaxis Observational Company decision to not conduct study Actual 0
NCT03452540 Suspended Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis Phase 2 Interventional Company Decision Anticipated 120
NCT03592459 Withdrawn Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer N/A Interventional Study halted prematurely, prior to enrollment of first participant Actual 0
NCT03773055 Terminated Phase II Clinical Trial of NPC-06 in Patients With Neuropathic Pain in Cancer Phase 2 Interventional Low recruitment Actual 7
NCT03773991 Terminated Dyspnea Assessment in Hemodialysis Patients Observational Recruitment issues: Restrictions associated with the COVID-19 pandemic have made much of the research procedures unfeasible due to organizational and safety issues (for both staff and patient protection). Actual 7
NCT04435808 Terminated Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19 Phase 1/Phase 2 Interventional Stopped for futility by DSMB Actual 1
NCT04494178 Terminated G-PUR® for Reduced Dietary Fumonisin Bioavailability N/A Interventional Several analytical laboratories failed to develop and validate a suitable assay of urine fumonisin (the primary endpoint) up to date. Because of missing alternatives for an analytical laboratory the objective of the study cannot be met. Actual 7
NCT04540393 Suspended AZD1222 Vaccine for the Prevention of COVID-19 Phase 3 Interventional Study has been suspended due to the occurrence of SUSAR at University of Oxford sponsored Phase2/3 study. Study will continue to be on hold until Russian MOH approval is received. Anticipated 100
NCT03479463 Terminated Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy Observational [Patient Registry] Slow enrollment Actual 8
NCT04284787 Suspended BLAST MRD AML-2: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Azacitidine and Venetoclax as Frontline Therapy in Unfit Patients With Acute Myeloid Leukemia Phase 2 Interventional pending amendment approval Anticipated 76
NCT04628533 Withdrawn Exploring the Optimal Duration of a Group-based Online Behavioral Weight Loss Program N/A Interventional COVID-19. Recruitment never began. Actual 0
NCT02205723 Withdrawn Smartphone-facilitated Asthma Control N/A Interventional Study was not initiated because we could not secure funding. Actual 0
NCT02234557 Suspended Tai Chi Training for Children With ADHD N/A Interventional Due to COVID-19, we have suspended enrollment for this study. Anticipated 40
NCT02431000 Withdrawn Male Fertility and Sperm Cryopreservation Observational PI is no longer at this University. Actual 0
NCT02443142 Withdrawn Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury Phase 2 Interventional Lack of study participants. Actual 0
NCT02458482 Withdrawn Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute Asthma Exacerbation in Children N/A Interventional The trainee for whom I designed the study did not begin enrollment and has left our institution. Actual 0
NCT02563561 Terminated A Study of Intravesical Apaziquone as a Surgical Adjuvant in Patient Undergoing TURBT Phase 3 Interventional Actual 62
NCT02587026 Terminated Biorepository for Precision Genomics Observational [Patient Registry] Study team has decided to close enrollment, and all subjects are being rolled into a different clinical trial: Total Cancer Care Actual 480
NCT02589860 Withdrawn Analysis of Oral Mucositis in Patient's Undergoing Melphalan Conditioning and Autologous Stem Cell Transplant Observational No accrual Actual 0
NCT02844933 Terminated Cannabidiol Oral Solution for the Treatment of Subjects With Prader-Willi Syndrome Phase 2 Interventional Insys Therapeutics filed Chapter 11 and terminated all studies. Actual 7
NCT03110484 Withdrawn Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study Phase 2 Interventional institution resource problem Actual 0
NCT03336242 Terminated Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures Phase 2 Interventional More patients in Cohort 1 than Cohort 2 demonstrated a clinically meaningful reduction of seizure count. Given this, enrollment of Cohort 3 was discontinued. Actual 20
NCT03355300 Terminated Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures Phase 2 Interventional Insys Therapeutics filed Chapter 11 and terminated all studies. Actual 6
NCT03421496 Terminated A Study to Assess the Efficacy, Safety, and Tolerability of Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms Phase 3 Interventional The study was terminated due to slow enrollment and failure to identify adequate patients that met entry criteria. Actual 2
NCT03434509 Suspended Ongoing Tai Chi Training for Children With ADHD N/A Interventional Due to COVID-19, we have suspended enrollment. Anticipated 50
NCT03458416 Terminated A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Patients With Prader-Willi Syndrome Phase 2 Interventional Insys Therapeutics filed Chapter 11 and terminated all studies. Actual 7
NCT03609450 Terminated Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 3) N/A Interventional COVID-19 Pandemic Actual 73
NCT03609749 Terminated Mindful Self-Regulation fMRI Study (MindfulPCfMRI) N/A Interventional COVID-19 pandemic Actual 21
NCT03705273 Terminated Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Phase 4 Interventional Dr. Arnold assisted in designing and initiating study for a pharmacology PhD candidate. The candidate left the institution and study enrollment was terminated. Actual 40
NCT03967093 Terminated A Study of BXQ-350 in Children and Young Adults With Relapsed Solid Tumors Phase 1 Interventional Bexion will not move forward with the Part 2 expansion portion of the trial in order to focus resources on the further development of BXQ-350 as an earlier treatment measure in the pediatric population. Actual 9
NCT04135326 Withdrawn Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy Early Phase 1 Interventional Per PI termination request, no patients enrolled Actual 0
NCT04158830 Withdrawn Aspirin (ASA) Therapy and Preeclampsia Prevention Phase 4 Interventional PI is no longer at this University. Actual 0
NCT04178525 Terminated Clinical Trial Evaluating the Safety and Efficacy of the Use of Chitosan Gel in Patients With Chronic Wounds N/A Interventional COVID-19 restrictions Actual 46
NCT04194983 Terminated The Effect of Fish Oils With Dairy or Plant Based Lipids on Mitochondrial and Physical, and Cognitive Function, in Elderly Humans N/A Interventional due to COVID-19 and lack of financial means to continue Actual 25
NCT04280588 Withdrawn Fingolimod in COVID-19 Phase 2 Interventional No participants enrolled Actual 0
NCT03685344 Terminated Safety and Antitumor Activity Study of Loncastuximab Tesirine and Durvalumab in Diffuse Large B-Cell, Mantle Cell, or Follicular Lymphoma Phase 1 Interventional In a limited number of patients, no additional activity was evident for the combination vs. Loncastuximab tesirine monotherapy. Actual 13
NCT04199442 Terminated Anxiety Assessment Before Regional Anesthesia. Observational Sanitary crisis du to Covid-19 Actual 200
NCT04209452 Terminated Improving Working Memory of Children With Autism N/A Interventional COVID-19 Actual 15
NCT04499352 Withdrawn A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have Advanced Anal Cancer Phase 2 Interventional Not due to safety reasons (sponsor decision). Actual 0
NCT04550234 Suspended A Study in Healthy Subjects to Assess Drug Availability of 2 Different Formulations of Verinurad and Allopurinol Phase 1 Interventional After internal evaluation of interim data, AZ team decided to postpone Study until Mid-2021 for further development of Phase 3 formulation. Anticipated 48
NCT04625231 Terminated Shared Decision-Making Tool for Opioid Prescribing After Ambulatory Hand Surgery in Veterans N/A Interventional Due to decreased case volume due to COVID-19 enrollment has stopped. Actual 45
NCT01363882 Terminated Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) N/A Interventional Insufficient enrollment & high rate of failure to complete protocol Actual 25
NCT02112643 Withdrawn Selenium in Mild Thyroid Eye Disease in North America N/A Interventional Lack of funding Actual 0
NCT02691455 Terminated The AGS Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study (ASSISTS) N/A Interventional Difficulty in recruiting participants Actual 43
NCT03261479 Terminated Validation of Thermal Imaging to Detect Pneumonia Observational Research stopped after lab-based data using mouse model did not support use of technology. Actual 22
NCT03381196 Terminated A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications Phase 3 Interventional Based on interim Analysis outcome being futile for FLZ3001; decision was taken to stop (early terminate) both FLZ3001/3002. There was no safety concern. Actual 553
NCT03477526 Terminated Status and Develepment Mental Quality of Life COPD/IPF Inpatients Before and After Pulmonary Rehabilitation N/A Interventional PhD Student stopped working on this project Actual 1
NCT03810690 Withdrawn Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia Phase 1/Phase 2 Interventional Study was terminated before the start of dosing due to a business decision and not due to safety or efficacy reasons. Actual 0
NCT03893292 Withdrawn Preop Cooled Radiofrequency Ablation for Total Knee Replacement Observational Lack of participants Actual 0
NCT04030624 Withdrawn Remote Electronic Patient Monitoring in Gastrointestinal Cancer N/A Interventional Funding discontinued due to changes in corporate structures Actual 0
NCT04061317 Terminated SPOT-FRAILTY Assessment of Frailty in Patients Over the Age of 70 Undergoing a Cardiac Intervention Observational COVID Restrictions in a vulnerable population. Actual 82
NCT04225299 Withdrawn Evaluation of Efficacy of TOOKAD® (VTP) Versus Active Surveillance for Intermediate Risk Localized Prostate Cancer Phase 3 Interventional FDA didn't approve the design of the protocol so we didn't start the study Actual 0
NCT04356456 Withdrawn A Double-Blind, Randomized, Placebo-Controlled Study Evaluating the Nutritional Supplement Lumenato and Its Impact on Skin Parameters in Healthy Female Subjects N/A Interventional Covid-19 Actual 0
NCT02906124 Terminated Study to Evaluate the Safety of Repatha® in Pregnancy Observational Actual 4
NCT03041688 Suspended KRT-232 (AMG-232) and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia Phase 1 Interventional Other - to update dosing schedule Anticipated 58
NCT03578731 Terminated Efficacy of the "Consilium" Smartphone App for Detecting Symptoms and Treatment Side Effects in Cancer Patients Observational Mainly due to insufficient recruitment Actual 224
NCT03731728 Terminated Group CBT and Exercise in Management of Depression N/A Interventional COVID-19 Actual 70
NCT03913676 Terminated Disseminating a Waitlist Treatment for Anxiety With Velibra N/A Interventional The study was not feasible. Actual 11
NCT04020211 Terminated HF10 Treatment of Chronic Knee Pain Observational Limited Enrollment Actual 3
NCT04028960 Terminated IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase Phase 2 Interventional Funding was rescinded Actual 5
NCT04366232 Terminated Efficacy of Intravenous Anakinra and Ruxolitinib During COVID-19 Inflammation (JAKINCOV) Phase 2 Interventional investigator decision Actual 2
NCT04393727 Terminated Transfusion of Convalescent Plasma for the Early Treatment of Patients With COVID-19 Phase 2 Interventional Study was stopped because the Promoter was changed and a new study on convalescent plasma promoted by AIFA was started in Italy. Actual 1
NCT04493099 Withdrawn Alvocidib in Combination With Decitabine and Venetoclax in Patients With Relapsed or Refractory AML or as Frontline Therapy in Unfit Patients With AML Phase 1/Phase 2 Interventional The original sponsor was acquired by a new company and has elected to end funding for all Investigator Sponsored Trials (ISTs) Actual 0
NCT04628819 Terminated Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children N/A Interventional Not enough patients included Actual 61
NCT04629417 Suspended Measuring Adherence to Home Shoulder Physiotherapy With Artificial Intelligence N/A Interventional Due to COVID-19 all research activities including recruitment have been paused. Anticipated 120
NCT01848431 Withdrawn Randomized Study on the Effects of Moderate Anaemia in Free Microvascular Tissue Transfer Observational staff change and lack of ressources Actual 0
NCT04188574 Suspended A Trial Involving Treatment of BB2603 in Subjects With Distal Subungual Onychomycosis of the Toenail Phase 2 Interventional Study pause due to COVID-19 pandemic impacts. Anticipated 220
NCT01925378 Withdrawn A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia Phase 2 Interventional The study is going to open in a new site Actual 0
NCT02196311 Withdrawn Treatment Of Supracondylar Fractures Closed Reduction And Circular Ring External Fixation Versus Open Reduction and Internal Fixation Observational no patient recruited Actual 0
NCT02761928 Terminated Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients Observational Insufficient enrollment, lack of funding to continue Actual 31
NCT02782403 Terminated Axitinib and Bosutinib in Treating Patients With Chronic, Accelerated, or Blastic Phase Chronic Myeloid Leukemia Phase 1/Phase 2 Interventional Terminated per PI's request at the time of CR Actual 6
NCT02842710 Withdrawn Staphylococcus Aureus Resistant to Methicillin (MRSA) Screening in Trauma N/A Interventional the study did not start due to a lack of staff Actual 0
NCT02850731 Withdrawn Motorized Platform and Autonomy Among the Frail and Pre-frail Older Adult (PLATAUTONOMIE) N/A Interventional Organisation problem Actual 0
NCT02897830 Terminated Ixazomib, Lenalidomide, Dexamethasone Induction and Extended Consolidation Plus Lenalidomide Maintenance in Multiple Myeloma Phase 2 Interventional negatives results Actual 46
NCT03100006 Terminated Phase Ib/IIa Trial to Evaluate Oregovomab and Nivolumab in Epithelial Cancer of Ovarian, Tubal or Peritoneal Origin Phase 1/Phase 2 Interventional The study had poor efficacy. Actual 13
NCT02077530 Withdrawn Metabolic Syndrome Cohort in Korea Observational [Patient Registry] Actual 0
NCT02642146 Terminated Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study Observational [Patient Registry] We decided to terminate recruit earlier because patient recruiting was not active as expected at the beginning of the study. Actual 71
NCT04183738 Withdrawn Inflammation and Co-Infections in D²EFT Phase 4 Interventional In the context of COVID-19 pandemic. Actual 0
NCT02444585 Withdrawn Longjohn Amgen Study - Effect of Denosumab... Phase 1 Interventional No participants enrolled in the trial Actual 0
NCT04214249 Suspended BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia Phase 2 Interventional Other - pending protocol updates Anticipated 124
NCT02230527 Terminated Establishing the Microcirculatory Effects of Ticagrelor on Tissue Perfusion in Critical Limb Ischemia Phase 2/Phase 3 Interventional Lack of enrollment Actual 27
NCT03202108 Withdrawn Evaluation of Krio in Children and Adults With Epilepsy N/A Interventional Product manufacturing issues. Actual 0
NCT00330434 Withdrawn Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism N/A Interventional Study was a F32 Fellowship. Trial was proposed however Principle Investigator does not believe trial took place. Actual 0
NCT01197482 Terminated Inhaled Steroids and Control of Severe Asthma Observational 6 out of 20 patients were included. The trend towards the treatment of severe asthma has meanwhile developed in a different direction, so that there is no longer any intention to pursue the study objective mentioned here. Actual 6
NCT03143894 Terminated Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation N/A Interventional Poor accrual (inability to enroll participants) Actual 7
NCT03963869 Suspended Effectiveness of Malaria Camps as Part of the Odisha State Malaria Elimination Drive N/A Interventional The study has been suspended because of COVID-19. We will resume as soon as COVID-19 restrictions are lifted. Anticipated 2700
NCT04274907 Suspended A Safety Study of Oral Venetoclax in Combination With Intravenous Pembrolizumab in Adult Participants With Previously Untreated Non-Small Cell Lung Cancer (NSCLC) With High Programmed Cell Death Ligand-1 (PD-L1) Expression Phase 1 Interventional Company Decision Actual 2
NCT01998035 Terminated Romidepsin Plus Oral 5-Azacitidine in Relapsed/Refractory Lymphoid Malignancies Phase 1/Phase 2 Interventional PI left institution Actual 52
NCT02004353 Terminated Observation of Benefits for Patients Implanted With a Hearing Implant of the Company Cochlear Observational [Patient Registry] Original study purpose accomplished Actual 1518
NCT01745224 Terminated Revlite Laser System Compared to the Candela Alex TriVantage System Refractory Mixed Type Melasma N/A Interventional The study stopped because patient enrollment requirements were not met. Actual 10
NCT02790034 Terminated Evaluation of the Efficacy, Safety, and Tolerability of Sarizotan in Rett Syndrome With Respiratory Symptoms Phase 2/Phase 3 Interventional The study did not demonstrate evidence of efficacy on the primary or secondary efficacy variables Actual 129
NCT03105219 Withdrawn IvaBradinE to Treat MicroalbumiNuria in Patients With Type 2 Diabetes and Coronary Heart Disease Phase 3 Interventional Shortfall in funding Actual 0
NCT03275792 Withdrawn Shiga Toxin Producing Escherichia Coli (STEC) Volume Expansion Phase 1 Interventional Funding not obtained. Actual 0
NCT03702062 Withdrawn Dynamic Heart Failure Prediction With Real-time Functional Status Data in the Ambulatory Setting N/A Interventional Study never started Actual 0
NCT03857659 Suspended Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care N/A Interventional COVID related termination Actual 113
NCT03922711 Terminated A Study to Assess the Safety and Effectiveness of Pridopidine Compared to Placebo in the Treatment of Levodopa-Induced Dyskinesia in Patients With Parkinson's Disease Phase 2 Interventional COVID-19 Actual 23
NCT03949998 Withdrawn The Immediate Effects of Dry Needling on Post-concussion Syndrome N/A Interventional no participants Actual 0
NCT03962231 Suspended Exercise Program in Patients With Shoulder Pain and Rotator Cuff Tear N/A Interventional Coronavirus Anticipated 78
NCT04042077 Terminated Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections Phase 3 Interventional COVID-19 seriously affected the study execution as required by the protocol Actual 269
NCT04149769 Withdrawn Mobility and Therapeutic Benefits Resulting From Exoskeleton Use in a Home and Community Setting (SC140121 Study 3) N/A Interventional COVID Actual 0
NCT02867618 Terminated Carfilzomib and TGR-1202 in Treatment of R/R Lymphoma Phase 1/Phase 2 Interventional PI left institution Actual 11
NCT04352868 Withdrawn Customizing Myopia Control With Multifocal Toric Contact Lens N/A Interventional COVID-19 Actual 0
NCT04621955 Withdrawn Observational Study of Home Administration of Carfilzomib Observational Not possible to conduct study Actual 0
NCT03163277 Terminated Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X) Phase 4 Interventional Sloww accrual and COVID-19 related problems (impossible to perform LPs) Actual 38
NCT03424031 Terminated A Very Early Standing Study in Elderly Stroke N/A Interventional Many study exits (many deaths, aggravations) that we had anticipated (but not enough). The patients did not stay long enough in the department to complete the protocol (many study exits that we had not anticipated). Actual 45
NCT04339816 Terminated Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial Phase 3 Interventional Steering Committee decision in accordance with stopping rule 1: Emergence of new data Actual 3
NCT04356040 Suspended TactiFlex PAF IDE Trial N/A Interventional Enrollment suspended due to temporary device unavailability. Anticipated 355
NCT04197219 Withdrawn Pembrolizumab With Axitinib in Recurrent Endometrial Cancer Phase 2 Interventional PI is leaving institution Actual 0
NCT01857557 Terminated Evaluation of an Aerobic Exercise Program in Migraine Management N/A Interventional Challenges with participant recruitment as a result of COVID-19 pandemic Actual 39
NCT02775149 Suspended Dental Erosion in Patients With Gastro-oesophageal Reflux Observational No participants Anticipated 30
NCT03033316 Terminated A Evaluation of the Safety of Oncocort IV Pegylated Liposomal Dexamethasone Phosphate in Patients With Progressive Multiple Myeloma Phase 1/Phase 2 Interventional Patient enrolment issues Actual 7
NCT03537131 Suspended Dapagliflozin During Exercise for the PrevenTion of Hypoglycaemia Phase 2 Interventional Temporary halt due to COVID-19 pandemic Anticipated 34
NCT03587896 Terminated Implementation of Self Help Plus in Adult Syrian Refugees in Turkey (RE-DEFINE) N/A Interventional 12-month assessment process has been stopped prematurely due to logistic reasons. Actual 642
NCT03629821 Suspended Effect of Classic Ballet Practice on School Children's Postural Balance N/A Interventional The study has been suspended because COVID pandemic. Anticipated 50
NCT03637257 Withdrawn Carbon Dioxide (CO2) Measurement With a CO2/O2 Guedel Airway N/A Interventional due to other priorities Actual 0
NCT03684369 Withdrawn Improving Mobility and Reducing Fatigue in People With Multiple Sclerosis by Electrical Stimulation Therapy N/A Interventional The project was not funded. Actual 0
NCT03743571 Suspended Augmenting Exposure Therapy for Social Anxiety With Transcranial Direct Current Stimulation N/A Interventional recruitment suspended due to COVID-related social distancing requirements Anticipated 128
NCT03827902 Withdrawn Diabetic Foot Ulcer and Wound Infection Observational Unable to recruit participants Actual 0
NCT03884959 Withdrawn A Safety and Efficacy Study of Infusions of HepaStem in Urea Cycle Disorders Pediatric Patients Phase 2 Interventional Sponsor decided to stop enrollment Actual 0
NCT03892525 Suspended Study of Intratumoral Selicrelumab With Atezolizumab in Patients With Refractory or Relapsed B Cell Lymphoma Phase 1 Interventional End of drug development Actual 4
NCT03917433 Suspended Augmenting Virtual Reality Exposure Therapy for Acrophobia N/A Interventional temporarily suspended recruitment due to COVID-related social distancing requirements Anticipated 128
NCT03962829 Terminated Effect of mCPP on Cognitive Control, Appetite, and Neural Responses N/A Interventional due to the Covid 19 pandemic Actual 32
NCT04181957 Terminated Effects of LDX on Cognitive Processes and Appetite N/A Interventional COVID-19 Actual 22
NCT04340102 Withdrawn Development of a Scalable Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness N/A Interventional Study was not funded. Actual 0
NCT04364815 Withdrawn The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial Phase 3 Interventional Investigators opted to change the design of the study. Actual 0
NCT04399824 Withdrawn Focal Radiation Therapy for the Treatment of Low or Intermediate-Risk Prostate Cancer N/A Interventional Study did not open Actual 0
NCT03699033 Withdrawn Hypofractionated Radiotherapy With Carboplatin and Paclitaxel in Non-Small Cell Lung Cancer Phase 2 Interventional No patients available Actual 0
NCT03844152 Terminated RIGHTWHEY - Responders In Gut HealTh Markers Using Fermented WHEY N/A Interventional COVID-19 Actual 43
NCT03869008 Terminated Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena. N/A Interventional Funding no longer available Actual 7
NCT03941119 Terminated Evaluating the Impact of VR-therapy on BPSD and QoL of Individuals With Dementia Admitted to Hospital N/A Interventional All recruitment activities for this study (with acutely ill inpatients with dementia) stopped due to the COVID pandemic. Actual 77
NCT03974984 Withdrawn Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery Observational Not feasable due to logistics Actual 0
NCT04047966 Terminated Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect Growth Observational Due to the current pandemic situation, recruitment has been disrupted by the inability to recruit more patients Actual 42
NCT04094766 Withdrawn Safety and Efficacy of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy in R/R Acute B Lymphoblastic Leukemia Phase 1 Interventional Production plan adjustment Actual 0
NCT04154059 Suspended Strengthening Program for Foot-ankle Muscles in People With Knee Osteoarthritis N/A Interventional The recruitment of potential participants is suspended due to the covid-19 pandemic. Anticipated 76
NCT04160182 Withdrawn Feasibility and Effectiveness of an Internet-based Intervention to Manage Fatigue in Breast Cancer Survivors N/A Interventional Due to COVID this trial never got up and running. Actual 0
NCT04230330 Withdrawn Nivolumab in Combination With GDP/ L-asparaginase in NK/ T-cell Lymphoma Phase 1 Interventional PI has left the institution. Actual 0
NCT04232319 Withdrawn Feasibility and Effectiveness of a Sleep Hygiene Education Program for Sleep Issues in Breast Cancer Survivors N/A Interventional Due to COVID this study was never started. Actual 0
NCT04232501 Suspended Radial, Sequential Compression Device Deep Venous Thrombosis Detection Study N/A Interventional Due to COVID-19, Radial slowed their operations. Hence the investigational device is not available. Anticipated 200
NCT04295681 Suspended Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Cognitive Disorders Phase 3 Interventional Due to pandemic COVID-19 Anticipated 246
NCT01930838 Withdrawn Complications After Bariatric Surgery - a Clinical Trial Observational [Patient Registry] Actual 0
NCT02464280 Terminated Tomosynthesis of Pathologies of the Chest and Skeletal Structures in Comparison to CT Observational Actual 60
NCT02953366 Withdrawn Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis Phase 3 Interventional Sponsor decision Actual 0
NCT02953379 Withdrawn Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis Phase 3 Interventional Sponsor decision Actual 0
NCT04620421 Suspended Effect of Rhythm-based Multitask Training on Falls Among Older Adults N/A Interventional COVID-19 Anticipated 126
NCT03839472 Suspended Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors N/A Interventional Revision to improve cell recovery Anticipated 20
NCT00120731 Withdrawn Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones N/A Interventional Determined not feasible Actual 0
NCT00986440 Terminated Study of CS-7017 in Colorectal Cancer Patients Who Have Achieved Disease Control Following First-Line Chemotherapy Phase 2 Interventional Due to changes to the standard of care within the proposed market for CS-7017. Actual 84
NCT01068171 Withdrawn Developing a Diabetic Foot Ulcer Protocol N/A Interventional no patients who met enrollment criteria Actual 0
NCT01960764 Withdrawn Examination of Whether Host Preconditioning Modifies Short-term Transplant Survival Phase 1 Interventional This sub-study was not done because main study results reached significance. Actual 0
NCT02144142 Withdrawn Evaluation of the Kinetic Properties of an Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients Phase 2 Interventional This sub-study was not done because main study results reached significance. Actual 0
NCT02538887 Withdrawn Use of a Supplemental Radiofrequency Detection System Subsequent to Manual Counting of Vaginal Textiles Following Vaginal Birth Observational Sponsor dissolved before study started Actual 0
NCT02555384 Withdrawn AMblyopia Treatment Through PErceptual Training in Children (AMPEL) N/A Interventional Inclusion and Exclusion criteria too stringent, no patient coluld be recruited Actual 0
NCT02573519 Terminated Gastrointestinal Motility Among Diabetes Patients N/A Interventional Renewal of PET/CT scanners and slow recruitment Actual 40
NCT02942758 Terminated Low-dose AZA, Pioglitazone, ATRA Versus Standard-dose AZA in Patients >=60 Years With Refractory AML Phase 2 Interventional Due to financial reasons. Actual 10
NCT02973295 Withdrawn Silymarin in NAFLD Phase 4 Interventional Sponsor withdrawn their agreement Actual 0
NCT03043898 Terminated Mapping Sound Propagation Through the Human Lung for Better Diagnosis Observational COVID-19 Actual 62
NCT03065634 Terminated Return to Work and Living Healthy After Head and Neck Cancer N/A Interventional insufficient recruitment rate Actual 39
NCT03229850 Suspended Dynamics of Insulin Absorption in Subclinical Lipohypertrophy Using the Euglycemic Clamp Technique N/A Interventional Study was suspended due to current COVID 19 research curtailment Anticipated 10
NCT03246620 Terminated Oral Olanzapine Versus Haloperidol or Diazepam Phase 4 Interventional The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias. Actual 12
NCT02446509 Terminated A Psychoeducation Intervention for Caregivers of Patients With Bipolar Disorder N/A Interventional Actual 12
NCT03168490 Suspended In Vivo Effects of the Gluten Friendly Bread in Coeliac Disease N/A Interventional Anticipated 60
NCT04325165 Withdrawn DBS of PPN to Improve Walking in Chronic SCI Patients N/A Interventional Recruitment issues Actual 0
NCT00793013 Withdrawn Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation Phase 2 Interventional IRB approval lapsed. Actual 0
NCT01822275 Terminated Phase II Trial of Low-Dose Whole Brain Radiotherapy With Concurrent Temozolomide and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma Multiforme Phase 2 Interventional Poor accrual Actual 23
NCT01922895 Suspended Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis N/A Interventional Lack of funding Actual 53
NCT01925573 Terminated Optune(NOVOTTF-100A)+ Bevacizumab+ Hypofractionated Stereotactic Irradiation Bevacizumab-Naive Recurrent Glioblastoma (GCC 1344) N/A Interventional Poor accrual Actual 7
NCT02020707 Suspended Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Phase 1 Interventional pending resolution of budget issues. Anticipated 36
NCT02435446 Terminated Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS) N/A Interventional PROBLEM of inclusion Actual 31
NCT02490332 Terminated The Effects of Ventilation Tubes - The SIUTIT Trial N/A Interventional Failed to include the required number of participants Actual 31
NCT02717390 Terminated Bright by Three (BB3) Effectiveness Study N/A Interventional Lack of funding to recruit target sample size Actual 100
NCT02754466 Suspended Oral Health and Its Relation to Development and Well-being of Schoolchildren Before and After Restorative Treatments N/A Interventional Children could not be examined due to COVID-19 pandemic and schools closure. Actual 270
NCT02765425 Withdrawn Training the Brain With a Robotic Device for Balance Recovery N/A Interventional Loss of department staff and COVID Actual 0
NCT02765737 Terminated Dehydrated Human Amnion Chorion Membrane (dHACM) vs. Control in the Treatment of Partial Thickness Burns. N/A Interventional Slow enrollment, issues with inclusion/exclusion and choice of control Actual 23
NCT02992782 Suspended Decongestive Exercise and Compression for Breast Cancer Related Lymphedema Management N/A Interventional Covid-19 Anticipated 60
NCT03160157 Withdrawn Comparing the Outcomes of Laparoscopic Cholecystectomy vs. Robotic Cholecystectomy Observational No enrollment Actual 0
NCT03503435 Withdrawn The Effect of Art Therapy on Total Laryngectomy Patients N/A Interventional Due to COVID-19 we are not able to recruit in the foreseeable future Actual 0
NCT03512483 Withdrawn VCH -- vAFC Phase 3 N/A Interventional COVID-19 Actual 0
NCT03546504 Terminated Program to Improve Dental Care: Children With ASD N/A Interventional ran out of money Actual 3
NCT03642990 Suspended NR in Chemo-induced Peripheral Neuropathy Phase 2 Interventional Evaluating safety data Anticipated 39
NCT03684278 Suspended Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind Multi-centre Trial (RAPID-I) Phase 2 Interventional COVID-19 Pandemic Anticipated 290
NCT03742375 Terminated Quantitative HPV Genotyping in Screening of Anal Intraepithelial Neoplasia in HIV-positive Patients N/A Interventional COVID-19 pandemic Actual 24
NCT03847324 Suspended Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty N/A Interventional COVID-19 Anticipated 60
NCT03889158 Terminated Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation Phase 4 Interventional COVID-19 Actual 34
NCT03924622 Terminated Pressure Injury Prevention in AE and PFC N/A Interventional Unable to continue to conduct study procedures due to pandemic Actual 54
NCT04010136 Suspended Identification of Elderly Patients in Need of Palliative Care by Family Physicians N/A Interventional We were not able to recruit participants to enrol the study. As it was not able, the investigation team decided not to proced. Anticipated 180
NCT04011098 Terminated Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour Phase 1 Interventional Unable to meet recruitment numbers, lack of participation Actual 5
NCT04072484 Terminated Effectiveness of Chest Compressions Under Mild Hypoxia N/A Interventional Research at the University of Chicago was halted in March 2020. Actual 19
NCT04081506 Withdrawn Targeting the Optimal Mean Arterial Pressure in Hypoxic Ischemic Brain Injury After Cardiac Arrest N/A Interventional COVID-19 pandemic Actual 0
NCT04087265 Withdrawn Accuracy of Trans-abdominal Ultrasound in Evaluating Bowel Preparation Adequacy Before Colonoscopy N/A Interventional The PI requested to terminate due to his schedule Actual 0
NCT04128462 Withdrawn MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function Phase 3 Interventional Study postponed before recruiting any participants - may start in 2nd or 3rd quarter 2021 Actual 0
NCT04138433 Suspended Mechanisms Underlying Spoken Language Production N/A Interventional Due to COVID-19 - recruitment suspended since March 2020 in line with guidance from the UCLH/UCL Joint Research Office Anticipated 60
NCT04141904 Suspended Tofacitinib in Depression (TIDE) Phase 1/Phase 2 Interventional Covid-19 pandemic Anticipated 50
NCT04279249 Suspended Home Air Filtration for Traffic-Related Air Pollution N/A Interventional Due to COVID-19 Anticipated 288
NCT04292392 Withdrawn Pain Levels and Opioid Usage in Three Nerve Block Cohorts in Primary TKA N/A Interventional Final protocol and ICF has not been approved by local IRB. No subjects have been enrolled. Study will not be pursued due to current COVID-19 pandemic. Actual 0
NCT04556032 Terminated Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women N/A Interventional Sponsor terminated study due to unforeseen recruitment circumstances amidst the COVID19 pandemic. Actual 4
NCT04573010 Withdrawn Reducing Intracranial atheroSclErosis With Repatha Phase 4 Interventional Duplicate entry Actual 0
NCT02455024 Terminated An Observational Registry to Evaluate the Incidence of and Risk Factors for Vascular Occlusive Events Associated With ICLUSIG® Observational Business Decision; Insufficient Enrollment Actual 3
NCT03184584 Terminated Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome Phase 2/Phase 3 Interventional Terminated early due to redeployment of study site staff during Covid-19 pandemic Actual 10
NCT03523507 Terminated fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population N/A Interventional Study terminated due to COVID-19 restrictions Actual 10
NCT03879200 Terminated Group Antenatal Care for Somali Born Women N/A Interventional Limited time frame and financial resources. The anticipated increase of eligable migrant women did not occur during the period because of changes in migration policies. Actual 136
NCT04164758 Terminated Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine Phase 2 Interventional Study enrollment impacted by COVID-19 pandemic and Sponsor terminated for business reasons Actual 11
NCT04231409 Terminated Fast-Acting Subperception Study (FAST) N/A Interventional Study follow-up activities affected by COVID-19 Actual 41
NCT04269265 Suspended The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Vaccination Phase 1/Phase 2 Interventional Recruitment is suspended and expected to resume Spring 2021. Anticipated 46
NCT04560972 Withdrawn LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer Phase 1 Interventional Administrative isse. Study team notified me to withdraw the study. Actual 0
NCT04612985 Withdrawn Evaluation of the XACT Robotic System for Image-guided Percutaneous Lung Procedures N/A Interventional The IDE wasn't approved Actual 0
NCT03334669 Suspended Family-centered Obesity Prevention: Communities for Healthy Living (CHL) N/A Interventional The primary trial was halted due to covid-19 in the last 6 months of the trial; as a result, the intervention was not fully implemented and the final outcomes were not measured. Outcomes will be assessed with the data available (BL, Y1, Y2). Actual 4280
NCT03762356 Withdrawn Questionnaire About Individual's Insight/Awareness of Risk of Violence Observational Study did not receive final approval however it was decided to not pursue. Actual 0
NCT04001998 Withdrawn Healthy Volunteer Study Comparing Tablet and Capsule Formulations Phase 1 Interventional On hold to determine chosen formulations Actual 0
NCT04610606 Terminated Pilot Prehabilitation Intervention in Lung Cancer N/A Interventional Covid-19 pandemic Actual 34
NCT01020864 Withdrawn Cetuximab in Combination With Chemotherapy for Patients With Head and Neck Cancer Phase 2 Interventional Actual 0
NCT01668277 Terminated Effects of Saline on Circulation in Children Phase 2 Interventional Actual 15
NCT01865630 Withdrawn Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage Phase 1 Interventional PI moved to another institution Actual 0
NCT03467633 Terminated Atrial Fibrillation Trial to Evade Recurrence: effectS of Hiit Before electrO-Cardioversion for 3-weeKs N/A Interventional Not enough participants recruited. Actual 12
NCT03948334 Terminated A Study to Assess the Safety and Efficacy of ZPL389 With TCS/TCI in Atopic Dermatitis Patients Phase 2 Interventional Coe terminated due to lack of efficacy Actual 123
NCT04001153 Withdrawn Occlusal Compensation After the Hall Technique Observational There will be no opportunity to recruit patients during the pandemic of COVID-19 and possibly even post-pandemic Actual 0
NCT04108143 Suspended Use of MonitorMe in COPD N/A Interventional COVID-19 (study will re-open for recruitment when possible) Anticipated 30
NCT04171089 Withdrawn Suicide Prevention in Prepubertal Children N/A Interventional Due to COVID-19 Pandemic Actual 0
NCT04340544 Terminated Hydroxychloroquine for the Treatment of Mild COVID-19 Disease Phase 2 Interventional It appeared to be impossible for the study centres to recruit the targeted number of patients, due to reduced incidence and reduced acceptance to IMP Actual 17
NCT04374552 Withdrawn Asymptomatic COVID-19 Trial Phase 2 Interventional The investigators have decided not to go forward with this protocol Actual 0
NCT04452643 Withdrawn Efficacy of BACMUNE (MV130) in the Prevention of Disease Due to COVID-19 Infection in Healthcare Personnel Phase 3 Interventional Not authorized by Cofepris (Mexico Competent Regulatory Authority) Actual 0
NCT04469491 Suspended Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study Phase 2 Interventional In anticipation for Data and Safety Monitoring Board Anticipated 60
NCT04610996 Withdrawn The Valid of GFR in Chronic Kidney Disease Patients Observational Actual 0
NCT04274933 Terminated A Study to Evaluate the Safety and Tolerability of Venetoclax Tablets in Combination With Capecitabine Tablets in Adult Participants With Hormone Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer Who Had Disease Progression During or After CDK4/6 Inhibitor Therapy Phase 1 Interventional Company Decision Actual 4
NCT02747238 Terminated Does Ultrasound Help Junior Anesthesia Residents With Placement of Labor Analgesia in Pregnant Patients N/A Interventional lack of enrollment Actual 32
NCT02757391 Terminated CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors Phase 1 Interventional Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention. Actual 1
NCT02981017 Withdrawn Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure N/A Interventional Decided to do a different clinical trial opportunity. Actual 0
