Clinical trials stopped by Covid-19

Benjamin Gregory Carlisle PhD

Charité – Universitätsmedizin Berlin, Germany
Berliner Institut für Gesundheitsforschung (BIG) / Berlin Institute of Health (BIH)
QUEST – Quality | Ethics | Open Science | Translation

The Covid-19 outbreak that became a global pandemic in 2020 has disrupted lives, families, industries and entire nations. This project is a weekly-updated "living paper" that aims to quantify some of the effects of Covid-19 on the enterprise of human research.

The following table contains all registry entries from ClinicalTrials.gov whose overall status changed to Terminated, Suspended or Withdrawn since 2019-12-01. Investigator-provided reasons that explicitly mention Covid-19 are highlighted in green. Click a row of the table for more details about the trial.

To date, 1747 clinical trials have been stopped for reasons that explicitly cite Covid-19.

These data and figures are available to be downloaded under a Creative Commons By-Attribution Non-Commercial license. This data set was last updated 2020-09-27.

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Covid-19 arm per-trial data set TSV
Comparator arm per-trial data set TSV
Drugs and biologics in stopped trials TSV
NCT ID Overall status Brief title Phase Study type Why stopped Enrollment
NCT03925428 Withdrawn Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas Phase 1 Interventional Other - Protocol moved to Disapproved Actual 0
NCT04116359 Withdrawn Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma Phase 1/Phase 2 Interventional Other - Protocol moved to Disapproved Actual 0
NCT00536939 Terminated Trial of Paclitaxel, Bevacizumab, and Enzastaurin Versus Paclitaxel, Bevacizumab and Placebo for Breast Cancer Phase 2 Interventional Study has been terminated due to slow enrollment Actual 2
NCT04563728 Suspended Use Surveillance Technology to Reduce Elder Abuse Recidivism N/A Interventional Covid-19 Anticipated 10
NCT03292835 Suspended Complex Cutaneous Leishmaniasis Healing Study in Algeria Observational [Patient Registry] Political Issues in Algeria and now Covod-19 lock-down Anticipated 100
NCT03391856 Terminated Prolonged Isolated Thrombocytopenia After Allo-SCT : N-acetyl-L-cysteine (NAC) Versus Supportive Therapy Phase 2/Phase 3 Interventional protocol changed Actual 15
NCT03698747 Terminated Myelin Imaging in Concussed High School Football Players Observational PI left organization Actual 13
NCT04153071 Withdrawn Unipolar Microplasma Radiofrequency Device: In-vivo Histologic Study N/A Interventional Per Investigator and sponsor decision Actual 0
NCT04236037 Terminated Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura N/A Interventional It is unrealistic to succeed with sufficient inclusion within the timeframe of the study, why it is terminated. Actual 5
NCT04343690 Withdrawn COPING With COVID-19( CWC-19) N/A Interventional Study Ended May 1, 2020 with no enrollment Actual 0
NCT03409341 Withdrawn Personalizing Immune Checkpoint Inhibitor Therapy Observational No enrollment Actual 0
NCT03673566 Withdrawn Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - CHMCO N/A Interventional Business pivot caused termination of study before enrollment. Actual 0
NCT03673579 Withdrawn Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - MHSB N/A Interventional Business pivot caused termination of study before enrollment. Actual 0
NCT03791541 Withdrawn A Study Evaluating the Use of Potential Predictors of Readmission in Hospitalized Medicine Patients N/A Interventional Pilot study results not meaningful. Students researchers graduated. Actual 0
NCT04039568 Suspended Meditation Versus Education for Improving Depression in Chronic Pain, a Randomized Controlled Trial N/A Interventional COVID-19 Pandemic. Update in-process. Anticipated 160
NCT04202471 Withdrawn Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries N/A Interventional COVID-19 pandemic Actual 0
NCT03486002 Terminated EFFEXTS OF THE CLEANSWEEP SUCTION CATHETER N/A Interventional Access to the devices was halted by the sponsor Actual 8
NCT03626623 Terminated Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care N/A Interventional Sponsor Discretion Actual 15
NCT03712930 Terminated Treatment of Metastatic Castration-Resistant Prostate Cancer With Homologous Recombination Deficiency Phase 2 Interventional Sponsor's decision to revisit the development approach for prostate cancer. Actual 13
NCT03793712 Terminated Study With Lu AF11167 for the Treatment of Negative Symptoms in Patients With Schizophrenia Phase 2 Interventional Lack of efficacy based on interim analysis Actual 168
NCT03929497 Terminated Flexible-dose Long-term Extension Study of Lu AF11167 in Patients With Schizophrenia With Prominent Negative Symptoms Phase 2 Interventional Lack of efficacy based on the interim analysis in the 17972A study Actual 96
NCT03932656 Suspended Latent Toxoplasmosis in Females With Borderline Personality Disorder Observational Funding issues Anticipated 100
NCT04018508 Suspended Massage Therapy for Self-efficacy in LVAD Recipients N/A Interventional COVID19 pandemic closed in-person clinics temporarily Anticipated 74
NCT04293978 Suspended Virtual Reality Relaxation for Addiction Inpatients N/A Interventional Recruitment and intervention provision paused due to COVID-19 situation. Planned to resume. Anticipated 40
NCT02285179 Suspended Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside Tamoxifen Phase 1/Phase 2 Interventional Inclusion stopped due to COVID-19 Anticipated 290
NCT03689985 Terminated Functionality and Accuracy of the smART System in Real-Life ICU Settings N/A Interventional Due to the company's intent to conduct a new study under a different protocol with the smART+ System which is a more advanced version of the smART System Actual 2
NCT04044950 Withdrawn A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer Phase 2 Interventional The study was closed due to investigator discretion based on the lack of ability to recruit patients and research goals of the program. Actual 0
NCT04428918 Withdrawn Biospecimen Procurement for Immunological Landscape Studies Following Hematopoietic Cell Transplantation Observational The study was closed due to investigator discretion based on the lack of ability to recruit patients and research goals of the program. Actual 0
NCT01663766 Terminated Phase I Study of Milatuzumab for Graft Versus Host Disease Phase 1 Interventional PIs agreed no safety signals were shown, drug did not appear to lessen the risk of preventing GVHD no further patients would be enrolled Actual 12
NCT02161679 Withdrawn Phase II Study of IMMU-132 Alone or in Combination With Carboplatin in Patients With Triple-Negative Breast Cancer Phase 2 Interventional FDA asked to administratively split from IND115621- to open a new IND you need to file a protocol we only drafted it to get the IND open - never initiated Actual 0
NCT02548494 Terminated Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes N/A Interventional Project terminated due to insufficient resources for recruitment. Actual 17
NCT02826655 Terminated Adaptive Optics for Ophthalmic Technologies N/A Interventional lack of funding Actual 4
NCT03121079 Withdrawn Interferon-α Prevents Leukemia Relapse of AML Patients After Transplantation N/A Interventional there was almost no patient would enroll in this study. Actual 0
NCT03304184 Suspended The Role of Biodentine in Class V Dental Lesions on Oral Health Related Quality of Life Phase 3 Interventional COVID Anticipated 40
NCT03379558 Terminated Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study Observational (due to change in the post-marketing requirement to assess alirocumab during pregnancy) Actual 37
NCT03362021 Terminated Comparison of Two Different Sedation Protocols During Transvaginal Oocyte Retrieval Observational Primary investigator transferred in another hospital; ongoing pandemic; Actual 80
NCT03867708 Withdrawn Outcomes of Transcatheter ASD Closure Guided by 3D-TEE Observational No participants found Actual 0
NCT03960242 Suspended Evaluation of Clinical Progression in Patients With Motor Predominant Parkinson Disease. Observational Temporary halt of the trial due to COVID-19 crisis related delays Anticipated 30
NCT01007136 Terminated Transcranial Direct Current Stimulation (tDCS)-Enhanced Stroke Recovery N/A Interventional Funding limit reached due to slower then anticipated recruitment. Actual 62
NCT02301000 Terminated IMT for Primary Clostridium Difficile Infection Phase 2/Phase 3 Interventional Slow recruitment in pilot phase. A follow-up trial is launched (NCT03796650). Actual 21
NCT03021252 Terminated Respiratory Muscle Training in Stroke Swallowing Disorders N/A Interventional Because of the SARS-COV2 pandemic. Recruitment stopped at 48 patients Actual 50
NCT03059407 Suspended Impact of Therapy Dog Presence on Pediatric Echocardiogram N/A Interventional Due to COVID-19, the study has been put on hold. Anticipated 160
NCT03332355 Suspended Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 Phase 1 Interventional Business Reasons Anticipated 9
NCT03721796 Terminated Cancer Treatment Decision-making in the HIV Population: an Observational Study of Physician-patient Interactions Observational study design changed due to COVID-19 Actual 14
NCT03896334 Suspended Effect of Isometric Handgrip Training on Ambulatory Blood Pressure in Patients With Hypertension N/A Interventional The study is suspended because of the COVID-19 pandemic Anticipated 250
NCT04421664 Terminated Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada) Phase 3 Interventional Request of Health Canada after publication of https://doi.org/10.7326/M20-4207 Actual 70
NCT00894751 Terminated Two Anesthetic Techniques in Magnetic Resonance Imaging (MRI) Phase 1 Interventional low enrollment and high participant withdraw Actual 98
NCT01658852 Withdrawn Effects and Safety of Metronidazole in Patients With Gastrectomy Phase 3 Interventional Because of difficulties on recruiting participants Actual 0
NCT02920190 Withdrawn Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat Phase 4 Interventional Lack of funds to cover the costs of the study medications Actual 0
NCT04145193 Withdrawn Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC Phase 2 Interventional Study withdrawn prior to enrollment due to changing standard of care landscape. Actual 0
NCT02488278 Withdrawn GLUCOME USABILITY STUDY N/A Interventional Actual 0
NCT03384238 Suspended Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery Phase 1/Phase 2 Interventional Interim Analysis Anticipated 27
NCT03517696 Withdrawn Membrane Sweeping in Early Labor and Delivery Outcomes N/A Interventional Study IRB approval expired Actual 0
NCT03551535 Withdrawn Monitored Home Exercise in Pregnancy N/A Interventional Study IRB approval expired Actual 0
NCT03704285 Suspended Development of pk/pd Model of Propofol in Patients With Severe Burns Observational Outbreak COVID 19 Anticipated 30
NCT03705338 Suspended Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol Observational Outbreak COVID 19 Anticipated 20
NCT03855683 Suspended Stress, Anxiety, and Mood Group Therapy N/A Interventional Social distancing regulations related to COVID19. Anticipated 50
NCT04220476 Withdrawn CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer Phase 2 Interventional Initiating a new study with revised Statistics. Actual 0
NCT02844855 Terminated Memory for Action in Neurological Patients N/A Interventional failure to recruit 83/99 Actual 83
NCT03224975 Terminated Acute Pain Memory Among Former Burned: Exploration of fMRI. N/A Interventional failure to recruit Actual 24
NCT03604991 Suspended Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery Phase 2/Phase 3 Interventional Scheduled Interim Monitoring Anticipated 278