NCT03493412 Withdrawn Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease Phase 4 Interventional discontinued due to change in operating plans prior to study initiation and enrollment Actual 0
NCT03744832 Suspended Point of Care Streptococcal Pharyngitis Testing N/A Interventional The study was stopped secondary to the research curtailment and reallocation of testing resources secondary to the COVID-19 pandemic. Actual 145
NCT03974152 Suspended Effects of Nicotine Salt Aerosol on Cigarette Smokers N/A Interventional COVID concerns Anticipated 15
NCT04257357 Withdrawn Supervised Exercise Following Pulmonary Embolism N/A Interventional Due to Covid-19 pandemia the study was never initiated Actual 0
NCT04581070 Terminated The COVID-IYON Study - Study Examining Data Pertaining to Clinical Outcomes and Organisational Responses to the 2020 SARS-CoV-2 Pandemic" Observational Study stopped due to low accrual Actual 4
NCT03340103 Withdrawn Early Administration of the Lutein/Zeaxanthin in Premature Newborns N/A Interventional Recruitment was not possible Actual 0
NCT04347889 Withdrawn Preventing COVID-19 in Healthcare Workers With HCQ: A RCT Phase 2 Interventional Evidence that HCQ ineffective, loss of HCW interest, Actual 0
NCT04140734 Suspended Spacer Graft Study N/A Interventional Study has expired with the IRB Anticipated 100
NCT04220632 Terminated A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease Phase 1/Phase 2 Interventional Adverse events of the first patient Actual 1
NCT04342897 Terminated A Study of LY3127804 in Participants With COVID-19 Phase 2 Interventional Trial terminated for futility. Actual 95
NCT04363866 Withdrawn Assessing Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19) Phase 2 Interventional discontinued in favor of more promising directions that may benefit patients Actual 0
NCT04613102 Withdrawn The Efficacy and Safety of 3% Cannabidiol (CBD) Cream in Patients With Epidermolysis Bullosa: A Phase II/III Trial Phase 2/Phase 3 Interventional The study protocol will be updated (major updates), following Health Canada request Actual 0
NCT00336154 Withdrawn Study to Evaluate the Efficacy of Tetracycline in Epidermolysis Bullosa Phase 4 Interventional Actual 0
NCT03731702 Withdrawn Optimization of Collection Methods for Studies of the Human Microbiota Observational Deemed not human subjects research Actual 0
NCT03937791 Terminated Immunotherapy With E7 T Cell Receptor T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions Phase 2 Interventional All analysis with identifiable specimens/data is complete or site has no identifiers linked to the specimens/data. The one enrolled pt has been taken off study Actual 1
NCT04606810 Terminated Measuring the Impact of an Innovative Educational Intervention in Inflammatory Arthritis N/A Interventional Difficulties at recruiting enough participants for this study Actual 112
NCT00895024 Terminated Caregiver Assessments of the Quality of Home Hospice Care Observational PRMS No Slow Accrual Actual 74
NCT03601247 Suspended Silicone Gel for Postsurgical Scars of the Eyelid N/A Interventional The principal investigator suspended the study temporarily because of the COVID pandemic. We do not want patients to attend their follow-up visits at this time unless absolutely necessary. Anticipated 100
NCT03605589 Suspended Pembro + Blina Combination in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Leukemia or Lymphoma Phase 1 Interventional Slow recruitment. Amendment pending Anticipated 24
NCT04030351 Terminated Effect of Dried Fruit Intake on Acid-base Balance N/A Interventional Institution shut down due to COVID-19 Actual 109
NCT04034381 Suspended Dietary Intake, Health and Micronutrient Status in Haiti Observational Study suspended due to civil unrest and corresponding safety concerns and logistical challenges. Anticipated 1290
NCT04127721 Withdrawn Itacitinib for the Prevention of Graft Versus Host Disease in Patients Undergoing Donor Stem Cell Transplantation Phase 2 Interventional 0 ACTUAL Enrollment must have Overall Recruitment Status Actual 0
NCT00206375 Terminated Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Phase 4 Interventional Actual 16
NCT02885051 Terminated Evaluation of Pain in Preterm Newborn N/A Interventional At the end of the inclusion period, the observed correlations were much lower than expected. Thus, it did not seem relevant to prolong the inclusions. Actual 91
NCT03054870 Terminated A Comparison of Technegas and Xenon-133 Planar Lung Imaging in Subjects Referred for Ventilation Scintigraphy Phase 3 Interventional Trial met primary efficacy endpoint target. No additional subjects necessary. Actual 226
NCT04138485 Withdrawn Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc) Phase 2 Interventional Due to business reasons, not safety issues Actual 0
NCT04364009 Suspended Anakinra for COVID-19 Respiratory Symptoms Phase 3 Interventional Efficiency and safety reasons Actual 71
NCT04603963 Terminated Inspiratory Muscle Training in Patients With COVID 19 N/A Interventional There was a change in the institutional flow reducing the cases of covid 19 Actual 55
NCT02208271 Suspended A Validated Necrosis Assay to Determine the Need for Revision Surgery in Metal-on-metal Total Hip Arthroplasty Observational The lab was acquired by another company and has put this study's samples on hold. Actual 174
NCT02530502 Terminated Radiation Therapy With Temozolomide and Pembrolizumab in Treating Patients With Newly Diagnosed Glioblastoma Phase 1 Interventional The protocol was amendment to be stopped after phase I (phase 2 removed from protocol) Actual 4
NCT03176498 Suspended Human Umbilical Cord Mesenchymal Stem Cell Therapy for Cerebral Infarction Patients in Convalescent Period. Phase 1/Phase 2 Interventional Others Anticipated 40
NCT03180450 Suspended The Study of Heart Failure With Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSC) Phase 1/Phase 2 Interventional Others Anticipated 60
NCT03180463 Suspended The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells Phase 1/Phase 2 Interventional Others Anticipated 30
NCT03184935 Suspended Research for Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Myelodysplastic Syndrome (MDS) Phase 1/Phase 2 Interventional Others Anticipated 40
NCT03186456 Suspended The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Acute Cerebral Infarction Phase 1 Interventional Others Anticipated 40
NCT03569150 Withdrawn Culturally-Adapting a Communication Intervention to Improve Palliative Care Literacy on Two Native American Reservations N/A Interventional Study not funded. Actual 0
NCT03619746 Terminated Point-of-Care Ultrasound Educational Initiative for Insect Bites N/A Interventional Lack of accrual. We were unable to enroll enough participants to have meaningful results. Actual 71
NCT03816852 Suspended The Safety and Efficiency Study of Mesenchymal Stem Cell in Premature Ovarian Insufficiency Phase 2 Interventional Others Anticipated 12
NCT04058977 Withdrawn Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness Phase 1/Phase 2 Interventional Withdrawn prior to participant enrollment due to funding status Actual 0
NCT04088903 Withdrawn Study of Daratumumab for Decreasing Circulating Antibodies in Sensitized Patients Awaiting Heart Transplantation Phase 1 Interventional Protocol changed to use subcutaneous rather than intravenous daratumumab. Actual 0
NCT04163913 Withdrawn Radial Medical - GAPS N/A Interventional Insufficient funding Actual 0
NCT04250740 Suspended The Morning Coffee Study N/A Interventional Due to COVID-19 this research needed to pause in March 2020. We plan to start the study again when we have approval to do so. Anticipated 30
NCT04315155 Withdrawn Evaluating Safety & Efficacy Belinostat Combo w Nivo Alone & w Ipi in Patients w Treated Metastatic/Advanced Carcinomas w ARID1A Lof Mutation Phase 1 Interventional study abandoned for funding issues Actual 0
NCT04360876 Withdrawn Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot Randomized Clinical Trial Phase 2 Interventional Funding not received Actual 0
NCT04610879 Terminated Changing Agendas on Sleep, Treatment and Learning in Epilepsy Phase 4 Interventional Following the internal pilot, the study did not meet prespecified stop/go criteria for continuation. Actual 5
NCT04344288 Terminated Corticosteroids During Covid-19 Viral Pneumonia Related to SARS-Cov-2 Infection Phase 2 Interventional Competent Authority's decision Actual 11
NCT04602884 Suspended Early Detection of COVID-19 Using Breath Analysis N/A Interventional no additional parcipitants could be recruited at site. Actual 50
NCT02243397 Suspended Molecular and Cellular Analysis of Breast Cancer Observational Safety Anticipated 500
NCT03084861 Terminated A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Phase 1/Phase 2 Interventional Low recruitment. No safety issue associated. Actual 9
NCT03349476 Suspended Model Based Fast Anatomical Mapping N/A Interventional study to reopen with additional enrollment Anticipated 150
NCT03499353 Terminated Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer Phase 2 Interventional This study was terminated based on Pfizer's change in clinical development strategy not related to safety and efficacy. Actual 61
NCT03510208 Suspended Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery Phase 1/Phase 2 Interventional Regulatory Anticipated 23
NCT03630809 Suspended Immune Response and Potential Booster for Patients Who Have Received HER2-pulsed DC1 Phase 2 Interventional Suspended for protocol revisions Anticipated 40
NCT03861403 Terminated A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid Tumors Phase 1/Phase 2 Interventional Product development discontinued unrelated to safety. Actual 10
NCT04233814 Suspended Safety, Tolerability and Pharmacokinetic Study of LTI-03 in Healthy Adult Subjects Phase 1 Interventional pending clinical laboratory analyses Anticipated 56
NCT04371406 Withdrawn Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients Phase 3 Interventional Regulatory approvals have not been obtained Actual 0
NCT02610335 Terminated Evaluation of Spinal Mobility Reeducation in Patients Treated for a Lumbar Spinal Stenosis After Epidural Infiltration N/A Interventional The recruitment of participants was very difficult despite a change in the organisation. The inclusion criteria did not result in the expected number of participants, and the credits ran out. Actual 23
NCT02689739 Withdrawn Validation of Ultrasound in Predicting a Low Lying Placenta Throughout Pregnancy Observational Actual 0
NCT03526536 Terminated Pilot: Insulin Sensitivity/Management in Hyperglycemic Patients in Perioperative Period ESRD/Non-ESRD Phase 4 Interventional The study required more participants than anticipated for statistical significance. Actual 40
NCT03647995 Terminated Probiotics in the Prevention of Antibiotic Induced Diarrhea and Clostridium Difficile Associated Diarrhea. N/A Interventional Were not able to enroll enough participants due to shortage of study staff Actual 25
NCT03923010 Terminated A Study of Itraconazole in the Management of Superficial Fungal Infections in India Phase 4 Interventional Further recruitment not possible due to COVID 19 impact. Hence a decision to close study was taken at the antifungal CDT in Aug 2020. Actual 40
NCT03975192 Withdrawn Neurostimulation for Opiate Withdrawal in the PICU N/A Interventional There was no enrollment. Actual 0
NCT04100083 Withdrawn Spironolactone for Hidradenitis Suppurativa Phase 4 Interventional Lack of funding Actual 0
NCT04231864 Withdrawn Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic Epstein-Barr Virus Positive Nasopharyngeal Cancer Phase 2 Interventional Feasibility Actual 0
NCT01897714 Terminated Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients Phase 1/Phase 2 Interventional The study was terminated at median 46-48 months long term follow-up and mature overall survival follow-up data. Actual 75
NCT02595918 Terminated Nivolumab in Treating Patients With High-Risk Kidney Cancer Before Surgery Phase 1 Interventional Inadequate accrual rate Actual 19
NCT04034927 Suspended Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer Phase 2 Interventional Scheduled Interim Monitoring Anticipated 170
NCT04567589 Withdrawn A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization Measures Among Healthcare Professionals in Canada Observational This study was cancelled before any data collection due to business reasons. Actual 0
NCT01801878 Withdrawn Pilot Study of Skin Quality Improvement After Adipose-drived Stem Cell Transfer in Irradiated Breasts N/A Interventional Difficulty in recruiting research subjects Actual 0
NCT01898377 Terminated Imatinib Mesylate and Mycophenolate Mofetil for Steroid-Refractory Sclerotic/Fibrotic cGVHD in Children Phase 2 Interventional New treatment option introduced for patients with the study indication Actual 9
NCT02982499 Terminated Biomechanics of Optic Neuropathy Observational Principal investigator's decision due to lack of resources Actual 10
NCT03089567 Withdrawn Comparison of the Salivary Levels of Streptococcus Mutans in Pediatric Patients With Early Childhood Caries After the Application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish Early Phase 1 Interventional Study was not conducted. No participants were enrolled Actual 0
NCT03458910 Terminated Heart Rate Variability and Emotion Regulation N/A Interventional COVID-19 increased risk of participation Actual 193
NCT03735095 Suspended Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer Early Phase 1 Interventional Analysis of Data Anticipated 6
NCT03748173 Terminated Infasurf®(Calfactant) Aerosol for Infants With Bronchiolitis-AERO-04 Phase 1 Interventional slowdown due to covid Actual 13
NCT03796403 Terminated Bupivacaine Plus Diclofenac Versus Bupivacaine Alone for Postoperative Pain Relief in Gynecologic Cancer Patients N/A Interventional Diclofenac is no longer recommend for intramuscular administration by the Medical Council of Thailand Actual 140
NCT03846583 Withdrawn Tucatinib + Abemaciclib + Herceptin for HER2+ MBC Phase 1 Interventional Study halted prematurely, prior to enrollment of first participant. Actual 0
NCT03902977 Terminated Effect of Quilting Sutures on Post-operative Drainage After Mastectomy and/or Axillary Lymph Node Dissection N/A Interventional insufficient recruitment Actual 10
NCT04060888 Withdrawn A Study of Ustekinumab in Chinese Participants With Active Systemic Lupus Erythematosus Phase 3 Interventional Pre-planned IA (global study) showed lack of efficacy in this indication. No new safety signals observed, findings consistent with known profile. Actual 0
NCT04503538 Withdrawn Telemedicine for Early Detection of Cytokine Release Syndrome and Neurotoxicity N/A Interventional Principal investigator decided not to pursue trial Actual 0
NCT04567095 Withdrawn A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization Measures Among Patients in Canada Observational This study was cancelled before any data collection due to business reasons. Actual 0
NCT02218567 Terminated Behavioural Problems in Huntington Disease : Analysis and Enhancement of Caregiver and Patient Experience N/A Interventional inclusion difficult Actual 12
NCT02403518 Terminated Clinical Outcomes of the Freedom Spinal Cord Stimulation (SCS) System for the Management of Chronic Back and Leg Pain N/A Interventional Lack of recruitment Anticipated 45
NCT02503280 Withdrawn The Transendocardial Autologous Cells (hMSC) or (hMSC) and (hCSC) in Ischemic Heart Failure Trial. Phase 1/Phase 2 Interventional Study has never enrolled any subjects Actual 0
NCT02537964 Terminated Effectiveness of Chlorhexidine Bathing in the Neonatal Intensive Care Unit N/A Interventional funding not available Actual 24
NCT02699723 Withdrawn Arsenic Trioxide and Itraconazole in Treating Patients With Advanced Basal Cell Cancer Early Phase 1 Interventional Logistics Actual 0
NCT00796107 Terminated A Study of R1507 in Combination With Letrozole in Postmenopausal Women With Advanced Breast Cancer Phase 2 Interventional Due to the discontinuation of compound development, this study has been terminated. Actual 6
NCT03177252 Withdrawn Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients Phase 1 Interventional Investigator decided not to go forward with the trial. Actual 0
NCT03603080 Suspended Efficacy of Pharmacotherapy to Enhance Weight Loss Following Sleeve Gastrectomy Phase 4 Interventional Difficulty with enrollment and then Covid pandemic Anticipated 110
NCT03675113 Withdrawn Effect of Upper Extremity Aerobic Exercise Training on Exercise Capacity Patients With Chronic Heart Failure N/A Interventional This study was a doctorate thesis and student changed the subject of her thesis. Actual 0
NCT03768115 Withdrawn Autologous Plasma Treatment for Severe Dry Eye Patients Early Phase 1 Interventional The inclusion criteria for plasmapheresis is too stringent to get any potential subjects. Actual 0
NCT03944733 Withdrawn Iron Status, Maternal Depressive Symptoms, and Mother-child Interactions N/A Interventional The study was never started as a result of change of personnel and funding Actual 0
NCT04014400 Terminated Suprathel Versus Xeroform for the Management of Skin Graft Donor Sites N/A Interventional We observed that using the Suprathel dressing required additional treatment of the wound and had a longer healing time than the standard of care Xeroform dressing; it did not dry the wound out properly to promote healing. Actual 10
NCT04113083 Suspended An Observational Study for Evaluation of for the Prevalence of Cerebrotendinous Xanthomatosis (CTX) Disease Observational Due to COVID 19 Pandemic Actual 22
NCT04158596 Withdrawn Safety and Efficacy of SDX-3101 for the Treatment of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) N/A Interventional Covid-19 Actual 0
NCT04341987 Withdrawn Treating Nightmares Among Domiciliary Patients N/A Interventional Covid-related Actual 0
NCT04467151 Withdrawn Administration of Anti-SARS-CoV-2 Convalescent Plasma in Hospitalized, Non-ICU Patients With COVID-19 Phase 2 Interventional Did not obtain funding to proceed with study Actual 0
NCT03436420 Terminated Gemcabene for the Treatment of Pediatric NAFLD Phase 2 Interventional Terminated due to lack of efficacy and safety concerns. Actual 6
NCT02022735 Terminated Deep Brain Stimulation Effects on Gait and Balance in Patients With Parkinson's Disease N/A Interventional funding not secured Actual 11
NCT02175082 Terminated Cycling in Parkinson's Disease N/A Interventional Terminated prior to enrollment goals due to difficulty with recruiting subjects Actual 12
NCT02522975 Terminated Biosimilar Erythropoietin in Anaemia Treatment (Correction Phase Study) Phase 4 Interventional Actual 16
NCT02755194 Terminated "Drugs in Lactation" Analysis Consortium Observational This infrastructure project has been taken over by another study. Actual 68
NCT03052361 Terminated Triage Administration of Ondansetron for Gastroenteritis in Children Phase 2/Phase 3 Interventional The recruitment was much slower than expected and the COVID pandemic added new barriers to recruitment. Actual 81
NCT03373877 Terminated Evaluation of Ruxolitinib in Combination With PU-H71 for Treatment of Myelofibrosis Phase 1 Interventional Samus is focusing all of their efforts in myelofibrosis on the new oral formulation of PU-H71. Actual 4
NCT03443622 Withdrawn Phase I Study of SC-43 Oral Solution in Subjects With Refractory Solid Tumors Phase 1 Interventional Another study has been started in other country. Actual 0
NCT03557684 Suspended Leucine for Depression Study (L-DEP) Early Phase 1 Interventional COVID-19 Anticipated 90
NCT03597503 Terminated Treatment of Impulsive Aggression (IA) in Adolescent With ADHD in Conjunction With Standard ADHD Treatment Phase 3 Interventional Financial decision Actual 186
NCT03779555 Terminated Lenalidomide Adherence in Older Adults Observational Principal Investigator left the university Actual 17
NCT04133480 Withdrawn Investigation of Cognitive Outcomes With Cannabidiol Oral Solution Phase 4 Interventional The decision to withdraw the study was based on pandemic-related concerns of conducting a Phase IV study requiring multiple clinic visits when medication is commercially available. The study was withdrawn before any participants were recruited. Actual 0
NCT04227626 Withdrawn Inpatient Closed Loop Glucose Control With the Gen 2 GlucoSTAT N/A Interventional The study has not started, the device is not ready so the study will be delayed Actual 0
NCT04290962 Withdrawn Web-Based Lifestyle Intervention for the Improvement of Health in African American Cancer Survivors N/A Interventional no accrual Actual 0
NCT04434040 Suspended Ipatasertib + Atezolizumab to Prevent Recurrence in TNBC Phase 2 Interventional Study team plans to revise one of the agents used in the treatment plan of the study. Anticipated 40
NCT04153422 Suspended IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS or FGFR-3 Antibodies Phase 2 Interventional Recruitment not started at Loyola, PI leaving Loyola, PI may resume at next affiliating instituation. Anticipated 20
NCT03197025 Terminated Immunotherapy With E6 T Cell Receptor (TCR) T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions Phase 1 Interventional The study was closed due to investigator discretion based on the lack of perceived clinical activity observed in the study. Actual 1
NCT04600648 Withdrawn Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children N/A Interventional poor enrollment Actual 0
NCT04270461 Withdrawn NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors Phase 1 Interventional Study is withdrawn because of administrative reasons Actual 0
NCT02660528 Terminated Tocilizumab Augmentation in Treatment-Refractory Major Depressive Disorder Phase 2 Interventional Study staff change. Actual 3
NCT02750254 Terminated Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation Phase 1 Interventional Toxicity. Only enrolled patients in phase I portion of trial. Actual 5
NCT02859428 Terminated Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31 Observational Investigator left NIH Actual 51
NCT02885987 Withdrawn Use of Accessory Device AmplifEYE During Average Risk Screening Colonoscopy to Increase Adenoma Detection Rate N/A Interventional decided not to go ahead with study at this time Actual 0
NCT02919553 Withdrawn Modified Wet Suction Versus Capillary Techniques for EUS Guided Fine Needle Aspiration and Biopsy of Solid Lesions N/A Interventional decided not to proceed with study at this time Actual 0
NCT02930122 Terminated IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions Phase 2 Interventional Lack of funding Actual 6
NCT03327987 Withdrawn Early Flu Shots in SOT Observational The study was on hold and later withdrawn due to shortage of staff Actual 0
NCT03487731 Withdrawn Allogeneic Human Mesenchymal Stem Cell Injection in PAtieNts With FaceTogenic Back Pain Phase 1/Phase 2 Interventional PI decided to not proceed with study Actual 0
NCT03508427 Suspended Toi Même: a Mobile System for Measuring Bipolar Illness N/A Interventional Suspended since april 2020 as the application is temporarily unavailable Anticipated 93
NCT02703311 Terminated REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System N/A Interventional Edwards acquired Valtech Cardio Ltd in 2017 and opted to replace this study with NCT03600688.11 patients were enrolled in REPAIR and follow-up is complete. Actual 11
NCT03741062 Terminated Effects of Laser Stimulation on Wound Healing of Human Palatal Tissue N/A Interventional COVID-19 Actual 11
NCT00769002 Terminated PET-CT Scans in Healthy Volunteers After Flu Vaccination N/A Interventional Actual 18
NCT03376321 Terminated A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection Phase 3 Interventional Study terminated early (date of study termination decision: 28 August 2020) as a result of the outcome of the pre-planned Interim Analysis. Actual 334
NCT02010567 Terminated Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer Phase 1/Phase 2 Interventional The study was halted prematurely at the funding partner's request. Actual 32
NCT02452359 Terminated Clinical Evaluation of Using Intense Pulsed Light for Improving the Appearance of Striae Distensae N/A Interventional Continuing the trial was considered to be superfluous. Actual 54
NCT02452398 Terminated Clinical Evaluation of Hair Removal and Permanent Hair Reduction for Skin Types VI Using Intense Pulsed Light N/A Interventional Study withdrawn as technology already proven with data no longer needed. Actual 79
NCT03259425 Terminated Neoadjuvant Trial of Nivolumab in Combination With HF10 Oncolytic Viral Therapy in Resectable Stage IIIB, IIIC, IVM1a Melanoma Phase 2 Interventional DSMC Recommendation Actual 7
NCT03819504 Withdrawn Stereotactic Non-invasive Ablation of Ventricular Tachycardia N/A Interventional Change in the design of the study Actual 0
NCT04589897 Suspended Manuka Honey Sinus Rinse Study N/A Interventional Paused for Covid-19 Anticipated 40
NCT04591288 Terminated FES to Improve Gait in CP N/A Interventional Closed by the sponsor for not fully meeting subject recruitment targets. Actual 2
NCT01938716 Terminated Gemcitabine Pharmacokinetics After Preoperative Chemoradiation Therapy N/A Interventional Early termination due to low accrual Actual 12
NCT00759083 Withdrawn Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Phase 4 Interventional The study was discontinued early due to inadequate patient enrollment. No patients were enrolled. Actual 0
NCT01003795 Withdrawn Promus - Registry Experience at the Washington Hospital Center, Drug-eluting Stent (DES) Observational Not Funded Actual 0
NCT01806064 Terminated Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell Carcinoma Phase 1/Phase 2 Interventional The study did not meet endpoint. Actual 173
NCT02100735 Withdrawn Evaluation of an Analgosedation Protocol in Mechanically Ventilated Patients N/A Interventional Difficulty in with enrollment of patient Actual 0
NCT02354144 Terminated Lubricant Investigation in Men to Inhibit Transmission of HPV Infection Phase 2/Phase 3 Interventional Mandated by DSMB because of lack of protective effect of carrageenan, higher proportion of adverse events in the carrageenan compared to placebo arm, and low probability that continued accrual would lead to a significant protective effect. Actual 258
NCT02607124 Terminated A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy Phase 1/Phase 2 Interventional A competing trial was opened for patient population with combination of ribociclib and everolimus. Actual 11
NCT02642939 Terminated Study of Oral Mifepristone as Salvage Therapy in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Phase 2 Interventional Lack of enrollment Actual 3
NCT03008772 Withdrawn REWARDS- In-stent Restenosis Observational [Patient Registry] Not funded Actual 0
NCT03037645 Terminated Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers Phase 1/Phase 2 Interventional Phase 1b portion completed. Sponsor decided not to proceed with P2 portion of study. Vecabrutinib was very well tolerated, there was insufficient evidence of activity at the doses tested in the Phase 1b to advance to Phase 2. Actual 39
NCT03273257 Terminated Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Phase 2 Interventional The study was stopped due to slower than expected recruitment and the additional limitations on clinical research imposed by the COVID-19 pandemic, both of which made study completion within a reasonable timeframe appear unlikely. Actual 14
NCT03682055 Terminated Phase 1/2a Study of VK-2019 in Patients With Epstein-Barr Virus (EBV)-Positive Nasopharyngeal Carcinoma (NPC) Phase 1/Phase 2 Interventional Lack of efficacy Actual 14
NCT03800420 Terminated Efficacy and Safety of BBT-401-1S in Ulcerative Colitis Phase 2 Interventional to carry out the rest of the study with new CRO and modified protocol as a multi-regional study. Actual 16
NCT03945331 Terminated Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans With Motor Complete Paraplegia N/A Interventional COVID-19 disrupted interventions irrecoverably. Actual 2
NCT04106050 Withdrawn Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy Phase 1 Interventional Sponsor Decision Actual 0
NCT04323969 Terminated Gait Modification for Knee Osteoarthritis N/A Interventional COVID-related laboratory shutdown. Actual 3
NCT00927108 Withdrawn Rajavtihi Neuronal Adult Stem Cells Project Phase 2 Interventional Actual 0
NCT01130324 Withdrawn VIBATIV Pregnancy Registry Observational [Patient Registry] Released by he FDA from this Post-Marketing Commitment Actual 0
NCT02363647 Suspended Personalized Cancer Therapy for Patients With Metastatic Medullary Thyroid or Metastatic Colon Cancer N/A Interventional No Current Funding Actual 10
NCT02595996 Terminated Propranolol Dose Escalation in Lymphedema in Patients Phase 2 Interventional Lack of funding Actual 1
NCT02965508 Terminated Home-based Primary Care for Homebound Seniors N/A Interventional The Data Safety Monitoring Board determined that the serious adverse event rate was higher among patients awaiting enrollment in the home-based primary care intervention compared to those who had initiated home-based primary care. Actual 230
NCT03110588 Withdrawn Phase I Trial of PACE for Metastatic Prostate Cancer Phase 1 Interventional PI left the institution Actual 0
NCT03264092 Terminated Comparison of Three Tissue Acquiring Techniques During EUS Guided Biopsies of Solid Tumors. N/A Interventional Preliminary analysis of the results showed no statistically significant difference Actual 54
NCT03625336 Withdrawn MR Imaging of Prostatic Calcifications Observational study on hold for an undetermined time Actual 0
NCT03945227 Withdrawn Clinical Trial for Evaluating Efficacy and Safety of PDR001 in Concurrent Plus Consolidation Versus Consolidation Only in Addition to Standard Chemoradiotherapy in Unresectable Stage III NSCLC Patients (PASTURE) Phase 2 Interventional Due to the delay in the study shceduled, due to the start of competitive study and the approval of Durvalumab from the Ministry of Food and Drug Safety, it was judged that it was difficult to enroll subjects. Actual 0
NCT04426344 Withdrawn Core Warming of COVID-19 Patients N/A Interventional Internal decision Actual 0
NCT02064959 Terminated To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients N/A Interventional interim analysis revealed it was futile, we would not reach an answer at N=60. Actual 32
NCT03567694 Suspended Single and Multiple Doses of HA115 and Food Effect in Healthy Adult Volunteers Phase 1 Interventional Business decision Anticipated 120
NCT00004026 Terminated CT-2584 in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Previous Therapy Phase 2 Interventional Anticipated 80
NCT00551239 Withdrawn Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma Phase 3 Interventional Actual 0
NCT02425878 Terminated Ulipristal Acetate 10 mg and Asisted Reproduction Phase 3 Interventional Lack of availibility of eligible subjects Actual 2
NCT03203993 Terminated China Ovarian Cancer BRCA Testing Study Observational Failure to obtain HGR approval. Actual 29
NCT02876094 Terminated Effect of Low-Dose Celecoxib on SMN2 in Patients With Spinal Muscular Atrophy Phase 2 Interventional Terminated: Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention Actual 1
NCT02946346 Terminated Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women N/A Interventional Difficulty to continue follow-up during the coronavirus epidemic Actual 190
NCT03449160 Withdrawn Postural Training Device (UPRIGHT) for Back Pain N/A Interventional COVID 19 which is preventing outpatient and elective procedures Actual 0
NCT03484962 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Liver Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT01118715 Terminated Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial N/A Interventional Impractical to enroll the #s needed for statistical significance; project manager relocated Actual 128
NCT03501056 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Lung Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03509298 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Pancreatic Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03524261 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Breast Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03524274 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03540199 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Kidney Cancer Phase 2 Interventional No participant enrolled Actual 0
NCT03554395 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Gastric Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT04333628 Terminated Chloroquine for Mild Symptomatic and Asymptomatic COVID-19 Phase 2/Phase 3 Interventional Teminated due to changes in treatment guidelines . Actual 5
NCT03793686 Terminated A Study of Safety of PBCLN-003 Following Antibiotic Therapy in Subjects With C.Difficile-associated Diarrhea Phase 1 Interventional Unable to enroll subjects Actual 26
NCT03796416 Withdrawn Obesity Study to Assess Induction of Labor N/A Interventional in error Actual 0
NCT03871400 Suspended The NanoStrand Clinical Study N/A Interventional Study halted prematurely and will not resume; participants are no longer receiving intervention due to coronavirus pandemic and unexpected enrollment delays. Actual 18
NCT03963024 Terminated Treosulfan-TMI Conditioning and Rapamycin GvHD Prophylaxis Before Allo-HSCT Phase 1 Interventional low rate of enrolment Actual 9
NCT03973021 Withdrawn Very Small Embryonic-like Stem Cells for Erectile Dysfunction Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT03975101 Withdrawn Very Small Embryonic-like Stem Cells for Knee Osteoarthritis Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT03976206 Withdrawn Very Small Embryonic-like Stem Cells for Facial Skin Antiaging Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT03985462 Withdrawn Very Small Embryonic-like Stem Cells for Ovary Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT04058301 Suspended Text-Enabled Ascertainment and Community Linkage for Health N/A Interventional COVID-19 Anticipated 200
NCT04165668 Terminated Wellbeing and Stress Among Mobile Phone Dispatched Lay Responders Observational Due to the COVID-19 Pandemic. Actual 460
NCT04234581 Terminated The Effect of Lysulin on Glycemic Control and Advanced Glycation N/A Interventional Sponsor decision Actual 59
NCT04388189 Withdrawn Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion Phase 4 Interventional No participants enrolled Actual 0
NCT04388202 Withdrawn Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram Phase 4 Interventional No participants enrolled Actual 0
NCT04516603 Withdrawn Influence of Fampridine on Working Memory in Healthy Subjects Phase 2 Interventional Changement of study design. Restart spring 2021. Actual 0
NCT01601496 Terminated Evaluation of FUSION™ Vascular Graft for Above Knee Targets N/A Interventional Slow Enrollment Actual 117
NCT02547376 Terminated Genetic and Telomere Characteristics of High of Grade Soft Tissue Sarcomas Observational Covid-19 Actual 77
NCT02812849 Withdrawn Somatostatin Receptor Imaging in Cardiac Sarcoidosis Observational Logistic reasons Actual 0
NCT02687815 Terminated Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma) Phase 2 Interventional Futility of vitamin D supplementation based on protocol threshold: <30% conditional power to detect pre-specified effect- 16% reduction in severe exacerbations. Actual 192
NCT02843568 Suspended Improving Pulmonary Function Following Radiation Therapy N/A Interventional Administrative suspension at the request of the Director, Office of Industry Engagement Anticipated 120
NCT02941016 Withdrawn Vascular Inflammation and Cholesterol Lowering Therapy Phase 4 Interventional Logistic reasons Actual 0
NCT03259308 Terminated Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 279
NCT03342859 Terminated Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned Phase 1 Interventional Due to findings in the preclinical carcinogenicity studies for vilaprisan (BAY1002670) Actual 10
NCT03697954 Withdrawn Direct Full-stage Implantation of Sacral Neuromodulation Observational Work has already been published by other groups Actual 0
NCT04085978 Terminated Effects of a Hypoglycemia Protocol With Glucose Gel on Neonatal Intensive Care Unit (NICU) Admission Observational The standard of care had changed during our wait for the Program Letter of Agreement between Phoenix Children's Hospital and Banner to administering IV glucose in the newborn nursery so we weren't able to meet our objective. Actual 400
NCT04246411 Withdrawn Ultrasound vs. Auscultation for Optimal Depth of the Cuffless RAE Tube N/A Interventional It was confirmed that cuffed RAE tubes with small diameter could be used, so there was no reason to use RAE cuffless tubes. Actual 0
NCT04335071 Terminated Tocilizumab in the Treatment of Coronavirus Induced Disease (COVID-19) Phase 2 Interventional 1.) Not possible to recruit the planned number of patients during the planned study period; 2.) "Dexamethason" was included in the standard of care for the study population during the course of the study and inclusion criteria could no longer be met. Actual 5
NCT04462757 Suspended SCIL-1Ra in COVID-19 Feasibility & PK/PD Phase 2 Interventional Lack of patients in the trial population from which to recruit and lack of funding Actual 5
NCT03122470 Withdrawn Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer N/A Interventional PI departure - study not conducted. Actual 0
NCT04519424 Withdrawn CSL324 in COVID-19 Phase 2 Interventional Due to business reasons, not safety issues. Actual 0
NCT04592380 Withdrawn Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF Phase 3 Interventional Product was divested to Chiesi USA, who decided to not move forward with study. Actual 0
NCT02611128 Suspended Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia Observational temporarily closed to enrollment due to COVID Anticipated 65
NCT02701322 Terminated Influence of Medical Clowning in Videofluoroscopic Examination of Pediatric Speech Disorder N/A Interventional machine malfunction and updated work rutines Actual 10
NCT03604523 Terminated Esophageal Dysmotility - Prospective Study Evaluating Methods for Esophageal Dilation N/A Interventional Slow enrollment Actual 10
NCT03763175 Terminated Efficacy and Safety of SYN-010 in IBS-C Phase 2 Interventional Interim Futility Analysis Actual 59
NCT04585022 Terminated Whole Blood Metal Ion Concentrations in Metal-on-metal Total Hip Arthroplasty and Hip Resurfacing N/A Interventional High early failure rates and adverse reactions in similar devices Actual 75
NCT01863498 Terminated Prospective Trial: Pain Management After Pectus Excavatum Repair, Epidural Versus PCA N/A Interventional Institution converted to an alternative strategy for pain control Actual 65
NCT03515941 Terminated Postoperative Chemoradiation or Chemotherapy After Preoperative Chemotherapy for Gastric Cancers Early Phase 1 Interventional The PI has decided to close the study due to the outdated study design. Actual 6
NCT04128020 Withdrawn Azacitidine Plus Nivolumab Following Reduced-intensity Allogeneic PBSC Transplantation for Patients With AML and High-risk Myelodysplasia Phase 1 Interventional Funder withdrew funding after not accruing any subjects after 1 year. Actual 0
NCT04460105 Withdrawn Lanadelumab in Participants Hospitalized With COVID-19 Pneumonia Phase 1 Interventional Study was withdrawn due to challenges in site recruitment and lack of patient enrollment Actual 0
NCT00538681 Terminated Study for Participants With Advanced, Not Amenable to Surgery, or Metastatic Lung Cancer Comparing Treatment With Pemetrexed + Cisplatin + Enzastaurin Versus Pemetrexed + Cisplatin + Placebo Phase 2 Interventional Terminated due to lack of efficacy demonstrated in relevant participant population in other clinical trials. Actual 35
NCT02824211 Withdrawn Demonstrating the Feasibility of a Novel Oxygen Delivery Device N/A Interventional Was unable to obtain funding Actual 0
NCT02907918 Terminated Neoadjuvant Study of Palbociclib in Combination With Letrozole and Trastuzumab in Stage II-III ER+ HER2+ Breast Cancer Phase 2 Interventional Futility Actual 26
NCT03013127 Terminated A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surgery Phase 2 Interventional Inclusion of patients was stopped because ≤2 patients had clinical benefit. Actual 12
NCT03056508 Terminated Lifestyle, Exercise and Diet: The LEAD Study N/A Interventional Due to COVID-19, recruitment and enrollment was suspended and never resumed. COVID-related changes have been made to the clinical program which houses our intervention, and we could not compare new participants with our previous cohort. Actual 14
NCT03636373 Suspended Pilot Study Evaluating The Efficacy Of Etanercept In Acute Gout Phase 4 Interventional Temporarily paused due to COVID 19 and expected to resume Anticipated 40
NCT03886493 Terminated Neoadjuvant Dupilumab in Men With Localized High-Risk Prostate Cancer Phase 2 Interventional Low accrual due to COVID-19 pandemic. Actual 7
NCT03947203 Withdrawn Oral Health Promotion: Youth as Agents Of Change N/A Interventional Unable to staff the project Actual 0
NCT03992716 Terminated Reaching Protein Target With SmofKabiven® Extra Nitrogen vs Olimel N9E During the Early Phase of Acute Critical Illness Phase 4 Interventional Study had to be put on hold after the outbreak of Covid-19 in the participating countries and was terminated in September 2020 since a date for re-starting was not foreseeable. Actual 7
NCT04129320 Withdrawn Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and Neck Phase 2/Phase 3 Interventional Change in study design Actual 0
NCT04212065 Withdrawn Long Acting Subcutaneous vs Short Acting Sublingual Buprenorphine in Pregnant and Lactating Women Phase 4 Interventional closed due to new safety concerns of subcutaneous buprenorphine in pregnant patients Actual 0
NCT03891641 Terminated Momentum-enabled Treadling Methodology to Improve Gait and Enhance Mobility N/A Interventional COVID-19 continues to prevent recruitment of people over the age of 65 years. Actual 17
NCT02152670 Terminated Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET N/A Interventional Study drug became unaffordable for the purposes of the research. Actual 1
NCT04322773 Terminated Anti-il6 Treatment of Serious COVID-19 Disease With Threatening Respiratory Failure Phase 2 Interventional The study has been terminated due to changed clinical conditions and too few patients available Actual 20
NCT01244191 Terminated Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Phase 3 Interventional Sponsor decision due to the protocol-defined stopping boundary for futility was met based on the interim OS data. Actual 1048
NCT04581564 Suspended Rhythm-based Intervention in Aphasia Early Phase 1 Interventional Due to COVID-19 Anticipated 20
NCT02438371 Terminated Nifedipine or Nifedipine Plus Indomethacin for Treatment of Acute Preterm Labor Phase 4 Interventional Study halted due to slow recruitment Actual 37
NCT02285283 Terminated Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps Phase 2/Phase 3 Interventional Recruitment failure. Actual 58
NCT02455817 Withdrawn REWARDS-Angina at Follow up Post Stenting Observational Actual 0
NCT02630355 Terminated Remote Ischaemic Preconditioning to Prevent Dialysis Induced Cardiac Injury Phase 2 Interventional The study was terminated prematurely after ad-interim analysis for the primary outcome. Actual 32
NCT03547206 Terminated Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Phase 2 Interventional Terminated by Sponsor Actual 165
NCT03786380 Terminated Diabetic Gastroparesis Study 05 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 202
NCT03850535 Terminated A Study Evaluating the Safety and Efficacy of Idasanutlin in Combination With Cytarabine and Daunorubicin in Patients Newly Diagnosed With Acute Myeloid Leukemia (AML) and the Safety and Efficacy of Idasanutlin in the Maintenance of First AML Complete Remission Phase 1/Phase 2 Interventional Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2. Actual 24
NCT03947814 Terminated A Study of Orally Administered Pimodivir in Adult Participants With Renal Impairment Phase 1 Interventional Strategic decision to stop pimodivir phase 1 studies Actual 29
NCT04264533 Terminated Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia Phase 2 Interventional the study was started in the second half of the outbreak, and the number of qualifying COVID-19 patients decreased with the control of the epidemic so that we had to stop our trial before reaching the predefined sample size. Actual 56
NCT04089761 Terminated Safety and Efficacy of Nerivio™ for the Acute Treatment of Migraine in Adolescents N/A Interventional Due to the outbreak of the COVID-19 pandemic in the USA on March 2020, all study sites stopped enrolling patients to the study Actual 60
NCT04280068 Terminated Targeting Non-virally Suppressed Adults With Alcohol Use Disorder in HIV Primary Care N/A Interventional Due to COVID-19 recruitment and enrollment of participants was halted Actual 3
NCT04311112 Suspended Safety and Efficacy of Zuretinol Acetate in Subjects With Inherited Retinal Disease Phase 2/Phase 3 Interventional Company dissolved Anticipated 45
NCT03027401 Withdrawn Clinical Sequencing of Cancer and Tissue Repository: OncoGenomics Observational closed by PI and FDA Actual 0
NCT03788486 Withdrawn Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device N/A Interventional Covid Actual 0
NCT03827564 Terminated Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease N/A Interventional Study discontinued due to business reasons. Actual 14
NCT04007926 Suspended Mechanisms of Insulin Resistance and Exercise in South Asians N/A Interventional COVID-19 Anticipated 66
NCT04010682 Suspended Late Pregnancy Sample Collection Study Observational sufficient volunteer recruited for the moment. Study may be re-opened at a later date Anticipated 40
NCT04088266 Withdrawn An Open-Label, Single-Center Study to Evaluate the Exposure-Response Relationship Between the Plasma Drug Concentrations and the Change From Baseline in QTc at Steady State Following Once-daily Administration of CASSIPA® in Opioid Dependent Subjects. Phase 4 Interventional Study delayed indefinetly Actual 0
NCT04464460 Withdrawn A Study to Evaluate the Safety, Pharmacokinetics (PK), and Efficacy of TAK-671 for the Treatment of Coronavirus Disease (COVID) 2019 in Adults Phase 1 Interventional Business Decision (no enrollment) Actual 0
NCT00785135 Terminated Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria N/A Interventional Unable to recruit - multiple reasons.- inclusion/exclusion criteria too strict was th emain reason. Actual 13
NCT02036502 Terminated A Study of Pembrolizumab (MK-3475) in Combination With Standard of Care Treatments in Participants With Multiple Myeloma (MK-3475-023/KEYNOTE-023) Phase 1 Interventional Business Reasons Actual 77
NCT02720341 Terminated VIT-ARMin Virtual, Intensified and Patient-tailored Robotic Arm Therapy With the Exoskeleton Robot ARMin N/A Interventional Doctoral students on project defended their thesis. Actual 222
NCT02880904 Terminated Vulvar Scarring Grading Scale for Lichen Sclerosus Observational Investigator is no longer at Northwestern University Actual 30
NCT02881229 Terminated Vulvar Mucosal Specialty Clinic Chart Review Observational Investigator is no longer at Northwestern University Actual 719
NCT03315143 Terminated Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk Phase 3 Interventional study terminated prematurely for financial reasons and Covid-19 pandemic Actual 10584
NCT03389893 Terminated Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis Phase 4 Interventional Due to inability to meet accrual goals within the funding period. Actual 72
NCT03497117 Terminated 19F MRI of Ventilation in Subjects With Cystic Fibrosis Undergoing Treatment for Pulmonary Exacerbation Early Phase 1 Interventional Enrollment barriers made study completion impossible Actual 5
NCT03521934 Terminated Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial) Phase 3 Interventional study terminated prematurely for financial reasons and Covid-19 pandemic Actual 1222
NCT03837418 Withdrawn DESIGNING A PROGRAMMING LANGUAGE FOR PATIENT-ORIENTED PRESCRIPTIONS (POP-PL) Observational Investigator is no longer at Northwestern University. Actual 0
NCT03921476 Withdrawn Acne and Mood: Impact of Treatment on Depression, Anxiety, and Sexual Function Observational Investigator left Northwestern University Actual 0
NCT03955471 Suspended Study to Evaluate the Efficacy and Safety of the Combination of Niraparib and Dostarlimab (TSR-042) in Participants With Platinum Resistant Ovarian Cancer Phase 2 Interventional This study has temporarily held recruitment activities to perform a pre-planned interim analysis. Other elements of this study are still ongoing. Anticipated 150
NCT04386668 Terminated Let It Out (LIO) and COVID19: Testing an Online Emotional Disclosure-based Intervention During the COVID19 Pandemic N/A Interventional Interim analysis indicated adaptations to intervention may be required. Actual 80
NCT00152308 Terminated Non-Polymer-Based, Rapamycin-Eluting Stents to Prevent Restenosis Phase 4 Interventional Slow enrolement Anticipated 333
NCT01289340 Withdrawn Wound Healing and Pain Management in Partial Thickness Burns Observational Actual 0
NCT01742273 Terminated Vitamin K1 to Slow Progression of Vascular Calcification in HD Patients Phase 3 Interventional Termination stopped due to low recruitment rates Actual 63
NCT01974726 Terminated Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction N/A Interventional End of funding Actual 95
NCT02204202 Terminated PET Assessment of Acute Lung Transplant Rejection Observational PI left institution Actual 28
NCT02402803 Terminated Dried Blood Spot- Statin Pilot Study Observational No recruitment Actual 20
NCT03012737 Terminated Palliation of Dyspnea With Mouth Piece Ventilation N/A Interventional Difficulty in finding suitable patients. Actual 22
NCT03025425 Terminated Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD N/A Interventional Difficulty in finding suitable patients Actual 20
NCT03383146 Terminated A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 451
NCT03420781 Terminated A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 03 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 467
NCT03441334 Terminated rTMS Combined With BWSTT in Stroke With Body Weight Supported Treadmill Training (BWSTT) After Stroke N/A Interventional The enrollment was not achieved within proposed timeframe. Actual 1
NCT03499587 Terminated Effects of Maternal Obesity on Offspring Brain Development Observational study population limited Actual 13
NCT03511716 Terminated Observational Study of the Heart Repair Technologies Mitral Bridge in Treating Mitral Valve Regurgitation Observational Could not enroll enough patients and ran out of $$ to manufacture more devices Actual 34
NCT03518996 Withdrawn Non-Invasive Brain Stimulation and Delirium N/A Interventional EEG data collection instrument unavailable Actual 0
NCT03529916 Suspended Endothelial Cell Gene Networks of CVD Observational No eligible participants were recruited Anticipated 20
NCT03575494 Withdrawn Relationship Between Oral Health Status and Unexplained Female Infertility in Turkish Population Observational this study does not need to get a clinicaltrials number Actual 0
NCT03630081 Withdrawn Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Phase 3 Interventional Change in business strategy Actual 0
NCT02220855 Suspended A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas Phase 2 Interventional Not stated by Pharmaceutical Company Actual 14
NCT03802422 Withdrawn Vitamin B12 for Carpal Tunnel Syndrome N/A Interventional It is hard to enroll patients due to Covid-19 pandemic. Actual 0
NCT03883607 Terminated Elafibranor, PK and Safety in Children and Adolescents 8 to 17 Years of Age With Non Alcoholic Steatohepatitis (NASH) Phase 2 Interventional Continuation of the trial cannot serve a scientific purpose, no safety concerns identified Actual 10
NCT03963492 Suspended Intermittent vs Continuous Walking in People With Multiple Sclerosis N/A Interventional COVID-19 Pandemic Anticipated 24
NCT04060693 Withdrawn Device Accuracy of Non-invasive Glucose Measurements in Ethnic Skin N/A Interventional Miscommunication with the CRO that was hired to help with the regulatory submission process Actual 0
NCT04076345 Terminated Interest of the Presepsin Assay as a Biomarker of Bacterial Infection, in the Management of Newborns and Infants Under 3 Months of Age Admitted for Fever in Pediatric Emergency Service (Presepsin) Observational investigator not available Actual 31
NCT04111861 Suspended Singing for Chronic Pain, a New Intervention for the Management of Chronic Pain N/A Interventional COVID-19 - unable to bring patients for intervention due to C-19 restrictions at present Anticipated 24
NCT04146779 Terminated Yoga Intervention in Head and Neck Cancer Patients Undergoing Concurrent Chemo-Radiation N/A Interventional COVID-19 Actual 19
NCT04258020 Suspended Postextubation Management in Patients at Risk for Extubation Failure N/A Interventional Study is on hold due to significant impact of COVID pandemic Actual 3
NCT04304365 Withdrawn Home Follow-up After Medication Abortion N/A Interventional Unable to implement the study due to delays from COVID-19 policies which postponed the start. Actual 0
NCT00515528 Terminated Vaccination Plus Ontak in Patients With Metastatic Melanoma Phase 2 Interventional The immune monitoring data failed to demonstrate an improvement in any biologic endpoint with denileukin diftitox. Actual 17
NCT03452267 Withdrawn Insulin Signaling in Skeletal Muscle Phase 2/Phase 3 Interventional Lack of funding Actual 0
NCT03758352 Withdrawn The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient N/A Interventional Large sample size Actual 0
NCT04000191 Withdrawn Ice as an Adjunct for Local Anesthesia During Anorectal Surgeries N/A Interventional Study was neer started and PI left the institution. Actual 0
NCT04015219 Terminated Management of Signs and Symptoms Associated With Dry Eye Disease N/A Interventional enrollment constraints Actual 3
NCT04081584 Suspended Trans-abdominal Fetal Pulse Oximetry: Tissue Light Scattering Observational COVID-19 Anticipated 30
NCT04081623 Suspended Trans-abdominal Fetal Pulse Oximetry: Signal Integrity Observational COVID-19 Anticipated 50
NCT04254172 Terminated A Low Interventional Study to Monitor Activity Using Wearable Sensors in Duchenne Muscular Dystrophy Observational This low-interventional study (involving no study drug) has been terminated early due to the COVID-19 pandemic, and not for any safety or efficacy reasons. Actual 2
NCT04342156 Withdrawn Safety And Efficacy Of Hydroxychloroquine For At Risk Population (SHARP) Against COVID-19 Phase 3 Interventional The number of patients with COVID-19 in Singapore was coming down for the community and the concerns about the potential side effects particularly when the baseline ECG and serum electrolytes was not proposed. Actual 0
NCT04359277 Terminated A Randomized Trial of Anticoagulation Strategies in COVID-19 Phase 3 Interventional the PROTECT study is being transitioned to ACTIV4 ACUTE anticoagulation inpatient study Actual 77
NCT04447729 Withdrawn A Study to Test if Fremanezumab Reduces Pain in Patients With Interstitial Cystitis-Bladder Pain Syndrome Phase 2 Interventional Withdrawn due to logistic reasons Actual 0
NCT01673386 Terminated A Subject Treatment Preference Study of Tivozanib Versus Sunitinib in Subjects With Metastatic RCC Phase 2 Interventional Sponsor Actual 58
NCT03161470 Terminated Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) N/A Interventional Physicians/audiologists preferred to manage patients with BPPV immediately rather than enrolling in study except for difficult to treat cases. Actual 13
NCT03725358 Withdrawn A Cluster-RCT to Increase the Uptake of LARCs Among Adolescent Females and Young Women in Cameroon. N/A Interventional Problems with the Performance-Based Financing System in Cameroon, combined with the restrictions on movement brought on by the Covid-19 pandemic. Actual 0
NCT04067362 Terminated Chicory Fiber Effect on Satiety and GI Tolerance N/A Interventional COVID-19 Actual 30
NCT04113135 Withdrawn The Utilization of Yoga as a Therapeutic Tool to Promote Physical Activity Behavior Change and Improved Postural Control in Individuals With Multiple Sclerosis N/A Interventional Unable to complete initial data collection due to tornado and then COVID-19 has limited in person data collection/intervention. Actual 0
NCT02433067 Terminated Physical Activity Intervention on Myocardial Function in Patients With HER2 + Breast Cancer N/A Interventional Actual 89
NCT04583397 Suspended Effects of WiFi Exposure on Sleep in Women N/A Interventional Corona Anticipated 34
NCT01811693 Terminated Field Administration of Stroke Therapy-Blood Pressure Lowering Phase 2 Interventional The funding period for the study has ended. Actual 4
NCT00001978 Terminated Determination of Kidney Function Observational All analysis with identifiable specimens/data is complete or site has no identifiers linked to the specimens/data Actual 456
NCT00896610 Terminated Natural History of Autoimmune Diabetes and Its Complications Observational All analysis with identifiable specimens/data is complete or site has no identifiers linked to the specimens/data Actual 356
NCT01907594 Withdrawn Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers Phase 2 Interventional Ran out of funding Actual 0
NCT02232477 Terminated Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in MPS I N/A Interventional Termination of study by investigator related to COVID pandemic. Actual 6
NCT02431663 Terminated Ketamine in Refractory Convulsive Status Epilepticus Phase 3 Interventional Futility Actual 57
NCT02558205 Withdrawn Correlation Between CT Perfusion and Post Y-90 TARE PET/CT Dosimetry Observational unable to rectuir Actual 0
NCT04265690 Withdrawn A Multi-Component Nutrition Program for Pregnant and Parenting Teens N/A Interventional The study never launched due to several COVID-19 related barriers. Actual 0
NCT03101592 Terminated INTERVAL: Varying Intervals of ART to Improve Outcomes in HIV N/A Interventional Enrollment completed. Outcomes measured after only 1 yr due to loss of funding. Actual 9118
NCT02463669 Terminated The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department Observational COVID pandemic Actual 200
NCT02822963 Withdrawn Impact of Anticoagulants and Antiplatelets in Patients on Transurethral Resection of the Prostate Observational No funding Actual 0
NCT03107325 Withdrawn Biokinetics Study for F-18 FDG in Pediatric Molecular Imaging Phase 4 Interventional No subjects who met the study criteria agreed to participate in two years prior to the COVID-19 crisis. Actual 0
NCT02387164 Terminated Prevention Trial: Immune-tolerance With Alum-GAD (Diamyd) and Vitamin D3 to Children With Multiple Islet Autoantibodies Phase 2 Interventional The study was interrupted early and terminated when only 26 out of 80 patients were enrolled due to new clinical study results indicating that the current study would not be informative. Actual 26
NCT00017069 Terminated Arsenic Trioxide and Dexamethasone in Treating Patients With Recurrent or Refractory Stage II or Stage III Multiple Myeloma Phase 2 Interventional 0
NCT00020969 Terminated Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes Phase 2 Interventional 0
NCT00054184 Terminated Polyglutamate Paclitaxel Compared With Docetaxel in Treating Patients With Progressive Non-Small Cell Lung Cancer Phase 3 Interventional Anticipated 350
NCT00054197 Terminated Polyglutamate Paclitaxel Compared With Gemcitabine or Vinorelbine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer Phase 3 Interventional 0
NCT00054210 Terminated Polyglutamate Paclitaxel Plus Carboplatin Compared With Paclitaxel Plus Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer Phase 3 Interventional 0
NCT00551733 Terminated Carboplatin With Either Paclitaxel Poliglumex or Paclitaxel in Treating Women With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer Phase 3 Interventional Anticipated 450
NCT00576225 Terminated CT-2103/Carboplatin vs Paclitaxel/Carboplatin for NSCLC in Women With Estradiol > 25 pg/mL Phase 3 Interventional Actual 43
NCT03745352 Suspended Pevonedistat With Azacitidine Versus Azacitidine Alone in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Phase 2 Interventional Other - Pending amendment to change study design Anticipated 72
NCT04575558 Withdrawn HOPE: A Trial of Hydroxichloroquine Plus Azithromycin in High Risk COVID-19 Phase 2 Interventional Withdrawn due to lack of study centers interested in participating. Actual 0
NCT00017433 Terminated Arsenic Trioxide in Treating Patients With Multiple Myeloma Phase 2 Interventional 0
NCT01849081 Withdrawn Evaluating the Efficacy of CPAP Therapy for the Treatment of Fatty Liver N/A Interventional Change in priorities, study closed prior to enrollment Actual 0
NCT04579796 Suspended The Accuracy of Ultrasound in the Detection of Placenta Site in the First Trimester. N/A Interventional lack of funding Anticipated 25
NCT03004001 Terminated Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome N/A Interventional Difficult recruitment Actual 3
NCT03265951 Terminated Ramelteon for Complex Insomnia in Veterans With PTSD Phase 4 Interventional Lack of response Actual 1
NCT04057014 Withdrawn Immediate Versus Delayed Treatment of Odontogenic Infections Phase 4 Interventional No funding available for the activity Actual 0
NCT01987596 Terminated Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Phase 3 Interventional Actual 23
NCT04293900 Withdrawn Diet, Physical Activity and Body Composition Changes During R-CHOP Observational Study never started due to COVID pandemic and lack of study funding. Actual 0
NCT04325893 Terminated Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease Phase 3 Interventional decrease in number of eligible patients Actual 259
NCT04349449 Withdrawn ENTYVIO in Bio-naive Patients With Moderate/Severe Crohn's Disease (CD) in Daily Practice Observational Business Decision (no enrollment) Actual 0
NCT04561817 Withdrawn To Evaluate the Safety and Efficacy of Ipatasertib (GDC-0068) in Combination With Paclitaxel in Platinum-resistant Recurrent Epithelial Ovarian Cancer Phase 2 Interventional Evolving data with Ipatasertib that changes the known risk / benefit background in pursuing future studies. Actual 0
NCT01636999 Withdrawn Comparing Sedara to Butorphanol in Early Labor N/A Interventional Actual 0
NCT02095210 Terminated HER2 PET Imaging in Breast Cancer Patients Using [68GA]ABY-025 Phase 1 Interventional slow recruitment Actual 2
NCT02137265 Withdrawn Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism N/A Interventional No funding obtained Actual 0
NCT02557945 Suspended Gabapentin in Patients at Clinical Risk for Psychosis Phase 1/Phase 2 Interventional This study is temporarily suspended due to COVID-19 Anticipated 48
NCT02758288 Withdrawn BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach Observational Actual 0
NCT02933073 Suspended Study of Oncoimmunome for the Treatment of Stage III/IV Ovarian Carcinoma Phase 1 Interventional Study recruitment is temporary on hold by the sponsor due to patient recruitment challenges and the ongoing review of the investigational adjuvant. Anticipated 15
NCT02975986 Withdrawn Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN) N/A Interventional Actual 0
NCT03234465 Terminated Efficacy, Safety and Tolerability of AG013 in Oral Mucositis Compared to Placebo When Administered Three Times Per Day Phase 2 Interventional No efficacy could be demonstrated, sponsor decided to prematurely end the study. Actual 200
NCT03286075 Terminated Impact of tDCS on Emotional Processing in Healthy Subjects. N/A Interventional The department in charge of this research is no longer able to follow this project. Only two inclusions this study is close Actual 2
NCT03656835 Suspended Nanochip Technology in Monitoring Treatment Response and Detecting Relapse in Participants With Diffuse Large B-Cell Lymphoma N/A Interventional Internal review to increase accruals Anticipated 40
NCT03744663 Suspended Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films Phase 2 Interventional Study team not ready to start enrolling and unsure of when this may happen. Anticipated 30
NCT03806023 Terminated EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals N/A Interventional Funding expired due to grant for new project (NCT03851302) Actual 8
NCT04113291 Withdrawn Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure N/A Interventional Insufficient funding Actual 0
NCT04206865 Withdrawn Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output Phase 4 Interventional New study initiated Actual 0
NCT04401631 Withdrawn Analytical Validation of the abioSCOPE Device With an IgE Test Panel: Point-of-Care Precision, Sample Type Comparison and Method Correlation Observational Sponsor financial has been stopped Actual 0
NCT04442932 Withdrawn abioSCOPE IgE Assay to Aid in the Diagnosis of Allergies Observational Sponsor financial has been stopped. Actual 0
NCT03219866 Terminated Nebulizer Versus Dry Powdered Inhalers for COPD Phase 4 Interventional Lower enrollment than Sponsor expected - Sponsor stopped study Actual 40
NCT03285308 Terminated A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis 01 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 336
NCT03369184 Terminated Elective Percutaneous Coronary Intervention With or Without Supplemental OXYgen Phase 3 Interventional Slow recruitment Actual 65
NCT03421678 Withdrawn Ethnic/Racial Differences in Metabolism and DNA Adduct Formation Observational Study was completed at other sites Actual 0
NCT03426345 Terminated Study to Evaluate the Safety and Efficacy of Relamorelin in Patients With Diabetic Gastroparesis Study 02 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision Actual 311
NCT03741803 Suspended Relationship Between Delayed Cord Clamping at Birth and Neonatal Bilirubin Levels in Parturients With a Prior Child Requiring Therapy for Neonatal Jaundice N/A Interventional Study paused due to COVID-19 Anticipated 100
NCT03801889 Withdrawn SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare Anemias Phase 2 Interventional Protocol suspended prior to patient enrollment Actual 0
NCT03984604 Terminated Investigation of the Efficacy and Safety of CHI-921 in Insomnia. Phase 2 Interventional COVID-19 Actual 21
NCT04048746 Terminated Evaluation of the Written Information Delivered by the General Practitioner of the Patients Presenting to the Emergency Room for an Aggravation of Asthma Observational The PI decided to stop. Actual 10
NCT04171648 Terminated Effect of Dry Roasted Peanuts and Boiled Peanuts on Glycemic Control N/A Interventional Covid-19 Pandemic halted my study due to exposure risks. Actual 24
NCT04201743 Withdrawn An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2mL Injection) in the Treatment of Osteoarthritis of the Knee Phase 4 Interventional Resources limited secondary to COVID-19 pandemic. Actual 0
NCT04379375 Terminated Nudges to Improve Health Behaviors That Limit COVID-19 Spread N/A Interventional Slow enrollment rate Actual 45
NCT02715765 Terminated The Use of Transcranial Electrical Stimulation for Hallucinations N/A Interventional PI left university, the grant could not be transferred, no data was collected Actual 3
NCT02416193 Terminated Can Vitamin D3 Improve Cognitive Function in Individuals With Type 2 Diabetes? (THINK-D) Phase 2 Interventional the study was halted prematurely due to slow recruitment and expiration of funding Actual 56
NCT01052896 Withdrawn Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition Phase 3 Interventional Unable to recruit subjects - unworkable Actual 0
NCT00969956 Suspended Time To Complications Occurs in Diabetes Observational Local regulations Anticipated 950
NCT00991315 Terminated Collecting and Storing Blood and Tumor Tissue Samples From Patients Undergoing Prostatectomy or Transurethral Resection of the Prostate Observational Specimens are now collected through the BRS protocol. Actual 126
NCT03189030 Terminated Study of Personalized Immunotherapy in Adults With Metastatic Colorectal Cancer Phase 1 Interventional Study terminated due to business realignment Actual 28
NCT03333694 Terminated Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis) Phase 1 Interventional The study fully enrolled and completed after last patient completed the study Actual 40
NCT03428763 Withdrawn ELECTOR Treat-to-target Via Home-based Disease Activity Monitoring of Patients With Rheumatoid Arthritis N/A Interventional Technical problems with POC Actual 0
NCT04230291 Terminated Hidradenitis Suppurativa Written Action Plan N/A Interventional Principal investigator is not longer at this institution Actual 8
NCT02240706 Terminated Phase I/II Trial to Investigate BI 836858 in Myelodysplastic Syndromes Phase 2 Interventional Actual 25
NCT02505087 Terminated Pharmacological Treatment of a Rare Genetic Disease: N-acetylcysteine in Myopathy Associated Selenoprotein N-related Myopathy (SEPN1-RM) Phase 2/Phase 3 Interventional Actual 7
NCT04574427 Suspended INtra-operative Evaluation of a Novel FLUorescENt C-mEt Tracer in Penile and Tongue Observational Tracer not available. Anticipated 20
NCT01803334 Terminated Impact of Marking Surgical Incision on Patient's Abdomen N/A Interventional Not enough participants could be enrolled and so the PI decided to close the study. No participants completed the study Actual 4
NCT02476955 Terminated Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole Phase 1 Interventional Actual 41
NCT02808806 Terminated A Reduction in Time With Electronic Monitoring In Stroke N/A Interventional technical difficulties Actual 80
NCT03277612 Terminated Effects of C-section Delivery on Infant Brain Development Observational Study halted prematurely and will not resume; participants are no longer being examined Actual 9
NCT03699904 Terminated Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial Phase 2 Interventional In light of the evolving Covid19 pandemic ongoing study recruitment was felt to pose an unacceptable risk to patient safety. Actual 85
NCT03838835 Terminated Equine Facilitated CBT Group Therapy for Youth Anxiety N/A Interventional COVID-19 Actual 59
NCT03981250 Suspended Effect of One Minute of Resistance Exercise Per Day on Muscular Strength (The ONE Study) N/A Interventional Covid-19 Anticipated 56
NCT04085393 Withdrawn Granisetron Extended Release Injection (GERSC) for the Prevention of Chemotherapy-induced Nausea and Vomiting Phase 2 Interventional sponsor withdrew study Actual 0
NCT04118374 Suspended A Pilot Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes N/A Interventional research-related activities have been impacted by the COVID-19 outbreak (participant recruitment/enrollment/on-site subject visits) Anticipated 10
NCT04379492 Withdrawn A Study of Hydroxycholoroquine Compared to Placebo as Treatment for People With COVID-19 Phase 2 Interventional Emerging evidence does not support the use of HCQ for treatment or prevention of SARS -CoV2 infection. No pts have been enrolled. Actual 0
NCT00843531 Terminated RAD001 and Erlotinib in Patients With Neuroendocrine Tumors Phase 2 Interventional Low Accrual Actual 17
NCT04019067 Withdrawn Magnetically Controlled Capsule Endoscopy First vs. Standard Algorithm in Patients With Melena N/A Interventional few patients met all the inclusion criteria Actual 0
NCT00213720 Terminated Treatment of Subclinical Hyperthyroidism Observational recruitment difficulties Actual 145
NCT01675154 Terminated Phase 2 Study of Orlistat and SLx-4090 for the Treatment of Type 1 Hyperlipoproteinemia Phase 2 Interventional Due to unavailability of the drug. Actual 5
NCT02283905 Terminated Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Phase 4 Interventional Poor enrollment numbers of patients Actual 2
NCT02764164 Terminated Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS) N/A Interventional Lack of funding Actual 1
NCT03843476 Withdrawn Personalized Spine Study Group Registry Observational [Patient Registry] Requested by surgeons to pursue new study Actual 0
NCT03953625 Suspended Interest of the Return to Primary Care of the "Low Back Pain Booklet" of Health Insurance in the Recovery of Common Acute Low Back Pain N/A Interventional The PI decided. Anticipated 100
NCT04130282 Terminated VAC077: Safety and Immunogenicity of the Pfs25-IMX313/Matrix-M Vaccine Phase 1 Interventional Delays caused by Covid-19 Actual 1
NCT04348890 Withdrawn Proof of Concept Trial of Vamorolone in Pediatric Ulcerative Colitis Phase 1/Phase 2 Interventional Programmatic decision Actual 0
NCT04365582 Suspended OUTpatient Treatment of COVID-19 in Patients With Risk Factor for Poor Outcome Phase 3 Interventional The PI decided. Anticipated 640
NCT04480879 Suspended Evaluation of AZD8154 Concentrations in Blood Phase 1 Interventional Need for evaluation of emerging pre-clinical toxicology findings Anticipated 15
NCT04571814 Suspended Targeting the ERN Computerized Intervention Targeting the Error-related Negativity in Young Children N/A Interventional COVID-19 Anticipated 175
NCT01831596 Terminated Evaluation of a Novel Post-Surgical Dressing N/A Interventional The study was terminated by Spiracur. Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 59
NCT03839277 Suspended Adenoma Detection Rate Using Endocuff Vision in China N/A Interventional One investigator is out-of-service due to carrying out another task. Anticipated 1200
NCT03888534 Withdrawn Intravenous Ixazomib in Pediatric Participants With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy) Phase 1 Interventional Business decision (no safety or efficacy concerns) Actual 0
NCT04042623 Terminated Study of Safety and Efficacy of AVB-S6-500 in Patients With IgA Nephropathy Phase 2 Interventional Business reasons Actual 1
NCT04233359 Terminated A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer. N/A Interventional To few patients recruited to allow for study completion within ph.d. project. Actual 4
NCT04275128 Terminated Cooled Versus Conventional Genicular Radiofrequency Ablation for Chronic Knee Pain Observational Insurance companies no longer cover this procedure Actual 1
NCT04358081 Terminated Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease Phase 3 Interventional low enrollment Actual 20
NCT04537143 Withdrawn Image Biomarkers for Progression of AMD Observational Funding for staff no longer available Actual 0
NCT04569214 Withdrawn The Efficacy and Safety of PAZ320 on PPG and Insulin Blood Levels in Type II Diabetic Patients Phase 2 Interventional Actual 0
NCT03925428 Withdrawn Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas Phase 1 Interventional Other - Protocol moved to Disapproved Actual 0
NCT04116359 Withdrawn Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma Phase 1/Phase 2 Interventional Other - Protocol moved to Disapproved Actual 0
NCT01930175 Terminated Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Phase 2 Interventional The study recruitment was terminated in Dec-2015 for strategic reasons related to the development of the compound. Actual 13
NCT02300961 Suspended Feasibility Neurocognitive Outcome After Transplant N/A Interventional Covid-19 Anticipated 35
NCT02563015 Terminated Can Correction of Low Vitamin D Status in Infancy Program for a Leaner Body Composition? N/A Interventional Covid19 pandemic prevented continuation of study visits Actual 132
NCT02858466 Terminated Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity N/A Interventional failure to recruit Actual 68
NCT02858479 Terminated Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic N/A Interventional failure to recruit Actual 41
NCT03151772 Terminated Bioavailability of Disulfiram and Metformin in Glioblastomas Early Phase 1 Interventional Problems with including patients Actual 3
NCT03435042 Suspended A Hypnosis-based Group Intervention to Improve Quality of Life in Children With Cancer and Their Parents. N/A Interventional Recruitment and organisational difficulties Anticipated 30
NCT00536939 Terminated Trial of Paclitaxel, Bevacizumab, and Enzastaurin Versus Paclitaxel, Bevacizumab and Placebo for Breast Cancer Phase 2 Interventional Study has been terminated due to slow enrollment Actual 2
NCT04563728 Suspended Use Surveillance Technology to Reduce Elder Abuse Recidivism N/A Interventional Covid-19 Anticipated 10
NCT03292835 Suspended Complex Cutaneous Leishmaniasis Healing Study in Algeria Observational [Patient Registry] Political Issues in Algeria and now Covod-19 lock-down Anticipated 100
NCT03391856 Terminated Prolonged Isolated Thrombocytopenia After Allo-SCT : N-acetyl-L-cysteine (NAC) Versus Supportive Therapy Phase 2/Phase 3 Interventional protocol changed Actual 15
NCT03698747 Terminated Myelin Imaging in Concussed High School Football Players Observational PI left organization Actual 13
NCT04153071 Withdrawn Unipolar Microplasma Radiofrequency Device: In-vivo Histologic Study N/A Interventional Per Investigator and sponsor decision Actual 0
NCT04236037 Terminated Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura N/A Interventional It is unrealistic to succeed with sufficient inclusion within the timeframe of the study, why it is terminated. Actual 5
NCT02331095 Terminated Statin Use in Patients With Acute VTE Early Phase 1 Interventional Low recruitment Actual 21
NCT04343690 Withdrawn COPING With COVID-19( CWC-19) N/A Interventional Study Ended May 1, 2020 with no enrollment Actual 0
NCT03409341 Withdrawn Personalizing Immune Checkpoint Inhibitor Therapy Observational No enrollment Actual 0
NCT03673566 Withdrawn Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - CHMCO N/A Interventional Business pivot caused termination of study before enrollment. Actual 0
NCT03673579 Withdrawn Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - MHSB N/A Interventional Business pivot caused termination of study before enrollment. Actual 0
NCT03791541 Withdrawn A Study Evaluating the Use of Potential Predictors of Readmission in Hospitalized Medicine Patients N/A Interventional Pilot study results not meaningful. Students researchers graduated. Actual 0
NCT04039568 Suspended Meditation Versus Education for Improving Depression in Chronic Pain, a Randomized Controlled Trial N/A Interventional COVID-19 Pandemic. Update in-process. Anticipated 160
NCT04202471 Withdrawn Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries N/A Interventional COVID-19 pandemic Actual 0
NCT03486002 Terminated EFFEXTS OF THE CLEANSWEEP SUCTION CATHETER N/A Interventional Access to the devices was halted by the sponsor Actual 8
NCT03626623 Terminated Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care N/A Interventional Sponsor Discretion Actual 15
NCT03712930 Terminated Treatment of Metastatic Castration-Resistant Prostate Cancer With Homologous Recombination Deficiency Phase 2 Interventional Sponsor's decision to revisit the development approach for prostate cancer. Actual 13
NCT03793712 Terminated Study With Lu AF11167 for the Treatment of Negative Symptoms in Patients With Schizophrenia Phase 2 Interventional Lack of efficacy based on interim analysis Actual 168
NCT03929497 Terminated Flexible-dose Long-term Extension Study of Lu AF11167 in Patients With Schizophrenia With Prominent Negative Symptoms Phase 2 Interventional Lack of efficacy based on the interim analysis in the 17972A study Actual 96
NCT03932656 Suspended Latent Toxoplasmosis in Females With Borderline Personality Disorder Observational Funding issues Anticipated 100
NCT04018508 Suspended Massage Therapy for Self-efficacy in LVAD Recipients N/A Interventional COVID19 pandemic closed in-person clinics temporarily Anticipated 74
NCT04293978 Suspended Virtual Reality Relaxation for Addiction Inpatients N/A Interventional Recruitment and intervention provision paused due to COVID-19 situation. Planned to resume. Anticipated 40
NCT02285179 Suspended Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside Tamoxifen Phase 1/Phase 2 Interventional Inclusion stopped due to COVID-19 Anticipated 290