NCT00226746 Withdrawn Efficacy Study of Gemcitabine, Paclitaxel, and Irradiation in the Treatment of Pancreatic Cancer Phase 2 Interventional Actual 0
NCT04558892 Terminated Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome. Phase 2/Phase 3 Interventional The primary objectives were achieved. Actual 65
NCT02033278 Terminated Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure. Phase 2 Interventional Low recruitment rate, bibliographic evidence of lack of efficacy Actual 27
NCT02395237 Withdrawn COMPOUND (INN): HOE490O - GLIMEPIRIDE / METFORMIN HCl (Amaryl® M)0 (Glimepiride/Metformin Hydrochloride Immediate Release Combination Tablet) in Fed Conditions in Healthy Male and/or Female Subjects. Phase 1 Interventional Actual 0
NCT02972281 Terminated Systematic Search for Primary Immunodeficiency in Adults With Infections N/A Interventional deficient inclusions Actual 120
NCT03311568 Terminated Microcirculatory Alterations in Critical Disease: New Ultrasound Technology N/A Interventional Researcher has quit. Question still unanswered. A related study (observational, not to be registered) has started recently. Actual 30
NCT03559517 Terminated Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305) Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 30
NCT03860753 Terminated Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot) Phase 1/Phase 2 Interventional Halted enrollment due to COVID-19 Actual 4
NCT04532554 Withdrawn Growth Hormone in Obese Cases With Covid-19 Phase 4 Interventional No participants enrolled Actual 0
NCT02153684 Suspended Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform Observational Temporarily suspended due to COVID-19 Anticipated 120
NCT02925364 Terminated Functional and Anatomical MRI of the Spinal Cord and Peri-spinal Tissues Observational Slow recruitment Actual 30
NCT02952573 Terminated Testing JNJ-42756493 In Combination With Dexamethasone in Multiple Myeloma That Came Back After a Period of Improvement Phase 2 Interventional Low patient accrual Actual 20
NCT03017287 Terminated Safety and Efficacy of the GlucoMe APP in Patients With Uncontrolled Diabetes Treated With MDI N/A Interventional Actual 40
NCT03018756 Suspended Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea Phase 3 Interventional Temporarily suspended due to COVID-19 Actual 21
NCT03357692 Withdrawn All-on-Four Implants With Ultrasonic N/A Interventional no enough patients have been enrolled Actual 0
NCT03405090 Suspended Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators Phase 4 Interventional Temporarily suspended due to COVID-19 Anticipated 17
NCT03767829 Terminated A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease Phase 1/Phase 2 Interventional The sponsor decided not to proceed with Part B for business reasons. Actual 32
NCT03769961 Terminated Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect Observational Low enrollment Actual 6
NCT03786367 Suspended Dyspnea in Chronic Thromboembolic Pulmonary Hypertension Observational Temporarily suspended due to COVID-19 Anticipated 20
NCT03790774 Terminated Neurofeedback in Alzheimer's Disease N/A Interventional Due to COVID-19 concerns and restrictions in our at-risk population, interactions were halted. Actual 5
NCT03824535 Suspended 18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules Phase 2 Interventional Suspended Due to Covid-19 Anticipated 50
NCT03957096 Terminated A Safety Study of SGN-CD47M in Patients With Solid Tumors Phase 1 Interventional Sponsor decision based on portfolio prioritization Actual 16
NCT04077385 Withdrawn Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity N/A Interventional PI resigned from faculty position and K23 award was terminated early Actual 0
NCT04098016 Suspended Healthy Roots Digital Intervention N/A Interventional Aim 1 enrollment and study activities have been completed. Aim 2 start date is now anticipated for 01/11/2021. Anticipated 50
NCT04239222 Suspended Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot N/A Interventional Study suspended due to COVID 19 Anticipated 24
NCT04558580 Withdrawn Safety Study of Rufinamide Given as an add-on Therapy to Treat Patients With Seizures Phase 3 Interventional Actual 0
NCT02817113 Terminated Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer Phase 1 Interventional Strategy change Actual 4
NCT02923232 Terminated Ocular Adaptation and Visual Performance for Accommodative Contact Lens N/A Interventional Funding organization requested to stop the study Actual 32
NCT03567356 Suspended Treatment of Opioid Use: Medication Adherence Therapy N/A Interventional IRB temporarily suspended study due to COVID-19 Anticipated 50
NCT03858621 Suspended Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl N/A Interventional COVID 19 outbreak Anticipated 100
NCT04008602 Suspended Effectiveness of Quick Icing (QI) Technique on Strenght of Jump. N/A Interventional COVID-19 Anticipated 150
NCT04243031 Withdrawn QuantiFERON Access Clinical Performance Study Protocol Observational Business Decision Actual 0
NCT04306783 Withdrawn In-Home Sensor Monitoring of Older Adults With Cancer N/A Interventional Investigator is leaving the university Actual 0
NCT04360512 Terminated Dose-response of Talus Mobilizations N/A Interventional Suspended due to the covid-19 pandemic. Actual 42
NCT02787902 Suspended Weight Management in Mothers and Adult Daughters N/A Interventional Trial suspended due to COVID-19. Anticipated 168
NCT03212963 Terminated Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05% Phase 4 Interventional Sponsor's Decision Actual 16
NCT03045705 Withdrawn Evaluation of the Effect the Medical Team in the Delivery Room Has on Pain Management During Labor. N/A Interventional Problem with patient recruitment Actual 0
NCT03046654 Terminated Cervical Cerclage Position Throughout the Pregnancy. N/A Interventional Difficulty in patient recruitment Actual 7
NCT03930290 Terminated Physiologic Elasticity Changes During Pregnancy and After Labor. Observational Difficulty in patient recruiting Actual 12
NCT02522273 Withdrawn Evaluation of the 'SensPoint' Lactate Meter in the Estimation of Foetal Scalp Blood and Umbilical Cord Blood Lactate Observational Actual 0
NCT04274452 Withdrawn A Study to Assess the Efficacy and Safety of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP) Phase 3 Interventional The ARGX-113-1908 study will be replaced by a similar design with a subcutaneous formulation (ARGX-113-2004) Actual 0
NCT04548622 Terminated Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Results N/A Interventional Dr. Ralph Hoffman unexpectedly passed away. Actual 15
NCT02648932 Terminated The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients Phase 2 Interventional Poor accrual Actual 9
NCT02822196 Withdrawn Serratus Anterior Muscle Plane Block vsThoracic Paravertebral Block For Unilateral Mastectomies Phase 4 Interventional Critical study personnel left the institution Actual 0
NCT02936206 Terminated Examination of Breast Cancer Cells of Pre-menopausal and Post-menopausal Women Before and After Exposure to Tamoxifen or Fulvestrant. Phase 1 Interventional low accrual rate Actual 4
NCT03348826 Withdrawn Study of Sodium Bicarbonate in Restoring Blocked Catheters Phase 2 Interventional No participants were enrolled Actual 0
NCT03566823 Terminated Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 306) Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 34
NCT04098887 Withdrawn Lattice Stereotactic Body Radiation Therapy (Lattice SBRT) for Localized Unresectable or Metastatic Conventional Type Chondrosarcoma N/A Interventional Investigator decided to not go forward with the study. Actual 0
NCT04256655 Withdrawn Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of CDX 6114 in PKU Patients Phase 1 Interventional study product composition to move from liquid to solid Actual 0
NCT04401527 Withdrawn Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite Phase 2 Interventional No recruitment Actual 0
NCT03760250 Suspended Imiquimod for Preventing Keloid Recurrence Phase 2 Interventional Investigator decision Actual 5
NCT01495247 Terminated Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer Phase 1/Phase 2 Interventional Study did not meet Phase Ib primary objective to establish the maximum tolerated dose/recommended dose for Phase II Actual 18
NCT02027012 Terminated Treatment of Resistant Hypertension by Renal Denervation in China N/A Interventional company strategic change Actual 1
NCT02252094 Terminated Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS N/A Interventional Device no longer available in Singapore Actual 8
NCT03179605 Terminated Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Phase 2 Interventional Difficulty in enrollment Actual 22
NCT03192995 Terminated Treatment With Lorcaserin for Cocaine Use: The TLC Study Phase 2 Interventional FDA alert regarding study drug safety Actual 22
NCT03328741 Suspended Evaluation of a Web-based Platform for Osteoarthritis Treatment N/A Interventional COVID-19 Anticipated 270
NCT03438760 Terminated Improving STEM Outcomes for Young Children With Language Learning Disabilities N/A Interventional with 2/3 of the data collected, we had to terminate the study because of COVID19. Actual 36
NCT03537716 Withdrawn Fat Reduction Induced by Magnetic Device - Ultrasonographic Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03545633 Withdrawn Changes in Abdominal Tissues Induced by Magnetic Device - MRI Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03545646 Withdrawn Changes in Abdominal Tissues Induced by Magnetic Device - CT Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03547934 Withdrawn Fat Reduction Induced by Magnetic Device - Waist Circumference Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03728855 Terminated Effects of Self-administration of Medication During Hospitalization on Medication Safety, Adherence, and Patient Satisfaction in Dutch Hospitals N/A Interventional Difficult recruitment, despite several interventions. Actual 193
NCT04008459 Terminated Walking and Balance Related to Sagittal Spinal Posture Alignment Observational Recruitment no longer viable as spinal classes were stopped due to the COVID-19 situation. Actual 41
NCT04044326 Withdrawn The Safety and Efficacy of Spherical Microwave Ablation for the Treatment of Malignant Liver Tumors N/A Interventional Machine cannot provide Actual 0
NCT04062383 Suspended Positive Emotions After Acute Coronary Events at Northwestern University N/A Interventional In-person recruitment suspended due to COVID Anticipated 10
NCT04361916 Terminated Home Care for Patients With COVID-19: Active Monitoring in Two Italian Health Units (Casale Monferrato and Torino) N/A Interventional interrupted early due to the drastic reduction in the number of cases Actual 37
NCT04394286 Suspended A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects Phase 1/Phase 2 Interventional Reevaluation of development strategy Anticipated 21
NCT04402580 Terminated Efficacy of Anti-CD20 Antibodies (Rituximab Biosimilar) in the Treatment of Childhood Steroid-dependent Nephrotic Syndrome Phase 2 Interventional due to unexpectedly high rate of relapse in the active comparator arm. Actual 30
NCT04440488 Withdrawn ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study Phase 4 Interventional Reevaluation of development strategy Actual 0
NCT03342326 Terminated Lexical Priming by Music in Alzheimer's Disease and Healthy Aging N/A Interventional failure to recruit Actual 58
NCT03399227 Withdrawn Liver Transplantation: Skeletal Effects Observational no funding Actual 0
NCT03560232 Terminated Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Phase 4 Interventional Unable to recruit patients in a timely fashion and unable to recruit sufficient patients Actual 17
NCT03624777 Suspended Efficacy of the Stroll Safe Outdoor Fall Prevention Program N/A Interventional Currently on hold due to COVID-19 restrictions in community program sites Anticipated 105