NCT03689985 Terminated Functionality and Accuracy of the smART System in Real-Life ICU Settings N/A Interventional Due to the company's intent to conduct a new study under a different protocol with the smART+ System which is a more advanced version of the smART System Actual 2
NCT04044950 Withdrawn A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer Phase 2 Interventional The study was closed due to investigator discretion based on the lack of ability to recruit patients and research goals of the program. Actual 0
NCT04428918 Withdrawn Biospecimen Procurement for Immunological Landscape Studies Following Hematopoietic Cell Transplantation Observational The study was closed due to investigator discretion based on the lack of ability to recruit patients and research goals of the program. Actual 0
NCT01663766 Terminated Phase I Study of Milatuzumab for Graft Versus Host Disease Phase 1 Interventional PIs agreed no safety signals were shown, drug did not appear to lessen the risk of preventing GVHD no further patients would be enrolled Actual 12
NCT02161679 Withdrawn Phase II Study of IMMU-132 Alone or in Combination With Carboplatin in Patients With Triple-Negative Breast Cancer Phase 2 Interventional FDA asked to administratively split from IND115621- to open a new IND you need to file a protocol we only drafted it to get the IND open - never initiated Actual 0
NCT02548494 Terminated Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes N/A Interventional Project terminated due to insufficient resources for recruitment. Actual 17
NCT02826655 Terminated Adaptive Optics for Ophthalmic Technologies N/A Interventional lack of funding Actual 4
NCT02267772 Terminated IV Acetaminophen vs IV Morphine for Pain Control in Pregnant Women N/A Interventional Difficulties in recruitment Actual 163
NCT03121079 Withdrawn Interferon-α Prevents Leukemia Relapse of AML Patients After Transplantation N/A Interventional there was almost no patient would enroll in this study. Actual 0
NCT03304184 Suspended The Role of Biodentine in Class V Dental Lesions on Oral Health Related Quality of Life Phase 3 Interventional COVID Anticipated 40
NCT03379558 Terminated Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study Observational (due to change in the post-marketing requirement to assess alirocumab during pregnancy) Actual 37
NCT03362021 Terminated Comparison of Two Different Sedation Protocols During Transvaginal Oocyte Retrieval Observational Primary investigator transferred in another hospital; ongoing pandemic; Actual 80
NCT03171051 Terminated LED Device for Non-Invasive Lipolysis N/A Interventional device development placed on hold Actual 10
NCT03615508 Terminated Exploration of Pupil Dilation in Horner's Patients Taking Flomax Phase 4 Interventional incomplete enrollment Actual 1
NCT03726996 Terminated Desipramine in Infantile Neuroaxonal Dystrophy (INAD). Phase 4 Interventional Funding exhausted Actual 4
NCT03742973 Terminated A Study of Baricitinib (LY3009104) in Participants With Primary Biliary Cholangitis Who do Not Respond or Cannot Take UDCA Phase 2 Interventional Study was terminated due to enrollment futility. Actual 2
NCT03867708 Withdrawn Outcomes of Transcatheter ASD Closure Guided by 3D-TEE Observational No participants found Actual 0
NCT03960242 Suspended Evaluation of Clinical Progression in Patients With Motor Predominant Parkinson Disease. Observational Temporary halt of the trial due to COVID-19 crisis related delays Anticipated 30
NCT01007136 Terminated Transcranial Direct Current Stimulation (tDCS)-Enhanced Stroke Recovery N/A Interventional Funding limit reached due to slower then anticipated recruitment. Actual 62
NCT02301000 Terminated IMT for Primary Clostridium Difficile Infection Phase 2/Phase 3 Interventional Slow recruitment in pilot phase. A follow-up trial is launched (NCT03796650). Actual 21
NCT03021252 Terminated Respiratory Muscle Training in Stroke Swallowing Disorders N/A Interventional Because of the SARS-COV2 pandemic. Recruitment stopped at 48 patients Actual 50
NCT01239160 Terminated Two Pneumatic Compression Devices in the Treatment of Lower Extremity Lymphedema N/A Interventional Futility and underpowering of endpoint data Actual 238
NCT03059407 Suspended Impact of Therapy Dog Presence on Pediatric Echocardiogram N/A Interventional Due to COVID-19, the study has been put on hold. Anticipated 160
NCT03332355 Suspended Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 Phase 1 Interventional Business Reasons Anticipated 9
NCT03721796 Terminated Cancer Treatment Decision-making in the HIV Population: an Observational Study of Physician-patient Interactions Observational study design changed due to COVID-19 Actual 14
NCT03896334 Suspended Effect of Isometric Handgrip Training on Ambulatory Blood Pressure in Patients With Hypertension N/A Interventional The study is suspended because of the COVID-19 pandemic Anticipated 250
NCT04421664 Terminated Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada) Phase 3 Interventional Request of Health Canada after publication of https://doi.org/10.7326/M20-4207 Actual 70
NCT03447730 Terminated Safety, Tolerability and Pharmacodynamics of SYNB1020 Phase 1/Phase 2 Interventional Interim futility analyses identified a lack of SYNB1020 efficacy. Actual 23
NCT00894751 Terminated Two Anesthetic Techniques in Magnetic Resonance Imaging (MRI) Phase 1 Interventional low enrollment and high participant withdraw Actual 98
NCT01658852 Withdrawn Effects and Safety of Metronidazole in Patients With Gastrectomy Phase 3 Interventional Because of difficulties on recruiting participants Actual 0
NCT02920190 Withdrawn Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat Phase 4 Interventional Lack of funds to cover the costs of the study medications Actual 0
NCT04145193 Withdrawn Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC Phase 2 Interventional Study withdrawn prior to enrollment due to changing standard of care landscape. Actual 0
NCT02488278 Withdrawn GLUCOME USABILITY STUDY N/A Interventional Actual 0
NCT03384238 Suspended Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery Phase 1/Phase 2 Interventional Interim Analysis Anticipated 27
NCT03517696 Withdrawn Membrane Sweeping in Early Labor and Delivery Outcomes N/A Interventional Study IRB approval expired Actual 0
NCT03551535 Withdrawn Monitored Home Exercise in Pregnancy N/A Interventional Study IRB approval expired Actual 0
NCT03704285 Suspended Development of pk/pd Model of Propofol in Patients With Severe Burns Observational Outbreak COVID 19 Anticipated 30
NCT03705338 Suspended Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol Observational Outbreak COVID 19 Anticipated 20
NCT03855683 Suspended Stress, Anxiety, and Mood Group Therapy N/A Interventional Social distancing regulations related to COVID19. Anticipated 50
NCT04220476 Withdrawn CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer Phase 2 Interventional Initiating a new study with revised Statistics. Actual 0
NCT02844855 Terminated Memory for Action in Neurological Patients N/A Interventional failure to recruit 83/99 Actual 83
NCT03224975 Terminated Acute Pain Memory Among Former Burned: Exploration of fMRI. N/A Interventional failure to recruit Actual 24
NCT03604991 Suspended Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery Phase 2/Phase 3 Interventional Scheduled Interim Monitoring Anticipated 278
NCT00226746 Withdrawn Efficacy Study of Gemcitabine, Paclitaxel, and Irradiation in the Treatment of Pancreatic Cancer Phase 2 Interventional Actual 0
NCT04558892 Terminated Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome. Phase 2/Phase 3 Interventional The primary objectives were achieved. Actual 65
NCT02033278 Terminated Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure. Phase 2 Interventional Low recruitment rate, bibliographic evidence of lack of efficacy Actual 27
NCT02395237 Withdrawn COMPOUND (INN): HOE490O - GLIMEPIRIDE / METFORMIN HCl (Amaryl® M)0 (Glimepiride/Metformin Hydrochloride Immediate Release Combination Tablet) in Fed Conditions in Healthy Male and/or Female Subjects. Phase 1 Interventional Actual 0
NCT02972281 Terminated Systematic Search for Primary Immunodeficiency in Adults With Infections N/A Interventional deficient inclusions Actual 120
NCT03311568 Terminated Microcirculatory Alterations in Critical Disease: New Ultrasound Technology N/A Interventional Researcher has quit. Question still unanswered. A related study (observational, not to be registered) has started recently. Actual 30
NCT03559517 Terminated Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305) Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 30
NCT03860753 Terminated Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot) Phase 1/Phase 2 Interventional Halted enrollment due to COVID-19 Actual 4
NCT04532554 Withdrawn Growth Hormone in Obese Cases With Covid-19 Phase 4 Interventional No participants enrolled Actual 0
NCT02153684 Suspended Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform Observational Temporarily suspended due to COVID-19 Anticipated 120
NCT02925364 Terminated Functional and Anatomical MRI of the Spinal Cord and Peri-spinal Tissues Observational Slow recruitment Actual 30
NCT02952573 Terminated Testing JNJ-42756493 In Combination With Dexamethasone in Multiple Myeloma That Came Back After a Period of Improvement Phase 2 Interventional Low patient accrual Actual 20
NCT03017287 Terminated Safety and Efficacy of the GlucoMe APP in Patients With Uncontrolled Diabetes Treated With MDI N/A Interventional Actual 40
NCT03018756 Suspended Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea Phase 3 Interventional Temporarily suspended due to COVID-19 Actual 21
NCT03357692 Withdrawn All-on-Four Implants With Ultrasonic N/A Interventional no enough patients have been enrolled Actual 0
NCT03405090 Suspended Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators Phase 4 Interventional Temporarily suspended due to COVID-19 Anticipated 17
NCT03767829 Terminated A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease Phase 1/Phase 2 Interventional The sponsor decided not to proceed with Part B for business reasons. Actual 32
NCT03769961 Terminated Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect Observational Low enrollment Actual 6
NCT03786367 Suspended Dyspnea in Chronic Thromboembolic Pulmonary Hypertension Observational Temporarily suspended due to COVID-19 Anticipated 20
NCT03790774 Terminated Neurofeedback in Alzheimer's Disease N/A Interventional Due to COVID-19 concerns and restrictions in our at-risk population, interactions were halted. Actual 5
NCT03824535 Suspended 18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules Phase 2 Interventional Suspended Due to Covid-19 Anticipated 50
NCT03957096 Terminated A Safety Study of SGN-CD47M in Patients With Solid Tumors Phase 1 Interventional Sponsor decision based on portfolio prioritization Actual 16
NCT04077385 Withdrawn Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity N/A Interventional PI resigned from faculty position and K23 award was terminated early Actual 0
NCT04098016 Suspended Healthy Roots Digital Intervention N/A Interventional Aim 1 enrollment and study activities have been completed. Aim 2 start date is now anticipated for 01/11/2021. Anticipated 50
NCT04239222 Suspended Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot N/A Interventional Study suspended due to COVID 19 Anticipated 24
NCT04558580 Withdrawn Safety Study of Rufinamide Given as an add-on Therapy to Treat Patients With Seizures Phase 3 Interventional Actual 0
NCT02817113 Terminated Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer Phase 1 Interventional Strategy change Actual 4
NCT02923232 Terminated Ocular Adaptation and Visual Performance for Accommodative Contact Lens N/A Interventional Funding organization requested to stop the study Actual 32
NCT03567356 Suspended Treatment of Opioid Use: Medication Adherence Therapy N/A Interventional IRB temporarily suspended study due to COVID-19 Anticipated 50
NCT03858621 Suspended Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl N/A Interventional COVID 19 outbreak Anticipated 100
NCT04008602 Suspended Effectiveness of Quick Icing (QI) Technique on Strenght of Jump. N/A Interventional COVID-19 Anticipated 150
NCT04243031 Withdrawn QuantiFERON Access Clinical Performance Study Protocol Observational Business Decision Actual 0
NCT04306783 Withdrawn In-Home Sensor Monitoring of Older Adults With Cancer N/A Interventional Investigator is leaving the university Actual 0
NCT04360512 Terminated Dose-response of Talus Mobilizations N/A Interventional Suspended due to the covid-19 pandemic. Actual 42
NCT02787902 Suspended Weight Management in Mothers and Adult Daughters N/A Interventional Trial suspended due to COVID-19. Anticipated 168
NCT03212963 Terminated Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05% Phase 4 Interventional Sponsor's Decision Actual 16
NCT03045705 Withdrawn Evaluation of the Effect the Medical Team in the Delivery Room Has on Pain Management During Labor. N/A Interventional Problem with patient recruitment Actual 0
NCT03046654 Terminated Cervical Cerclage Position Throughout the Pregnancy. N/A Interventional Difficulty in patient recruitment Actual 7
NCT03930290 Terminated Physiologic Elasticity Changes During Pregnancy and After Labor. Observational Difficulty in patient recruiting Actual 12
NCT00751101 Terminated Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer Phase 2 Interventional Low Accrual Actual 24
NCT02522273 Withdrawn Evaluation of the 'SensPoint' Lactate Meter in the Estimation of Foetal Scalp Blood and Umbilical Cord Blood Lactate Observational Actual 0
NCT04274452 Withdrawn A Study to Assess the Efficacy and Safety of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP) Phase 3 Interventional The ARGX-113-1908 study will be replaced by a similar design with a subcutaneous formulation (ARGX-113-2004) Actual 0
NCT04548622 Terminated Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Results N/A Interventional Dr. Ralph Hoffman unexpectedly passed away. Actual 15
NCT02648932 Terminated The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients Phase 2 Interventional Poor accrual Actual 9
NCT02822196 Withdrawn Serratus Anterior Muscle Plane Block vsThoracic Paravertebral Block For Unilateral Mastectomies Phase 4 Interventional Critical study personnel left the institution Actual 0
NCT02936206 Terminated Examination of Breast Cancer Cells of Pre-menopausal and Post-menopausal Women Before and After Exposure to Tamoxifen or Fulvestrant. Phase 1 Interventional low accrual rate Actual 4
NCT03348826 Withdrawn Study of Sodium Bicarbonate in Restoring Blocked Catheters Phase 2 Interventional No participants were enrolled Actual 0
NCT03566823 Terminated Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 306) Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 34
NCT04098887 Withdrawn Lattice Stereotactic Body Radiation Therapy (Lattice SBRT) for Localized Unresectable or Metastatic Conventional Type Chondrosarcoma N/A Interventional Investigator decided to not go forward with the study. Actual 0
NCT04256655 Withdrawn Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of CDX 6114 in PKU Patients Phase 1 Interventional study product composition to move from liquid to solid Actual 0
NCT04401527 Withdrawn Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite Phase 2 Interventional No recruitment Actual 0
NCT03760250 Suspended Imiquimod for Preventing Keloid Recurrence Phase 2 Interventional Investigator decision Actual 5
NCT01495247 Terminated Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer Phase 1/Phase 2 Interventional Study did not meet Phase Ib primary objective to establish the maximum tolerated dose/recommended dose for Phase II Actual 18
NCT02027012 Terminated Treatment of Resistant Hypertension by Renal Denervation in China N/A Interventional company strategic change Actual 1
NCT02252094 Terminated Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS N/A Interventional Device no longer available in Singapore Actual 8
NCT03179605 Terminated Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Phase 2 Interventional Difficulty in enrollment Actual 22
NCT03192995 Terminated Treatment With Lorcaserin for Cocaine Use: The TLC Study Phase 2 Interventional FDA alert regarding study drug safety Actual 22
NCT03328741 Suspended Evaluation of a Web-based Platform for Osteoarthritis Treatment N/A Interventional COVID-19 Anticipated 270
NCT03438760 Terminated Improving STEM Outcomes for Young Children With Language Learning Disabilities N/A Interventional with 2/3 of the data collected, we had to terminate the study because of COVID19. Actual 36
NCT03537716 Withdrawn Fat Reduction Induced by Magnetic Device - Ultrasonographic Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03545633 Withdrawn Changes in Abdominal Tissues Induced by Magnetic Device - MRI Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03545646 Withdrawn Changes in Abdominal Tissues Induced by Magnetic Device - CT Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03547934 Withdrawn Fat Reduction Induced by Magnetic Device - Waist Circumference Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03728855 Terminated Effects of Self-administration of Medication During Hospitalization on Medication Safety, Adherence, and Patient Satisfaction in Dutch Hospitals N/A Interventional Difficult recruitment, despite several interventions. Actual 193
NCT04008459 Terminated Walking and Balance Related to Sagittal Spinal Posture Alignment Observational Recruitment no longer viable as spinal classes were stopped due to the COVID-19 situation. Actual 41
NCT04044326 Withdrawn The Safety and Efficacy of Spherical Microwave Ablation for the Treatment of Malignant Liver Tumors N/A Interventional Machine cannot provide Actual 0
NCT04062383 Suspended Positive Emotions After Acute Coronary Events at Northwestern University N/A Interventional In-person recruitment suspended due to COVID Anticipated 10
NCT04361916 Terminated Home Care for Patients With COVID-19: Active Monitoring in Two Italian Health Units (Casale Monferrato and Torino) N/A Interventional interrupted early due to the drastic reduction in the number of cases Actual 37
NCT04394286 Suspended A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects Phase 1/Phase 2 Interventional Reevaluation of development strategy Anticipated 21
NCT04402580 Terminated Efficacy of Anti-CD20 Antibodies (Rituximab Biosimilar) in the Treatment of Childhood Steroid-dependent Nephrotic Syndrome Phase 2 Interventional due to unexpectedly high rate of relapse in the active comparator arm. Actual 30
NCT04440488 Withdrawn ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study Phase 4 Interventional Reevaluation of development strategy Actual 0
NCT02253992 Terminated An Investigational Immuno-therapy Study to Determine the Safety of Urelumab Given in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkin's Lymphoma Phase 1/Phase 2 Interventional Actual 232
NCT03342326 Terminated Lexical Priming by Music in Alzheimer's Disease and Healthy Aging N/A Interventional failure to recruit Actual 58
NCT03399227 Withdrawn Liver Transplantation: Skeletal Effects Observational no funding Actual 0
NCT03560232 Terminated Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Phase 4 Interventional Unable to recruit patients in a timely fashion and unable to recruit sufficient patients Actual 17
NCT03624777 Suspended Efficacy of the Stroll Safe Outdoor Fall Prevention Program N/A Interventional Currently on hold due to COVID-19 restrictions in community program sites Anticipated 105
NCT03730064 Suspended Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression Early Phase 1 Interventional Due to COVID-19 pandemic Anticipated 3
NCT03808935 Terminated Cannabis Extract in Refractory Epilepsy Study Phase 3 Interventional Participants are no longer being examined or receiving intervention. Actual 17
NCT03811951 Terminated Neuro Biomarkers of Smoking Behavior Phase 2 Interventional Different study initiation Actual 4
NCT03908203 Withdrawn Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction N/A Interventional The Study will be conducted in another research center. The Sponsor has changed. Actual 0
NCT03919214 Suspended Hypertension Management in Cancer Patients N/A Interventional Suspended due to Covid-19 Anticipated 40
NCT03959852 Terminated Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain Phase 4 Interventional Residency completed. Actual 6
NCT04054687 Suspended Intranasal TXA for Anterior Epistaxis in the Emergency Department Phase 2 Interventional Due to coronavirus pandemic Anticipated 86
NCT04137809 Withdrawn TREAT Foot Drop After Stroke With Ankle Robot N/A Interventional Study withdrawn due to logistical and safety concerns relating to Covid-19. Actual 0
NCT04141917 Suspended Test-and-treat for Influenza in Homeless Shelters Phase 4 Interventional Enrollments on hold until fall flu season. Anticipated 3200
NCT04269317 Suspended Clinical Study to Evaluate the Safety and Effectiveness of the Treatment With Tixel C on Acne Scars N/A Interventional Corona Virus delayed opening Anticipated 44
NCT04408846 Withdrawn Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis N/A Interventional The Study will be conducted in another research center. The Sponsor has changed. Actual 0
NCT02664077 Terminated A Study Evaluating Regorafenib Following Completion of Standard Chemotherapy for Patients With Colon Cancer Phase 3 Interventional Due to the significantly lower than expected accrual it was impossible to evaluate the endpoint in a timely fashion. Actual 34
NCT04091594 Suspended Investigating the Effects of Sensory Input Orthotics in Disorders of Posture and Movement N/A Interventional PI seeking alternative funding for the study Anticipated 50
NCT02353780 Terminated Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept Phase 4 Interventional Low enrollment Actual 10
NCT01030471 Withdrawn Supporting Treatment Adherence Needs in Diabetes N/A Interventional Actual 0
NCT01703338 Terminated Clinical and Biomechanics Research in Core Muscles After Lumbar Fusion Surgery Observational Actual 100
NCT02499627 Terminated Bendamustine Plus Brentuximab Vedotin in HL and CD30+ PTCL in First Salvage Setting Phase 2 Interventional expected accrual not reached Actual 43
NCT02932319 Terminated Outpatient Foley Catheter for Induction of Labor in Nulliparous for Prolonged Pregnancy N/A Interventional Deficient Inclusions Actual 43
NCT02949661 Withdrawn Local Wound Infiltration for Tracheal Reconstruction N/A Interventional Loss of interest in the subject Actual 0
NCT03718455 Terminated Evaluation of Magseed as Localization Device for Biopsy Proven Metastatic Axillary Lymph Nodes N/A Interventional Limited operating room availability Actual 1
NCT01948297 Terminated Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations Phase 1 Interventional Actual 77
NCT02336373 Terminated Treatment of Hemoglobin SC Disease With Hydroxyurea Phase 2 Interventional low enrollment Actual 32
NCT04204109 Terminated Interprofessional Versus Monoprofessional Case-based Learning in Childhood Cancer N/A Interventional Covid 19 and subsequent cancellation of all meeting activity Actual 49
NCT00592306 Withdrawn Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation Phase 3 Interventional lack of enrollment Actual 0
NCT02113280 Withdrawn DEMAND - DEgenerative Meniscal Tears - Arthroscopy vs. Dedicated Exercise N/A Interventional Failed funding application. Actual 0
NCT03306693 Terminated Educational Intervention to Increase the Emotional Competence of Patients With Oesogastric and Bronchopulmonary Cancers N/A Interventional insufficient inclusions Actual 23
NCT03580798 Terminated Ridge Preservation Comparing Simultaneous vs. Delayed Grafting N/A Interventional Not enough patients available Actual 7
NCT03607708 Suspended Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety N/A Interventional COVID-19 Anticipated 30
NCT03612167 Suspended Constructing A Model of Health Promotion and Active Aging for Community-Dwelling Older Adults N/A Interventional no funding Anticipated 150
NCT03721315 Terminated Health Literacy Activation RCT Among the COPD Patients and Designated Support Dyad N/A Interventional SARS-CoV2 pandemic Actual 6
NCT03778606 Suspended Oligosaccharide for Cdiff(+) Heme-onc Patients N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 12
NCT03950648 Withdrawn Spatial Cognitive Training for Chronic Vestibular Disorders N/A Interventional COVID-19 Actual 0
NCT03956251 Suspended Ridge Preservation With Putty Allografts N/A Interventional COVID Anticipated 30
NCT03979066 Terminated Study Evaluating NEOadjuvant Immunotherapy in Resectable PANCreatic Ductal Adenocarcinoma Phase 2 Interventional Loss of funding Actual 1
NCT03988842 Suspended Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism Phase 4 Interventional COVID-19 pandemic Actual 4
NCT04155268 Withdrawn Flotation-REST for Chronic Pain, Stress, and Sleep N/A Interventional Unable to conduct the study due to Covid-19. Actual 0
NCT04162964 Suspended Chair Yoga for Stress in Dementia N/A Interventional COVID-19 Anticipated 40
NCT02790996 Terminated Neonatal Vancomycin Trial Phase 2 Interventional Planned interim analysis yielded different event rate affecting sample size and ability to recruit sufficient numbers within remaining trial time frame Actual 242
NCT03088735 Terminated Transfer Strategy in an Oocyte Donation Programme N/A Interventional Due to the clinically and statistically significant inferior results for the D3 group following evaluation by the institutional review board. Actual 134
NCT02591394 Terminated STEPs to Blood Pressure Reduction. N/A Interventional Funding period ended and slow enrollment Actual 115
NCT02928887 Suspended Light Therapy in Cardiopulmonary Bypass Surgery N/A Interventional Cardiac surgeon collaborator has left the institution Anticipated 30
NCT02711059 Withdrawn Insulin Resistance in Primary Hyperparathyroidism N/A Interventional studien skjuts på framtiden Actual 0
NCT03357133 Terminated Tirofiban for Patients Treated With Alteplase Phase 2/Phase 3 Interventional The number and speed of enrollment were significantly less than expected. Actual 30
NCT04148300 Suspended The Impact of Oral Health Literacy on Dental Anxiety and Utilization of Oral Health Services Observational Due to COVID-19 and lock-down of the university Actual 550
NCT04546802 Withdrawn HepATocellular Cancer Hcv Therapy Study Phase 3 Interventional Recruitment will be too difficult due to available PBS funded treatment and recent Australian clinical guidelines will conflict with the premise of the study. Actual 0
NCT03073850 Terminated Antithrombotic Treatment in Patients With Effectively Maintained Sinus Rhythm After Atrial Fibrillation Ablation Phase 4 Interventional Majority of enrolled patients have withdrawn. Actual 48
NCT03204149 Terminated Evaluation of Safety of Low Level Laser Device Treatment in Chronic Wounds N/A Interventional Project termination Actual 5
NCT03377751 Terminated Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation? N/A Interventional Majority of enrolled patients have withdrawn. Actual 20
NCT03983070 Suspended The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size. N/A Interventional Covid-19. No in-person study procedures are currently allowable by the overseeing IRB. Anticipated 30
NCT00891917 Withdrawn Liq-NOL Efficacy in Pediatric Patients With Down Syndrome Phase 2 Interventional no funding Actual 0
NCT02434874 Withdrawn Sacral Nerve Stimulation to Treat Urgency Urinary Incontinence With Wireless Neuromodulation N/A Interventional Study will no longer take place. Actual 0
NCT03151408 Terminated An Efficacy and Safety Study Of Pracinostat In Combination With Azacitidine In Adults With Acute Myeloid Leukemia Phase 3 Interventional The IDMC recommended to stop the study prematurely due to a lack of efficacy. Actual 406
NCT03203837 Terminated Biomarker Analyses in Hepatocellular Carcinoma (HCC) Patients Treated With TheraSphere® Observational Funding Discontinued due to low accrual rate Actual 4
NCT03506139 Withdrawn Biologically-based Target Volumes to Treat Newly Diagnosed Glioblastoma Phase 2 Interventional Not funded Actual 0
NCT03742180 Withdrawn Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy N/A Interventional Unavailable drug in Egypt. Actual 0
NCT03896451 Withdrawn Comparison Between Two Total Knee Prosthesis Medacta GMK Sphere and Medacta GMK PS N/A Interventional Medacta GMK PS is not in use anymore Actual 0
NCT04097496 Terminated Effects of ACT OUT! Social Issue Theater on Youth and Adolescents N/A Interventional COVID-19 pandemic and related school policies. Actual 1537
NCT04122183 Suspended Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening N/A Interventional Subject contact has been suspended until it is safe to screen hearing and participants feel safe seeing clinicians. Anticipated 40
NCT03213665 Suspended Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Phase 2 Interventional Scheduled Interim Monitoring Anticipated 49
NCT04136561 Withdrawn Novel Strategy to Encourage Early Removal of Central Venous Catheters N/A Interventional No participants enrolled. Unable to enroll Actual 0
NCT02943447 Terminated Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis Phase 2 Interventional The study was terminated because of the availability of alternate therapies for primary biliary cholangitis (PBC). Actual 71
NCT00894361 Terminated Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs Phase 4 Interventional PI/study coordinator retired due to personal family health matters; study sponsor withdrew funding. Study terminated and no data collected or analyzed Actual 400
NCT00979147 Terminated Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty N/A Interventional PI/study coordinator retired due to personal family health matters; study sponsor withdrew funding. Study terminated and no data collected or analyzed Actual 400
NCT01113658 Withdrawn Clinical Evaluation of the SNaP Wound Care System N/A Interventional The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01349894 Withdrawn SNaP Wound Care System Over Skin Cancer Excision Sites and Split Thickness Skin Grafts (STSGs) Observational The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01417208 Withdrawn Clinical Evaluation of the SNaP Wound Care System in Promoting Healing in Chronic Wounds Observational The study was terminated by Spiraur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01623882 Withdrawn Clinical Evaluation of the Combined Use of Apligraf® and the SNaP® Pressure Wound Therapy System Observational The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT02051764 Terminated Imaging Characteristics of a Follow-up 18F-AV-1451 Scan Phase 2 Interventional Lower than expected enrollment Actual 44
NCT02192359 Suspended Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas Phase 1 Interventional Drug not available. Anticipated 53
NCT03088930 Withdrawn Evaluating Crizotinib in the Neoadjuvant Setting in Patients With Non-small Cell Lung Cancer Phase 2 Interventional Low Accrual Actual 0
NCT03120793 Terminated ARDS Esophageal Balloon Pressure Changes With Positioning Study Observational Failure to recruit/enroll Actual 2
NCT03133897 Terminated Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study Phase 3 Interventional it was felt by the sponsoring institution that the current standard of oversight expected by the Health Canada regulations, would not be possible to achieve Actual 20
NCT02772809 Terminated Usability Testing of Affordable Haptic Robots for Stroke Therapy N/A Interventional The robot was no longer available to the study. Actual 23
NCT03615924 Terminated Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease Phase 3 Interventional Recommendation from an independent data monitoring committee (DMC) and accepted by AstraZeneca. Actual 193
NCT03657095 Terminated A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension Phase 3 Interventional The pivotal study, BPS-314d-MR-PAH-302 (NCT01908699), failed to demonstrate efficacy. Actual 112
NCT03711786 Suspended The Sub-Saharan Africa Regional Partnership for Mental Health Capacity Building N/A Interventional COVID-19 - pause in in-person enrollment; follow-up by phone continuing Anticipated 1160
NCT03750656 Terminated Use of Hyoscyamine Versus Tamsulosin for Management of Ureteral Stent Irritation Phase 4 Interventional Not accruing patients quickly enough Actual 6
NCT03862027 Terminated Evaluating Safety of Transpulmonary Pressure Guided PEEP Management in Neurocritical Care Patients N/A Interventional Failure to enroll/recruit Actual 2
NCT03985215 Withdrawn The Value of Follow-Up After Childhood Acute Lymphoblastic Leukaemia in Denmark - Family Perspectives Observational Overlapping with another danish questionnaire study Actual 0
NCT04013763 Terminated Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care N/A Interventional 1. Limit number of patients during COVID-19 situation 2. Too small number of wheat allergic patients who are using wheat containing soap Actual 7
NCT04048057 Suspended The Effect of Different Exercise Programs in Coronary Artery Patients: A Randomized Controlled Study N/A Interventional Because of Covid-19 pandemia, The cardiac rehabilitation unit in the hospital conducting the study has been closed for a while. Anticipated 60
NCT04058145 Withdrawn AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma Phase 2 Interventional Funding Withdrawn Actual 0
NCT04073407 Terminated Study of the Safety and Tolerability of AXA1957 in Adolescent Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD) N/A Interventional Sponsor has determined that information it would have collected would not inform future development of a therapy with AXA 1957 for NAFLD Actual 9
NCT04106843 Withdrawn Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or Unresectable Rare Endocrine Cancers Phase 2 Interventional No Participants Registered Actual 0
NCT03423537 Terminated Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART Phase 3 Interventional Inability for further recruitment, change of position of the principal investigator, COVID-19 pandemic Actual 80
NCT03535584 Suspended Exercise to Treat Frailty and Decreased Physical Function in Transplant Candidates N/A Interventional Due to Covid19 pandemic at this time we are on pause Anticipated 50
NCT03636048 Terminated Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) N/A Interventional not enough participants Actual 20
NCT03691038 Terminated Comparison of Conventional Dose Regimen and New Dose Regimen of Pregabalin N/A Interventional Participants couldn't be enrolled due to complain of frequent visit. Actual 10
NCT03768726 Terminated Extension Study Evaluating The Safety And Tolerability Of Flexible Doses Of Oral Ziprasidone In Children And Adolescents With Bipolar I Disorder Phase 3 Interventional Pfizer has decided to perform the pre-specified final analysis at the current enrollment using a re-estimation of the sample size. Actual 23
NCT04084574 Suspended Diet and Hypertension Management in African Americans With Chronic Kidney Disease N/A Interventional Aim 1 enrollment and study activities have been completed. Aim 2 anticipated start date is 3/2021. Anticipated 50
NCT04175717 Terminated Feasibility of a Physiotherapy-led Follow-up Programme in Adult Critical Illness Survivors N/A Interventional Due to COVID pandemic Actual 3
NCT04249713 Withdrawn An Alternative Dose Interval Study in Participants With Hidradenitis Suppurativa Receiving Brodalumab Early Phase 1 Interventional Biomarker Samples Not Collected Actual 0
NCT04249947 Suspended P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Phase 1 Interventional FDA Clinical Hold Anticipated 40
NCT04254666 Suspended New Skills - No Scores Research Study N/A Interventional The COVID-19 pandemic required that we discontinue the study. Anticipated 30
NCT04377165 Terminated Innovative Tool to Limit Spread of SARS-CoV-2 in Residential Aged Care Facilities N/A Interventional Engagement issues, poor recruitment to study Actual 34
NCT04392128 Withdrawn Study Evaluating the Efficacy of Hydroxychloroquine and Azithromycine in Patients With COVID-19 and Hematological Malignancies (HYACINTHE) Phase 2 Interventional competent authority decision Actual 0
NCT04541719 Withdrawn Patient Controlled Remifentanil Analgesia for Normal Labour Phase 2 Interventional no participants enrolled Actual 0
NCT03008616 Terminated Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia Phase 2/Phase 3 Interventional Following a recommendation from the Data and Safety Monitoring Board (DSMB), the study was stopped early for futility. There were no safety concerns raised. Actual 59
NCT03473665 Terminated Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis Phase 4 Interventional Slow recruitment Actual 9
NCT01571791 Suspended Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Phase 2 Interventional No enough recruited cases Anticipated 90
NCT01718756 Suspended Continuous Lornoxicam Infusion for Orthopaedic Surgery Phase 1/Phase 2 Interventional No enough fund or cases Anticipated 96
NCT01861561 Terminated Low-dose VS High-dose IV Cyclophosphamide for Proliferative LN in Children Phase 4 Interventional The duration of the study is longer than 5 years and we can not recruit the participants to the target number. Actual 43
NCT01937884 Terminated Supplemental Parenteral Nutrition in Pediatric Respiratory Failure Phase 2 Interventional Unable to enroll patients Actual 18
NCT01945229 Terminated Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE) Observational Preliminary analyses of data indicated study should be terminated for futility Actual 110
NCT02420652 Terminated Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy Phase 2 Interventional Slow accrual Actual 27
NCT02432378 Suspended Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines Phase 1/Phase 2 Interventional Anticipated 25
NCT02607488 Suspended Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Bariatric Surgery Phase 1/Phase 2 Interventional No fund no enough recruiting centers Anticipated 180
NCT01799889 Terminated Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies Phase 2 Interventional Sponsor's decision to discontinue development of entospletinib. Actual 326
NCT03523091 Terminated OnabotulinumtoxinA Bladder Injection Study Phase 4 Interventional Lack of enrollment Actual 1
NCT02757976 Terminated Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial N/A Interventional Consensus RAFT-LVendo Steering Committee to terminate. Actual 8
NCT03909867 Suspended Emission Patterns of Respiratory Syncytial Virus Observational The emergence of SARS-CoV-2 required a temporary hold of recruitment Anticipated 29
NCT03015051 Terminated High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Phase 4 Interventional Difficulty in recruiting subjects who meet the inclusion/exclusion criteria Actual 30
NCT03106597 Terminated Manidipine Versus Amlodipine in Patients With Hypertension Phase 4 Interventional Difficulty in enrolling subjects Actual 46
NCT03221166 Terminated Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors Phase 3 Interventional Difficulty in recruiting subjects who meet the inclusion/exclusion criteria Actual 9
NCT04097093 Withdrawn Long-term Surival of GIST Patients ≥ 10 Years on Imatinib Observational [Patient Registry] Lack of feasibility Actual 0
NCT02219334 Terminated Comparing Nasal Suction Devices in Children With Bronchiolitis: A Pilot Study N/A Interventional The study was stopped due to low enrollment. Actual 55
NCT02429934 Terminated Abatacept for SLE Arthritis (IM101-330) Phase 1/Phase 2 Interventional Response rate in placebo group for primary outcome was 100% on interim analysis. Actual 28
NCT02507986 Suspended Mobile Phones in Cryptogenic Stroke Patients Bringing Single Lead ECGs to Detect Atrial Fibrillation N/A Interventional no personnel for recruitment Anticipated 200
NCT02577367 Terminated Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding Phase 4 Interventional Hospital has a new protocol holding off feeding 2 hours for LT4 administration. Actual 4
NCT02774551 Suspended Physical Activity Intervention Trial to Mitigate Muscle Loss and Increase Muscle Strength N/A Interventional Suspended since March 2020 due to the ongoing covid-19 situation Anticipated 160
NCT02964481 Terminated Malignant Hyperthermia Registry and Genetic Testing Observational Lack of funding to enroll additional participants Actual 64
NCT03060954 Terminated Non-Inferiority Study Comparing MINI WELL READY® and FineVision® in Patients With Cataract Surgery N/A Interventional The clinical study is closed to further enrolment based on the lack of perceived need to compare the study device with the control device. Actual 8
NCT03589755 Withdrawn The Impact of Mindfulness Meditation in Veterans With Epilepsy N/A Interventional unable to recruit enough candidates Actual 0
NCT03597282 Terminated A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma Phase 1 Interventional Closed due to historically slow enrollment compounded by the COVID-19 pandemic. Actual 22
NCT03682367 Terminated Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery Phase 3 Interventional Poor Recruitment Actual 10
NCT03821649 Suspended SOONER Feasibility Study Protocol N/A Interventional Suspended due to non-essential research prohibitions at the study's recruitment and outcome assessment sites in the context of COVID-19. Anticipated 80
NCT03907202 Terminated A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM Phase 1 Interventional The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects. Actual 25
NCT03978884 Withdrawn Phase 4 Study of the Efficacy of Losartan Based Therapy in Hypertensives With and Without Diabetes Phase 4 Interventional Unable to effective arrange trial logistics Actual 0
NCT04093115 Withdrawn Study of CX1106 in Patients With Advanced Head and Neck Squamous Cell Carcinoma Phase 2 Interventional The study was terminated voluntarily by the sponsor due to changes in clinical development strategy. Actual 0
NCT04130906 Suspended Theta Burst Stimulation in Binge Eating Disorder: A Single Session RCT N/A Interventional The study includes adults vulnerable to COVID-19 and procedures cannot accommodate social distancing. Anticipated 66
NCT04138602 Withdrawn BTL Emsella Chair Versus Sham for the Treatment of Fecal Incontinence N/A Interventional Lack of enrollment Actual 0
NCT04143490 Suspended Effects of Exercise in Patients With Ulcerative Colitis N/A Interventional Due to Covid-19 Anticipated 24
NCT04206800 Terminated Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients N/A Interventional Difficulty in enrolling participants Actual 5
NCT04228549 Suspended MyPADMGT Support of Out-Patients With Peripheral Arterial Disease N/A Interventional Outpatient clinic site suspended temporarily due to COVID 19 virus Anticipated 210
NCT04244825 Suspended Safety, Pharmacodynamics, and Pharmacokinetics of Orally Administered BLD-2660 in Subjects With IPF Phase 2 Interventional Suspended due to concerns for patient safety during COVID-19 crisis Anticipated 32
NCT04291508 Suspended Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Phase 2 Interventional Study put on hold due to CIV-19 pandemic and NHLBI directive for PETAL network to redirect efforts to COVI-19 specific treatment trials. Anticipated 900
NCT04300335 Suspended The Feasibility and Effects of Exercise on Patients Suffering From Multiple Myeloma N/A Interventional Due to COVID-19 and the fact that the study participants are part of the "high-risk" population, the start of the recruiting process has been delayed at will. Anticipated 45
NCT04377425 Withdrawn COVID-19 Prevalence and Cognitive Deficits in Neurological Patients Observational No acute neurological patients presented with concomitant COVID-19 Actual 0
NCT04430010 Suspended Multi-level Determinants of Implementation and Sustainment in the Education Sector N/A Interventional Schools opening remotely has prevented recruitment Anticipated 588
NCT02608944 Withdrawn Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging N/A Interventional MRI perfusion techniques development took years than expected. Actual 0
NCT02929394 Terminated Trabectedin Maintenance Post 1st-line in STS Phase 3 Interventional Poor accrual Actual 13
NCT03124628 Withdrawn Effects of Flywheel Exercise on Muscle and Walking Function in Teenagers and Young Adults With Cerebral Palsy N/A Interventional Lack of funding Actual 0
NCT03497598 Terminated Preventing Recurrent Urinary Tract Infections With α-D-mannose Phase 4 Interventional not enough patients Actual 15
NCT04540952 Terminated Randomized Trial Comparing Fluid Capture Efficiency of Total Capture Drape Versus Standard Drape for Hysteroscopy. N/A Interventional COVID-19 Actual 68
NCT03554356 Suspended Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE) N/A Interventional Device modifications required prior to trial proceeding. Anticipated 70
NCT03638596 Suspended Leveraging Transdermal Alcohol Monitoring to Reduce Drinking Among DWI Defendants N/A Interventional Suspended enrollment due to pandemic, follow-up visits still ongoing. Anticipated 440
NCT03648619 Suspended Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging N/A Interventional Insufficient recruitment Anticipated 50
NCT03698838 Terminated Myelin Imaging Changes In Patients With Neurosurgical Diseases Observational Principal Investigator left Institution Actual 20
NCT03829618 Terminated Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound Phase 3 Interventional COVID lack of cases/recruitment Actual 29
NCT02132598 Terminated Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases Phase 2 Interventional Trial stopped due to slow patient accrual. Actual 5
NCT03833596 Terminated Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD) Phase 4 Interventional Low recruitment Actual 3
NCT03883321 Terminated EssaiClinique_CBSM Observational few patient feedback and principal investigator disponibility Actual 25
NCT04037306 Terminated Measurements From Stool to Support Dietary Change N/A Interventional Weight loss center programming suspended due to COVID-19 pandemic Actual 7
NCT04059666 Suspended Gastrointestinal Tract Microbiome in Healthy Term Infants Receiving Mother'S-own Breast Milk or Cow's Milk-based Infant Formulas N/A Interventional COVID-19 Anticipated 111
NCT04170868 Withdrawn Psychoeducational Video Series - Proof of Concept N/A Interventional COVID Actual 0
NCT04220788 Withdrawn Pharmacist Enhanced Service for Cardiovascular Risk Reduction N/A Interventional No enrollment due to difficulty in recruitment of study sites Actual 0
NCT04325061 Suspended Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Phase 4 Interventional Lack of enrollment Anticipated 200
NCT04326075 Suspended Early CPAP in COVID-19 Patients With Respiratory Failure. N/A Interventional the insurance contract hasn't been drafted yet Anticipated 900
NCT04350086 Withdrawn Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection Phase 4 Interventional unfavorable opinion of the ethics committee Actual 0
NCT04360135 Suspended Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy Phase 2/Phase 3 Interventional PI has decided to put this study on hold at this time. Actual 208
NCT03613831 Withdrawn Multi-center Complex Atrial Tachycardia High-Resolution Mapping Registry (MATH) Observational The sponsor has decided to stop the study Actual 0
NCT00603941 Terminated A Phase 1/2 Study of CS7017, an Oral PPARγ Agonist, in Combination With Paclitaxel Phase 1/Phase 2 Interventional Due to low enrollment, no participant had a dose limiting toxicity, therefore a maximum tolerated dose could not be established Actual 19
NCT03953352 Withdrawn Evaluation of the Automatic Deformable Recontouring on the Daily MVCT for Head and Neck Cancer Adaptive Radiotherapy N/A Interventional Study cancelled Actual 0
NCT00182455 Terminated Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP) Phase 4 Interventional loss of funding Anticipated 12
NCT00936234 Withdrawn Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM). Phase 2/Phase 3 Interventional insufficient recruitment Actual 0
NCT00975468 Suspended Pressure-Controlled vs Volume-Controlled Ventilation During One Lung Ventilation N/A Interventional Financial shortages due to lack of funderx Anticipated 40
NCT01232153 Withdrawn Preoxygenation Before Prehospital Tracheal Intubation With NIV Versus Balloon N/A Interventional departure without replacement of the principal investigator Actual 0
NCT01539395 Withdrawn A Cross-Sectional Study of MSDx Complex 1 as a Marker for Active Disease in Multiple Sclerosis Observational Actual 0
NCT02859844 Terminated Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction N/A Interventional Termination after a few pilot participants due to further protocol development Actual 9
NCT03522480 Withdrawn The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 2 N/A Interventional Change of Research Objectives for Grant Funded Study Actual 0
NCT03527550 Suspended Cognitive Control Training for Urgency in a Naturalistic Clinical Setting N/A Interventional Recruitment paused due to COVID-19 Anticipated 90
NCT03530605 Withdrawn Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma N/A Interventional Study never initiated, PI left institution Actual 0
NCT03547349 Suspended The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 3 N/A Interventional COVID-19 Anticipated 169
NCT03047213 Suspended Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations Phase 2 Interventional Other - TSC1/TSC2 testing issues and futility analysis Anticipated 209
NCT03836482 Suspended Selective Cytopheretic Device (SCD) Trial N/A Interventional Study halted temporarily to obtain protocol amendment approval but potentially will resume. Anticipated 10
NCT04101006 Terminated Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function Observational recruitment difficulties, high postoperative drop-out rate Actual 78
NCT04538196 Withdrawn Coding Improvement Project: Resident Education on Documentation N/A Interventional Study staffing constraints Actual 0
NCT02640690 Suspended Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma N/A Interventional Recruitment has been suspended because of COVID related restrictions and limitations imposed on data collection Anticipated 210
NCT02949843 Terminated Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations Phase 2 Interventional Slow accrual, closed by IRB Actual 19
NCT03106571 Terminated Study of Pomaglumetad and Methamphetamine Phase 1 Interventional Deemed unable to enroll targeted participants in part due to COVID-19 shut downs Actual 19
NCT03515200 Terminated Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia Phase 1 Interventional Due to departure of PI from St. Jude Actual 12
NCT03648047 Terminated Digital Biofeedback System Versus Conventional Rehabilitation After Rotator Cuff Repair N/A Interventional COVID-19 pandemic imposed restrictions to normal study conduct Actual 50
NCT04163224 Withdrawn Minimal Invasive Approach for Surgical Repair of Rib Fractures With a Novel Intrathoracic Device Observational Sponsor strategy change Actual 0
NCT01784861 Terminated VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors Phase 1/Phase 2 Interventional Pharmaceutical company decision Actual 23
NCT02154984 Terminated Time Restricted Diet in Obese or Overweight Pre or Postmenopausal Participants N/A Interventional Study closed due to funding before accrual was met Actual 45
NCT02349633 Terminated Study For Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M) Phase 2 Interventional The study was ended for strategic reasons and changes in the external environment. The safety profile and risk benefit ratio for PF-0674775 remained unchanged. Actual 65
NCT02820077 Terminated Hemostatic Powder Versus Clinical Management for the Treatment of Upper Gastrointestinal Bleeding From Tumor Lesions N/A Interventional Global recall of Hemospray Actual 62
NCT03362593 Terminated A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses Phase 1 Interventional The program is canceled due to company strategic reasons. Actual 186
NCT03780205 Terminated Bilateral and Unilateral Amblyopia Treatment Study Observational Unable to recruit sufficient number of subjects Actual 1
NCT03877250 Withdrawn Analysis of Biopsy Specimens to Study Responses to PD-1 or PD-L1 Therapies Observational The primary objectives have not been met due to no patient enrollment therefore, the PI is requesting to close the study at this time. Actual 0
NCT03953456 Terminated Study to Evaluate the Effect of Elafibranor on Hepatic Lipid Composition in Subjects With Nonalcoholic Fatty Liver (NAFL) Phase 2 Interventional Continuation of the trial cannot serve a scientific purpose Actual 17
NCT04075071 Terminated A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start N/A Interventional Intervention and and final data collection point was not completed due to coronavirus school closures in March 2020. Actual 70
NCT00586209 Terminated L-Glutamine Therapy for Sickle Cell Anemia Phase 2 Interventional Due to inadequate supplies of study drug & internal business decisions. Actual 15
NCT02975336 Terminated A Phase II Study of M2951 in Systemic Lupus Erythematosus (SLE) Phase 2 Interventional Study is completed; primary analysis completed. Actual 480
NCT03237754 Terminated Neurostimulation in Chronic and Episodic Migraine N/A Interventional Recruitment problems (especially for chronic migraine patients) Actual 41
NCT03540368 Suspended Tranexamic Acid for The Treatment of Gastrointestinal Bleeding N/A Interventional increased number of patients death Anticipated 336
NCT03607500 Suspended Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation N/A Interventional Lack of funding Anticipated 30
NCT03752242 Suspended Evaluation of Topical Application of BMX-010 in Subjects With Acne Vulgaris. Phase 2 Interventional Enrollment stopped for chemistry work on investigational product. Actual 2
NCT03825913 Terminated 3-month Aerobic and Resistance Exercise Intervention for Individuals Diagnosed With Melanoma N/A Interventional two key faculty members are no longer part of the study and institution Actual 1
NCT03889873 Suspended Evaluating Change in Drinking Identity as a Mechanism for Reducing Hazardous Drinking - Study 2 N/A Interventional Paused enrollment due to COVID-19 pandemic; will resume Fall 2020 Anticipated 328
NCT04118569 Suspended Personalized Experiences to Inform Improved Communication for Patients With Life Limiting Illness N/A Interventional On hold due to COVID-19 pandemic. Anticipated 80
NCT04349228 Withdrawn Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals Phase 3 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT04351919 Withdrawn Assessment of Efficacy and Safety of HCQ and Antibiotics Administrated to Patients COVID19(+) Phase 4 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT03249272 Terminated Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Phase 4 Interventional Sponsor withdrew funding Actual 31
NCT04386434 Withdrawn Active for Life Assisted Living Feasibility and Acceptability Study N/A Interventional Pandemic, researchers no longer have access to residents of assisted living. Actual 0
NCT03871569 Terminated Medico-economical Evaluation on Buccodental Teleexpertise in Nursing Home N/A Interventional Difficulty recruiting and follow-up due to the epidemic context of COVID19 Actual 171
NCT04528927 Withdrawn Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia Phase 3 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT00860379 Terminated The Effect of Selenium Supplementation Among Pediatric Patients With Burns Phase 4 Interventional Due to a shift in primary responsibilities, the PI was not longer able to enroll subjects. Actual 14
NCT02429505 Withdrawn Treatment of Leishmaniasis With Impavido® (Miltefosine): Higher-Weight Patient Registry Observational [Patient Registry] This study was COMPLETED, but no patients were enrolled. Actual 0
NCT01334489 Terminated The Trial of Pessary After Laser for TTTS N/A Interventional Interim analysis unfavorable to continue the study Actual 352
NCT01535157 Terminated Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer Phase 1/Phase 2 Interventional drug combination not providing any efficacy. Will use this data in opening new trial Actual 12
NCT02090868 Withdrawn An Oral Intake Screening Tool for Patients Receiving Non-Invasive Ventilation Observational No patients recruited due to decreased levels of patients requiring non-invasive ventilation during the study. Actual 0
NCT02759120 Terminated CleanUP IPF for the Pulmonary Trials Cooperative Phase 3 Interventional Terminated for futility after review of first planned interim analysis. Actual 509
NCT02810236 Suspended Focal Breast Pain: Does a Normal Ultrasound Provide Reassurance? N/A Interventional The study is suspended due to the pandemic Anticipated 160
NCT02874820 Terminated I2PETPG - Imidazoline2 Binding Sites in a Group of Participants Diagnosed With AD Early Phase 1 Interventional Patient recruitment issues. Actual 2
NCT02927470 Withdrawn TMS of Visual Working Memory N/A Interventional Investigators are no longer at NYU Langone Health Actual 0
NCT03036891 Withdrawn Naloxegol for Opioid-Related Gastroparesis Phase 2 Interventional Actual 0
NCT03556930 Withdrawn Simulated Radiotherapy Treatment Assisted With Pediatric Radiation Oncology With Movie Induced Sedation Effect Technique Early Phase 1 Interventional Project was never initiated. Actual 0
NCT03693274 Terminated Mindfulness to Improve Functional Outcomes in Patients With Fibromyalgia or Central Sensitization N/A Interventional Principal investigator leaving institution. Actual 16
NCT04374474 Withdrawn Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19) Phase 4 Interventional Study withdrawn before any enrollment (site's research goals adjustments). Actual 0
NCT04384614 Withdrawn Covid-19 In Tunisia: An Observational Cross-Sectional Registry Study Observational [Patient Registry] The sponsor decided to withdraw the study for funding reasons. Actual 0
NCT04527796 Terminated Influence of a Residential Rehabilitation Program on Body Composition in Patients With Cystic Fibrosis N/A Interventional number included Actual 39
NCT02315625 Terminated Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery Phase 2 Interventional Study closed due to poor accrual. Actual 16
NCT03992079 Terminated A Multimodal Enhanced Recovery Program in Anorectal Surgery N/A Interventional PI is no longer at institution Actual 60
NCT04282681 Withdrawn XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU) Observational Sponsor decision due to clinical strategy changes Actual 0
NCT04332341 Suspended Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation Early Phase 1 Interventional COVID-19 hold Anticipated 20
NCT02638506 Terminated RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches Phase 4 Interventional Covid restrictions Actual 60
NCT02743169 Withdrawn Improvement of Ambulance Response Times in Karachi, Pakistan Observational Could not acquire data Actual 0
NCT03232632 Terminated Assessment of Cardiac Fixation During PET Using a New Drug Within Amyloid Cardiac Injuries. Early Phase 1 Interventional intervention programming Actual 7
NCT03251872 Terminated Olaparib for PAH: a Pilot Study Early Phase 1 Interventional OPTION pilot trial merged with the new NCT03782818 - OPTION multicenter trial Actual 6
NCT03289624 Withdrawn SHARE for Persons With Chronic Conditions and Their Family Caregivers N/A Interventional Lost Funding Actual 0
NCT03312127 Terminated Evaluation of Peri-surgical Results at Short and Mean Terms of the GORE ® Excluder Iliac Branch Endoprosthesis N/A Interventional End of inclusion period Actual 3
NCT03348111 Withdrawn Establishing a New Protocol for Early Mucositis and Peri-implantitis Treatment Using an Air-polishing Device N/A Interventional No participant enrolled Actual 0
NCT03738124 Withdrawn Evaluation of the Valiant Mona LSA Thoracic Stent Graft System in Thoracic Aortic Aneurysms and Chronic Dissections N/A Interventional Production of the medical device was stopped Actual 0
NCT04053543 Terminated CXA-10 Study in Subjects With Pulmonary Arterial Hypertension Phase 2 Interventional LOE Actual 33
NCT04066088 Withdrawn Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior Associated With Prader-Willi Syndrome Phase 4 Interventional PI departure from institution Actual 0
NCT04227938 Terminated Study of ALPN-101 in Steroid-resistant or Steroid-refractory Acute GVHD Versus Host Disease Phase 1 Interventional Change in sponsor strategy Actual 1
NCT04317924 Withdrawn Pneumostasis With Use of Bio-absorbable Mesh and Fibrin Sealant in Lung Resection N/A Interventional Resources not available to conduct the research. Actual 0
NCT03522805 Terminated Impact of Non-invasive Ventilation in Hypercapnic COPD N/A Interventional Failure to accrue subjects. All activity has stopped & no analysis will be done on what has been collected. Actual 6
NCT04142554 Withdrawn Parsaclisib in Newly Diagnosed Stage I-IIIC Triple Negative or HER2+ Breast Cancer Phase 1 Interventional Funding withdrawn from funding source. Actual 0
NCT04528758 Suspended F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow Early Phase 1 Interventional re-evaluation of radiotracer Anticipated 15
NCT04438551 Suspended Software Application for Low-Sodium Diet Trial (SALT) N/A Interventional Study is on hold until pilot study is completed. Anticipated 80
NCT04403685 Terminated Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers Phase 3 Interventional Safety Actual 129
NCT01096290 Terminated Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications Phase 4 Interventional Number of needed participants could not be obtained Actual 23
NCT02026726 Terminated Do Oral Steroid Dose Packs Predict How Well Epidural Steroid Injections Will Work? Observational could not recruit Actual 10
NCT02673151 Suspended 68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment Phase 2/Phase 3 Interventional logistics Anticipated 200
NCT02775422 Terminated Comparison of Serological Test s for the Virus Chicken Pox Virus (VZV) and Correlation With the Patient's Memory of the Infection or Vaccination N/A Interventional Low inclusion rate. Actual 308
NCT03202498 Terminated Safety and Tolerability of Yaq-001 in Patients With Cirrhosis N/A Interventional COVID-19 pandemic prevents patients from making in-hospital visits, which are mandatory to assessment of safety in this study Actual 31
NCT03665636 Suspended Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I Early Phase 1 Interventional due to COVID-19 Anticipated 5
NCT03821766 Withdrawn Haemodynamic Abnormalities Recorded With Cardiac Catheterization Along With Body's Surface Micro-accelerometers (KT-KCG) Observational Technical failure Actual 0
NCT03834584 Terminated A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma Phase 1 Interventional Terminated due to sponsor decision. Actual 11
NCT04100681 Terminated Intermittent Negative Pressure; Impact on Peripheral Artery Disease and Intermittent Claudication N/A Interventional The study was terminated early due to slow recruitment and inability to recruit patients during the Covid-19 situation. Actual 16
NCT04222985 Suspended Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2 Phase 1/Phase 2 Interventional (Enrollment suspended for 1 site due to Covid-19; For the other sites, enrollment completed in Part A and planned to be restarted for Part B at the end of 2022) Anticipated 381
NCT04358835 Withdrawn Keto-diet for Intubated Critical Care COVID-19 N/A Interventional Study did not begin enrollment, multiple competing studies at same institution Actual 0
NCT04526236 Suspended Influence of Aging on Perioperative Methadone Dosing Phase 4 Interventional pandemia of covid 19 Anticipated 60
NCT01508598 Terminated Validation of Circulating Endothelial Cells and Microparticles in Youth Observational Not enough subjects enrolled to be able to analyze data. Actual 390
NCT01977027 Terminated Strategies for Recovery of Dexterity Post Stroke N/A Interventional PI left insitution Actual 91
NCT02589314 Terminated Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2 Observational We could not achieve the number of participants necessary to continue with the study and limited money to continue with the study Actual 90
NCT01055067 Terminated ARQ 197 for Participants With Relapsed or Refractory Germ Cell Tumors Phase 2 Interventional The study was terminated early for futility according to the stopping rule of the Simon 2-stage design. Actual 27
NCT02558023 Terminated The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Phase 3 Interventional no candidats Actual 14
NCT02716701 Terminated Exercise in Multiple Sclerosis N/A Interventional lack of funding Anticipated 40
NCT02737930 Terminated Fluoxetine for Visual Recovery After Ischemic Stroke Phase 2 Interventional Slow recruitment and lack of funding to expand to other sites. Actual 17
NCT03330561 Suspended PRS-343 in HER2-Positive Solid Tumors Phase 1 Interventional Partial clinical hold Anticipated 110
NCT03370302 Terminated A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of TAK-228 as Single Agent in Adult East Asian Participants With Advanced Nonhematological Malignancies Phase 1 Interventional More favorable safety profile was observed in QD schedule, therefore further enrollment in QW schedule was terminated. Actual 28
NCT04525170 Withdrawn Clinical Evaluation of HPT Treated Rigid Contact Lenses Made From Hexafocon A N/A Interventional It was decided by the sponsor to not proceed. Actual 0
NCT01864018 Suspended Ixazomib Citrate, Cyclophosphamide, and Dexamethasone in Treating Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis Phase 1/Phase 2 Interventional Actual 71
NCT02373540 Terminated Algovita Post-Market Clinical Study: Spinal Cord Stimulation to Treat Chronic Pain Observational Actual 91
NCT04522466 Terminated Evaluation of the Pharmacokinetics and Pharmacodynamics of Hydroxychloroquine in COVID-19 Intensive Care Unit Patients Phase 3 Interventional Stop of the study by competent authority (ANSM) Actual 7
NCT02266147 Terminated Study of SD-101 in Combination With Localized Low-dose Radiation in Patients With Untreated Low-grade B-cell Lymphoma Phase 1/Phase 2 Interventional The sponsor terminated the trial early because there was sufficient data to make a decision about SD-101 in the lymphoma development program. Actual 29
NCT01951378 Terminated Comparison of Nebulizers in ED in Pediatric Asthma Patients Phase 4 Interventional No data are available for this study as the PI has left the institution. Actual 40
NCT04275011 Suspended Bone Response to Exercise in Women on Antiresorptive Medications N/A Interventional The study has been suspended until further notice due to COVID-19. Anticipated 46
NCT04493697 Withdrawn Using Neuromodulation to Improve Parkinson's Disease N/A Interventional Device provider has requested withdrawal citing modifications needed for study integrity. Actual 0
NCT03538015 Terminated Carvedilol in Treating Hypoglycemia Unawareness Phase 2 Interventional Sponsor was impacted by COVID-19 and did not have sufficient funds to continue. Actual 1
NCT04520620 Withdrawn Concentration-effect Relationship of Enoxaparin for Thromboembolic Prevention Phase 4 Interventional End of the COVID 19 epidemic in the region and decision to participate in a national study on the same subject (COVI-DOSE). Actual 0
NCT00031174 Terminated Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers Observational Due to technical and logistical constraints and a change in the study team's focus of research Actual 151
NCT00756834 Terminated Case Collection Study for Collecting Images for the Development and Validation of Computer Aided Detection Software Observational No longer pursuing FDA submission/approval. Actual 135
NCT01213563 Terminated Management of Type 2 Diabetes After Gastric Bypass Surgery N/A Interventional Data were published that superseded this study. Actual 50
NCT01391520 Withdrawn Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent Phase 3 Interventional Actual 0
NCT02422667 Withdrawn iCORE: Collaborative Orthopedics Outcomes Registry Observational [Patient Registry] Study cancelled - no results Actual 0
NCT02608125 Terminated A Dose Escalation Study in Solid Tumors and a Dose Expansion Study of PRN1371 in Adult Patients With Metastatic Urothelial Carcinoma Phase 1 Interventional focus portfolio on immune-mediated diseases Actual 45
NCT02872467 Suspended Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology Phase 1 Interventional Due to COVID-19 restrictions, recruitment suspended until Spring 2021 Anticipated 32
NCT03233854 Suspended CD19/CD22 Chimeric Antigen Receptor(CAR) T Cells in Adults With Recurrent/Refractory B Cell Malignancies Phase 1 Interventional Logistics Anticipated 57
NCT03396861 Terminated Treatment of Macular Edema After Cataract Surgery With Subconjunctival Aflibercept Phase 1 Interventional Low enrollment Actual 1
NCT03507127 Terminated Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1 Phase 2 Interventional Low rate of enrollment Actual 21
NCT03529162 Terminated A Prospective Study Comparing Suture Anchor and Soft Tissue Pectoralis Major Tendon Techniques for Biceps Tenodesis N/A Interventional COVID-19, followed by PI leaving institution. Actual 4
NCT03831295 Suspended SD-101 and BMS-986178 in Treating Patients With Advanced or Metastatic Solid Malignancies Phase 1 Interventional Business Decision Anticipated 27
NCT03858933 Suspended Train Your Brain: Neurofeedback Intervention for PTSD N/A Interventional COVID-19 Regulations Anticipated 100
NCT03867487 Suspended SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease Phase 2 Interventional COVID-19 Anticipated 40
NCT04004325 Terminated A Study of FT 4101 in Overweight/Obese Participants With NASH Phase 1/Phase 2 Interventional sponsor decision Actual 14
NCT04294082 Withdrawn Study of Mindfulness Course for Parents of Adults With Intellectual Disabilities Observational Study stopped due to the outbreak of the covid-19 pandemic. Actual 0
NCT03120910 Withdrawn Pleth Variability Index (PVI) to Predict Fluid Responsiveness N/A Interventional Actual 0
NCT03172559 Withdrawn Radiotherapy Versus no Intervention in Adult Patients With Hepatocellular Carcinoma Not Eligible for Transarterial Chemoembolization or Ablation Prior to Liver Transplant (RADBRI) N/A Interventional Investigator decided not to pursue the study due to other competing studies. Actual 0
NCT03310034 Terminated NAD Supplementation Study N/A Interventional Concluded study following COVID19 outbreak and inability to complete study as designed. Actual 14
NCT03336580 Terminated A Study of PRX004 in Subjects With Amyloid Transthyretin (ATTR) Amyloidosis Phase 1 Interventional Because of the impact of COVID-19 pandemic Actual 21
NCT03517566 Terminated A Study to Assess the Safety and Efficacy of ZPL389 in Patients With Moderate to Severe Atopic Dermatitis Phase 2 Interventional Lack of efficacy Actual 293
NCT03847922 Terminated Nitrous Oxide for Analgesia During Office Urethral Bulking Phase 4 Interventional Due to staffing changes in the hospital, we will be unable to complete this study for the requested 84 subjects. As such, we have decided to close this study. Actual 2
NCT03949725 Suspended Hans Kai Trial: an Evaluation of a Peer-led Preventative Health Intervention N/A Interventional Covid 19 pandemic, will restart in the future Anticipated 72
NCT04298710 Terminated Effects of Arm Cycling and Leg Cycling on Postprandial Blood Glucose Levels in Healthy Persons N/A Interventional Research lab not accessible due to the pandemic. Actual 4
NCT04350476 Withdrawn COVID-19 Remote Monitoring N/A Interventional closed due to lack of interest and enrollment Actual 0
NCT04353271 Terminated Trial of Hydroxychloroquine In Covid-19 Kinetics Phase 2/Phase 3 Interventional FDA recommendations to not use outside of the hospital setting or in a clinical trial due to the risk of cardiac arrhythmias Actual 58
NCT02297607 Terminated Routine Post-Operative Supplemental Nutrition N/A Interventional Poor accrual. Patients were reluctant to agree if they would need tube feeding for a month. Actual 30
NCT00513552 Withdrawn Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Phase 4 Interventional No patient Actual 0
NCT02938078 Terminated Ocular Comfort and Inflammation in Lid Hygiene Therapy N/A Interventional Actual 14
NCT03539484 Terminated A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors Phase 1 Interventional Study terminated due to change in benefit-risk ratio, driven by high incidence GI toxicity in absence of clinically significant anti-tumor efficacy. Actual 26
NCT01369433 Terminated A Rollover Protocol to Allow Continued Access to Tivozanib (AV 951) for Subjects Enrolled in Other Tivozanib Protocols N/A Interventional Lack of new studies contributing subjects to this study Actual 225
NCT01317771 Withdrawn Analysis of the Fixation of the Proximal Biceps Tendon Observational PI decided to not activate Actual 0
NCT02929589 Suspended Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy Phase 3 Interventional PI deployed. Anticipated 185
NCT03213626 Terminated Cabozantinib and Erlotinib for Patients With EGFR and c-Met Co-expressing Metastatic Pancreatic Adenocarcinoma Phase 2 Interventional There were no objective responses by patient 7. Actual 7
NCT03150303 Terminated Oral Anticoagulant Peri-procedural Management in Patients Undergoing an Oral Surgery, Implantology or Periodontology Observational Lack of budget Actual 532
NCT03509870 Terminated Bone Marrow Derived Allogeneic Mesenchymal Stromal Cells to Non-healing Diabetic Foot Wounds Phase 1 Interventional study stopped because of lack of recruitment Actual 2
NCT03569943 Withdrawn Robot Based Tympanic Tube Placement N/A Interventional Change in medical practice on the management of the eligible population Actual 0
NCT03605745 Terminated Minimally Invasive Prostatic Vapor Ablation for the Treatment of BPH in Large Prostates (Rezūm XL) N/A Interventional Sponsor decided to terminate the study due to business reasons Actual 47
NCT03862170 Suspended Antibiotic Prophylaxis for HDR Brachytherapy in the Treatment of Prostate Cancer Phase 3 Interventional Covid-19 pandemic Anticipated 255
NCT02388165 Terminated Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation Phase 2 Interventional Study terminated by sponsor Actual 3450
NCT04355039 Withdrawn INCB053914 and Pomalidomide With Dexamethasone for Relapsed and/or Refractory Multiple Myeloma Phase 1 Interventional Terminated for lack of funding. Actual 0
NCT04398290 Withdrawn iNOPulse for COVID-19 Phase 2 Interventional IRB AND FDA REVIEWS DEFERRED Actual 0
NCT04425902 Suspended Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults Phase 1 Interventional Due to the COVID-19 pandemic, this study has temporarily suspended recruitment activities. Other elements of the study are ongoing. Anticipated 20
NCT02905981 Terminated Triferic IRIDA Protocol Phase 2 Interventional Limited subjects, patient compliance Actual 1
NCT03686514 Suspended The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics Phase 1 Interventional Recruitment and enrollment currently suspended due to COVID-19 Anticipated 60
NCT04198285 Terminated Post-Operative Voiding After Gynecological Surgery Trial N/A Interventional Due to cancellation of elective surgery (Covid-19) Actual 42
NCT03251495 Suspended Immunologic Responses to a Live Attenuated Oral Cholera Vaccine Phase 2 Interventional Recruitment and enrollment currently suspended due to COVID-19. Anticipated 50
NCT03551418 Terminated Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome N/A Interventional Interruption of COVID 19 pandemic Actual 21
NCT02122744 Withdrawn RCT Versus Placebo of rTMSQP Over Visual Cortex for the Prevention of Chronic Migraine N/A Interventional Actual 0
NCT02478138 Suspended Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging N/A Interventional Anticipated 30
NCT02629029 Suspended Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment N/A Interventional Actual 4
NCT00006472 Terminated Combination Chemotherapy Plus Radiation Therapy Followed By Surgery in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer Phase 2 Interventional Actual 4
NCT02540330 Terminated A Pre-Surgical PK Study of IM and Intraductally Delivered Fulvestrant Phase 2 Interventional Business decision Actual 3
NCT02612194 Terminated LCI-GU-URO-CRI-001: Crizotinib in Patients With c-MET or RON-Positive Metastatic Urothelial Cancer Phase 2 Interventional Study closed to accrual due to low accrual numbers. Anticipated 46
NCT02964325 Terminated Efficacy of Mirasol-treated Apheresis Platelets in Patients With Hypoproliferative Thrombocytopenia N/A Interventional Based interim analysis results, Data Monitoring Committee did not believe the primary efficacy endpoint would be met. No patient safety concerns. Actual 330
NCT03300947 Suspended Psilocybin for Treatment of Obsessive Compulsive Disorder Phase 1 Interventional Study enrollment has been temporarily suspended due to the coronavirus pandemic. Anticipated 15
NCT03386227 Terminated Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT N/A Interventional The study was prematurely stopped due to extremely low recruitment and lack of feasibility to continue. Actual 96
NCT03540160 Terminated Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) Phase 3 Interventional No longer pursuing development of serlopitant Actual 558
NCT03600623 Terminated Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer Early Phase 1 Interventional PI left the institution; no further accruals Actual 25
NCT03617562 Suspended Superior Capsule Reconstruction vs Partial Repair of Massive Rotator Cuff Tears N/A Interventional Due to COVID-19 all research activities including recruitment have been paused. Anticipated 44
NCT03738384 Suspended Knee Connect: Physiotherapy Exercise Performance With Visual Feedback After Total Knee Arthroplasty N/A Interventional Due to COVID-19 all research activities including recruitment have been paused. Anticipated 10
NCT04273191 Withdrawn A Study to Evaluate Multimodal Neuroimaging Parameters in Women With Postpartum Depression Who Are Receiving ZULRESSO™ (Brexanolone) Phase 4 Interventional Sage Therapeutics has decided not to proceed with this study at this time Actual 0
NCT04360759 Withdrawn Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 Phase 3 Interventional Equipoise for hydroxychloquine was lost Actual 0
NCT04409184 Withdrawn Whole Blood Collection From Individuals in the Convalescent Phase of SARS-CoV-2 Infection Observational Study was not opened. Actual 0
NCT02831556 Suspended Point of Care 3D Ultrasound for Various Applications: A Pilot Study Observational Enrollment on hold due to COVID-19 pandemic Anticipated 300
NCT03333148 Withdrawn Preoperative Oral ImmunoNuTrition to Improve Surgical Outcomes for IBD Patients (PINT) Early Phase 1 Interventional never enrolled Actual 0
NCT03488810 Withdrawn Apalutamide With Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer Phase 3 Interventional Extended study timelines and additional budget could no longer be supported. Actual 0
NCT03650348 Suspended PRS-343 in Combination With Atezolizumab in HER2-Positive Solid Tumors Phase 1 Interventional Partial clinical hold Anticipated 45
NCT03840694 Suspended Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior N/A Interventional COVID-19 Anticipated 70
NCT03911206 Suspended A Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma N/A Interventional Due to COVID19 Anticipated 35
NCT04011592 Terminated Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression Phase 2 Interventional Recruitment no feasible Actual 1
NCT04171388 Withdrawn Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia Phase 4 Interventional Trial withdrawn due to COVID-19. Actual 0
NCT03605693 Terminated Early Psychological Intervention to Prevent Cardiovascular Event-Induced PTSD (REACH Sub-study) N/A Interventional Lack of feasibility of engaging patients in written exposure therapy Actual 10
NCT00859495 Terminated Trimodal Lung-Sparing Treatment of Pleural Mesothelioma Phase 2 Interventional Actual 9
NCT00495300 Suspended Collection of Samples and Data for the National Marrow Donor Program Repository Observational Actual 305
NCT01280045 Terminated Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy N/A Interventional No grant was received then we stopped the recruitment Actual 5