NCT03730064 Suspended Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression Early Phase 1 Interventional Due to COVID-19 pandemic Anticipated 3
NCT03808935 Terminated Cannabis Extract in Refractory Epilepsy Study Phase 3 Interventional Participants are no longer being examined or receiving intervention. Actual 17
NCT03811951 Terminated Neuro Biomarkers of Smoking Behavior Phase 2 Interventional Different study initiation Actual 4
NCT03908203 Withdrawn Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction N/A Interventional The Study will be conducted in another research center. The Sponsor has changed. Actual 0
NCT03919214 Suspended Hypertension Management in Cancer Patients N/A Interventional Suspended due to Covid-19 Anticipated 40
NCT03959852 Terminated Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain Phase 4 Interventional Residency completed. Actual 6
NCT04054687 Suspended Intranasal TXA for Anterior Epistaxis in the Emergency Department Phase 2 Interventional Due to coronavirus pandemic Anticipated 86
NCT04137809 Withdrawn TREAT Foot Drop After Stroke With Ankle Robot N/A Interventional Study withdrawn due to logistical and safety concerns relating to Covid-19. Actual 0
NCT04141917 Suspended Test-and-treat for Influenza in Homeless Shelters Phase 4 Interventional Enrollments on hold until fall flu season. Anticipated 3200
NCT04269317 Suspended Clinical Study to Evaluate the Safety and Effectiveness of the Treatment With Tixel C on Acne Scars N/A Interventional Corona Virus delayed opening Anticipated 44
NCT04408846 Withdrawn Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis N/A Interventional The Study will be conducted in another research center. The Sponsor has changed. Actual 0
NCT02664077 Terminated A Study Evaluating Regorafenib Following Completion of Standard Chemotherapy for Patients With Colon Cancer Phase 3 Interventional Due to the significantly lower than expected accrual it was impossible to evaluate the endpoint in a timely fashion. Actual 34
NCT04091594 Suspended Investigating the Effects of Sensory Input Orthotics in Disorders of Posture and Movement N/A Interventional PI seeking alternative funding for the study Anticipated 50
NCT01030471 Withdrawn Supporting Treatment Adherence Needs in Diabetes N/A Interventional Actual 0
NCT01703338 Terminated Clinical and Biomechanics Research in Core Muscles After Lumbar Fusion Surgery Observational Actual 100
NCT02499627 Terminated Bendamustine Plus Brentuximab Vedotin in HL and CD30+ PTCL in First Salvage Setting Phase 2 Interventional expected accrual not reached Actual 43
NCT02932319 Terminated Outpatient Foley Catheter for Induction of Labor in Nulliparous for Prolonged Pregnancy N/A Interventional Deficient Inclusions Actual 43
NCT02949661 Withdrawn Local Wound Infiltration for Tracheal Reconstruction N/A Interventional Loss of interest in the subject Actual 0
NCT01948297 Terminated Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations Phase 1 Interventional Actual 77
NCT02336373 Terminated Treatment of Hemoglobin SC Disease With Hydroxyurea Phase 2 Interventional low enrollment Actual 32
NCT04204109 Terminated Interprofessional Versus Monoprofessional Case-based Learning in Childhood Cancer N/A Interventional Covid 19 and subsequent cancellation of all meeting activity Actual 49
NCT00592306 Withdrawn Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation Phase 3 Interventional lack of enrollment Actual 0
NCT02113280 Withdrawn DEMAND - DEgenerative Meniscal Tears - Arthroscopy vs. Dedicated Exercise N/A Interventional Failed funding application. Actual 0
NCT03306693 Terminated Educational Intervention to Increase the Emotional Competence of Patients With Oesogastric and Bronchopulmonary Cancers N/A Interventional insufficient inclusions Actual 23
NCT03580798 Terminated Ridge Preservation Comparing Simultaneous vs. Delayed Grafting N/A Interventional Not enough patients available Actual 7
NCT03607708 Suspended Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety N/A Interventional COVID-19 Anticipated 30
NCT03612167 Suspended Constructing A Model of Health Promotion and Active Aging for Community-Dwelling Older Adults N/A Interventional no funding Anticipated 150
NCT03721315 Terminated Health Literacy Activation RCT Among the COPD Patients and Designated Support Dyad N/A Interventional SARS-CoV2 pandemic Actual 6
NCT03778606 Suspended Oligosaccharide for Cdiff(+) Heme-onc Patients N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 12
NCT03950648 Withdrawn Spatial Cognitive Training for Chronic Vestibular Disorders N/A Interventional COVID-19 Actual 0
NCT03956251 Suspended Ridge Preservation With Putty Allografts N/A Interventional COVID Anticipated 30
NCT03979066 Terminated Study Evaluating NEOadjuvant Immunotherapy in Resectable PANCreatic Ductal Adenocarcinoma Phase 2 Interventional Loss of funding Actual 1
NCT03988842 Suspended Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism Phase 4 Interventional COVID-19 pandemic Actual 4
NCT04155268 Withdrawn Flotation-REST for Chronic Pain, Stress, and Sleep N/A Interventional Unable to conduct the study due to Covid-19. Actual 0
NCT04162964 Suspended Chair Yoga for Stress in Dementia N/A Interventional COVID-19 Anticipated 40
NCT02790996 Terminated Neonatal Vancomycin Trial Phase 2 Interventional Planned interim analysis yielded different event rate affecting sample size and ability to recruit sufficient numbers within remaining trial time frame Actual 242
NCT03088735 Terminated Transfer Strategy in an Oocyte Donation Programme N/A Interventional Due to the clinically and statistically significant inferior results for the D3 group following evaluation by the institutional review board. Actual 134
NCT02591394 Terminated STEPs to Blood Pressure Reduction. N/A Interventional Funding period ended and slow enrollment Actual 115
NCT02928887 Suspended Light Therapy in Cardiopulmonary Bypass Surgery N/A Interventional Cardiac surgeon collaborator has left the institution Anticipated 30
NCT02711059 Withdrawn Insulin Resistance in Primary Hyperparathyroidism N/A Interventional studien skjuts på framtiden Actual 0
NCT03357133 Terminated Tirofiban for Patients Treated With Alteplase Phase 2/Phase 3 Interventional The number and speed of enrollment were significantly less than expected. Actual 30
NCT04148300 Suspended The Impact of Oral Health Literacy on Dental Anxiety and Utilization of Oral Health Services Observational Due to COVID-19 and lock-down of the university Actual 550
NCT04546802 Withdrawn HepATocellular Cancer Hcv Therapy Study Phase 3 Interventional Recruitment will be too difficult due to available PBS funded treatment and recent Australian clinical guidelines will conflict with the premise of the study. Actual 0
NCT03073850 Terminated Antithrombotic Treatment in Patients With Effectively Maintained Sinus Rhythm After Atrial Fibrillation Ablation Phase 4 Interventional Majority of enrolled patients have withdrawn. Actual 48
NCT03204149 Terminated Evaluation of Safety of Low Level Laser Device Treatment in Chronic Wounds N/A Interventional Project termination Actual 5
NCT03377751 Terminated Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation? N/A Interventional Majority of enrolled patients have withdrawn. Actual 20
NCT03983070 Suspended The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size. N/A Interventional Covid-19. No in-person study procedures are currently allowable by the overseeing IRB. Anticipated 30
NCT00891917 Withdrawn Liq-NOL Efficacy in Pediatric Patients With Down Syndrome Phase 2 Interventional no funding Actual 0
NCT02434874 Withdrawn Sacral Nerve Stimulation to Treat Urgency Urinary Incontinence With Wireless Neuromodulation N/A Interventional Study will no longer take place. Actual 0
NCT03151408 Terminated An Efficacy and Safety Study Of Pracinostat In Combination With Azacitidine In Adults With Acute Myeloid Leukemia Phase 3 Interventional The IDMC recommended to stop the study prematurely due to a lack of efficacy. Actual 406
NCT03203837 Terminated Biomarker Analyses in Hepatocellular Carcinoma (HCC) Patients Treated With TheraSphere® Observational Funding Discontinued due to low accrual rate Actual 4
NCT03506139 Withdrawn Biologically-based Target Volumes to Treat Newly Diagnosed Glioblastoma Phase 2 Interventional Not funded Actual 0
NCT03742180 Withdrawn Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy N/A Interventional Unavailable drug in Egypt. Actual 0
NCT03896451 Withdrawn Comparison Between Two Total Knee Prosthesis Medacta GMK Sphere and Medacta GMK PS N/A Interventional Medacta GMK PS is not in use anymore Actual 0
NCT04097496 Terminated Effects of ACT OUT! Social Issue Theater on Youth and Adolescents N/A Interventional COVID-19 pandemic and related school policies. Actual 1537
NCT04122183 Suspended Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening N/A Interventional Subject contact has been suspended until it is safe to screen hearing and participants feel safe seeing clinicians. Anticipated 40
NCT03213665 Suspended Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Phase 2 Interventional Scheduled Interim Monitoring Anticipated 49
NCT04136561 Withdrawn Novel Strategy to Encourage Early Removal of Central Venous Catheters N/A Interventional No participants enrolled. Unable to enroll Actual 0
NCT02943447 Terminated Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis Phase 2 Interventional The study was terminated because of the availability of alternate therapies for primary biliary cholangitis (PBC). Actual 71
NCT00894361 Terminated Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs Phase 4 Interventional PI/study coordinator retired due to personal family health matters; study sponsor withdrew funding. Study terminated and no data collected or analyzed Actual 400
NCT00979147 Terminated Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty N/A Interventional PI/study coordinator retired due to personal family health matters; study sponsor withdrew funding. Study terminated and no data collected or analyzed Actual 400
NCT01113658 Withdrawn Clinical Evaluation of the SNaP Wound Care System N/A Interventional The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01349894 Withdrawn SNaP Wound Care System Over Skin Cancer Excision Sites and Split Thickness Skin Grafts (STSGs) Observational The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01417208 Withdrawn Clinical Evaluation of the SNaP Wound Care System in Promoting Healing in Chronic Wounds Observational The study was terminated by Spiraur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01623882 Withdrawn Clinical Evaluation of the Combined Use of Apligraf® and the SNaP® Pressure Wound Therapy System Observational The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT02051764 Terminated Imaging Characteristics of a Follow-up 18F-AV-1451 Scan Phase 2 Interventional Lower than expected enrollment Actual 44
NCT02192359 Suspended Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas Phase 1 Interventional Drug not available. Anticipated 53
NCT03088930 Withdrawn Evaluating Crizotinib in the Neoadjuvant Setting in Patients With Non-small Cell Lung Cancer Phase 2 Interventional Low Accrual Actual 0
NCT03120793 Terminated ARDS Esophageal Balloon Pressure Changes With Positioning Study Observational Failure to recruit/enroll Actual 2
NCT03133897 Terminated Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study Phase 3 Interventional it was felt by the sponsoring institution that the current standard of oversight expected by the Health Canada regulations, would not be possible to achieve Actual 20
NCT02772809 Terminated Usability Testing of Affordable Haptic Robots for Stroke Therapy N/A Interventional The robot was no longer available to the study. Actual 23