NCT01805817 Withdrawn Comparison of Levonorgestrel Intrauterine System, Copper T Intrauterine Device and Oral Contraceptives on Life Quality Phase 4 Interventional Actual 0
NCT02122757 Terminated Anodal Transcranial Direct Current Stimulation of the Visual Cortex Versus Sham Stimulation in the Episodic Migraine N/A Interventional Actual 19
NCT03413891 Terminated Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction Phase 4 Interventional Advice from DSMB Actual 222
NCT03581123 Suspended Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain Phase 3 Interventional Suspended temporarily due to COVID-19 Anticipated 1180
NCT04067544 Terminated Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women N/A Interventional Unforeseen complications due to COVID-19 and funding Actual 3
NCT03598816 Withdrawn PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma Phase 2 Interventional FDA Contingencies unresolved Actual 0
NCT03918642 Suspended Optimizing Psychotherapy for Older Veterans With Chronic Pain N/A Interventional Recruitment was temorarily suspended in order to comply with mandated Covid-19 restrictions to in-person research activities. Anticipated 160
NCT04192110 Withdrawn Diuretics and Volume Overload in Early CKD Phase 4 Interventional The project has ended prior to beginning. Actual 0
NCT02780791 Terminated Maturation of Follicles After Transplantation of Ovarian Tissue Into the Pelvic Wall and the Ovary N/A Interventional Insufficient recruited participants due to a lack of collaborating study centers Actual 1
NCT02875067 Terminated Safety & Efficacy Study of Combination of Pembrolizumab and Lenalidomide, in Patients With Relapsed Non-Hodgkin and Hodgkin Lymphoma Phase 1/Phase 2 Interventional Merck's decision for early termination of the data Actual 6
NCT02959034 Suspended Pediatric Metabolism and Microbiome Repository Observational COVID-19 protocol suspension per Duke Anticipated 350
NCT03212300 Terminated TSA Exercise Prehabilitation in Older Adults N/A Interventional Inadequate data analysis Actual 3
NCT03367078 Terminated tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury Observational Organizational problems, change of research priorities Actual 1
NCT03371862 Withdrawn Liraglutide on Decreasing Parenteral Support in Short Bowel Patients (SLIPS) Phase 2 Interventional No participants recruited. Not able to recruit due to COVID 19. Actual 0
NCT04320290 Withdrawn HCV + to HCV - Kidney Transplant Phase 4 Interventional New Related Protocol to be submitted Actual 0
NCT04353648 Suspended Assessing Muscle Metabolic Phenotype by MSK Ultrasound Observational Suspended due to COVID-19 Anticipated 200
NCT04425733 Withdrawn MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009) Phase 1 Interventional Business reasons Actual 0
NCT04510415 Terminated Olmutinib 600 mg QD in Patients With T790M-positive NSCLC After Treatment With an EGFR-TKI Phase 1 Interventional Study termination by the Sponsor Actual 2
NCT01650298 Terminated Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation N/A Interventional Due to slow enrollment. Actual 64
NCT01738724 Terminated Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Phase 4 Interventional PI went for a post-doc course and when he came back he moved for another job Actual 14
NCT02003911 Terminated Azithromycin for Children Hospitalized With Asthma Phase 4 Interventional Low accrual Actual 159
NCT02257125 Terminated ArmeoSenso - Reward N/A Interventional Stopped due to futility considerations: Sample size calculations have assumed smaller effect sizes than considered relevant now. Actual 38
NCT03104491 Suspended Inotuzumab Ozogamicin Post-Transplant For Acute Lymphocytic Leukemia Phase 1/Phase 2 Interventional Major revisions due Anticipated 44
NCT03178201 Terminated TGR1202 in Relapsed and Refractory Follicular Lymphoma Phase 2 Interventional PI left institution Actual 5
NCT03194581 Suspended Normoxic Challenges Utility to Evaluate Blood Loss Observational Profissional reasons, not related with the study Anticipated 20
NCT03684109 Suspended Non-invasive Glioma Characterization Through Molecular Imaging N/A Interventional Temporarily closed to accrual due to COVID-19 pandemic. Anticipated 30
NCT03954639 Withdrawn Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries Phase 3 Interventional Sponsor Decision. Actual 0
NCT04138875 Withdrawn A Risk Stratified Sequential Treatment With Rituximab, Brentuximab Vedotin and Bendamustine (RBvB) Phase 2 Interventional Lack of funding Actual 0
NCT04210947 Suspended Effect of Myofascial Release on Muscle Mechanical Properties N/A Interventional due to coronavirus pandemic Anticipated 12
NCT04233697 Withdrawn Copanlisib in Combination With Romidepsin in Patients With Relapsed or Refractory Mature T-cell Lymphoma Phase 1 Interventional Investigator left institution Actual 0
NCT04266353 Suspended Effect of Resveratrol on Serum IGF2 Among African American Women N/A Interventional Due to COVID-19 Anticipated 50
NCT04276454 Withdrawn Lymphedema Treatment in Head and Neck Cancer Patients N/A Interventional Per investigator's request. Actual 0
NCT02992418 Terminated Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Phase 3 Interventional No answer received from the Philippines Food and Drug Administration on protocol amendment issued due to IDMC recommendations. CYD vaccine 3rd dose not given. Actual 688
NCT03404310 Terminated Zinc Sulfate for Human Papillomavirus (HPV) N/A Interventional Lack of recruitment Actual 21
NCT02571595 Terminated A Sleep Program to Improve Sleep Quality in People With HIV N/A Interventional Actual 27
NCT04297137 Suspended The Bioavailability of Multiple Novel, Sustainable, Non-animal Derived Protein Sources N/A Interventional COVID-19 Anticipated 12
NCT01866917 Terminated Study of TAP and Laparoscopic and Robotic Gynecologic Procedures and Obese Women Phase 1/Phase 2 Interventional Pharmacy stopped dispensing study medication Actual 35
NCT03752372 Terminated Microbiome Alterations in IL10RA-deficient Patients After HSCT Observational COVID-19 Actual 13
NCT03818516 Suspended Impact of Inflammation on Reward Circuits, Motivational Deficits and Negative Symptoms in Schizophrenia Phase 4 Interventional Recruitment is currently suspended due to COVID-19. Anticipated 20
NCT03866616 Terminated Evaluation Study of the Impact of the New Brain Builders Parenting Class N/A Interventional The PI discontinued the evaluation study. Actual 145
NCT03921229 Suspended Tele-Coaching Intervention to Improve Treatment Adherence in Cystic Fibrosis N/A Interventional COVID pandemic Anticipated 100
NCT04133766 Terminated Community-based Nutrition Program Effectiveness Evaluation in Afghanistan N/A Interventional Funding for the study withdrawn by sponsor after baseline data collected Actual 4076
NCT04143958 Withdrawn To Assess the Glycosphingolipid Clearance and Clinical Effects of Switching to Agalsidase Beta (Fabrazyme) Versus Continuing on Agalsidase Alfa (Replagal) in Male Patients With Classic Fabry Disease Phase 4 Interventional The Sponsor terminated the study due to recruitment infeasibility without having enrolled any patient. Actual 0
NCT04250168 Terminated Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response Observational Ebola epidemic in N-Kivu has ended Actual 43
NCT01656629 Terminated Stem Cell Recruitment in Osteoporosis Therapy N/A Interventional Inability to analyze collected samples due to no funds. Actual 55
NCT00606463 Terminated Gen2 Isthmus-Dependent Atrial Flutter Ablation Study N/A Interventional Abbott funding allocated to a different project. Actual 30
NCT02090959 Terminated An Extension Study of Ataluren (PTC124) in Participants With Nonsense Mutation Dystrophinopathy Phase 3 Interventional Sponsor decision due to commercial availability of ataluren. Actual 219
NCT01927484 Terminated Hand OA AND Methotrexate Use N/A Interventional due to COVID-19 Pandemic Actual 2
NCT02184520 Terminated A Prospective Randomized Postmarket Clinical Study of the TRANSITION Stabilization System N/A Interventional Actual 1
NCT02539953 Withdrawn Ambulatory Blood Pressure Monitoring in Rivaroxaban Therapy N/A Interventional Actual 0
NCT03719300 Terminated Codex: Study of Inodiftagene Vixteplasmid (BC-819) in Unresponsive NMIBC Phase 2 Interventional Lack of efficacy Actual 32
NCT02769871 Terminated NICE: NeuroImaging in Cessation Education N/A Interventional Loss of team members. Actual 20
NCT02845245 Terminated Comminuted Intra-Articular Distal Tibia Fracture Fixation Using Computer Techniques N/A Interventional Enrollment goal was not met. Actual 20
NCT03165214 Withdrawn Embolization of Pelvic Veins in Treatment of Pelvic Congestion Syndrome N/A Interventional No patients recruited Actual 0
NCT00914940 Terminated Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD Phase 2 Interventional Did not reach one of the primary endpoints of decreased total acute GVHD Actual 41
NCT03430466 Terminated Anti PD-L1 Antibody + Anti CTLA-4 Antibody in Combination With Hormone Therapy in Patients With Hormone Receptor Positive HER2-negative Recurrent or Metastatic Breast Cancer Phase 2 Interventional Recruiting was not possible Actual 1
NCT03593902 Terminated Cardiac Safe Transplants for Systemic Sclerosis Phase 2/Phase 3 Interventional PI Sabbatical Actual 9
NCT03431337 Terminated Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate Phase 4 Interventional Futility found by interim analysis Actual 157
NCT04502069 Withdrawn Treatment of COVID-19 With Opaganib in Patients With Pneumonia Requiring Oxygen Phase 1/Phase 2 Interventional To be replaced with a randomized placebo-controlled study. Actual 0
NCT02511691 Terminated PET/MRI Imaging of Glutamate Release in the Brain Phase 2 Interventional Enough data for a publication, decision of Sponsor-PI Actual 10
NCT01805869 Suspended Tooth and Tissue Sample Collection During Wisdom Teeth Removal Observational Actual 720
NCT02893527 Terminated Implementation and Evaluation of a Social Journey Accompanied in Breast Cancer Diagnosis (EPARS SEIN) N/A Interventional An IDMC validated the premature termination of the study on 19/02/2016 for lack of inclusion, with continuation of the FU initially planned for women included Actual 11
NCT01984866 Terminated CPR Prediction After Neoadjuvant Using Excisional Biopsy By Radiofrequency In Breast Cancer From II-III UICC Stages. Observational Recruitment was very low. Actual 13
NCT02728284 Suspended Evaluation of Cardiac Function With Cardio-respiratory Synchronized MRI N/A Interventional COVID-19 Anticipated 100
NCT02728336 Suspended MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT) N/A Interventional COVID-19 Anticipated 110
NCT02741180 Suspended Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias N/A Interventional COVID-19 Anticipated 135
NCT03324828 Terminated Presurgery Anxiolysis in Children Treated With Hydroxyzine Versus Non-pharmacological Intervention (Distractoria Technique Clown) Phase 4 Interventional COVID-19 Actual 170
NCT03809039 Terminated A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-6345 in Healthy Subjects Phase 1 Interventional Preclinical finding Actual 52
NCT04063228 Terminated High Level Mobility Training in Ambulatory Patients With Acquired Non-progressive Central Neurological Injury N/A Interventional Lack of resources Actual 28
NCT04354389 Withdrawn DAS181 for STOP COVID-19 Phase 2/Phase 3 Interventional No COVID-19 in EU countries - Sponsor withdraw in regulatory stage Actual 0
NCT04415073 Suspended A Phase 2 Study to Evaluate Axatilimab for Hospitalized Patients With Respiratory Involvement Secondary to COVID-19 Phase 2 Interventional Given enrollment challenges, partly attributable to the constantly changing COVID-19 treatment landscape, the trial has been suspended. Anticipated 186
NCT04370834 Suspended Tocilizumab for Patients With Cancer and COVID-19 Disease Phase 2 Interventional pending evaluation of data from other trial Anticipated 217
NCT04504591 Terminated Validation Of A New S-ICD Algorithm To Reduce Oversensing Of Dynamic T-Waves In Patients With Brugada Syndrome Observational Early termination due to COVID19; preliminary data can be considered significant Actual 126
NCT01569438 Terminated The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005) Phase 2 Interventional Actual 107
NCT02459054 Terminated Syncardia 50cc TAH-t as a Bridge to Transplant N/A Interventional 50cc TAH-t received FDA approval March 5, 2020. Actual 16
NCT03117530 Suspended Measuring Brain Inflammation in Autism Phase 1 Interventional COVID Anticipated 30
NCT03150797 Terminated Melatonin for Adolescent Migraine Prevention Study Phase 2 Interventional Insufficient Fund Actual 72
NCT03449524 Terminated PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH) Phase 2 Interventional LOE Actual 69
NCT03738293 Withdrawn Continuous Glucose Monitoring of Late Preterm Birth After Corticosteroids Observational Study was not started at site. Actual 0
NCT04074577 Suspended Computer Aided Detection, Tandem Colonoscopy Study N/A Interventional suspended due to COVID-19, will resume Anticipated 196
NCT04076566 Withdrawn Malignant Ascites Alfapump® Study Observational Update to clinical strategy - COVID impact Actual 0
NCT04265898 Withdrawn Validating the Digital Virginia Tech Carilion Cognitive Examination Observational The study did not receive IRB approval and was withdrawn by the PI on April 9, 2020. Actual 0
NCT04336774 Withdrawn CAPTION AI to Minimize Risk of COVID Exposure N/A Interventional Technology was approved by FDA before study enrolled subjects Actual 0
NCT03558672 Terminated A Registry to Evaluate the Flexitouch System and Flexitouch Plus for Treatment of Head and Neck Lymphedema Observational [Patient Registry] Low enrollment numbers Actual 24
NCT04507100 Suspended Comprehensive Analysis of the Program:Salud Escolar N/A Interventional Schools are in lockdown due to COVID-19 pandemic Anticipated 1200
NCT02661087 Withdrawn Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility N/A Interventional Principal investigator departure Actual 0
NCT02859298 Withdrawn Feasibility Study and Predictive Value of the Uterine Cervix Polarimetric Imaging for the Management of the Threat of Premature Delivery. N/A Interventional Lack of human ressources Actual 0
NCT03115593 Withdrawn Compare the Performance of Targeted Biopsy Versus Aspiration Biopsy With a Pipette for the Diagnosis of Endometrial Cancer N/A Interventional Lack of human ressources Actual 0
NCT04039477 Withdrawn A Phase 2 Study to Evaluate the Safety and Efficacy of KZR-616 in Patients With AIHA and ITP Phase 2 Interventional Clinical trial activity slowdown due to COVID-19 pandemic, high screen fail rate, and lack of enrollment led to the decision to withdraw the MARINA study. Actual 0
NCT04236661 Withdrawn Reports on Sleep Quality and Thermoregulation Among Veterans N/A Interventional study team unable to start up study at this time Actual 0
NCT04327401 Terminated COVID-19-associated ARDS Treated With Dexamethasone: Alliance Covid-19 Brasil III Phase 3 Interventional The Data Monitoring Committee recommended to stop the trial based on the Recovery Trial results, which was accepted by the CoDEX Steering Committee. Actual 299
NCT03989752 Suspended Overground Walking Program With Robotic Exoskeleton in Long-term Manual Wheelchair Users With Spinal Cord Injury N/A Interventional COVID-19 - To resume most likely in 2021 Anticipated 20
NCT01876264 Withdrawn Crohn's Extent of Resection Trial N/A Interventional Study abandoned Actual 0
NCT02489448 Suspended Neoadjuvant MEDI4736 Concomitant With Weekly Nab-paclitaxel and Dose-dense AC for Stage I-III Triple Negative Breast Cancer Phase 1/Phase 2 Interventional Suspended due to COVID-19 Anticipated 71
NCT02730884 Terminated Single-Arm Study of the Efficacy and Safety of Oral Rigosertib in Patients With Myelofibrosis (MF) and Anemia Phase 2 Interventional Terminated Per PIs request due to low accrual Actual 3
NCT02910648 Suspended Healthy Behaviors Learning Task and Sleep N/A Interventional COVID-19; unable to continue to enroll due to pandemic Anticipated 110
NCT03259568 Suspended Effects of rTMS on Human Brain Activity Measured With EEG and fMRI N/A Interventional Covid-19 Anticipated 264
NCT03405727 Withdrawn Improvement of Sarcopenia in Patients Following Two Different Diets N/A Interventional Lack of human ressources Actual 0
NCT03449212 Suspended SOD1 Kinetics Measurements in ALS Patients Observational COVID-19 pandemic Anticipated 86
NCT03805360 Terminated The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients Phase 1 Interventional Insufficient enrollment Actual 4
NCT04038502 Suspended BRcA Deficient Prostate Cancer Treated With Carboplatin or Docetaxel Phase 2 Interventional Currently Suspended during modification of study drugs due to change in standard of care. Anticipated 40
NCT03328598 Terminated A Community-based Resilience Program of Only-child Loss Parents N/A Interventional Don't have enough funding to finish the project. Actual 144
NCT03517969 Suspended M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Phase 2 Interventional Scheduled Interim Monitoring Anticipated 130
NCT04123808 Withdrawn IpsiHand System for Rehabilitation of the Arm and Hand After Stroke N/A Interventional Closed by sponsor Actual 0
NCT00575328 Terminated Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in Females Phase 3 Interventional Only N=10 enrolled; funding ran out; too few subjects to yield useful data. Actual 10
NCT02767323 Suspended Using TMS to Increase Executive Function in Older Adults N/A Interventional Covid-19 Anticipated 350
NCT02932176 Suspended Machine Learning for Handheld Vascular Studies Observational COVID-19 Anticipated 100
NCT03053518 Terminated Validation of Machine Learning Based Personalized Nutrition Algorithm to Reduce Postprandial Glycemic Excursions Among North American Individuals With Newly Diagnosed Type 2 Diabetes N/A Interventional Withdrawal of Funding Actual 22
NCT03311828 Suspended Copper 64Cu-DOTA-Daratumumab Positron Emission Tomography in Diagnosing Patients With Relapsed Multiple Myeloma Phase 1 Interventional To determine if met the optimal imaging dose or if need to further escalate Anticipated 21
NCT03710421 Suspended CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma Phase 1 Interventional FDA Clinical Hold Anticipated 30
NCT03797144 Terminated Fenestrated Screw Study N/A Interventional Delay in enrollment as compared to plan (impacted by COVID-19 pandemic) and availability of data from alternative data sources to support the products in scope. Actual 27
NCT04005079 Suspended Pilocarpine After Combined Cataract/Trabectome Surgery Phase 3 Interventional not performing Trabectomes Anticipated 140
NCT04022720 Withdrawn Platelet-Rich Fibrin in Intraoral Soft Tissue Regeneration N/A Interventional No patients enrolled. Also, impacted of COVID on enrolling subjects hindered recruitment. Actual 0
NCT04176406 Suspended Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub) N/A Interventional Covid-19 Anticipated 60
NCT04232306 Suspended Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section Phase 4 Interventional Decision was made to suspend enrollment until further notice. Anticipated 144
NCT00527709 Withdrawn Hold Parameters on Likely Cardiovascular Depressant Medications Observational The study was a retrospective chart review and was mistakenly registered in ClinicalTrials.gov Actual 0
NCT03245970 Withdrawn Impedance Cardiography to Decrease the Risk of Preeclampsia Early Phase 1 Interventional Investigator retired. Other investigators did not want to continue study. Actual 0
NCT03371914 Terminated Costs, Efficiency and the Role of Management in HIV Prevention Interventions for Female Sex Workers in Nigeria N/A Interventional Due to defunding of USAID project that supported the majority of the sites selected in the randomization. Actual 32
NCT03395353 Terminated A Study of Duloxetine (LY248686) in the Treatment of Japanese Children and Adolescents With Depressive Disorder Phase 3 Interventional Business decision Actual 151
NCT03420456 Terminated Transcranial Pulse Near-Infrared Light in Generalized Anxiety Disorder: a Placebo-Controlled Study N/A Interventional Sponsor withdrew funding for reasons unrelated to safety or efficacy Actual 17
NCT03529552 Terminated Evaluation After Reconstruction of the Anterior Cruciate Ligament of the Knee Using the Bioresorbable Interference Screw (SMS): Resorbability, Per- and Post-operative Complications and Articular Functional Recovery. N/A Interventional The Dm production has been stopped Actual 40
NCT03587129 Terminated Clinical Study of Apatinib in the Treatment of Platinum Resistant Recurrent Ovarian Cancer Phase 2 Interventional No patient enter this study. Actual 1
NCT03638336 Withdrawn Evaluation of the Performance of a Robotic Flexible Ureteroscopy (ILY) in Laser Treatment of Nephrolithiasis N/A Interventional No actual DM Actual 0
NCT03650660 Terminated Concordance Between Echocardiographic Assessment Performed in the Initial Phase of Decompensated Cirrhosis With Edema and Ascites by an Expert Intensive Care Physician and a Non-expert Gastroenterologist Observational departure of the principal recruiter in the study Actual 55
NCT03727165 Suspended Nocturnal Cyclic Enteral Nutrition Infusion Versus Continuous Infusion of Enteral Nutrition N/A Interventional Covid pandemia. Is one temporal decision. Anticipated 260
NCT04008550 Terminated Prognostic Impact of the Evolution of PAH 3 Months After TAVI (HTP-TAVI) N/A Interventional - Delay in enrolment (24% at 1 year) - Lower than estimated prevalence of PAH (15% instead of 50%) - Refusal of patients with PAH to participate Actual 101
NCT04295616 Terminated Additional Effect of Intrapulmonary Percussive Ventilation (IPV) on Respiration in People With Multiple Sclerosis (MS). N/A Interventional Due to COVID-19 situation IPV is no longer allowed in the center Actual 5
NCT04408391 Withdrawn Brain MRI Imaging in Patients With SARS-Cov2 (COVID-19) Infection With or Without Anosmia Observational No Inclusion potentiel Actual 0
NCT02756013 Terminated Weight-based Dosing for Dense Weekly Paclitaxel and Carboplatin in Overweight Patients w/ Body Surface Area (BSA) > 2.0 Phase 2 Interventional Lack of accrual - terminated Actual 3
NCT02758899 Terminated Diabetes and Glycosylation in Cervical Spondylosis Observational Actual 21
NCT03642457 Terminated Efficacy Between Serratus Plane Block And Local Infiltration In Vats Phase 4 Interventional PI left institution and unable to find new PI Actual 65
NCT01961804 Terminated PREVACT : Preventive REversal of Vitamine K Antagonist in Minor Craniocerebral Trauma Phase 3 Interventional Actual 202
NCT02952586 Terminated Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100) Phase 3 Interventional Actual 697
NCT04501211 Withdrawn Open Label Transdermal Granisetron to Relieve Chronic Nausea and Emesis Phase 2 Interventional Abandoned due to limited resources Actual 0
NCT03163459 Suspended Short-duration Selective Brain Cooling for Patients Undergoing Mechanical Thrombectomy Phase 2/Phase 3 Interventional Interim analysis Anticipated 120
NCT04287543 Withdrawn Melatonin on Clock Genes in Parkinson's Disease Phase 2/Phase 3 Interventional Due to the COVID-19 pandemic, we were unable to begin the study Actual 0
NCT04321850 Terminated Impact of the Use of Zinc in the Prevention of Oral Mucositis in Pediatric Patients With Lymphoblastic Acute Leukemia. N/A Interventional Health restrictions due to the COVID-19 pandemic Actual 21
NCT04353505 Withdrawn Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache Phase 1 Interventional PI closed the study before any enrollment Actual 0
NCT04424537 Suspended SOAR-2: Intervening in Obesity Through Reduction of Dietary Branched Chain Amino Acids Early Phase 1 Interventional Suspended due to lack of funding Anticipated 132
NCT03073759 Terminated Effect of Transcranial Direct Current Stimulation on Peripheral Neuropathy N/A Interventional Not enough participants Actual 4
NCT00156429 Terminated Genetic Predictors of Outcome in HCM Patients Observational Preliminary analyses did not reveal significant associations. Actual 98
NCT02799836 Withdrawn The Effect of Light Deprivation on Visual Functions in Adult Amblyopes N/A Interventional This study never started, did not receive IRB approval and was closed administratively at the site. Therefore, no subjects were recruited or enrolled. Actual 0
NCT03313076 Terminated Vitamin D and n-3 PUFAs to Prevent Chronic Pain Following Major Thermal Burn Injury Phase 2 Interventional COVID-19 global pandemic, and study funding period ended 7/31/2020. Actual 24
NCT03583931 Suspended Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication N/A Interventional Lack of study personnel Anticipated 36
NCT03839485 Suspended Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic Phase 3 Interventional Follow-ups paused temporarily since March 16th, 2020 due to COVID-19 Actual 98
NCT03949530 Terminated A Study of Safety & Blood Levels of IDL-2965 in Healthy Subjects and Patients With a Special Type of Pulmonary Fibrosis Phase 1 Interventional Due to development challenges associated with the SARS-CoV-2 pandemic and emerging nonclinical data Actual 6
NCT04260360 Withdrawn Trial of NanoDoce Intratumoral Injection in Renal Cell Carcinoma Phase 1 Interventional Not initiated Actual 0
NCT02828098 Terminated Exploratory Study of BO-112 in Adult Patients With Aggressive Solid Tumors Phase 1 Interventional Actual 44
NCT03294200 Terminated Clinical Trial Evaluation of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System N/A Interventional As per sponsor Actual 18
NCT03632967 Terminated Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System N/A Interventional as per sponsor Actual 7
NCT03662009 Suspended Multi-limb Dual-task Control in Parkinson's Disease Observational Temporary Restrictions on in-person contact due to COVID-19 Anticipated 60
NCT00714272 Terminated Granulocytapheresis in Psoriasis N/A Interventional Primary outcome not achieved. Actual 4
NCT02436135 Terminated Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Idelalisib in Adults Receiving Ruxolitinib as Therapy for Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis With Progressive or Relapsed Disease Phase 1 Interventional Actual 10
NCT02151019 Terminated Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer Phase 1/Phase 2 Interventional Actual 94
NCT02424955 Suspended Feasibility 3D Perfusion Ultrasound for Liver Cancer SABR Planning and Response Evaluation N/A Interventional Suspended due to Covid Anticipated 20
NCT02834481 Terminated Assessment of Pain Monitoring With ANI/NIPE Monitor Program in Pediatric Cardiac Surgery Postoperative. N/A Interventional too complicated recruitment Actual 20
NCT03303235 Withdrawn Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections Early Phase 1 Interventional Collaborators left the institution. Actual 0
NCT03381677 Suspended Pedicle Osteotomy for Stenosis Trial N/A Interventional In light of the ongoing COVID-19 pandemic and its impact on clinical trials Anticipated 344
NCT03762681 Terminated A Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection Phase 1 Interventional The study was terminated due to program discontinuation. Actual 55
NCT03784963 Terminated Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD Phase 1/Phase 2 Interventional Low enrollment Actual 35
NCT04264052 Suspended Characterisation of Large Airway Collapse During Exercise (LACE) Observational Due to COVID-19 Royal Brompton Hospital's internal imposed restrictions Anticipated 40
NCT04418934 Withdrawn Clinical Investigation to Evaluate the Hemanext® Red Blood Cell Processing System for Extended Storage of Leukoreduced Red Blood Cells Phase 2 Interventional Grant application for study was rejected Actual 0
NCT03465735 Terminated Vascular Boot Warming Program After Acute Deep Vein Thrombosis (DVT) ± Pulmonary Embolism (PE) N/A Interventional Due to lack of recruitment of eligible participants Actual 15
NCT01387477 Withdrawn Lactate to Treat Hypoglycemia Phase 4 Interventional Actual 0
NCT01794559 Suspended Study to Evaluate the Safety and Efficacy of PEER Interactive Versus Treatment as Usual in Subjects With a Primary Diagnosis of Depression N/A Interventional No site recruitment due to Covid-19 Anticipated 1922
NCT02021721 Terminated Next Generation DNA Sequencing in Patients With Idiopathic Male Infertility Observational Lack of funding Actual 5
NCT02229175 Withdrawn Laser vs Bevacizumab Injection Alone in Treatment of Diabetic Macular Edema Phase 2/Phase 3 Interventional Study not feasible with current resources. Actual 0
NCT02679560 Terminated Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures Phase 2 Interventional Poor recruitment Actual 1
NCT02685111 Terminated Intermittent G-CSF in Patients With Breast Cancer Receiving Adjuvant Docetaxel, Doxorubicin, and Cyclophosphamide (TAC) Phase 2 Interventional Actual 22
NCT02762318 Terminated Identification and Characterization of Bone-related Genetic Variants in Families Observational Lack of funding Actual 5
NCT03059615 Withdrawn A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS Phase 2 Interventional No recruitment since initiation Actual 0
NCT03113617 Suspended 68Ga-RM2 PET/CT in Detecting Regional Nodal and Distant Metastases in Patients With Intermediate or High-Risk Prostate Cancer Phase 2 Interventional Suspended due to Covid Anticipated 90
NCT03854214 Suspended Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury Early Phase 1 Interventional Patient recruitment is temporarily suspended due to COVID-19. Anticipated 48
NCT04220892 Withdrawn Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma Early Phase 1 Interventional One of the study drugs will no longer be supplied by manufacturer and the pembrolizumab + abemaciclib study arm is removed due to toxicity seen in other trials. Actual 0
NCT04316598 Terminated Cannabis Effects on Electroencephalography Phase 1 Interventional Terminated by the sponsor in the context of COVID-19 pandemia Actual 16
NCT04335552 Terminated Pragmatic Factorial Trial of Hydroxychloroquine, Azithromycin, or Both for Treatment of Severe SARS-CoV-2 Infection Phase 2 Interventional Poor recruitment, strong evidence from larger trials of no therapeutic benefit Actual 11
NCT04412252 Withdrawn Safety and Efficacy of Tofacitinib in Hospitalized Participants With COVID-19 Pneumonia Who Are Receiving Standard of Care Therapy Phase 2 Interventional Due to the pursuit of other SARS-CoV-2-related research including alternative trials with tofacitinib, this trial was canceled prior to subject enrollment. Actual 0
NCT02258464 Terminated Study of Radium-223 Dichloride Versus Placebo and Hormonal Treatment as Background Therapy in Subjects With Bone Predominant HER2 (Human Epidermal Growth Factor Receptor 2) Negative Hormone Receptor Positive Metastatic Breast Cancer Phase 2 Interventional Due to lower than expected recruitment since the start of study Actual 99
NCT02665143 Suspended A Randomized Trial of a Combination of Nintedanib/Placebo in Combination With Induction Chemotherapy for Patients With Refractory or First Relapse Acute Myeloid Leukemia Phase 1/Phase 2 Interventional Anticipated 60
NCT00983528 Terminated Alemtuzumab and Clofarabine for Relapsed or Refractory Acute Lymphoblastic Leukemia Phase 1/Phase 2 Interventional Support withdrawn due to slow accrual Actual 6
NCT04493528 Suspended Needle-free Dental Anesthesia N/A Interventional COVID-19 Anticipated 30
NCT00889083 Withdrawn Hepatic Mitochondrial Function in Sepsis Observational no patients to include Actual 0
NCT01199211 Terminated Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism Observational IRB approval expired Actual 187
NCT03907813 Withdrawn Liposomal Bupivacaine After Cesarean Delivery Phase 4 Interventional change in design Actual 0
NCT02394106 Terminated Ofatumumab in Children With Drug Resistant Idiopathic Nephrotic Syndrome Phase 2 Interventional Actual 13
NCT02648971 Terminated Controlled Trial to Compare Single Versus Two Portal Knee Arthroscopy Techniques N/A Interventional Actual 37
NCT04249180 Withdrawn Eye Rubbing and Keratoconus in Montpellier CHU Observational CPP Actual 0
NCT04419493 Suspended A Study in Healthy Men to Compare 2 Different Formulations of Alteplase Phase 1 Interventional The study was put on hold after observation of unexpected laboratory findings. Root cause analysis is ongoing. Anticipated 60
NCT01498445 Terminated An Open-Label, Phase I/II Study of Two Different Schedules of Dasatinib (Sprycel) and Decitabine (Dacogen) Used in Combination for Patients With Accelerated or Blastic Phase Chronic Myelogenous Leukemia (Protocol CA180357) Phase 1/Phase 2 Interventional Terminated per memo from PI/study team Actual 33
NCT01974154 Terminated COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function Observational Lack of funding. Actual 206
NCT02514252 Terminated Sublingual Fentanyl for the Management of Breakthrough Pain Phase 2 Interventional Actual 6
NCT02693717 Terminated Pemetrexed Disodium in Treating Patients With Previously Treated Metastatic Urothelial Cancer Phase 2 Interventional The trial was closed due to the changing efficacy of treatments for metastatic urothelial cancer. Actual 7
NCT02737202 Terminated Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis Phase 2 Interventional Actual 28
NCT02740114 Terminated Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway Phase 3 Interventional Per PIs request Actual 105
NCT02765165 Terminated Phase 1/2 Study of USL311 Alone and in Combination With Lomustine in Subjects With Advanced Solid Tumors and Relapsed/Recurrent Glioblastoma Multiforme (GBM) Phase 1/Phase 2 Interventional Business reasons not related to safety Actual 26
NCT03135470 Terminated Pain Medication After Ambulatory Surgery Observational Phase II recruitment unsuccesful, phase III lacking personnel resources Actual 146
NCT03345953 Terminated Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome Phase 2 Interventional Study facing recruitment difficulties related to stringent eligibility criteria Actual 29
NCT03448874 Withdrawn Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study] N/A Interventional The company will design a new study Actual 0
NCT03505606 Suspended New Visual Acuity and Crowding Tests for Better Detection of Amblyopia N/A Interventional Clinic building closed due to COVID pandemic. Anticipated 48
NCT03736642 Withdrawn Study of the Microbiological Profile of Stool in Patients With Anorexia Nervosa Observational never started Actual 0
NCT03847389 Terminated Clobetasol Topical Oil for Children With Moderate to Severe Atopic Dermatitis Phase 1/Phase 2 Interventional Difficulty in enrollment and COVID-19 pandemic. Actual 8
NCT03886753 Terminated Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products Observational Feasibility Actual 10
NCT04021797 Terminated Autonomic Mechanisms of Sleep-dependent Memory Consolidation N/A Interventional Study stopped due to COVID-19 Actual 12
NCT04267315 Suspended Trigger Point Injections for Post-Mastectomy Pain Syndrome Phase 2 Interventional COVID pandemic Anticipated 120
NCT02926248 Suspended Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement Phase 4 Interventional Continuing IRB review was not submitted. Study was inactivated with the institutional IRB. Anticipated 112
NCT02654704 Terminated Vaccination Responses in Young and Older Adults Observational There was insufficient enrollment of subjects. Actual 61
NCT03511222 Terminated Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors Phase 1 Interventional Low accrual Actual 16
NCT00293215 Terminated Biodistribution Study of CMD-193 in Patients With Advanced Tumours Expressing the Lewis-Y Antigen Phase 1 Interventional Abnormal distribution and lack of tumor targeting were observed. Actual 9
NCT03750773 Withdrawn Gabapentin for Relief of Immediate Postoperative Pain Phase 1/Phase 2 Interventional Lack of funding Actual 0
NCT03809130 Terminated Effectiveness of an Online Intervention Targeting Cancer-related Fatigue N/A Interventional Terminated Per PI Actual 27
NCT03876132 Terminated Perception of the Risks of Alcohol and Individual Vulnerabilities in Young Adults Observational The number of patients is suffisant to answer to the primary outcome Actual 23
NCT03881007 Terminated A Trial to Compare Antibacterial vs. Placebo Mouthwash to Reduce the Incidence of STIs in MSM Taking HIV PrEP N/A Interventional An interim analysis, planned because of the influence of the COVID-lockdown, showed the LCM mouthwash did not affect the incidence of Ng, Ct and syphilis. Actual 343
NCT03947437 Withdrawn Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients Phase 1/Phase 2 Interventional Finances Actual 0
NCT04013373 Suspended Home-Based Fluid Status Monitoring in Heart Failure Patients Observational Covid-19 pandemic Anticipated 200
NCT04038424 Suspended The Effect of Art Therapy on Patients With Stroke N/A Interventional Due to the Pandemic of COVID-19 Anticipated 60
NCT04248959 Suspended Prehabilitation to Improve Cancer Surgery Outcomes in AYA Patients With Extremity Sarcomas N/A Interventional COVID-19 Anticipated 30
NCT04290832 Terminated Developing and Testing Interventions to Address Conscientious Objection to Abortion Care in Mexico and South Africa N/A Interventional The study was stopped prematurely due to the COVID-19 pandemic Actual 317
NCT01715571 Terminated Assessment of Penile Vibratory Stimulation Using the Viberect in Men With Mild-Moderate ED N/A Interventional Unable to obtain adequate recruitment Actual 7
NCT02507232 Terminated Study of NovoTTF-200A Alone and With Temozolomide in Patients With Low-Grade Gliomas Early Phase 1 Interventional low enrollment Actual 2
NCT03013608 Terminated Children's Nail Bed Injuries : Study of the Efficacy of the Simple Relocation of Nail Plate N/A Interventional recruitment difficulty Actual 7
NCT03170583 Terminated SJM Brady MRI Post Approval Study Observational Abbott received FDA approval to transition the ongoing Brady MRI PAS study to EP a new EP-Passion Real World Evidence methodology Actual 1768
NCT03287180 Withdrawn Adolescent Community Reinforcement Approach in Combination With Buprenorphine/Naloxone for Severe Opioid Use N/A Interventional unable to enroll any participants Actual 0
NCT03698370 Suspended Gallium Ga 68 DOTA-NeoBOMB1 and Gallium Ga 68 PSMA-R2 PET/MRI in Diagnosing Participants With Recurrent Prostate Cancer Phase 2 Interventional Due to Covid-19 issues Anticipated 50
NCT03831711 Suspended 68-Ga-RM2 PET/MRI in Imaging Patients With Estrogen Receptor-Positive Breast Cancer Phase 1/Phase 2 Interventional Due to Covid issues Anticipated 20
NCT03949517 Suspended A Pilot Study of 68-Ga PSMA 11 PET/MRI and 68-Ga RM2 PET/MRI for Evaluation of Prostate Cancer Response to HIFU or HDR Therapy Phase 1/Phase 2 Interventional Due to Covid Anticipated 10
NCT04105842 Suspended Refitting Daily Disposable Contact Lens Wearers With Dry Eye Disease With A Different Daily Disposable Lens Type N/A Interventional COVID-19 Anticipated 43
NCT04159935 Suspended Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease Phase 4 Interventional COVID-19 Anticipated 52
NCT04201639 Suspended Evaluating the Performance of Precision1 Daily Disposable Contact Lens in a Group of Heavy Digital Device Users N/A Interventional COVID-19 Anticipated 35
NCT04205162 Suspended Evaluating the Initial Lens Handling Experience of Neophyte Contact Lens Wearers Fitted With Precision1 and 1-Day Acuvue Moist Contact Lenses N/A Interventional COVID-19 Anticipated 60
NCT04209530 Suspended Impact of CCH Treatment of Buttock and Thigh Cellulite in Adult Women Phase 2 Interventional Study temporarily suspended due to COVID-19 related disruptions Anticipated 19
NCT04264208 Suspended HDR Brachytherapy 68-Ga-RM2 PET, 68-Ga-PSMA-11 PET &Multi Parametric MRI in Prostate Cancer Phase 2 Interventional Due to Covid Issues Anticipated 100
NCT04322903 Withdrawn Passport to Freedom: Health and Housing N/A Interventional Due to COVID 19 restrictions and protocol could not to be implemented safely for participants and researchers. Actual 0
NCT04490863 Suspended Noninvasive Hemoglobin Repeatability and Reproducibility in a Blood Donation Setting N/A Interventional Enrollment paused due to Covid-19 pandemic Anticipated 26