NCT03615924 Terminated Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease Phase 3 Interventional Recommendation from an independent data monitoring committee (DMC) and accepted by AstraZeneca. Actual 193
NCT03657095 Terminated A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension Phase 3 Interventional The pivotal study, BPS-314d-MR-PAH-302 (NCT01908699), failed to demonstrate efficacy. Actual 112
NCT03711786 Suspended The Sub-Saharan Africa Regional Partnership for Mental Health Capacity Building N/A Interventional COVID-19 - pause in in-person enrollment; follow-up by phone continuing Anticipated 1160
NCT03750656 Terminated Use of Hyoscyamine Versus Tamsulosin for Management of Ureteral Stent Irritation Phase 4 Interventional Not accruing patients quickly enough Actual 6
NCT03862027 Terminated Evaluating Safety of Transpulmonary Pressure Guided PEEP Management in Neurocritical Care Patients N/A Interventional Failure to enroll/recruit Actual 2
NCT03985215 Withdrawn The Value of Follow-Up After Childhood Acute Lymphoblastic Leukaemia in Denmark - Family Perspectives Observational Overlapping with another danish questionnaire study Actual 0
NCT04013763 Terminated Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care N/A Interventional 1. Limit number of patients during COVID-19 situation 2. Too small number of wheat allergic patients who are using wheat containing soap Actual 7
NCT04048057 Suspended The Effect of Different Exercise Programs in Coronary Artery Patients: A Randomized Controlled Study N/A Interventional Because of Covid-19 pandemia, The cardiac rehabilitation unit in the hospital conducting the study has been closed for a while. Anticipated 60
NCT04058145 Withdrawn AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma Phase 2 Interventional Funding Withdrawn Actual 0
NCT04073407 Terminated Study of the Safety and Tolerability of AXA1957 in Adolescent Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD) N/A Interventional Sponsor has determined that information it would have collected would not inform future development of a therapy with AXA 1957 for NAFLD Actual 9
NCT04106843 Withdrawn Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or Unresectable Rare Endocrine Cancers Phase 2 Interventional No Participants Registered Actual 0
NCT03423537 Terminated Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART Phase 3 Interventional Inability for further recruitment, change of position of the principal investigator, COVID-19 pandemic Actual 80
NCT03535584 Suspended Exercise to Treat Frailty and Decreased Physical Function in Transplant Candidates N/A Interventional Due to Covid19 pandemic at this time we are on pause Anticipated 50
NCT03636048 Terminated Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) N/A Interventional not enough participants Actual 20
NCT03691038 Terminated Comparison of Conventional Dose Regimen and New Dose Regimen of Pregabalin N/A Interventional Participants couldn't be enrolled due to complain of frequent visit. Actual 10
NCT03768726 Terminated Extension Study Evaluating The Safety And Tolerability Of Flexible Doses Of Oral Ziprasidone In Children And Adolescents With Bipolar I Disorder Phase 3 Interventional Pfizer has decided to perform the pre-specified final analysis at the current enrollment using a re-estimation of the sample size. Actual 23
NCT04084574 Suspended Diet and Hypertension Management in African Americans With Chronic Kidney Disease N/A Interventional Aim 1 enrollment and study activities have been completed. Aim 2 anticipated start date is 3/2021. Anticipated 50
NCT04175717 Terminated Feasibility of a Physiotherapy-led Follow-up Programme in Adult Critical Illness Survivors N/A Interventional Due to COVID pandemic Actual 3
NCT04249713 Withdrawn An Alternative Dose Interval Study in Participants With Hidradenitis Suppurativa Receiving Brodalumab Early Phase 1 Interventional Biomarker Samples Not Collected Actual 0
NCT04249947 Suspended P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Phase 1 Interventional FDA Clinical Hold Anticipated 40
NCT04254666 Suspended New Skills - No Scores Research Study N/A Interventional The COVID-19 pandemic required that we discontinue the study. Anticipated 30
NCT04377165 Terminated Innovative Tool to Limit Spread of SARS-CoV-2 in Residential Aged Care Facilities N/A Interventional Engagement issues, poor recruitment to study Actual 34
NCT04392128 Withdrawn Study Evaluating the Efficacy of Hydroxychloroquine and Azithromycine in Patients With COVID-19 and Hematological Malignancies (HYACINTHE) Phase 2 Interventional competent authority decision Actual 0
NCT04541719 Withdrawn Patient Controlled Remifentanil Analgesia for Normal Labour Phase 2 Interventional no participants enrolled Actual 0
NCT03008616 Terminated Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia Phase 2/Phase 3 Interventional Following a recommendation from the Data and Safety Monitoring Board (DSMB), the study was stopped early for futility. There were no safety concerns raised. Actual 59
NCT03473665 Terminated Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis Phase 4 Interventional Slow recruitment Actual 9
NCT01571791 Suspended Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Phase 2 Interventional No enough recruited cases Anticipated 90
NCT01718756 Suspended Continuous Lornoxicam Infusion for Orthopaedic Surgery Phase 1/Phase 2 Interventional No enough fund or cases Anticipated 96
NCT01861561 Terminated Low-dose VS High-dose IV Cyclophosphamide for Proliferative LN in Children Phase 4 Interventional The duration of the study is longer than 5 years and we can not recruit the participants to the target number. Actual 43
NCT01937884 Terminated Supplemental Parenteral Nutrition in Pediatric Respiratory Failure Phase 2 Interventional Unable to enroll patients Actual 18
NCT01945229 Terminated Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE) Observational Preliminary analyses of data indicated study should be terminated for futility Actual 110
NCT02420652 Terminated Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy Phase 2 Interventional Slow accrual Actual 27
NCT02432378 Suspended Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines Phase 1/Phase 2 Interventional Anticipated 25
NCT02607488 Suspended Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Bariatric Surgery Phase 1/Phase 2 Interventional No fund no enough recruiting centers Anticipated 180
NCT01799889 Terminated Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies Phase 2 Interventional Sponsor's decision to discontinue development of entospletinib. Actual 326
NCT03523091 Terminated OnabotulinumtoxinA Bladder Injection Study Phase 4 Interventional Lack of enrollment Actual 1
NCT02757976 Terminated Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial N/A Interventional Consensus RAFT-LVendo Steering Committee to terminate. Actual 8
NCT03909867 Suspended Emission Patterns of Respiratory Syncytial Virus Observational The emergence of SARS-CoV-2 required a temporary hold of recruitment Anticipated 29
NCT03015051 Terminated High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Phase 4 Interventional Difficulty in recruiting subjects who meet the inclusion/exclusion criteria Actual 30
NCT03106597 Terminated Manidipine Versus Amlodipine in Patients With Hypertension Phase 4 Interventional Difficulty in enrolling subjects Actual 46
NCT03221166 Terminated Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors Phase 3 Interventional Difficulty in recruiting subjects who meet the inclusion/exclusion criteria Actual 9
NCT04097093 Withdrawn Long-term Surival of GIST Patients ≥ 10 Years on Imatinib Observational [Patient Registry] Lack of feasibility Actual 0
NCT02219334 Terminated Comparing Nasal Suction Devices in Children With Bronchiolitis: A Pilot Study N/A Interventional The study was stopped due to low enrollment. Actual 55
NCT02429934 Terminated Abatacept for SLE Arthritis (IM101-330) Phase 1/Phase 2 Interventional Response rate in placebo group for primary outcome was 100% on interim analysis. Actual 28
NCT02507986 Suspended Mobile Phones in Cryptogenic Stroke Patients Bringing Single Lead ECGs to Detect Atrial Fibrillation N/A Interventional no personnel for recruitment Anticipated 200
NCT02577367 Terminated Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding Phase 4 Interventional Hospital has a new protocol holding off feeding 2 hours for LT4 administration. Actual 4
NCT02774551 Suspended Physical Activity Intervention Trial to Mitigate Muscle Loss and Increase Muscle Strength N/A Interventional Suspended since March 2020 due to the ongoing covid-19 situation Anticipated 160
NCT02964481 Terminated Malignant Hyperthermia Registry and Genetic Testing Observational Lack of funding to enroll additional participants Actual 64
NCT03060954 Terminated Non-Inferiority Study Comparing MINI WELL READY® and FineVision® in Patients With Cataract Surgery N/A Interventional The clinical study is closed to further enrolment based on the lack of perceived need to compare the study device with the control device. Actual 8
NCT03589755 Withdrawn The Impact of Mindfulness Meditation in Veterans With Epilepsy N/A Interventional unable to recruit enough candidates Actual 0
NCT03597282 Terminated A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma Phase 1 Interventional Closed due to historically slow enrollment compounded by the COVID-19 pandemic. Actual 22
NCT03682367 Terminated Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery Phase 3 Interventional Poor Recruitment Actual 10
NCT03821649 Suspended SOONER Feasibility Study Protocol N/A Interventional Suspended due to non-essential research prohibitions at the study's recruitment and outcome assessment sites in the context of COVID-19. Anticipated 80
NCT03907202 Terminated A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM Phase 1 Interventional The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects. Actual 25
NCT03978884 Withdrawn Phase 4 Study of the Efficacy of Losartan Based Therapy in Hypertensives With and Without Diabetes Phase 4 Interventional Unable to effective arrange trial logistics Actual 0
NCT04093115 Withdrawn Study of CX1106 in Patients With Advanced Head and Neck Squamous Cell Carcinoma Phase 2 Interventional The study was terminated voluntarily by the sponsor due to changes in clinical development strategy. Actual 0
NCT04130906 Suspended Theta Burst Stimulation in Binge Eating Disorder: A Single Session RCT N/A Interventional The study includes adults vulnerable to COVID-19 and procedures cannot accommodate social distancing. Anticipated 66
NCT04138602 Withdrawn BTL Emsella Chair Versus Sham for the Treatment of Fecal Incontinence N/A Interventional Lack of enrollment Actual 0
NCT04143490 Suspended Effects of Exercise in Patients With Ulcerative Colitis N/A Interventional Due to Covid-19 Anticipated 24
NCT04206800 Terminated Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients N/A Interventional Difficulty in enrolling participants Actual 5
NCT04228549 Suspended MyPADMGT Support of Out-Patients With Peripheral Arterial Disease N/A Interventional Outpatient clinic site suspended temporarily due to COVID 19 virus Anticipated 210
NCT04244825 Suspended Safety, Pharmacodynamics, and Pharmacokinetics of Orally Administered BLD-2660 in Subjects With IPF Phase 2 Interventional Suspended due to concerns for patient safety during COVID-19 crisis Anticipated 32
NCT04291508 Suspended Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Phase 2 Interventional Study put on hold due to CIV-19 pandemic and NHLBI directive for PETAL network to redirect efforts to COVI-19 specific treatment trials. Anticipated 900
NCT04300335 Suspended The Feasibility and Effects of Exercise on Patients Suffering From Multiple Myeloma N/A Interventional Due to COVID-19 and the fact that the study participants are part of the "high-risk" population, the start of the recruiting process has been delayed at will. Anticipated 45
NCT04377425 Withdrawn COVID-19 Prevalence and Cognitive Deficits in Neurological Patients Observational No acute neurological patients presented with concomitant COVID-19 Actual 0
NCT04430010 Suspended Multi-level Determinants of Implementation and Sustainment in the Education Sector N/A Interventional Schools opening remotely has prevented recruitment Anticipated 588
NCT02608944 Withdrawn Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging N/A Interventional MRI perfusion techniques development took years than expected. Actual 0
NCT02929394 Terminated Trabectedin Maintenance Post 1st-line in STS Phase 3 Interventional Poor accrual Actual 13
NCT03124628 Withdrawn Effects of Flywheel Exercise on Muscle and Walking Function in Teenagers and Young Adults With Cerebral Palsy N/A Interventional Lack of funding Actual 0
NCT03497598 Terminated Preventing Recurrent Urinary Tract Infections With α-D-mannose Phase 4 Interventional not enough patients Actual 15
NCT04540952 Terminated Randomized Trial Comparing Fluid Capture Efficiency of Total Capture Drape Versus Standard Drape for Hysteroscopy. N/A Interventional COVID-19 Actual 68
NCT03554356 Suspended Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE) N/A Interventional Device modifications required prior to trial proceeding. Anticipated 70
NCT03638596 Suspended Leveraging Transdermal Alcohol Monitoring to Reduce Drinking Among DWI Defendants N/A Interventional Suspended enrollment due to pandemic, follow-up visits still ongoing. Anticipated 440
NCT03648619 Suspended Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging N/A Interventional Insufficient recruitment Anticipated 50
NCT03698838 Terminated Myelin Imaging Changes In Patients With Neurosurgical Diseases Observational Principal Investigator left Institution Actual 20
NCT03829618 Terminated Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound Phase 3 Interventional COVID lack of cases/recruitment Actual 29
NCT02132598 Terminated Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases Phase 2 Interventional Trial stopped due to slow patient accrual. Actual 5
NCT03833596 Terminated Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD) Phase 4 Interventional Low recruitment Actual 3
NCT03883321 Terminated EssaiClinique_CBSM Observational few patient feedback and principal investigator disponibility Actual 25
NCT04037306 Terminated Measurements From Stool to Support Dietary Change N/A Interventional Weight loss center programming suspended due to COVID-19 pandemic Actual 7
NCT04059666 Suspended Gastrointestinal Tract Microbiome in Healthy Term Infants Receiving Mother'S-own Breast Milk or Cow's Milk-based Infant Formulas N/A Interventional COVID-19 Anticipated 111
NCT04170868 Withdrawn Psychoeducational Video Series - Proof of Concept N/A Interventional COVID Actual 0
NCT04220788 Withdrawn Pharmacist Enhanced Service for Cardiovascular Risk Reduction N/A Interventional No enrollment due to difficulty in recruitment of study sites Actual 0
NCT04325061 Suspended Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Phase 4 Interventional Lack of enrollment Anticipated 200
NCT04326075 Suspended Early CPAP in COVID-19 Patients With Respiratory Failure. N/A Interventional the insurance contract hasn't been drafted yet Anticipated 900
NCT04350086 Withdrawn Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection Phase 4 Interventional unfavorable opinion of the ethics committee Actual 0
NCT04360135 Suspended Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy Phase 2/Phase 3 Interventional PI has decided to put this study on hold at this time. Actual 208
NCT03613831 Withdrawn Multi-center Complex Atrial Tachycardia High-Resolution Mapping Registry (MATH) Observational The sponsor has decided to stop the study Actual 0
NCT00603941 Terminated A Phase 1/2 Study of CS7017, an Oral PPARγ Agonist, in Combination With Paclitaxel Phase 1/Phase 2 Interventional Due to low enrollment, no participant had a dose limiting toxicity, therefore a maximum tolerated dose could not be established Actual 19
NCT03953352 Withdrawn Evaluation of the Automatic Deformable Recontouring on the Daily MVCT for Head and Neck Cancer Adaptive Radiotherapy N/A Interventional Study cancelled Actual 0
NCT00182455 Terminated Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP) Phase 4 Interventional loss of funding Anticipated 12
NCT00936234 Withdrawn Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM). Phase 2/Phase 3 Interventional insufficient recruitment Actual 0
NCT00975468 Suspended Pressure-Controlled vs Volume-Controlled Ventilation During One Lung Ventilation N/A Interventional Financial shortages due to lack of funderx Anticipated 40
NCT01232153 Withdrawn Preoxygenation Before Prehospital Tracheal Intubation With NIV Versus Balloon N/A Interventional departure without replacement of the principal investigator Actual 0
NCT01539395 Withdrawn A Cross-Sectional Study of MSDx Complex 1 as a Marker for Active Disease in Multiple Sclerosis Observational Actual 0
NCT02859844 Terminated Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction N/A Interventional Termination after a few pilot participants due to further protocol development Actual 9
NCT03522480 Withdrawn The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 2 N/A Interventional Change of Research Objectives for Grant Funded Study Actual 0
NCT03527550 Suspended Cognitive Control Training for Urgency in a Naturalistic Clinical Setting N/A Interventional Recruitment paused due to COVID-19 Anticipated 90
NCT03530605 Withdrawn Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma N/A Interventional Study never initiated, PI left institution Actual 0
NCT03547349 Suspended The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 3 N/A Interventional COVID-19 Anticipated 169
NCT03047213 Suspended Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations Phase 2 Interventional Other - TSC1/TSC2 testing issues and futility analysis Anticipated 209
NCT03836482 Suspended Selective Cytopheretic Device (SCD) Trial N/A Interventional Study halted temporarily to obtain protocol amendment approval but potentially will resume. Anticipated 10
NCT04101006 Terminated Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function Observational recruitment difficulties, high postoperative drop-out rate Actual 78
NCT04538196 Withdrawn Coding Improvement Project: Resident Education on Documentation N/A Interventional Study staffing constraints Actual 0
NCT02640690 Suspended Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma N/A Interventional Recruitment has been suspended because of COVID related restrictions and limitations imposed on data collection Anticipated 210
NCT02949843 Terminated Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations Phase 2 Interventional Slow accrual, closed by IRB Actual 19
NCT03106571 Terminated Study of Pomaglumetad and Methamphetamine Phase 1 Interventional Deemed unable to enroll targeted participants in part due to COVID-19 shut downs Actual 19
NCT03515200 Terminated Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia Phase 1 Interventional Due to departure of PI from St. Jude Actual 12
NCT03648047 Terminated Digital Biofeedback System Versus Conventional Rehabilitation After Rotator Cuff Repair N/A Interventional COVID-19 pandemic imposed restrictions to normal study conduct Actual 50
NCT04163224 Withdrawn Minimal Invasive Approach for Surgical Repair of Rib Fractures With a Novel Intrathoracic Device Observational Sponsor strategy change Actual 0
NCT01784861 Terminated VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors Phase 1/Phase 2 Interventional Pharmaceutical company decision Actual 23
NCT02154984 Terminated Time Restricted Diet in Obese or Overweight Pre or Postmenopausal Participants N/A Interventional Study closed due to funding before accrual was met Actual 45
NCT02349633 Terminated Study For Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M) Phase 2 Interventional The study was ended for strategic reasons and changes in the external environment. The safety profile and risk benefit ratio for PF-0674775 remained unchanged. Actual 65
NCT02820077 Terminated Hemostatic Powder Versus Clinical Management for the Treatment of Upper Gastrointestinal Bleeding From Tumor Lesions N/A Interventional Global recall of Hemospray Actual 62
NCT03362593 Terminated A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses Phase 1 Interventional The program is canceled due to company strategic reasons. Actual 186
NCT03780205 Terminated Bilateral and Unilateral Amblyopia Treatment Study Observational Unable to recruit sufficient number of subjects Actual 1
NCT03877250 Withdrawn Analysis of Biopsy Specimens to Study Responses to PD-1 or PD-L1 Therapies Observational The primary objectives have not been met due to no patient enrollment therefore, the PI is requesting to close the study at this time. Actual 0
NCT03953456 Terminated Study to Evaluate the Effect of Elafibranor on Hepatic Lipid Composition in Subjects With Nonalcoholic Fatty Liver (NAFL) Phase 2 Interventional Continuation of the trial cannot serve a scientific purpose Actual 17
NCT04075071 Terminated A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start N/A Interventional Intervention and and final data collection point was not completed due to coronavirus school closures in March 2020. Actual 70
NCT00586209 Terminated L-Glutamine Therapy for Sickle Cell Anemia Phase 2 Interventional Due to inadequate supplies of study drug & internal business decisions. Actual 15
NCT02975336 Terminated A Phase II Study of M2951 in Systemic Lupus Erythematosus (SLE) Phase 2 Interventional Study is completed; primary analysis completed. Actual 480
NCT03237754 Terminated Neurostimulation in Chronic and Episodic Migraine N/A Interventional Recruitment problems (especially for chronic migraine patients) Actual 41
NCT03540368 Suspended Tranexamic Acid for The Treatment of Gastrointestinal Bleeding N/A Interventional increased number of patients death Anticipated 336
NCT03607500 Suspended Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation N/A Interventional Lack of funding Anticipated 30
NCT03752242 Suspended Evaluation of Topical Application of BMX-010 in Subjects With Acne Vulgaris. Phase 2 Interventional Enrollment stopped for chemistry work on investigational product. Actual 2
NCT03825913 Terminated 3-month Aerobic and Resistance Exercise Intervention for Individuals Diagnosed With Melanoma N/A Interventional two key faculty members are no longer part of the study and institution Actual 1
NCT03889873 Suspended Evaluating Change in Drinking Identity as a Mechanism for Reducing Hazardous Drinking - Study 2 N/A Interventional Paused enrollment due to COVID-19 pandemic; will resume Fall 2020 Anticipated 328
NCT04118569 Suspended Personalized Experiences to Inform Improved Communication for Patients With Life Limiting Illness N/A Interventional On hold due to COVID-19 pandemic. Anticipated 80
NCT04349228 Withdrawn Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals Phase 3 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT04351919 Withdrawn Assessment of Efficacy and Safety of HCQ and Antibiotics Administrated to Patients COVID19(+) Phase 4 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT03249272 Terminated Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Phase 4 Interventional Sponsor withdrew funding Actual 31
NCT04386434 Withdrawn Active for Life Assisted Living Feasibility and Acceptability Study N/A Interventional Pandemic, researchers no longer have access to residents of assisted living. Actual 0