NCT02904876 Terminated Evaluation of Early Changes Visible to the Diffusion MRI in Response to Two Years of Treatment With Tysabri in Patients With Multiple Sclerosis Phase 4 Interventional Actual 70
NCT04114019 Withdrawn The Effect of Pelvic Floor Physiotherapy on Vaginal Elasticity Observational The study device became unavailable for use. Actual 0
NCT04140539 Suspended A Clinical Study to Enable Process Validation of Commercial Grade OTL-101 Phase 2/Phase 3 Interventional Recruitment on hold for business reasons Anticipated 3
NCT02269345 Terminated Auricular Acupuncture in Ureteral Stent Pain N/A Interventional Unworkable. This study had several PIs and attempted several avenues of recruitment. Still were only able to recruit 34 out of the 120 needed. Actual 34
NCT02608307 Terminated Medical Treatment Decision Making Using Adaptive Conjoint Analysis Observational Slow accrual and COVID-19 restrictions Actual 14
NCT02678351 Suspended 68Ga-PSMA-11 PET/MRI in Finding Tumors in Patients With Intermediate or High-Risk Prostate Cancer Undergoing Surgery Phase 2/Phase 3 Interventional Due to Covid-19 Anticipated 200
NCT02722512 Terminated Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Phase 1 Interventional Lack of substantial evidence for immune responses in response to vaccination. Actual 10
NCT01341730 Terminated The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Phase 4 Interventional Actual 41
NCT02749526 Terminated Endostar Combined With MPFC Adjuvant Treatment of Esophageal Cancer Clinical Trial Phase 2 Interventional low accrual rate Anticipated 70
NCT02959411 Terminated Tolvaptan for Advanced or Refractory Heart Failure Phase 4 Interventional Low accrual rate Actual 9
NCT03115840 Suspended Measuring Outcomes of Activity in Intensive Care Observational Study enrollment halted due to COVID-19 Anticipated 312
NCT03978390 Withdrawn Improving Children's Cooperation During Dental Injection N/A Interventional Change in research direction Actual 0
NCT04040127 Withdrawn Residual Dental Pulp Tissue and Cord Blood Stem Cells Phase 2 Interventional Did not obtain IRB approval Actual 0
NCT01798043 Terminated Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance N/A Interventional Due to slow enrolment Actual 29
NCT04136847 Withdrawn Study to Evaluate the Efficacy and Tolerability of the SkinPen on Male and Female Subjects' Dorsal Hands as a Treatment for Signs of Hand Aging N/A Interventional Due to COVID 19 the Study did not start enrolling Actual 0
NCT04285749 Withdrawn Prevention of Recurrence and Metastasis in Genetically High-Risk Melanomas Early Phase 1 Interventional PI moving to new institution prior to study activation Actual 0
NCT02727127 Terminated Brain Ion Homeostasis, Lithium and Bipolar Disorder Observational Lost funding due to low enrollment Actual 26
NCT02911467 Terminated Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in Castration-Resistant Prostate Cancer Phase 1 Interventional Low Accrual Actual 8
NCT03198156 Terminated Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy N/A Interventional Funding Stopped Actual 39
NCT03216538 Terminated Safety and Efficacy of AS101 1% Oral Solution in Patients With Neovascular Age-Related Macular Degeneration (AMD) Phase 1/Phase 2 Interventional Sponsor's decision. Actual 20
NCT03651531 Terminated Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus Phase 3 Interventional Trial halted early due to limited ability to recruit participants Actual 1
NCT03822195 Withdrawn Lectine Pathway in Unstable Carotid Plaque Observational PI changed Institution Actual 0
NCT03839940 Suspended Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer Phase 3 Interventional New drug distribution process Anticipated 279
NCT03879044 Terminated Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD) N/A Interventional Funding stopped Actual 16
NCT04034914 Terminated Yoga Intervention in Supporting Children With Cancer and Their Parents During Chemotherapy Infusion N/A Interventional Funding unavailable Actual 10
NCT01982149 Terminated Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer Observational Lack of funding Actual 27
NCT04487548 Suspended Perioperative Smoking Cessation BUndle in Tertiary Care - Can Timing Improve OUTcomes? N/A Interventional COVID19 changed the workflow within the department and the study is no longer feasible Anticipated 214
NCT02188511 Terminated Effects of Electronic Cigarettes on Lung Biology N/A Interventional Lack of funding Actual 13
NCT02247648 Terminated Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy Phase 2 Interventional Actual 100
NCT02531295 Suspended Immunologic Response to Kansui in Treated HIV+ Individuals: a Dose Escalation Study Phase 1 Interventional Temporary pause on non-COVID clinical trial recruitment at study site Anticipated 9
NCT02675218 Terminated Bone MicroArchitecture Abatacept (BMA2) Observational No more inclusion Actual 13
NCT02687477 Terminated PADN to Treat Severe Obstructive Sleep Apnea N/A Interventional Lack of patients meeting the criteria for admission Actual 1
NCT03390413 Withdrawn Robot-assisted Surgical Resection vs. Cryoablation of Localised Renal Cancer Phase 3 Interventional Logistics and lack of funding Actual 0
NCT03393117 Withdrawn Bupivacaine Versus Liposomal Bupivacaine For Breast Pain Management After Breast Recontruction Phase 2 Interventional No accrual Actual 0
NCT01652157 Terminated Long-term Study in US Cystic Fibrosis Patients Receiving Digestive Enzyme Supplements to Assess Narrowing of the Large Intestine Causing Adverse Intestinal Symptoms (Fibrosing Colonopathy) Observational Strategic considerations Actual 17
NCT02075047 Terminated Efficacy and Safety Trial of Flexible Doses of Oral Ziprasidone in Children and Adolescents With Bipolar I Disorder Phase 3 Interventional Based on recent input from FDA, the pre-specified final analysis will be performed at the current enrollment using a re-estimation of the sample size. Anticipated 194
NCT02180152 Withdrawn Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial N/A Interventional Actual 0
NCT02717650 Suspended The Alfred Step Test Exercise Protocol (A-STEP), for Adults With Cystic Fibrosis. N/A Interventional Validation study suspended due to Covid-19 restrictions-will resume when able Anticipated 30
NCT02864355 Terminated Does Perioperative Goal Directed Therapy Using Flotrac Improve Outcomes in Esophagectomy Patients N/A Interventional Minimally invasive surgical methods have ceased enrollment Actual 35
NCT03067480 Terminated Comparison of 3 Versus 6-Month Use of CGMS in Non-Insulin Using T2DM Patients N/A Interventional Low enrollment Actual 12
NCT03128580 Terminated Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles Observational After an interim analysis, it was decided to discontinue the study after a stochastic curtailment analysis. Actual 40
NCT03324516 Withdrawn The Effect of Temporal Muscle Suspension of Temporal Hollowing N/A Interventional Due to limited support staff and time, study was unable to get started Actual 0
NCT03331666 Terminated Impact of LDL-cholesterol Lowering on Platelet Activation Phase 4 Interventional Terminated Prematurely due to COVID-19 Actual 4
NCT03341143 Suspended Fecal Microbiota Transplant (FMT) in Melanoma Patients Phase 2 Interventional Study suspended due to COVID 19. Study recruitment estimated to resume by September, 2020. Anticipated 20
NCT03586778 Suspended Dry Needling for Patients With Back Pain N/A Interventional COVID-19 Anticipated 48
NCT03730896 Terminated Effectiveness of Dry Needling of the Sternocleidomastoid in Patients With Cervicogenic Headaches N/A Interventional Not enough viable subjects Actual 17
NCT03930225 Suspended Effectiveness of A Stigma Directed Interventional Program in Schizophrenia N/A Interventional Covid 19 Break has caused the research to stop temporarily for safety of participants and conductors Anticipated 160
NCT03993379 Terminated PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors Phase 2 Interventional Sponsor's Decision Actual 3
NCT04059653 Terminated Evaluation of a New Technology for the Treatment of Bladder Leakage in Women N/A Interventional COVID19 pandemic. Cannot recruit from primary care during pandemic Actual 86
NCT04199481 Withdrawn Univation XM France Observational Study stopped due to product discontinuation by manufacturer Actual 0
NCT02662634 Withdrawn A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer Phase 2 Interventional Actual 0
NCT03304990 Withdrawn Panomics Relationships in the Epidemiology of Cancer Through In Silico Expression (PRECISE) Observational [Patient Registry] PI has left our Inst. Actual 0
NCT03513458 Withdrawn Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation Phase 1/Phase 2 Interventional [The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic. Actual 0
NCT03513471 Withdrawn Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation Phase 1/Phase 2 Interventional The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic. Actual 0
NCT03652298 Terminated Effects of a Neuroscience-based Technique on Cancer Patients Announced of a Palliative Disease Progression and Partners Phase 2 Interventional Lack of recruitment and of study staff Actual 19
NCT03663790 Suspended Effects of Gait Retraining on Lower Extremity Biomechanics N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 51
NCT03676712 Terminated The Effect of Flexible Thoracolumbar Brace on Idiopathic Scoliosis, Prospective, Randomized, Open-label Trial N/A Interventional Recruitment of subjects was not successful. Actual 17
NCT03687476 Withdrawn Safety and Tolerability Study of VTS-270 in Pediatric Participants With Niemann-Pick Type C (NPC) Disease Phase 2 Interventional Business decision to Cancel Actual 0
NCT03776864 Suspended Umbralisib and Pembrolizumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma Phase 2 Interventional Unacceptable Toxicity Anticipated 20
NCT03864393 Suspended Effect of Multimodal Exercise Training on Walking Economy in Individuals With Parkinson's Disease N/A Interventional Paused due to COVID-19. Expected to resume. Not a suspension of IRB approval. Anticipated 30
NCT03872336 Terminated Acute Labetalol Use in Preeclampsia Phase 4 Interventional Slow enrollment Actual 15
NCT03877692 Terminated Acute Control of Chronic Hypertension Phase 4 Interventional Slow enrollment Actual 10
NCT04023721 Terminated Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic, Hepatitis B e Antigen-negative Subjects Infected With HBV Virus and Receiving or Stopping Treatment With a NUC Inhibitor Phase 2 Interventional Safety Actual 64
NCT04248361 Suspended TEM-PCR™ Prospective Clinical Utility Study Phase 4 Interventional COVID-19 Anticipated 314
NCT03239951 Terminated Study to Assess the Efficacy, Safety and Tolerability of (iTind) N/A Interventional Due to the COVID-19 outbreak and the overall low recruitment Actual 5
NCT03588936 Terminated Nivolumab and Tocilizumab for Relapsed Hematological Malignancy Post-allogeneic Transplant Phase 1 Interventional Halted for convenience due to COVID19 challenges. Actual 2
NCT03955718 Withdrawn Developing and Testing Motherly App: a Smartphone Application to Promote Mothers' Mental Health N/A Interventional The study stopped because of delays in the development of the smartphone app intervention Actual 0
NCT03234387 Suspended A CFit Study - Baseline Observational Poor recruitment Anticipated 45
NCT03237767 Suspended A CFit Study - Acute Exercise N/A Interventional Poor recruitment Anticipated 16
NCT02651116 Terminated Dextromethorphan Pediatric Acute Cough Study Phase 4 Interventional The study was prematurely discontinued due to slow enrollment during the 2019/2020 cold season. No safety or efficacy concerns led to the decision to terminate Actual 131
NCT03545165 Terminated 177Lu−J591 and 177Lu−PSMA−617 Combination for mCRPC Phase 1/Phase 2 Interventional Sponsor withdrawal Actual 6
NCT03586934 Terminated Multimodal Analgesia in Shoulder Arthroplasty Phase 3 Interventional Difficult to enroll patients for the study Actual 18
NCT03607864 Terminated Coral Bone Graft Verses Xenograft With Immediate Implant in Maxillary Anterior Esthetic Zone N/A Interventional because bone osteointegration is completed Actual 18
NCT03978416 Terminated Development of Novel Behavioral Intervention for Sustainable Weight Loss in Hispanic Adults With Obesity N/A Interventional The study was terminated due to the SARS-CoV-2 pandemic. Aim 1 was completed. Actual 23
NCT04277442 Suspended Testing Nivolumab in Combination With Decitabine and Venetoclax in Patients With Newly Diagnosed TP53 Gene Mutated Acute Myeloid Leukemia Phase 1 Interventional Other - Pending amendment to address FDA comments Anticipated 13
NCT04439305 Withdrawn Testing Dasatinib as a Potential Targeted Treatment in Cancers With DDR2 Genetic Changes (MATCH-Subprotocol X) Phase 2 Interventional zero accrual Actual 0
NCT02781961 Terminated Identification of In-vivo Probe Based Confocal Laser Endomicroscopy Cellular Characteristics in Obese Women Observational Actual 10
NCT03632954 Terminated Cytal® Wound Matrix and MicroMatrix® Wound Study Observational Sponsor Decision Actual 39
NCT04475861 Withdrawn Metabolomics and Wound Healing in Diabetes N/A Interventional no participants enrolled Actual 0
NCT00388739 Withdrawn Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department N/A Interventional Different study was designed Actual 0
NCT03008980 Withdrawn The Analysis of WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) Increased Yield of Barrett's Esophagus and Esophageal Dysplasia Observational Study halted prematurely, prior to enrollment of first participant. Actual 0
NCT03214809 Terminated The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams N/A Interventional Slow inclusion rate (partly due to Covid-19) Actual 100
NCT03214835 Withdrawn CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions N/A Interventional Study halted prematurely, prior to enrollment of first participant. Actual 0
NCT03399097 Withdrawn Characterizing the Intestinal Hormonal Secretion in Non-obese, Obese and Non-obese Patients After Bariatric Surgery Observational change sites Actual 0
NCT03414112 Suspended The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa Early Phase 1 Interventional Recruitment is suspended due to COVID-19. Anticipated 40
NCT04043520 Suspended Bioenergetic Effects of Aging and Menopause (BEAM) Phase 4 Interventional COVID-19 Closure Anticipated 95
NCT04231188 Terminated User Experience of a Mobile Application Observational Delay in recruitment due to corona virus pandemic resulted in a newer version of mobile app made available and testing on the old version will be redundant. Actual 6
NCT04298814 Withdrawn Safety Related Factors of Endotracheal Intubation in Patients With Severe Covid-19 Pneumonia Observational It was repeated with other studies in the same department Actual 0
NCT04477642 Withdrawn Abatacept for Patients With COVID-19 and Respiratory Distress Phase 1/Phase 2 Interventional Funding Actual 0
NCT02798939 Terminated Evaluation of Lactoferrin, Procalcitonin and Aution® Urine Dipsticks for the Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Observational investigator choice Actual 123
NCT02819544 Withdrawn Evaluation of the Interest of the Instillation of Saline Intraperitoneally (INSI ) Versus Instillation of Naropin the Surgical Site Versus Lung Recruitment Maneuvers ( PVM ) in the Management of Pain After Laparoscopic Cholecystectomy in Ambulatory Care Phase 3 Interventional investigator choice Actual 0
NCT02828800 Terminated Cartography of Allodynic and Hypoasthetic Territories Following TKA Observational investigator choice Actual 38
NCT03132818 Withdrawn Impact of the Assumption in Charge of Medical Aid to the Procreation With Donation of Gametes on the Sexuality of the Couple Observational investigator choice Actual 0
NCT03145870 Withdrawn Prevalence of Asymptomatic Thrombosis in Multiple Myeloma N/A Interventional investigator choice Actual 0
NCT03149952 Withdrawn A Pilot Study of the Feasibility of Setting up a Logbook for Allogeneic Haematopoietic Stem Cell Patients at the University Hospital of Amiens N/A Interventional investigator choice Actual 0
NCT02845336 Terminated Celecoxib for Thyroid Eye Disease Phase 2 Interventional Poor enrollment Actual 7
NCT03295656 Withdrawn Contrast-Enhanced Ultrasound Diagnosis of Acute Appendicitis Phase 1 Interventional Unanticipated delays. Actual 0
NCT03342638 Terminated Maximizing Outcome of Multiple Sclerosis Transplantation Phase 3 Interventional PI Sabbatical Actual 66
NCT03167151 Terminated Pembrolizumab in Intermediate Risk Recurrent Non-muscle Invasive Bladder Cancer (NMIBC) Phase 1/Phase 2 Interventional The study failed to recruit within the permitted timeframe Actual 6
NCT03537521 Withdrawn Reversal Agent Use in Patients Treated With Direct Oral Anticoagulants or Vitamin K Antagonists (RADOA). Focus on New Antidots Observational [Patient Registry] due to corona pandemic crisis Actual 0
NCT03696901 Terminated Xydalba Utilization Registry in Germany Observational Terminated Actual 16
NCT03797430 Withdrawn Determination of Normal Values for the Star Excursion Balance Test (SEBT) in Handball Players Observational NO PARTICIPANTS ENROLLED Actual 0
NCT03983486 Withdrawn Rationale for Cytogenetic Risk Stratification by Imaging Flow Cytometry in Multiple Myeloma Observational technical problem Actual 0
NCT04192513 Suspended Observer-Blinded Dose Escalating, Single Dose to Study Safety and Antimicrobial Efficacy of Gel vs. Placebo Phase 2 Interventional Covid-19 has shut the clinic indefinitely Anticipated 12
NCT04315051 Suspended A Trial of Safety/Efficacy of Test Article in Patients With Interdigital T. Pedis Phase 2 Interventional Covid- 19 has shut the clinic Anticipated 80
NCT04345614 Suspended A Study of Auxora in Patients With Severe COVID-19 Pneumonia Phase 2 Interventional FDA strongly recommended transitioning to blinded, placebo-controlled RCT. Anticipated 400
NCT02032784 Terminated Prophylactic Octreotide to Prevent Post Duodenal EMR and Ampullectomy Bleeding Phase 4 Interventional Difficult to enroll subjects Actual 33
NCT03809650 Terminated A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Phase 3 Interventional Due to a change in the development strategy Actual 9
NCT03910790 Withdrawn Liver Biopsy Using a 19 Gauge Fine Needle Biopsy Needle N/A Interventional A competing study made it challenging to enroll subjects. Actual 0
NCT02333409 Terminated Acupuncture for Pain Control in Patients With Inoperable Pancreatic Cancer N/A Interventional Expertise resigned Actual 1
NCT03303690 Terminated AS: Ankle Spacer for Talar Osteochondral Defects N/A Interventional Arthrex stopped manufacturing the device Actual 2
NCT03676725 Suspended Assessing the Frequency of Lidocaine Ineffectiveness in the General Population Early Phase 1 Interventional Pandemic (Covid-19) Anticipated 100
NCT04167189 Suspended Assessing the Frequency of Lidocaine Ineffectiveness in ADHD Early Phase 1 Interventional Pandemic (Covid 19) Anticipated 40
NCT04411134 Withdrawn E7 TCR T Cell Immunotherapy for High-Grade Cervical Intraepithelial Neoplasia Phase 1 Interventional Closed based on the lack of perceived clinical activity observed from a different study treating a similar patient population with same study agent. Actual 0
NCT00992030 Terminated R-ABVD vs ABVD-RT in Early Stage Hodgkin's Lymphoma Phase 3 Interventional Low recruitment and difficulty in having study data Actual 112
NCT01113567 Suspended Effect of Lactose in Patients With Chronic Liver Disease and Minimal Hepatic Encephalopathy N/A Interventional The hospital was converte to attend only COVID19 patiens Actual 18
NCT01518959 Terminated The Effect of 25-OH-Vitamin-D3 Substitution in Patients With Malignant and Immune-hematologic Diseases Phase 3 Interventional Insufficient recruitment rate; technical issues with sample storage Actual 31
NCT02439307 Suspended Effycacy of Rifaximin on Reverse Minimal Hepatic Encephalopathy and Elimation Small Intestinal Bacterial N/A Interventional The hospital was converted to attend only covid19 patients Anticipated 46
NCT02547948 Withdrawn CD19-targeting CAR T Cells for B Cell Lymphoma Phase 1/Phase 2 Interventional Actual 0
NCT02547961 Withdrawn Chimeric Antigen Receptor-Modified T Cells for Breast Cancer Phase 1/Phase 2 Interventional Project terminated due to revision of local regulations Actual 0
NCT02565901 Terminated Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Phase 1/Phase 2 Interventional Terminated due to insufficient funding Actual 28
NCT02575261 Withdrawn CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients Phase 1/Phase 2 Interventional Actual 0
NCT02712905 Terminated An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies Phase 1/Phase 2 Interventional Strategic Business Decision Actual 116
NCT02723942 Withdrawn CAR-T Cell Immunotherapy for HCC Targeting GPC3 Phase 1/Phase 2 Interventional Project terminated due to revision of local regulations Actual 0
NCT02732015 Terminated Rolapitant Hydrochloride in Preventing Nausea/Vomiting in Patients With Sarcoma Receiving Chemotherapy Phase 2 Interventional Terminated per PI's request Actual 37
NCT03252171 Withdrawn CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients Phase 1/Phase 2 Interventional Project terminated due to revision of local regulations Actual 0
NCT03259659 Terminated Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Observational [Patient Registry] Principal Investigator was leaving the institution. Actual 20
NCT03439150 Terminated Resistance STEMI Study N/A Interventional slow enrolment Actual 5
NCT03445663 Terminated Study Evaluating AMG 424 in Subjects With Multiple Myeloma Phase 1 Interventional Sponsor business decision not to proceed with the AMG 424 asset. Actual 27
NCT03514407 Terminated A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma Phase 1 Interventional Strategic Business Decision Actual 25
NCT03621124 Suspended Maladaptive Adipose Tissue Activity in Cancer N/A Interventional Pause due to COVID-19 Pandemic Anticipated 36
NCT03669549 Terminated Nevanimibe HCl for the Treatment of Classic CAH Phase 2 Interventional Following an interim data review, further investment in nevanimibe has been discontinued Actual 15
NCT03755960 Suspended ACUpuncture in Diabetic Peripheral Neuropathy N/A Interventional due to the pandemic clin.research was suspended from 04/2020 on- tbc in 09/2020 Anticipated 110
NCT03862846 Terminated A Study of the Safety of REN001 in Patients With Primary Mitochondrial Myopathy Phase 1 Interventional COVID-19 Pandemic sufficient data gathered to achieve the study objective Actual 23
NCT04088032 Withdrawn Neoadjuvant Study of Abemaciclib, Durvalumab, and an Aromatase Inhibitor Early Stage Breast Cancer Early Phase 1 Interventional Per sponsor Actual 0
NCT04135768 Withdrawn A Study Examining The Effect Of Wrist Joint Haematoma Washout As An Adjunct Procedure To Plating Of The Distal Radius In Fractures Of The Distal Radius Involving The Wrist Joint N/A Interventional COVID19 pandemic: national lockdown imposed and study centre diverted all trauma cases to surrounding hospitals Actual 0
NCT04176978 Suspended PsA T2T Statin Trial on Carotid and Coronary Atherosclerosis N/A Interventional Lack of funding Anticipated 142
NCT04476693 Suspended Metabolic Responses to Breakfast in Adolescent Girls N/A Interventional Unable to recruit due to school closures in response to Covid-19 Anticipated 18
NCT02894086 Withdrawn A Retrospective Study of the Feasibility of Ambulatory Appendicectomy for Acute Appendicitis (Based on Data From the PMSI French National Hospital Information System) in the Adults Hospitalized Between December 2013 and December 2014 Observational Investigator choice Actual 0
NCT02973009 Withdrawn Impact of the Systematic Closure of the Epigastric Trocar on Postoperative Incisional Hernia After Sleeve Gastrectomy Rate of First Intention. Monocentric Study, Before / After Prospective. Observational investigator choice Actual 0
NCT03004482 Suspended Analysis of Video Imaging in Newborns Observational lack of Funding Anticipated 80
NCT03027934 Withdrawn A Single Center Study to Evaluate Ticagrelor Mechanism of Action in Inhibiting Juvenile Platelet ADP Response Phase 4 Interventional Study population difficult to recruit Actual 0
NCT03079661 Terminated Impact of Air Quality on Exacerbations of COPD in the Somme Observational investigator choice Actual 179
NCT03107390 Terminated Evaluation of NT-proBNP in Chronic Inflammatory Bowel Disease N/A Interventional investigator choice Actual 159
NCT03115138 Terminated Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas. N/A Interventional investigator choice Actual 19
NCT03139825 Withdrawn Connectivity and Social Cognition in Adolescent Girls With Borderline Personality Disorder, a Pilot Study N/A Interventional Not accepted Actual 0
NCT03144661 Terminated An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies Phase 1 Interventional Strategic Business Decision Actual 25
NCT03311074 Withdrawn Retroviral Insertion Site Methodology Study Phase 4 Interventional Replaced with new observational study design Actual 0
NCT03407976 Terminated Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies Phase 1 Interventional Funding source withdrew financial support prior to start of Phase II portion of study Actual 5
NCT03602872 Withdrawn Safety of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells in Subjects With Osteoarthritis Phase 1 Interventional Sponsor to start with different protocol, postponed due to COVID Actual 0
NCT03647085 Suspended Data Collection Atrial Fibrillation Exploratory Study Observational Due to COVID-19 Anticipated 50
NCT03698227 Terminated OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma Patients Phase 2 Interventional Lack of efficacy on olaratumab Actual 2
NCT03721393 Suspended Data Collection - Of Syncope Tilt Table Testing Study Observational Due to COVID-19, part of the budget used to fund the COST3 trial has been eliminated. The study will start again in the near future. Anticipated 50
NCT03847675 Suspended Reach Out and Read Arabic to Promote Arabic Literacy in Toddlers N/A Interventional Awaiting IRB approval of amendment Anticipated 206
NCT04049682 Withdrawn Start Times and Restful Sleep Observational Study never recruited subjects Actual 0
NCT04101890 Suspended The Healthy Baby Bottoms Study Phase 4 Interventional Pandemic preventing recruitment due to regulations limiting personnel in clinical spaces. Anticipated 100
NCT04150666 Withdrawn The Water Intake Trail and Primary Aldosteronism Postoperation(WIT-PAP) N/A Interventional No subjects are willing to participating. Actual 0
NCT04272645 Withdrawn Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate Cancer Phase 2 Interventional Coordinating site change Actual 0
NCT04293172 Withdrawn Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease. Phase 3 Interventional Study halted prematurely, prior to enrolment of first patient. Actual 0
NCT04331834 Suspended Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic Phase 3 Interventional The study has been suspended until a new epidemic curve occurs. Anticipated 440
NCT04474652 Suspended Guide for Prioritisation of Patients for Referral to Breast Clinics Observational COVID-19 Anticipated 4000
NCT04474795 Suspended Clinic to Community Connections N/A Interventional due to COVID-19 Anticipated 115
NCT02193152 Terminated Pazopanib in Molecularly Selected Patients With Advanced NSCLC Phase 2 Interventional Terminated by sponsor Actual 16
NCT03090126 Withdrawn Assessment of Therapeutic Education About Non Invasive Ventilation in Patients With Chronic Respiratory Failure (QoVNI) Observational No possibility to recruit. Actual 0
NCT03285165 Suspended Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU Patients Phase 2/Phase 3 Interventional NO AVAILABLE FUND Anticipated 60
NCT02050607 Withdrawn Fecal Microbiota Transplantation for the Treatment of Metabolic Syndrome Phase 2 Interventional Actual 0
NCT02078934 Withdrawn Endoscopic Gastric Plication for Weight Loss in Morbidly Obese Patients Prior to Incisional Hernia Repair N/A Interventional Did not receive funding for recruitment. Actual 0
NCT02418039 Suspended High Protein Diet Versus Normal Protein Diet in Treating Patients With Minimal Hepatic Encephalopathy N/A Interventional The hospital was convert to attend only COVID19 Anticipated 80
NCT02752230 Withdrawn Comparison of Exparel to Marcaine in Post-Surgical Analgesia in Bariatrics Phase 4 Interventional Attending physician left network Actual 0
NCT02814344 Terminated Comparative Study of the Propagation of Uterine Electrical Activity (EHG) in Pregnant Women During Pregnancy and During Labour Observational Investigator choice Actual 27
NCT02815501 Withdrawn Thyroid Dysfunction and Obstetric Complications Observational Investigator choice Actual 0
NCT02848508 Withdrawn Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Phase 2 Interventional Investigator choice Actual 0
NCT02281994 Terminated Odontoid Fracture Study Treated With Pulsed Electromagnetic Fields N/A Interventional Anticipated 360
NCT02436590 Terminated Efficacy and Safety of an Active Pulsed Electromagnetic Field for the Treatment of Osteoarthritis of the Knee N/A Interventional Anticipated 150
NCT02453490 Terminated Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis Phase 3 Interventional difficultly recruiting Anticipated 360
NCT03253679 Suspended AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification Phase 2 Interventional Other - Protocol amendment required for expansion Anticipated 32
NCT04272034 Withdrawn Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors Phase 1 Interventional Business Decision Actual 0
NCT03686176 Terminated Virtual Reality During Procedures in Pediatric Patients N/A Interventional Coronavirus (COVID-19)-related pause on all clinical research studies. Actual 64
NCT04471857 Terminated Hypnosis for Children Undergoing Anorectal Manometry N/A Interventional Due to COVID-19 recruitement stopped since intended sample size was an estimation and not based on power calculation Actual 34
NCT04472520 Withdrawn Use of AliveCor ECG Monitoring to Replicate ECG Lead Recording N/A Interventional lack of enrollment Actual 0
NCT02903407 Terminated Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU Phase 4 Interventional All enrolled participants completed the study protocol but the study was terminated prior to the goal number of participants due to low recruitment Actual 7
NCT04265014 Withdrawn Comparison of Goal-directed and Liberal Fluid Management N/A Interventional we didn't have any patient Actual 0
NCT04468373 Terminated Study of WA-NG (NG-IMT) Telescope Prosthesis in Patients With End-stage Age-related Macular Degeneration N/A Interventional Development of next-generation device Actual 9
NCT04468854 Terminated Influence of Luteolin on Memory in Healthy Subjects N/A Interventional Corona-Virus Lockdown (16th March in Switzerland) Actual 40
NCT00003086 Terminated Repeated Bone Marrow Transplantation in Treating Women With Advanced Breast Cancer Phase 1/Phase 2 Interventional no participants enrolled in a three year period Anticipated 12
NCT02527681 Terminated Pharmacokinetics and Safety of Ceftobiprole in Neonates and Infants up to 3 Months Treated With Systemic Antibiotics Phase 1 Interventional on 07Jul2020 due to slow enrollment; there were no safety concerns. Actual 15
NCT03225924 Terminated Study of Entospletinib (ENTO) in Newly Diagnosed DLBCL Patients With aaIPI>=1 Treated by Chemiotherapy Phase 1/Phase 2 Interventional Stop of drug development Actual 25
NCT03380091 Terminated Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial Phase 4 Interventional Recruitment challenges Actual 3
NCT03518320 Terminated Safety and Tolerability of TAR-200 and Nivolumab in Subjects With Muscle-Invasive Bladder Cancer Phase 1 Interventional Business objectives have changed Actual 13
NCT03661983 Terminated Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Subjects With Tourette's Disorder Phase 4 Interventional Lack of feasibility for completion of the trial within a reasonable time frame. Actual 36
NCT03672474 Terminated REGEnLIFE RGn530 - Feasibility Pilot N/A Interventional Covid19 sanitary crisis Actual 60
NCT03781089 Suspended Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients Phase 4 Interventional Covid-19 Anticipated 40
NCT04032483 Suspended A Survey of Financial Toxicity in Rural Cancer Patients Observational Study recruitment temporarily halted due to COVID-19. Anticipated 100
NCT04055012 Suspended Effects of Metformin on Low Back Pain Phase 2 Interventional FDA Recall of Metformin Anticipated 400
NCT04127695 Withdrawn A Study to Evaluate the Safety and Tolerability of ABBV-0805 in Patients With Parkinson's Disease Phase 1 Interventional Strategic considerations Actual 0
NCT04223011 Withdrawn Initiating Substance Use Disorder Treatment for Hospitalized Alcohol Use Disorder Patients N/A Interventional Due to COVID-19, recruitment was halted before we were able to enroll participants. Currently we are unable to resume recruitment due to study staff changes. Actual 0
NCT04392648 Withdrawn A Study to Evaluate the Safety, Tolerability and Efficacy of Intravenous TAK-573 as Part of Combination Therapy in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Phase 1 Interventional Business Decision (no enrollment) Actual 0
NCT02741505 Withdrawn Brain Sleep Deprivation MRI Effects (BEDTIME) N/A Interventional Funding was not obtained Actual 0
NCT02851056 Suspended Survivin Vaccine : Multiple Myeloma Autologous Hematopoietic Cell Transplant (HCT) Early Phase 1 Interventional Temporary lack of funding Anticipated 20
NCT03231527 Withdrawn Outcomes of Total Arterial Coronary Artery Bypass Grafting Observational research group's decision Actual 0
NCT03330834 Terminated CAR-T Cell Immunotherapy for Advanced Lung Cancer Phase 1 Interventional Serious adverse events Actual 1
NCT03461861 Suspended Network-Level Mechanisms for Preclinical Alzheimer's Disease Development Phase 2 Interventional COVID-19 Anticipated 50
NCT03797612 Withdrawn Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Knee Replacement in Patients With High PCS Scores Phase 2 Interventional Study initiation delayed due to COVID 19 Actual 0
NCT03878563 Terminated Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC) Observational Sponsor-PI left Switzerland Actual 26
NCT04104919 Withdrawn Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Mastectomy in Patients With High PCS Scores Phase 2 Interventional Study Initiation delayed due to COVID 19 Actual 0
NCT04138199 Terminated A Study to Assess Effectiveness and Safety of Fixed Dose Combination of Lopinavir/Ritonavir (LPV/r) in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Patients After Switching From Kaletra in the Routine Clinical Settings of Russian Federation Observational Strategic Considerations Actual 239
NCT04235621 Suspended A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN) Observational Sponsor decision for administrative reasons Anticipated 160
NCT04379947 Withdrawn Preoperative Use of Fractional Flow Reserve in CABG Use and Effectiveness of FFR-based CABG in Real-life Practice Observational research group's decision Actual 0
NCT00820716 Terminated Exercise Training in Asthma N/A Interventional Difficulties in recruiting patient Actual 2
NCT02050646 Suspended The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis N/A Interventional Study PI changed institutions Actual 20
NCT02056054 Suspended De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Observational Study PI has moved institutions Anticipated 180
NCT03361085 Terminated Modular Prevention Bundle for Non-ventilator-associated Hospital-acquired Pneumonia (nvHAP) N/A Interventional COVID-Epidemic with changes in patient mix, restructuring of wards/departments, new standard-precautions Actual 45000
NCT03653533 Terminated Evaluation of the Function "Stop Before Hypoglycemia" on External Insulin Pump N/A Interventional Difficulties for recruitment Actual 8
NCT01705080 Terminated IntErnational Long-term Follow-up Study of Patients With Uncontrolled HyperTensioN Observational Abbott made a decision to not further develop the RDN program. Actual 354
NCT03819933 Suspended Optimizing Family Counseling for Anticipated Extremely Preterm Delivery N/A Interventional Study has temporarily suspended enrollment due to the Covid-19 pandemic. Anticipated 460
NCT01988090 Terminated High Dose Vitamin D vs Standard Dose Vitamin D Study Phase 2 Interventional An interim analysis demonstrated no benefit of high dose vitamin D when compared to standard dose vitamin D in the reduction or prevention of arthralgia Actual 93
NCT02412371 Terminated A Study Evaluating the Efficacy and Tolerability of Veliparib in Combination With Paclitaxel/Carboplatin-Based Chemoradiotherapy Followed by Veliparib and Paclitaxel/Carboplatin Consolidation in Adults With Stage III Non-Small Cell Lung Cancer (NSCLC) Phase 1/Phase 2 Interventional Phase 2 was not conducted due to a change in the standard of care for newly diagnosed, unresectable Stage III NSCLC Actual 48
NCT04467632 Withdrawn Circadian & Homeostatic Synchronization Effect on Waking Mobility in Parkinson's Disease N/A Interventional The principal investigator left the hospital Actual 0
NCT02899156 Terminated Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Exposure Phase 4 Interventional A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis. Actual 22
NCT01757899 Withdrawn Effects and Safety of Infusion of Low-Doses of Methylprednisolone in Early ALI and ARDS in Children Phase 2 Interventional Technical problems Actual 0
NCT02174770 Terminated Blood Flow Restriction Training in Rehabilitation Patients N/A Interventional Lack of resources Actual 10
NCT02227134 Withdrawn Ultrasound to Predict a Pediatric Difficult Airway and Obstructive Sleep Apnea Syndrome in Children N/A Interventional Unable to perform the ultrasound. Actual 0
NCT02323477 Terminated Human Umbilical Cord Stroma MSC in Myocardial Infarction Phase 1/Phase 2 Interventional Due to budget limitations as allocated for a given period. Actual 46
NCT02610608 Terminated Medical Assistance for the Procreation and Risk of Thrombosis. Observational RECRUITMENT DIFFICULTIES Actual 129
NCT02717507 Suspended Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors Phase 2 Interventional Evaluation of currently enrolled patients Anticipated 250
NCT02840513 Terminated Smartphone App and CO Self-monitoring for Smoking Cessation Phase 4 Interventional Due to insufficient patient recruitment and lack of funding Actual 81
NCT02887118 Terminated Dense Red Blood Cells in Sickle Cell Children Observational The recruiting centre was no longer presenting new patients for inclusion Actual 82
NCT02901431 Terminated A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD) Phase 2 Interventional The 24-week analysis indicated no clinical or statistical benefit for the primary endpoint for the overall study population. No new safety concerns identified. Anticipated 340
NCT03002506 Terminated Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Burns Phase 4 Interventional Much slower recruitment than anticipated Actual 6
NCT03003728 Withdrawn 2015-10: Expanded Natural Killer Cells and Elotuzumab for High-Risk Myeloma Post- Autologous Stem Cell Transplant (ASCT) Phase 2 Interventional Withdrawal of study support Actual 0
NCT03321864 Suspended Capture of Prostatic Trans-rectal Ultrasound Scans for Research N/A Interventional PI has left Trust currently. Anticipated 150
NCT03430544 Suspended Cariprazine Effects on Brain and Behavior in Cocaine Use Disorder Phase 2 Interventional Suspended: Study halted prematurely but potentially will resume Anticipated 60
NCT03432572 Withdrawn Investigating Oral Agents for Urine Staining to Facilitate Intraoperative Observation of Ureteral Jets Early Phase 1 Interventional enrollment proved difficult Actual 0
NCT03573076 Terminated Treatment of Photodamaged Skin of the décolleté Phase 4 Interventional The second study arm including radio-frequency microneedling was withdrawn due to availability of newer treatment options. Actual 12