NCT03871569 Terminated Medico-economical Evaluation on Buccodental Teleexpertise in Nursing Home N/A Interventional Difficulty recruiting and follow-up due to the epidemic context of COVID19 Actual 171
NCT04528927 Withdrawn Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia Phase 3 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT00860379 Terminated The Effect of Selenium Supplementation Among Pediatric Patients With Burns Phase 4 Interventional Due to a shift in primary responsibilities, the PI was not longer able to enroll subjects. Actual 14
NCT02429505 Withdrawn Treatment of Leishmaniasis With Impavido® (Miltefosine): Higher-Weight Patient Registry Observational [Patient Registry] This study was COMPLETED, but no patients were enrolled. Actual 0
NCT01334489 Terminated The Trial of Pessary After Laser for TTTS N/A Interventional Interim analysis unfavorable to continue the study Actual 352
NCT01535157 Terminated Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer Phase 1/Phase 2 Interventional drug combination not providing any efficacy. Will use this data in opening new trial Actual 12
NCT02090868 Withdrawn An Oral Intake Screening Tool for Patients Receiving Non-Invasive Ventilation Observational No patients recruited due to decreased levels of patients requiring non-invasive ventilation during the study. Actual 0
NCT02759120 Terminated CleanUP IPF for the Pulmonary Trials Cooperative Phase 3 Interventional Terminated for futility after review of first planned interim analysis. Actual 509
NCT02810236 Suspended Focal Breast Pain: Does a Normal Ultrasound Provide Reassurance? N/A Interventional The study is suspended due to the pandemic Anticipated 160
NCT02874820 Terminated I2PETPG - Imidazoline2 Binding Sites in a Group of Participants Diagnosed With AD Early Phase 1 Interventional Patient recruitment issues. Actual 2
NCT02927470 Withdrawn TMS of Visual Working Memory N/A Interventional Investigators are no longer at NYU Langone Health Actual 0
NCT03036891 Withdrawn Naloxegol for Opioid-Related Gastroparesis Phase 2 Interventional Actual 0
NCT03556930 Withdrawn Simulated Radiotherapy Treatment Assisted With Pediatric Radiation Oncology With Movie Induced Sedation Effect Technique Early Phase 1 Interventional Project was never initiated. Actual 0
NCT03693274 Terminated Mindfulness to Improve Functional Outcomes in Patients With Fibromyalgia or Central Sensitization N/A Interventional Principal investigator leaving institution. Actual 16
NCT04374474 Withdrawn Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19) Phase 4 Interventional Study withdrawn before any enrollment (site's research goals adjustments). Actual 0
NCT04384614 Withdrawn Covid-19 In Tunisia: An Observational Cross-Sectional Registry Study Observational [Patient Registry] The sponsor decided to withdraw the study for funding reasons. Actual 0
NCT04527796 Terminated Influence of a Residential Rehabilitation Program on Body Composition in Patients With Cystic Fibrosis N/A Interventional number included Actual 39
NCT02315625 Terminated Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery Phase 2 Interventional Study closed due to poor accrual. Actual 16
NCT03992079 Terminated A Multimodal Enhanced Recovery Program in Anorectal Surgery N/A Interventional PI is no longer at institution Actual 60
NCT04282681 Withdrawn XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU) Observational Sponsor decision due to clinical strategy changes Actual 0
NCT04332341 Suspended Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation Early Phase 1 Interventional COVID-19 hold Anticipated 20
NCT02638506 Terminated RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches Phase 4 Interventional Covid restrictions Actual 60
NCT02743169 Withdrawn Improvement of Ambulance Response Times in Karachi, Pakistan Observational Could not acquire data Actual 0
NCT03232632 Terminated Assessment of Cardiac Fixation During PET Using a New Drug Within Amyloid Cardiac Injuries. Early Phase 1 Interventional intervention programming Actual 7
NCT03251872 Terminated Olaparib for PAH: a Pilot Study Early Phase 1 Interventional OPTION pilot trial merged with the new NCT03782818 - OPTION multicenter trial Actual 6
NCT03289624 Withdrawn SHARE for Persons With Chronic Conditions and Their Family Caregivers N/A Interventional Lost Funding Actual 0
NCT03312127 Terminated Evaluation of Peri-surgical Results at Short and Mean Terms of the GORE ® Excluder Iliac Branch Endoprosthesis N/A Interventional End of inclusion period Actual 3
NCT03348111 Withdrawn Establishing a New Protocol for Early Mucositis and Peri-implantitis Treatment Using an Air-polishing Device N/A Interventional No participant enrolled Actual 0
NCT03738124 Withdrawn Evaluation of the Valiant Mona LSA Thoracic Stent Graft System in Thoracic Aortic Aneurysms and Chronic Dissections N/A Interventional Production of the medical device was stopped Actual 0
NCT04053543 Terminated CXA-10 Study in Subjects With Pulmonary Arterial Hypertension Phase 2 Interventional LOE Actual 33
NCT04066088 Withdrawn Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior Associated With Prader-Willi Syndrome Phase 4 Interventional PI departure from institution Actual 0
NCT04227938 Terminated Study of ALPN-101 in Steroid-resistant or Steroid-refractory Acute GVHD Versus Host Disease Phase 1 Interventional Change in sponsor strategy Actual 1
NCT04317924 Withdrawn Pneumostasis With Use of Bio-absorbable Mesh and Fibrin Sealant in Lung Resection N/A Interventional Resources not available to conduct the research. Actual 0
NCT03522805 Terminated Impact of Non-invasive Ventilation in Hypercapnic COPD N/A Interventional Failure to accrue subjects. All activity has stopped & no analysis will be done on what has been collected. Actual 6
NCT04142554 Withdrawn Parsaclisib in Newly Diagnosed Stage I-IIIC Triple Negative or HER2+ Breast Cancer Phase 1 Interventional Funding withdrawn from funding source. Actual 0
NCT04528758 Suspended F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow Early Phase 1 Interventional re-evaluation of radiotracer Anticipated 15
NCT04438551 Suspended Software Application for Low-Sodium Diet Trial (SALT) N/A Interventional Study is on hold until pilot study is completed. Anticipated 80
NCT04403685 Terminated Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers Phase 3 Interventional Safety Actual 129
NCT01096290 Terminated Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications Phase 4 Interventional Number of needed participants could not be obtained Actual 23
NCT02026726 Terminated Do Oral Steroid Dose Packs Predict How Well Epidural Steroid Injections Will Work? Observational could not recruit Actual 10
NCT02673151 Suspended 68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment Phase 2/Phase 3 Interventional logistics Anticipated 200
NCT02775422 Terminated Comparison of Serological Test s for the Virus Chicken Pox Virus (VZV) and Correlation With the Patient's Memory of the Infection or Vaccination N/A Interventional Low inclusion rate. Actual 308
NCT03202498 Terminated Safety and Tolerability of Yaq-001 in Patients With Cirrhosis N/A Interventional COVID-19 pandemic prevents patients from making in-hospital visits, which are mandatory to assessment of safety in this study Actual 31
NCT03665636 Suspended Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I Early Phase 1 Interventional due to COVID-19 Anticipated 5
NCT03821766 Withdrawn Haemodynamic Abnormalities Recorded With Cardiac Catheterization Along With Body's Surface Micro-accelerometers (KT-KCG) Observational Technical failure Actual 0
NCT03834584 Terminated A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma Phase 1 Interventional Terminated due to sponsor decision. Actual 11
NCT04100681 Terminated Intermittent Negative Pressure; Impact on Peripheral Artery Disease and Intermittent Claudication N/A Interventional The study was terminated early due to slow recruitment and inability to recruit patients during the Covid-19 situation. Actual 16
NCT04222985 Suspended Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2 Phase 1/Phase 2 Interventional (Enrollment suspended for 1 site due to Covid-19; For the other sites, enrollment completed in Part A and planned to be restarted for Part B at the end of 2022) Anticipated 381
NCT04358835 Withdrawn Keto-diet for Intubated Critical Care COVID-19 N/A Interventional Study did not begin enrollment, multiple competing studies at same institution Actual 0
NCT04526236 Suspended Influence of Aging on Perioperative Methadone Dosing Phase 4 Interventional pandemia of covid 19 Anticipated 60
NCT01508598 Terminated Validation of Circulating Endothelial Cells and Microparticles in Youth Observational Not enough subjects enrolled to be able to analyze data. Actual 390
NCT01977027 Terminated Strategies for Recovery of Dexterity Post Stroke N/A Interventional PI left insitution Actual 91
NCT02589314 Terminated Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2 Observational We could not achieve the number of participants necessary to continue with the study and limited money to continue with the study Actual 90
NCT01055067 Terminated ARQ 197 for Participants With Relapsed or Refractory Germ Cell Tumors Phase 2 Interventional The study was terminated early for futility according to the stopping rule of the Simon 2-stage design. Actual 27
NCT02558023 Terminated The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Phase 3 Interventional no candidats Actual 14
NCT02716701 Terminated Exercise in Multiple Sclerosis N/A Interventional lack of funding Anticipated 40
NCT02737930 Terminated Fluoxetine for Visual Recovery After Ischemic Stroke Phase 2 Interventional Slow recruitment and lack of funding to expand to other sites. Actual 17
NCT03330561 Suspended PRS-343 in HER2-Positive Solid Tumors Phase 1 Interventional Partial clinical hold Anticipated 110
NCT03370302 Terminated A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of TAK-228 as Single Agent in Adult East Asian Participants With Advanced Nonhematological Malignancies Phase 1 Interventional More favorable safety profile was observed in QD schedule, therefore further enrollment in QW schedule was terminated. Actual 28
NCT04525170 Withdrawn Clinical Evaluation of HPT Treated Rigid Contact Lenses Made From Hexafocon A N/A Interventional It was decided by the sponsor to not proceed. Actual 0
NCT01864018 Suspended Ixazomib Citrate, Cyclophosphamide, and Dexamethasone in Treating Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis Phase 1/Phase 2 Interventional Actual 71
NCT02373540 Terminated Algovita Post-Market Clinical Study: Spinal Cord Stimulation to Treat Chronic Pain Observational Actual 91
NCT04522466 Terminated Evaluation of the Pharmacokinetics and Pharmacodynamics of Hydroxychloroquine in COVID-19 Intensive Care Unit Patients Phase 3 Interventional Stop of the study by competent authority (ANSM) Actual 7
NCT02266147 Terminated Study of SD-101 in Combination With Localized Low-dose Radiation in Patients With Untreated Low-grade B-cell Lymphoma Phase 1/Phase 2 Interventional The sponsor terminated the trial early because there was sufficient data to make a decision about SD-101 in the lymphoma development program. Actual 29
NCT01951378 Terminated Comparison of Nebulizers in ED in Pediatric Asthma Patients Phase 4 Interventional No data are available for this study as the PI has left the institution. Actual 40
NCT04275011 Suspended Bone Response to Exercise in Women on Antiresorptive Medications N/A Interventional The study has been suspended until further notice due to COVID-19. Anticipated 46
NCT04493697 Withdrawn Using Neuromodulation to Improve Parkinson's Disease N/A Interventional Device provider has requested withdrawal citing modifications needed for study integrity. Actual 0
NCT03538015 Terminated Carvedilol in Treating Hypoglycemia Unawareness Phase 2 Interventional Sponsor was impacted by COVID-19 and did not have sufficient funds to continue. Actual 1
NCT04520620 Withdrawn Concentration-effect Relationship of Enoxaparin for Thromboembolic Prevention Phase 4 Interventional End of the COVID 19 epidemic in the region and decision to participate in a national study on the same subject (COVI-DOSE). Actual 0
NCT00031174 Terminated Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers Observational Due to technical and logistical constraints and a change in the study team's focus of research Actual 151
NCT00756834 Terminated Case Collection Study for Collecting Images for the Development and Validation of Computer Aided Detection Software Observational No longer pursuing FDA submission/approval. Actual 135
NCT01213563 Terminated Management of Type 2 Diabetes After Gastric Bypass Surgery N/A Interventional Data were published that superseded this study. Actual 50
NCT01391520 Withdrawn Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent Phase 3 Interventional Actual 0
NCT02422667 Withdrawn iCORE: Collaborative Orthopedics Outcomes Registry Observational [Patient Registry] Study cancelled - no results Actual 0
NCT02608125 Terminated A Dose Escalation Study in Solid Tumors and a Dose Expansion Study of PRN1371 in Adult Patients With Metastatic Urothelial Carcinoma Phase 1 Interventional focus portfolio on immune-mediated diseases Actual 45
NCT02872467 Suspended Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology Phase 1 Interventional Due to COVID-19 restrictions, recruitment suspended until Spring 2021 Anticipated 32
NCT03233854 Suspended CD19/CD22 Chimeric Antigen Receptor(CAR) T Cells in Adults With Recurrent/Refractory B Cell Malignancies Phase 1 Interventional Logistics Anticipated 57
NCT03396861 Terminated Treatment of Macular Edema After Cataract Surgery With Subconjunctival Aflibercept Phase 1 Interventional Low enrollment Actual 1
NCT03507127 Terminated Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1 Phase 2 Interventional Low rate of enrollment Actual 21
NCT03529162 Terminated A Prospective Study Comparing Suture Anchor and Soft Tissue Pectoralis Major Tendon Techniques for Biceps Tenodesis N/A Interventional COVID-19, followed by PI leaving institution. Actual 4
NCT03831295 Suspended SD-101 and BMS-986178 in Treating Patients With Advanced or Metastatic Solid Malignancies Phase 1 Interventional Business Decision Anticipated 27
NCT03858933 Suspended Train Your Brain: Neurofeedback Intervention for PTSD N/A Interventional COVID-19 Regulations Anticipated 100
NCT03867487 Suspended SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease Phase 2 Interventional COVID-19 Anticipated 40
NCT04004325 Terminated A Study of FT 4101 in Overweight/Obese Participants With NASH Phase 1/Phase 2 Interventional sponsor decision Actual 14
NCT04294082 Withdrawn Study of Mindfulness Course for Parents of Adults With Intellectual Disabilities Observational Study stopped due to the outbreak of the covid-19 pandemic. Actual 0
NCT03120910 Withdrawn Pleth Variability Index (PVI) to Predict Fluid Responsiveness N/A Interventional Actual 0
NCT03172559 Withdrawn Radiotherapy Versus no Intervention in Adult Patients With Hepatocellular Carcinoma Not Eligible for Transarterial Chemoembolization or Ablation Prior to Liver Transplant (RADBRI) N/A Interventional Investigator decided not to pursue the study due to other competing studies. Actual 0
NCT03310034 Terminated NAD Supplementation Study N/A Interventional Concluded study following COVID19 outbreak and inability to complete study as designed. Actual 14
NCT03336580 Terminated A Study of PRX004 in Subjects With Amyloid Transthyretin (ATTR) Amyloidosis Phase 1 Interventional Because of the impact of COVID-19 pandemic Actual 21
NCT03517566 Terminated A Study to Assess the Safety and Efficacy of ZPL389 in Patients With Moderate to Severe Atopic Dermatitis Phase 2 Interventional Lack of efficacy Actual 293
NCT03847922 Terminated Nitrous Oxide for Analgesia During Office Urethral Bulking Phase 4 Interventional Due to staffing changes in the hospital, we will be unable to complete this study for the requested 84 subjects. As such, we have decided to close this study. Actual 2
NCT03949725 Suspended Hans Kai Trial: an Evaluation of a Peer-led Preventative Health Intervention N/A Interventional Covid 19 pandemic, will restart in the future Anticipated 72
NCT04298710 Terminated Effects of Arm Cycling and Leg Cycling on Postprandial Blood Glucose Levels in Healthy Persons N/A Interventional Research lab not accessible due to the pandemic. Actual 4
NCT04350476 Withdrawn COVID-19 Remote Monitoring N/A Interventional closed due to lack of interest and enrollment Actual 0
NCT04353271 Terminated Trial of Hydroxychloroquine In Covid-19 Kinetics Phase 2/Phase 3 Interventional FDA recommendations to not use outside of the hospital setting or in a clinical trial due to the risk of cardiac arrhythmias Actual 58
NCT02297607 Terminated Routine Post-Operative Supplemental Nutrition N/A Interventional Poor accrual. Patients were reluctant to agree if they would need tube feeding for a month. Actual 30
NCT00513552 Withdrawn Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Phase 4 Interventional No patient Actual 0
NCT02938078 Terminated Ocular Comfort and Inflammation in Lid Hygiene Therapy N/A Interventional Actual 14
NCT03539484 Terminated A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors Phase 1 Interventional Study terminated due to change in benefit-risk ratio, driven by high incidence GI toxicity in absence of clinically significant anti-tumor efficacy. Actual 26
NCT01369433 Terminated A Rollover Protocol to Allow Continued Access to Tivozanib (AV 951) for Subjects Enrolled in Other Tivozanib Protocols N/A Interventional Lack of new studies contributing subjects to this study Actual 225
NCT01317771 Withdrawn Analysis of the Fixation of the Proximal Biceps Tendon Observational PI decided to not activate Actual 0
NCT02929589 Suspended Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy Phase 3 Interventional PI deployed. Anticipated 185
NCT03213626 Terminated Cabozantinib and Erlotinib for Patients With EGFR and c-Met Co-expressing Metastatic Pancreatic Adenocarcinoma Phase 2 Interventional There were no objective responses by patient 7. Actual 7
NCT03150303 Terminated Oral Anticoagulant Peri-procedural Management in Patients Undergoing an Oral Surgery, Implantology or Periodontology Observational Lack of budget Actual 532
NCT03509870 Terminated Bone Marrow Derived Allogeneic Mesenchymal Stromal Cells to Non-healing Diabetic Foot Wounds Phase 1 Interventional study stopped because of lack of recruitment Actual 2
NCT03569943 Withdrawn Robot Based Tympanic Tube Placement N/A Interventional Change in medical practice on the management of the eligible population Actual 0
NCT03605745 Terminated Minimally Invasive Prostatic Vapor Ablation for the Treatment of BPH in Large Prostates (Rezūm XL) N/A Interventional Sponsor decided to terminate the study due to business reasons Actual 47
NCT03862170 Suspended Antibiotic Prophylaxis for HDR Brachytherapy in the Treatment of Prostate Cancer Phase 3 Interventional Covid-19 pandemic Anticipated 255
NCT02388165 Terminated Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation Phase 2 Interventional Study terminated by sponsor Actual 3450
NCT04355039 Withdrawn INCB053914 and Pomalidomide With Dexamethasone for Relapsed and/or Refractory Multiple Myeloma Phase 1 Interventional Terminated for lack of funding. Actual 0
NCT04398290 Withdrawn iNOPulse for COVID-19 Phase 2 Interventional IRB AND FDA REVIEWS DEFERRED Actual 0
NCT04425902 Suspended Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults Phase 1 Interventional Due to the COVID-19 pandemic, this study has temporarily suspended recruitment activities. Other elements of the study are ongoing. Anticipated 20
NCT02905981 Terminated Triferic IRIDA Protocol Phase 2 Interventional Limited subjects, patient compliance Actual 1
NCT03686514 Suspended The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics Phase 1 Interventional Recruitment and enrollment currently suspended due to COVID-19 Anticipated 60
NCT04198285 Terminated Post-Operative Voiding After Gynecological Surgery Trial N/A Interventional Due to cancellation of elective surgery (Covid-19) Actual 42
NCT03251495 Suspended Immunologic Responses to a Live Attenuated Oral Cholera Vaccine Phase 2 Interventional Recruitment and enrollment currently suspended due to COVID-19. Anticipated 50
NCT03551418 Terminated Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome N/A Interventional Interruption of COVID 19 pandemic Actual 21
NCT02122744 Withdrawn RCT Versus Placebo of rTMSQP Over Visual Cortex for the Prevention of Chronic Migraine N/A Interventional Actual 0
NCT02478138 Suspended Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging N/A Interventional Anticipated 30
NCT02629029 Suspended Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment N/A Interventional Actual 4
NCT00006472 Terminated Combination Chemotherapy Plus Radiation Therapy Followed By Surgery in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer Phase 2 Interventional Actual 4
NCT02540330 Terminated A Pre-Surgical PK Study of IM and Intraductally Delivered Fulvestrant Phase 2 Interventional Business decision Actual 3
NCT02612194 Terminated LCI-GU-URO-CRI-001: Crizotinib in Patients With c-MET or RON-Positive Metastatic Urothelial Cancer Phase 2 Interventional Study closed to accrual due to low accrual numbers. Anticipated 46
NCT02964325 Terminated Efficacy of Mirasol-treated Apheresis Platelets in Patients With Hypoproliferative Thrombocytopenia N/A Interventional Based interim analysis results, Data Monitoring Committee did not believe the primary efficacy endpoint would be met. No patient safety concerns. Actual 330
NCT03300947 Suspended Psilocybin for Treatment of Obsessive Compulsive Disorder Phase 1 Interventional Study enrollment has been temporarily suspended due to the coronavirus pandemic. Anticipated 15
NCT03386227 Terminated Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT N/A Interventional The study was prematurely stopped due to extremely low recruitment and lack of feasibility to continue. Actual 96
NCT03540160 Terminated Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) Phase 3 Interventional No longer pursuing development of serlopitant Actual 558
NCT03600623 Terminated Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer Early Phase 1 Interventional PI left the institution; no further accruals Actual 25
NCT03617562 Suspended Superior Capsule Reconstruction vs Partial Repair of Massive Rotator Cuff Tears N/A Interventional Due to COVID-19 all research activities including recruitment have been paused. Anticipated 44
NCT03738384 Suspended Knee Connect: Physiotherapy Exercise Performance With Visual Feedback After Total Knee Arthroplasty N/A Interventional Due to COVID-19 all research activities including recruitment have been paused. Anticipated 10
NCT04273191 Withdrawn A Study to Evaluate Multimodal Neuroimaging Parameters in Women With Postpartum Depression Who Are Receiving ZULRESSO™ (Brexanolone) Phase 4 Interventional Sage Therapeutics has decided not to proceed with this study at this time Actual 0
NCT04360759 Withdrawn Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 Phase 3 Interventional Equipoise for hydroxychloquine was lost Actual 0
NCT04409184 Withdrawn Whole Blood Collection From Individuals in the Convalescent Phase of SARS-CoV-2 Infection Observational Study was not opened. Actual 0
NCT02831556 Suspended Point of Care 3D Ultrasound for Various Applications: A Pilot Study Observational Enrollment on hold due to COVID-19 pandemic Anticipated 300