NCT03757351 Terminated Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis Phase 1 Interventional Due to change in Sanofi's development strategy for DNL747/SAR443060 - not due to any safety concerns Actual 15
NCT03881995 Terminated Effects of Insulin Glargine and Lixisenatide on the Brain Phase 4 Interventional insufficient recruitment Actual 1
NCT03904706 Terminated Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan N/A Interventional We were unable to continue field activities due to COVID-19 Actual 1871
NCT04085549 Suspended Effects of a Berry Oil Cream on Atopic Eczema and Skin N/A Interventional Study was suspended due to Covid-19 situation. Anticipated 90
NCT04090853 Terminated Subject Evaluation of a 1064nm Diode Laser/RF N/A Interventional Slow enrolment and Covid19 Actual 13
NCT04185155 Terminated Simple Cognitive Task After Trauma EKUT RCT N/A Interventional Halted prematurely - Covid-19 pandemic prevented recruitment/testing in ED Actual 16
NCT03444311 Terminated Combined Nutritional Therapies for the Treatment of Ulcerative Colitis N/A Interventional Low tolerability of fibers included in the product Actual 12
NCT04462341 Suspended Efficacy of an Oral Hygiene Implant Protocol N/A Interventional COVID-19 Anticipated 28
NCT01335113 Terminated A Scan Ultrasonography in the Evaluation of Retinopathy of Prematurity Observational Unable to get accurate measurements with existing technology Actual 1
NCT01551043 Terminated Allo CART-19 Protocol Phase 1 Interventional Administrative Reasons Actual 2
NCT01711307 Terminated Operative vs. Non-Operative Treatment of Acute Ruptures of the Achilles Tendon N/A Interventional Anticipated 220
NCT01823237 Suspended Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19 Anticipated 15
NCT02544503 Suspended Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 150
NCT02565199 Suspended Premotor Cortex: A New Target for Stroke Motor Rehabilitation N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 50
NCT03460964 Terminated Measuring Sweat Glucose of Patients With Diabetes - The ENGAGE Study N/A Interventional Could not perform accurate measures due to equipment and sensor issues. Actual 2
NCT03504917 Terminated A Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension Phase 3 Interventional A futility analysis assessed that the study is highly unlikely to meet the pre-defined primary objective of the study. No new safety concerns were identified. Actual 322
NCT03609502 Suspended Perceptual Learning and Memory Consolidation in Adults With and Without LI N/A Interventional research facilities temporarily closed due to COVID-19 Anticipated 100
NCT03628053 Withdrawn Tisagenlecleucel vs Blinatumomab or Inotuzumab for Patients With Relapsed/Refractory B-cell Precursor Acute Lymphoblastic Leukemia Phase 3 Interventional Novartis is no longer pursuing this study because of planned investigation of novel CAR-T therapies in this patient population. Actual 0
NCT03685773 Suspended The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients Phase 2 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 60
NCT03714867 Withdrawn Pre-Operative Pregabalin for Post-Operative Pain in Head and Neck Cancer Surgery Phase 4 Interventional Inability to recruit patients Actual 0
NCT03869814 Withdrawn Non-invasive Liquid Biopsy Analysis of Epigenomics Signatures in Multiple Cancer Types Observational Developing new protocol Actual 0
NCT01445821 Terminated Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial Phase 3 Interventional Developed a better regimen: DIAD. Cast. 2018 NCT03593902 Actual 44
NCT03948464 Suspended Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder Phase 3 Interventional Temporarily suspended due to COVID-19 precautions Anticipated 198
NCT04060329 Terminated Measuring and Improving Coproduction Using coopeRATE N/A Interventional Reasons associated with COVID-19 pandemic led to cancellation of Phase 2 Actual 280
NCT04468048 Withdrawn Music Utilization in Sedation and Induction in Colonoscopy Observational No participants Actual 0
NCT04090242 Terminated Impact of App Based Diabetes Training Program in Conjunction With the BD Nano Pen Needle in People With T2 Diabetes N/A Interventional Enrollment halted prematurely due to the Covid-19 pandemic Actual 57
NCT04465071 Suspended Lubricating Eye Drops After Routine Cataract Surgery N/A Interventional No active recruitment at present due to COVID-19 pandemic Anticipated 168
NCT03209869 Suspended Treatment of Relapsed or Refractory Neuroblastoma With Expanded Haploidentical NK Cells and Hu14.18-IL2 Phase 1 Interventional resources limited due to COVID-19 Anticipated 6
NCT03265717 Terminated DNA Plasmid Encoding a Modified Human Telomerase Reverse Transcriptase (hTERT), Invac-1 in Chronic Lymphocytic Leukemia Phase 2 Interventional sponsor decision Actual 26
NCT03281902 Suspended Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy Observational Budget Anticipated 250
NCT03586414 Suspended MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women N/A Interventional COVID-19 Anticipated 60
NCT03708380 Suspended Diabetes Prevention for Black Men N/A Interventional COVID-19 Anticipated 20
NCT03775915 Terminated Neurofeedback for Stroke Rehabilitation N/A Interventional COVID-19 lockdown and halt of clinical trials Actual 26
NCT04106505 Terminated Efficacy of a Novel App-based Migraine Treatment Platform - a Pilot Study N/A Interventional Recruitment terminated prematurely due to SARS-CoV-2 pandemic Actual 23
NCT02655861 Terminated A Multi-center, Prospective Evaluation of Infants and Children With Congenital Ichthyosis Observational Actual 21
NCT02695641 Withdrawn Reduction of Plasma Free VEGF-A Using Low-dose Bevacizumab in Hemodialysis Patients Early Phase 1 Interventional Unable to enroll patients for the trial. Actual 0
NCT02825446 Terminated Angioplasty of the Tibial Arteries Augmented Radio Frequency Denervation of the Popliteal Artery N/A Interventional a significant number of patients were not selected Actual 15
NCT02959502 Suspended Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression N/A Interventional temporarily suspended due to COVID-19 Anticipated 40
NCT04265235 Terminated EXerCise Intervention in cholesTatic LivEr Disease: The EXCITED Study N/A Interventional COVID pandemic. Recruited 31 out of target 40 patients. Actual 31
NCT04302350 Suspended Application of Nitrous Oxide in Inflation-deflation Process During Thoracoscopic Segmentectomy N/A Interventional because of the COVID-19 pandemic. Anticipated 100
NCT02994914 Terminated GEriatric Determinants of Curative RAdiotherapy Scheme Choice for Breast Cancer ELderly Patient Treatment Compliance and Tolerance N/A Interventional Low rythm of inclusions Actual 241
NCT02999152 Terminated Validation of Radio-induced Damage Biomarkers N/A Interventional Low rythm of inclusions, financial support terminated Actual 16
NCT03643679 Terminated Tobacco Cessation for Sexual Minorities N/A Interventional Covid-19 quarantines and closures prevented recruitment and assessment of participants. Actual 32
NCT03743961 Terminated Geriatric Intervention Contribution on Quality of Life of Elderly Patients With Metastatic Neoplasia Observational Low rythm of inclusions Actual 28
NCT04083469 Terminated Identifying Student Opinion Leaders to Lead E-cigarette Interventions N/A Interventional Covid-19 resulted in school closures. Actual 686
NCT04187378 Suspended Effect of Active Warming on Surgical Site Infections N/A Interventional Due to the COVID-19 pandemic, elective surgeries were temporarily delayed in our country. It's targeted to take cases again as of August 2020. Anticipated 48
NCT04236453 Terminated A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat When Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Co-administration of the Separate Agents Phase 1 Interventional COVID-19 pandemic impacted the BE assessment of the trial. The clinical team decided to terminate the trial in order to start a new pivotal BE trial Actual 16
NCT04322227 Terminated Study Investigating Effects of Foliglurax in Patients With Parkinson's Disease (PD) and Healthy Subjects Phase 1 Interventional Study termination due to efficacy results of another study Actual 6
NCT03588741 Terminated Evaluation of Safety Following Immune Tolerance Induction Treatment With Turoctocog Alfa in Patients With Haemophilia A Following Inhibitor Development in NN7170-4213 Trial Phase 3 Interventional The trial was terminated as the participant withdrew from the trial. Actual 1
NCT02700191 Terminated Cardiovascular Diagnosis Using µ-Cor - an Interventional Pilot Trial N/A Interventional Lack of interest Actual 8
NCT03390335 Suspended Decompression Tables for Diving at Altitude N/A Interventional COVID-19 research suspension Anticipated 72
NCT03628976 Suspended Noninvasive VNS for Neuromotor Adaptations N/A Interventional COVID-19 pandemic Anticipated 24
NCT03921359 Terminated SMARTfit Training for Parkinson's Disease N/A Interventional In compliance with research restrictions imposed due to the COVID-19 pandemic. Actual 9
NCT03931928 Suspended Genotype and Phenotype Guided Supplementation of TAMoxifen Standard Therapy With ENDOXifen in Breast Cancer Patients Phase 2 Interventional COVID-19 pandemic Anticipated 750
NCT03953209 Withdrawn Spironolactone for the Treatment of Melasma Phase 1 Interventional Conflict with funding Actual 0
NCT04174326 Suspended CBT Program for Pain Management for Children and Youth With CP (CBT=Cognitive Behavioral Therapy; CP= Cerebral Palsy) N/A Interventional COVID-19 restrictions Anticipated 16
NCT04207138 Withdrawn To Study the Association Among Labor Pain and Physical Parameters in Laboring Pregnant Women Observational change sponsor Actual 0
NCT04271839 Withdrawn Efficiency Control of Fluticasone/Formoterol K-haler (Medium Strength) vs ICS/LABA (High Strength) in Asthma Patients Phase 4 Interventional The trial has been terminated early due to the SARS-CoV-2 pandemic. Actual 0
NCT02530008 Suspended Breast Cancer 2-PREVENT Translational Center of Excellence (TCE) - Metastatic Markers of Recurrent Tumor Phenotype for Breast Cancer Observational Study is suspended due to Abramson Cancer Center suspension of Observational research studies due to the COVID-19 Pandemic. Anticipated 600
NCT03161158 Terminated PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure N/A Interventional Low recruitment Actual 48
NCT03492710 Withdrawn Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Phase 3 Interventional A change in sponsor's developmental strategy Actual 0
NCT03778528 Terminated Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome Observational researcher left the institution study will not continue Actual 1
NCT03890380 Terminated Safety and Performance Evaluation of the Magneto Wire N/A Interventional Sponsor's decision Actual 4
NCT03925155 Withdrawn RCT Investigating Pre-cesarean Vaginal Wash of Chlorhexidine vs Povidone-iodine for Patient With Ruptured Amniotic Membrane. Phase 3 Interventional The study was withdrawn from the IRB Actual 0
NCT04073160 Withdrawn TRIO Bladder: A Study of Durvalumab Plus Tremelimumab Followed by Concurrent Durvalumab Plus Bladder Radiation in Muscle-Invasive Bladder Cancer Phase 1 Interventional Study will not be completed. No participants were enrolled. Actual 0
NCT04455919 Terminated Yoga for Chronic Chikungunya N/A Interventional covid health crisis Actual 42
NCT02670083 Terminated A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD). Phase 3 Interventional This study was discontinued due to an interim analysis in this study, which indicated that Crenezumab was unlikely to meet its primary endpoint. Actual 813
NCT03114657 Terminated A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD) Phase 3 Interventional This study was discontinued due to an interim analysis in the BN29552 study, which indicated that Crenezumab was unlikely to meet its primary endpoint. Actual 806
NCT00915681 Terminated Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning Phase 2 Interventional Sponsor decision Actual 104
NCT02196051 Withdrawn Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver. N/A Interventional Study halted permanently participants are not being enrolled Actual 0
NCT02652702 Terminated Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of Colorectal Cancer Patients Phase 2 Interventional Not enough patients recruited Anticipated 60
NCT02742844 Terminated Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Phase 1/Phase 2 Interventional COVID-19 pandemic and patient recruitment issues Actual 13
NCT03169114 Terminated Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation N/A Interventional Poor recruitment and terminated during COVID-19 pandemic Actual 81
NCT04361461 Withdrawn Use of Hydroxychloroquine Alone or Associated for Inpatients With SARS-CoV2 Virus (COVID-19) Phase 3 Interventional This study was canceled before enrollment due to a decision by the Sponsor Actual 0
NCT02600429 Terminated Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Phase 3 Interventional Business decision Actual 18
NCT03017105 Terminated Cross-education for Proximal Humerus Fracture Rehabilitation Phase 1/Phase 2 Interventional Logistical difficulties leading to an extremely slow recruitment rate Anticipated 40
NCT03023813 Suspended Individualizing Disease Prevention for Middle-Aged Adults N/A Interventional Enrollment is temporarily paused due to COVID-19; interactions/interventions with current participants continue. This is not a suspension of IRB approval. Anticipated 130
NCT03076710 Withdrawn Post-Operative Pain Management Following Spine Surgery Observational No participants were identified per inclusion/exclusion criteria Actual 0
NCT04457427 Withdrawn Randomized Study to Investigate the Safety and Performance of Diaphragm Stimulation Coupled With Mechanical Ventilation N/A Interventional Study not started Actual 0
NCT03376399 Withdrawn Potential Benefits of Sleeve Gastrectomy Surgery on Diabetic Gastroparesis Symptoms Observational No participants enrolled. Study terminated at PI's discretion Actual 0
NCT03598907 Terminated Point-of-care Management of Coagulopathy in Lung Transplantation Observational After interim statistical analysis, a statistician reccommended to stop study, because results are significant and in favour of POC approach. Actual 67
NCT03684187 Suspended Mindfulness - Based Intervention in the Treatment of Fatigue in Patients With Primary Biliary Cholangitis N/A Interventional Covid - 19, will resume when able. Anticipated 20
NCT03707457 Terminated Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma Phase 1 Interventional Funding/material support withdrawn Actual 3
NCT03890198 Terminated A Phase 1 Study of LCAR-C182A Cells in the Treatment of Advanced Gastric Cancer and Pancreatic Ductal Adenocarcinoma Early Phase 1 Interventional the Preliminary data, progress of this study and the adjustment of the pipeline and strategy . Actual 2
NCT03902275 Terminated Validation of a Quantra Supported Hemotherapy Algorithm in Cardiac Surgery N/A Interventional SARS-CoV-2 Pandemic Actual 20
NCT04051996 Suspended GLAD-AML - Glasdegib (Pf-04449913) With Two Standard Decitabine Regimens for Older Patients With Poor-risk Acute Myeloid Leukemia Phase 2 Interventional Temporary Recruitment Hold due to COVID-19 Anticipated 46
NCT04125030 Suspended Convergent and Concurrent Validity Between Clinical Recovery and Personal-civic Recovery in Mental Health Observational [Patient Registry] COVID-19 pandemic Anticipated 200
NCT04132700 Withdrawn Longitudinal Evaluation of Energy Expenditure in ICU Patients From Admission to Discharge Using A Novel Indirect Calorimeter: LEEP-Forward Trial N/A Interventional LEEP-COVID study (NCT04350073) initiation enables inclusion of COVID-positive subjects Actual 0
NCT04395118 Withdrawn STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention for Elevated LFTs N/A Interventional Study will not be conducted as a RCT due to limited project timeline. Actual 0
NCT02624700 Terminated 2nd Line Treatment With Pemetrexed and Sorafenib for Recurrent or Metastatic Triple Negative Breast Cancer Phase 2 Interventional Actual 13
NCT03923348 Terminated Pelvic Floor Muscle Training With Leva System for Urge Incontinence N/A Interventional Slow Recruitment and Re-prioritizing of Sponsor-funding Actual 5
NCT03339921 Terminated Botulinum for Chronic Exertional Compartment Syndrome Phase 2/Phase 3 Interventional This study is being closed because it is unworkable. Actual 3
NCT01089374 Suspended Phyllodes Tumor Partial Breast Radiation Study N/A Interventional continuing review Anticipated 50
NCT02387125 Terminated Phase 1b Safety Study of CMB305 in Patients With Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1 Phase 1 Interventional This study did not meet the efficacy objective Actual 79
NCT02485990 Terminated Study of Tremelimumab Alone or Combined With Olaparib for Patients With Persistent EOC (Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma) Phase 1/Phase 2 Interventional Withdrawal of sponsor support Actual 24
NCT02826967 Terminated Feasibility and Effectiveness of Colonic Irrigation N/A Interventional COVID-19 institutional restrictions on screening colonoscopies Actual 36
NCT02847130 Suspended Identifying, Understanding, and Overcoming Barriers to the Use of Clinical Practice Guidelines in Pediatric Oncology Observational Reviewing enrolled patients Anticipated 694
NCT03471559 Terminated Cannabidiol - an in Vivo Innovative Drug Delivery Study Phase 1 Interventional Two step study, step two was not feasible based on results from phase one. Actual 8
NCT04078438 Terminated Neurofeedback In Treatment Resistant Depression N/A Interventional Because of researcher foreign training Actual 70
NCT04146012 Suspended BEACH Trial: Bovine Early Access, Compatibility and Hemostasis Trial Phase 3 Interventional Company was sold and clinical trial was suspended Anticipated 75
NCT03791008 Suspended Assessment of Feasibility and Acceptability of Personalized Breast Cancer Screening N/A Interventional Recrutiment was suspended on March 12, 2020 due to the coronavirus pandemic Anticipated 385
NCT04323631 Withdrawn Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death Early Phase 1 Interventional Trial not started due to accumulating evidence against HCQ for COVID Actual 0
NCT04164082 Suspended Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer Phase 2 Interventional Other - Planned safety stopping Anticipated 163
NCT03846492 Suspended Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS N/A Interventional Suspended due to COVID-19 Anticipated 90
NCT00003060 Terminated Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Metastatic Melanoma Phase 1 Interventional lack of patient accrual Anticipated 6
NCT03396484 Withdrawn Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 Diabetes Phase 2 Interventional Study not begun due to continued laboratory work on the feasibility of outcome measures. Actual 0
NCT03944707 Terminated Study of Efficacy and Safety of LOU064 in Inadequately Controlled Asthma Patients Phase 2 Interventional Company decision Actual 76
NCT04020549 Withdrawn Single-Session Computerized Mental Health Intervention for Rural Indian Adolescents N/A Interventional In collaboration with community partners, we determined that the reading level required for the intervention did not make it suitable for the adolescents. Actual 0
NCT04160091 Terminated Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis Phase 2 Interventional The study was terminated prematurely due to the COVID-19 pandemic creating uncertainty impacting trial progress and costs. Actual 19
NCT04290637 Suspended The Galway Sea Swimmers Study N/A Interventional Unable to recruit during COVID-19 crisis Anticipated 150
NCT04330300 Suspended Coronavirus (COVID-19) ACEi/ARB Investigation Phase 4 Interventional Challenges with funding and very low incidence of COVID-19 at Irish study site Anticipated 2414
NCT02609984 Terminated Study to Compare the Safety and Efficacy of CMB305 With Atezolizumab to Atezolizumab Alone in Participants With Sarcoma (IMDZ-C232/V943A-002) Phase 2 Interventional This study did not meet the efficacy objective Actual 89
NCT01510691 Withdrawn Vitrectomy Retinal Oxygenation Observational Difficulties in recruiting participants Actual 0
NCT02477124 Suspended A See and Treat Paradigm for Cervical Pre-cancer N/A Interventional COVID-19 Anticipated 200
NCT02673021 Terminated MARK 1A Series: Percutaneous Microwave Ablation for Patients With Lung Tumor(s) N/A Interventional Funding suspended prior to completing enrollment of all participants. Actual 6
NCT03323645 Terminated Prosthetics Registry and Outcomes in Urology at Duke Observational change of study structure and resource allocation Actual 190
NCT03339973 Terminated Allogeneic ABCB5-positive Stem Cells for Treatment of PAOD Phase 1/Phase 2 Interventional Very slow recruitment of patients and the current COVID-19 pandemic situation. Actual 24
NCT03457818 Terminated Therapy of the Skeletal Disease of Type 2 Diabetes With Denosumab Phase 2 Interventional Due to enrollment difficulties compounded by the COVID pandemic. Actual 8
NCT04409483 Withdrawn Evaluation of Additional Treatments for COVID-19: a Randomized Trial in Niger Phase 3 Interventional Epidemic dynamics Actual 0
NCT02753595 Terminated Study of Eribulin Mesylate in Combination With PEGylated Recombinant Human Hyaluronidase (PEGPH20) Versus Eribulin Mesylate Alone in Subjects With Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, High-Hyaluronan (HA) Metastatic Breast Cancer (MBC) Phase 1/Phase 2 Interventional evolving standard of care and difficulties of enrolling participants Actual 25
NCT03491150 Terminated An Open-Label Crenezumab Study in Participants With Alzheimer's Disease Phase 3 Interventional This study was discontinued due to an interim analysis in the BN29552 study, which indicated that Crenezumab was unlikely to meet its primary endpoint. Actual 149
NCT04451382 Terminated PTNS vs Botox of Refractory OAB Observational Low recruitment Actual 150
NCT03143985 Suspended Vactosertib in Combination w/ Pomalidomide in Relapsed or Relapsed and Refractory Multiple Myeloma Phase 1 Interventional Major revisions due Anticipated 18
NCT02985554 Terminated Phase I Study to Assess the Tolerability and Efficacy of Nivolumab in Patients With Hematologic Malignancies Phase 1 Interventional Study stopped early due to slow accrual and safety concerns. Actual 3
NCT01301482 Terminated Ear Acupuncture for Acute Sore Throat in Patients Unable to Take Non-steroidal Anti-inflammatory Agents (NSAIDs) N/A Interventional Study is no longer necessary (outmoded, outdated, science has changed) Actual 2
NCT03020264 Terminated Frequency of Hypoglycemia in Patients With Type 2 Diabetes Under Insulin Therapy Older Than 75 Years in Real Life N/A Interventional COVID-19 Actual 161
NCT03475043 Suspended Neuroplasticity in Auditory Aging_Project 2 N/A Interventional coronavirus pandemic, no human subjects research at UMD Anticipated 405
NCT03868436 Suspended PENTHROX™ in the Canadian Emergency Department (ED) Phase 4 Interventional Recruitment is complete however study suspended due to COVID 19 Actual 99
NCT03910322 Terminated The Effect of a Probiotic Strain on Aspirin-induced GI Damage N/A Interventional Decision made by Sponsor Actual 30
NCT04231682 Withdrawn A Study to Evaluate Efficacy and Safety of Denosumab for Prevention and Treatment of Osteoporosis in 1st Time Liver Transplant Recipients. Phase 2 Interventional Grant support was withdrawn from Amgen Pharmaceuticals Actual 0
NCT04259190 Withdrawn A Comparison of Treatment Rationales on Willingness to Tolerate Distress in Interoceptive Exposure N/A Interventional Halted due to COVID-19. Actual 0
NCT04329403 Withdrawn Clinical Endpoint Bioequivalence Study of Adapalene Gel 0.1% Phase 3 Interventional Market reasons Actual 0
NCT03051698 Terminated C1-inhibitor in Allergic ASThma Patients Phase 4 Interventional Interim analysis showed no differences between groups Actual 37
NCT00839787 Withdrawn The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision N/A Interventional Unable to enroll more patients Actual 0
NCT01785069 Terminated Safety and Effectiveness of NATRELLE® 410 Highly Cohesive, Anatomically Shaped, Silicone-filled X-Style and L-Style Breast Implants N/A Interventional There was no indication that long-term follow-up would differ between any of the studies that have evaluated devices within the 410 Style Matrix. Actual 355
NCT03255213 Suspended Lingual Muscle Training in Late-Onset Pompe Disease (LOPD) N/A Interventional Due to COVID19 restrictions Anticipated 5
NCT03488147 Suspended Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery Phase 2 Interventional Change in Investigational Drug Service policies resulting in the need to change the operational design of the overall protocol. Anticipated 500
NCT03567291 Terminated Evaluation of Safety and Tolerability of Long-term TEV-50717 (Deutetrabenazine) for Treatment of Tourette Syndrome in Children and Adolescents Phase 3 Interventional The parent trials did not meet the primary endpoints of reduction in motor and phonic tics. Actual 228
NCT03836885 Withdrawn Apremilast - Oral Lichen Planus Trial Phase 2 Interventional Study was terminated due to delay in enrollment. Actual 0
NCT03890861 Suspended Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)" N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 200
NCT04020926 Terminated Impact of Hyponatremia on Muscle Strength, Gait and Cognitive Function Observational Study was stopped due to COVID-19 pandemic. Actual 8
NCT04162145 Terminated BRIDGE Device for Treatment of Opioid Withdrawal N/A Interventional Due to COVID-19 pandemic Actual 12
NCT04177459 Terminated Rehabilitation of Adolescents Living With Chronic Fatigue N/A Interventional Covid-19 Actual 3
NCT04285008 Withdrawn Randomized Controlled Study Comparing Colon Evaluation With The Pure-Vu System To A Standard Colonoscopy In Patients Who Are High Risk For Inadequate Bowel Preparation N/A Interventional Sponsor has terminated study due to COVID-19 related concerns Actual 0
NCT04354441 Withdrawn Effect of Hydroxychloroquine in COVID-19 Positive Pregnant Women Phase 2 Interventional Not started Actual 0
NCT03128931 Terminated SedLine Engineering Data Collection Study in Pediatric Patients Undergoing General Anesthesia or Sedation N/A Interventional Study was terminated as enrollment rate did not meet the requirement of the Sponsor. Actual 45
NCT03728673 Suspended A Study Utilizing Escitalopram in Glioma Patients Phase 2 Interventional COVID-19 safety precautions Anticipated 20
NCT04449445 Suspended Perioperative Nutritional Optimization in Head and Neck Cancer Patients N/A Interventional COVID-19 Anticipated 300
NCT02351869 Terminated Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder Phase 2 Interventional This study was terminated due to COVID-19 pandemic-related halting of recruitment in the context of an upcoming replacement of the study MRI scanner. Actual 25
NCT02362191 Terminated Targeting Inter-Hemispheric Alpha Coherence With tACS To Treat PMDD N/A Interventional The study was terminated because the dense treatment schedule precluded successful recruitment of study participants. Actual 13
NCT03082612 Suspended Overcoming Psychological Distress Through Hymns N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Actual 12
NCT03135262 Terminated A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL) Phase 1/Phase 2 Interventional Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2. Actual 29
NCT03375606 Terminated Assessing the Safety and Tolerability of CSL730 in Healthy Caucasian and Japanese Adults Phase 1 Interventional The Sponsor decided to terminate this study in favor of development of subcutaneous administration. Actual 26
NCT03540043 Terminated Thykamine Safety and Efficacy Study in Mild-to-Moderate Atopic Dermatitis Phase 2 Interventional Reached required analyzable sample size; COVID-19 recruitment challenges Actual 162
NCT04202718 Withdrawn VitalConnect VitalPatch ECG Interpretation/Arrhythmia Detection N/A Interventional Study never started due to COVID-19 pandemic Actual 0
NCT01832727 Terminated Phase 1b/2, Multicenter, Open-label Study of Oprozomib and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma Phase 1/Phase 2 Interventional Enrollment halted during phase 2 to reformulate the investigational product Actual 65
NCT02996448 Terminated Safety, Tolerability, and Immunogenicity of One Dose of NDV 3A Vaccine in People With STAT3-Mutated Hyper-IgE Syndrome Phase 2 Interventional Safety concerns led to early termination. Actual 3
NCT03982537 Withdrawn Effect of N-Acetyl Cysteine (NAC) on the Oral Microbiome Phase 2 Interventional Concept is withdrawn and a different concept will be submitted the near future. Actual 0
NCT04190069 Withdrawn Effects of Behavioral Interventions on Weight Loss and Weight Maintenance N/A Interventional IRB recommended change to registry study or quality improvement project status Actual 0
NCT00263562 Terminated Steroid Treatment for Sickle Cell Pain Crisis Phase 3 Interventional poor enrollment, availability of more effective medications Actual 18
NCT02395627 Terminated Reversing Therapy Resistance With Epigenetic-Immune Modification Phase 2 Interventional Insufficient efficacy in an unselected patient population Actual 38
NCT02352155 Terminated Second-look Endoscopy in High Risk Patients After Endoscopic Hemostasis to Their Bleeding Peptic Ulcers Improves Their Outcomes N/A Interventional Actual 157
NCT02899481 Terminated Role of Intrapartum Ultrasound in Instrumental Delivery N/A Interventional Data Safety Monitoring Committee recommended stopping the trial due to futility. Actual 222
NCT02953119 Terminated Prehabilitation for Elective Major Abdominal Surgery N/A Interventional Difficulty recruiting patients Actual 20
NCT03064152 Terminated Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery N/A Interventional slow enrollment, outcome measures collected but actual enrollment is below target enrollment Actual 49
NCT03736421 Suspended Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients Observational Enrollment and other trial activities have temporarily paused due to COVID-19 and are expected to resume in the future; This is not a suspension of IRB approval Anticipated 280
NCT04140591 Terminated Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis Phase 2/Phase 3 Interventional 1. Most patients with liver cirrhosis already use PPI and NSBB 2. 90 % Peptic ulcer size is smaller than 5cm Actual 10
NCT04251182 Suspended Clinical Study Evaluating Efficacy and Safety of T3D-959 in Mild-to-moderate AD Subjects Phase 2 Interventional COVID-19 Panemic Anticipated 256
NCT03136900 Terminated Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of With Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation,After Surgery for Congenital Heart Disease, in Infants. N/A Interventional Recuitment to slow Actual 41
NCT02708849 Terminated The Sustained Effects of Ketamine Phase 1 Interventional Actual 3
NCT01803984 Terminated MIBRAIN - Migraine and the Brain: Consequences, Causes, and Vascular Interaction Observational Actual 166
NCT02501473 Terminated Study of Intratumoral G100 With Or Without Pembrolizumab or Rituximab In Patients With Follicular Non-Hodgkin's Lymphoma (MK-3475-174/IMDZ-G142) Phase 1/Phase 2 Interventional Business reasons Actual 52
NCT02702518 Terminated rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host Disease Phase 1/Phase 2 Interventional The DSMB committee recommended closing the trial because of the COVID-19 risk in this "at-risk" oGVHD population if they came for study visits. Actual 58
NCT03532009 Terminated Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure Phase 2 Interventional Study stopped early due to the COVID-19 pandemic Actual 182
NCT03732196 Terminated Food Frequency Questionnaire for Chinese Pregnant Women Observational Unable to recruit enough participants Actual 68
NCT03925493 Suspended Exercise Prescription in Cardiac Rehabilitation N/A Interventional The COVID-19 pandemic has caused us to suspend recruitment. Anticipated 60
NCT04225078 Suspended A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants Phase 1 Interventional Trial was put On Hold due to COVID-19. The Site will not start recruiting activities until further notice Anticipated 52
NCT04232878 Terminated A Single Ascending Dose Trial of CVL-936 in Healthy Subjects Phase 1 Interventional Sufficient data has been obtained to meet current objectives Actual 10
NCT04346355 Terminated Efficacy of Early Administration of Tocilizumab in COVID-19 Patients Phase 2 Interventional Based on interim analysis for futility and given an enrolment rate almost nil Actual 126
NCT04363203 Suspended VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL) Phase 3 Interventional concerns related to study drug Anticipated 300
NCT04416178 Suspended Sickle Cell Disease and the Genomic Needs of Parent and Pediatric Stakeholders Observational Temporary Enrollment Hold due to COVID-19 Anticipated 300
NCT04390386 Withdrawn Controlled Study of IC14 for Treatment of ALS Phase 2 Interventional contract not yet signed Actual 0
NCT01697293 Terminated Triciribine Phosphate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer Phase 1/Phase 2 Interventional criteria for continuing enrollment in Phase 2 portion was not met Actual 34
NCT02069431 Terminated Oxytocin Aging Study Phase 1 Interventional This study was halted prematurely due to the COVID-19 pandemic, resulting in the inability to enroll participants. Funding for this project has also ended. Actual 153
NCT02070666 Terminated Preventive Strategies in Acute Respiratory Distress Syndrome (ARDS) N/A Interventional Low recruitment and published data with no benefit Actual 98
NCT03051282 Suspended Genetic Determinants of ACEI Prodrug Activation Phase 4 Interventional Enrollment and interactions/interventions are paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 36
NCT03326804 Suspended H1 Hip Resurfacing Arthroplasty Observational awaiting data points for data analysis Anticipated 250
NCT03894579 Withdrawn Autologous Natural Killer Cells in Subjects With Plaque Psoriasis Phase 1 Interventional Study withdrawn per NKMax America Actual 0
NCT03978936 Suspended Medication Adherence With Telehealthcare Medication Therapy Management Phase 3 Interventional Study recruitment temporarily suspended due to COVID-19 pandemic. Anticipated 300
NCT03998514 Suspended A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease Phase 1 Interventional COVID-19 related delay Anticipated 86
NCT04240158 Terminated IW-6463 Safety Study in Healthy Elderly Subjects Phase 1 Interventional Some subjects could not complete the second crossover period due to COVID-19-related site closure. The study was closed to allow analysis of all collected data. Actual 24
NCT04362332 Terminated Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19 Phase 4 Interventional Currently, almost no patients admitted to Dutch hospitals. If any effect of HCQ is to be expected we need more than 1000 inclusions Actual 25
NCT04369742 Suspended Treating COVID-19 With Hydroxychloroquine (TEACH) Phase 2 Interventional Investigator decision Anticipated 626
NCT03790683 Suspended Intraoperative Warming During Major Surgical Procedures Using the Esophageal Temperature Management System N/A Interventional Sponsor funding limitations Anticipated 48
NCT03234153 Terminated Neoadjuvant Immunotherapy With Durvalumab and Tremelimumab for Bladder Cancer Patients Ineligible for Cisplatin Phase 2 Interventional low accrual Actual 6
NCT04361552 Withdrawn Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection) Phase 3 Interventional Study abandoned due to drug billing issues Actual 0
NCT03502954 Terminated A Study to Investigate the Safety, Tolerability and Pharmacokinetics of ABY-039 Phase 1 Interventional Halted prematurely Actual 66
NCT02220790 Suspended BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia Observational [Patient Registry] Final enrollment on hold due to COVID-19 restrictions Anticipated 515
NCT02419105 Terminated Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors Phase 3 Interventional Delayed recruitment mainly due to a screening to inclusion rate much lower than expected. Due to the delayed recruitment IMP reached the end of its shelf life. Actual 91
NCT02565511 Terminated A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease Phase 2/Phase 3 Interventional Study was terminated by Novartis after a planned review by DMC of unblinded data identified worsening in some measures of cognitive function Actual 480
NCT02733614 Suspended Proof-of-concept Study to Assess the Efficacy and Safety of SRX246 in Adults With PTSD Phase 2 Interventional COVID-19 Anticipated 52
NCT02868827 Terminated Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency. Phase 2/Phase 3 Interventional The initial plan was 2 years but due to slow recruitment. We were able to screen 635 patients in 4 years and recruited only 127 patients. Actual 127
NCT03132428 Terminated Registry to Evaluate INOmax in Newborn Babies With Pulmonary Hypertension Observational Positive results at interim analysis Actual 140
NCT03246919 Terminated Ideal Time of Oxytocin Infusion During Cesarean Section Phase 4 Interventional PI left Loyola and Sub-I graduated. Actual 68
NCT03472924 Terminated The Effects of Kinesio Tape® on Arthrogenic Muscle Inhibition and Rate of Torque Development N/A Interventional Insufficient recruitment and enrollment. Reduction in study personnel capacity. Actual 6
NCT03475602 Terminated Membranous Nephropathy-associated Serological Antibody Predict the Prognosis of Idiopathic Membranous Nephropathy Observational [Patient Registry] Our center had adopted a new detection method for anti-PLA2R antibodies in all membranous nephropathy patients. Actual 85
NCT03543033 Withdrawn Preoperative Corticosteroid Epidural Injection and Lumbar Decompression Surgery Outcomes N/A Interventional The study was closed by the investigators due to lack of study population to enroll. Actual 0
NCT03598036 Terminated Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosis Phase 2 Interventional Low recruitment rate Actual 5
NCT03718338 Suspended Mechanisms of Metabolic and Hormone Action on Plaque Formation in Brain and Carotid Vessels in Prostate Adenocarcinoma Observational COVID19 Suspension Anticipated 30
NCT03850509 Terminated Efficacy and Safety of Oral OPS-2071 in Subjects With Crohn's Disease Showing Symptoms of Active Inflammation Phase 2 Interventional Sponsor Decision Actual 3
NCT02193282 Suspended Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) Phase 3 Interventional Other - Modifications to MCF Anticipated 450
NCT04175132 Terminated Binding of Foliglurax to Regions in the Brain in Healthy Participants and in Patients With Parkinson's Disease (PD) Phase 1 Interventional New efficacy data from another study Actual 6
NCT04242966 Withdrawn The Effect of Higher Protein Dosing in Critically Ill Patients Ultrasound a Sub-study Phase 3 Interventional Study never started. Operational issues prevented study from rolling out Actual 0
NCT04282798 Withdrawn Racial Variation in Response to Music Interventions for People With Alzheimer's Dementia N/A Interventional COVID delay and subsequent unavailability of staff. Actual 0
NCT03127124 Suspended QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer Phase 1/Phase 2 Interventional IRB Recommendation Anticipated 64
NCT03418649 Suspended Eplerenone as a Supplement to Epidural Steroid Injections Phase 4 Interventional Unable to recruit during COVID-19 epidemic restrictions on associated clinical practice Anticipated 40
NCT04436770 Suspended Medical Recovery and Social Reintegration for Post-stroke Patients Using Virtual Reality N/A Interventional Due to the COVID-19 pandemic Actual 52
NCT03906448 Terminated FORWARD Optune and Adjuvant TMZ in Grade II/III Astrocytoma Phase 2 Interventional The study was terminated because the Study Chair/IDE Sponsor and Novocure determined that conducting this trial was not feasible without CMS approval. Actual 2
NCT03957278 Suspended A Study to Evaluate the DAISe System During Neurointervention for Acute Ischemic Stroke N/A Interventional Device modifications Anticipated 120