NCT03333148 Withdrawn Preoperative Oral ImmunoNuTrition to Improve Surgical Outcomes for IBD Patients (PINT) Early Phase 1 Interventional never enrolled Actual 0
NCT03488810 Withdrawn Apalutamide With Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer Phase 3 Interventional Extended study timelines and additional budget could no longer be supported. Actual 0
NCT03650348 Suspended PRS-343 in Combination With Atezolizumab in HER2-Positive Solid Tumors Phase 1 Interventional Partial clinical hold Anticipated 45
NCT03840694 Suspended Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior N/A Interventional COVID-19 Anticipated 70
NCT03911206 Suspended A Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma N/A Interventional Due to COVID19 Anticipated 35
NCT04011592 Terminated Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression Phase 2 Interventional Recruitment no feasible Actual 1
NCT04171388 Withdrawn Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia Phase 4 Interventional Trial withdrawn due to COVID-19. Actual 0
NCT03605693 Terminated Early Psychological Intervention to Prevent Cardiovascular Event-Induced PTSD (REACH Sub-study) N/A Interventional Lack of feasibility of engaging patients in written exposure therapy Actual 10
NCT00859495 Terminated Trimodal Lung-Sparing Treatment of Pleural Mesothelioma Phase 2 Interventional Actual 9
NCT00495300 Suspended Collection of Samples and Data for the National Marrow Donor Program Repository Observational Actual 305
NCT01280045 Terminated Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy N/A Interventional No grant was received then we stopped the recruitment Actual 5
NCT01805817 Withdrawn Comparison of Levonorgestrel Intrauterine System, Copper T Intrauterine Device and Oral Contraceptives on Life Quality Phase 4 Interventional Actual 0
NCT02122757 Terminated Anodal Transcranial Direct Current Stimulation of the Visual Cortex Versus Sham Stimulation in the Episodic Migraine N/A Interventional Actual 19
NCT03413891 Terminated Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction Phase 4 Interventional Advice from DSMB Actual 222
NCT03581123 Suspended Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain Phase 3 Interventional Suspended temporarily due to COVID-19 Anticipated 1180
NCT04067544 Terminated Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women N/A Interventional Unforeseen complications due to COVID-19 and funding Actual 3
NCT03598816 Withdrawn PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma Phase 2 Interventional FDA Contingencies unresolved Actual 0
NCT03918642 Suspended Optimizing Psychotherapy for Older Veterans With Chronic Pain N/A Interventional Recruitment was temorarily suspended in order to comply with mandated Covid-19 restrictions to in-person research activities. Anticipated 160
NCT04192110 Withdrawn Diuretics and Volume Overload in Early CKD Phase 4 Interventional The project has ended prior to beginning. Actual 0
NCT02780791 Terminated Maturation of Follicles After Transplantation of Ovarian Tissue Into the Pelvic Wall and the Ovary N/A Interventional Insufficient recruited participants due to a lack of collaborating study centers Actual 1
NCT02875067 Terminated Safety & Efficacy Study of Combination of Pembrolizumab and Lenalidomide, in Patients With Relapsed Non-Hodgkin and Hodgkin Lymphoma Phase 1/Phase 2 Interventional Merck's decision for early termination of the data Actual 6
NCT02959034 Suspended Pediatric Metabolism and Microbiome Repository Observational COVID-19 protocol suspension per Duke Anticipated 350
NCT03212300 Terminated TSA Exercise Prehabilitation in Older Adults N/A Interventional Inadequate data analysis Actual 3
NCT03367078 Terminated tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury Observational Organizational problems, change of research priorities Actual 1
NCT03371862 Withdrawn Liraglutide on Decreasing Parenteral Support in Short Bowel Patients (SLIPS) Phase 2 Interventional No participants recruited. Not able to recruit due to COVID 19. Actual 0
NCT04320290 Withdrawn HCV + to HCV - Kidney Transplant Phase 4 Interventional New Related Protocol to be submitted Actual 0
NCT04353648 Suspended Assessing Muscle Metabolic Phenotype by MSK Ultrasound Observational Suspended due to COVID-19 Anticipated 200
NCT04425733 Withdrawn MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009) Phase 1 Interventional Business reasons Actual 0
NCT04510415 Terminated Olmutinib 600 mg QD in Patients With T790M-positive NSCLC After Treatment With an EGFR-TKI Phase 1 Interventional Study termination by the Sponsor Actual 2
NCT01650298 Terminated Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation N/A Interventional Due to slow enrollment. Actual 64
NCT01738724 Terminated Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Phase 4 Interventional PI went for a post-doc course and when he came back he moved for another job Actual 14
NCT02003911 Terminated Azithromycin for Children Hospitalized With Asthma Phase 4 Interventional Low accrual Actual 159
NCT02257125 Terminated ArmeoSenso - Reward N/A Interventional Stopped due to futility considerations: Sample size calculations have assumed smaller effect sizes than considered relevant now. Actual 38
NCT03104491 Suspended Inotuzumab Ozogamicin Post-Transplant For Acute Lymphocytic Leukemia Phase 1/Phase 2 Interventional Major revisions due Anticipated 44
NCT03178201 Terminated TGR1202 in Relapsed and Refractory Follicular Lymphoma Phase 2 Interventional PI left institution Actual 5
NCT03194581 Suspended Normoxic Challenges Utility to Evaluate Blood Loss Observational Profissional reasons, not related with the study Anticipated 20
NCT03684109 Suspended Non-invasive Glioma Characterization Through Molecular Imaging N/A Interventional Temporarily closed to accrual due to COVID-19 pandemic. Anticipated 30
NCT03954639 Withdrawn Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries Phase 3 Interventional Sponsor Decision. Actual 0
NCT04138875 Withdrawn A Risk Stratified Sequential Treatment With Rituximab, Brentuximab Vedotin and Bendamustine (RBvB) Phase 2 Interventional Lack of funding Actual 0
NCT04210947 Suspended Effect of Myofascial Release on Muscle Mechanical Properties N/A Interventional due to coronavirus pandemic Anticipated 12
NCT04233697 Withdrawn Copanlisib in Combination With Romidepsin in Patients With Relapsed or Refractory Mature T-cell Lymphoma Phase 1 Interventional Investigator left institution Actual 0
NCT04266353 Suspended Effect of Resveratrol on Serum IGF2 Among African American Women N/A Interventional Due to COVID-19 Anticipated 50
NCT04276454 Withdrawn Lymphedema Treatment in Head and Neck Cancer Patients N/A Interventional Per investigator's request. Actual 0
NCT02992418 Terminated Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Phase 3 Interventional No answer received from the Philippines Food and Drug Administration on protocol amendment issued due to IDMC recommendations. CYD vaccine 3rd dose not given. Actual 688
NCT03404310 Terminated Zinc Sulfate for Human Papillomavirus (HPV) N/A Interventional Lack of recruitment Actual 21
NCT02571595 Terminated A Sleep Program to Improve Sleep Quality in People With HIV N/A Interventional Actual 27
NCT04297137 Suspended The Bioavailability of Multiple Novel, Sustainable, Non-animal Derived Protein Sources N/A Interventional COVID-19 Anticipated 12
NCT01866917 Terminated Study of TAP and Laparoscopic and Robotic Gynecologic Procedures and Obese Women Phase 1/Phase 2 Interventional Pharmacy stopped dispensing study medication Actual 35
NCT03752372 Terminated Microbiome Alterations in IL10RA-deficient Patients After HSCT Observational COVID-19 Actual 13
NCT03818516 Suspended Impact of Inflammation on Reward Circuits, Motivational Deficits and Negative Symptoms in Schizophrenia Phase 4 Interventional Recruitment is currently suspended due to COVID-19. Anticipated 20
NCT03866616 Terminated Evaluation Study of the Impact of the New Brain Builders Parenting Class N/A Interventional The PI discontinued the evaluation study. Actual 145
NCT03921229 Suspended Tele-Coaching Intervention to Improve Treatment Adherence in Cystic Fibrosis N/A Interventional COVID pandemic Anticipated 100
NCT04133766 Terminated Community-based Nutrition Program Effectiveness Evaluation in Afghanistan N/A Interventional Funding for the study withdrawn by sponsor after baseline data collected Actual 4076
NCT04143958 Withdrawn To Assess the Glycosphingolipid Clearance and Clinical Effects of Switching to Agalsidase Beta (Fabrazyme) Versus Continuing on Agalsidase Alfa (Replagal) in Male Patients With Classic Fabry Disease Phase 4 Interventional The Sponsor terminated the study due to recruitment infeasibility without having enrolled any patient. Actual 0
NCT04250168 Terminated Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response Observational Ebola epidemic in N-Kivu has ended Actual 43
NCT01656629 Terminated Stem Cell Recruitment in Osteoporosis Therapy N/A Interventional Inability to analyze collected samples due to no funds. Actual 55
NCT00606463 Terminated Gen2 Isthmus-Dependent Atrial Flutter Ablation Study N/A Interventional Abbott funding allocated to a different project. Actual 30
NCT02090959 Terminated An Extension Study of Ataluren (PTC124) in Participants With Nonsense Mutation Dystrophinopathy Phase 3 Interventional Sponsor decision due to commercial availability of ataluren. Actual 219
NCT01927484 Terminated Hand OA AND Methotrexate Use N/A Interventional due to COVID-19 Pandemic Actual 2
NCT02184520 Terminated A Prospective Randomized Postmarket Clinical Study of the TRANSITION Stabilization System N/A Interventional Actual 1
NCT02539953 Withdrawn Ambulatory Blood Pressure Monitoring in Rivaroxaban Therapy N/A Interventional Actual 0
NCT03719300 Terminated Codex: Study of Inodiftagene Vixteplasmid (BC-819) in Unresponsive NMIBC Phase 2 Interventional Lack of efficacy Actual 32
NCT02769871 Terminated NICE: NeuroImaging in Cessation Education N/A Interventional Loss of team members. Actual 20
NCT02845245 Terminated Comminuted Intra-Articular Distal Tibia Fracture Fixation Using Computer Techniques N/A Interventional Enrollment goal was not met. Actual 20
NCT03165214 Withdrawn Embolization of Pelvic Veins in Treatment of Pelvic Congestion Syndrome N/A Interventional No patients recruited Actual 0
NCT00914940 Terminated Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD Phase 2 Interventional Did not reach one of the primary endpoints of decreased total acute GVHD Actual 41
NCT03430466 Terminated Anti PD-L1 Antibody + Anti CTLA-4 Antibody in Combination With Hormone Therapy in Patients With Hormone Receptor Positive HER2-negative Recurrent or Metastatic Breast Cancer Phase 2 Interventional Recruiting was not possible Actual 1
NCT03593902 Terminated Cardiac Safe Transplants for Systemic Sclerosis Phase 2/Phase 3 Interventional PI Sabbatical Actual 9
NCT03431337 Terminated Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate Phase 4 Interventional Futility found by interim analysis Actual 157
NCT04502069 Withdrawn Treatment of COVID-19 With Opaganib in Patients With Pneumonia Requiring Oxygen Phase 1/Phase 2 Interventional To be replaced with a randomized placebo-controlled study. Actual 0
NCT02511691 Terminated PET/MRI Imaging of Glutamate Release in the Brain Phase 2 Interventional Enough data for a publication, decision of Sponsor-PI Actual 10
NCT01805869 Suspended Tooth and Tissue Sample Collection During Wisdom Teeth Removal Observational Actual 720
NCT02893527 Terminated Implementation and Evaluation of a Social Journey Accompanied in Breast Cancer Diagnosis (EPARS SEIN) N/A Interventional An IDMC validated the premature termination of the study on 19/02/2016 for lack of inclusion, with continuation of the FU initially planned for women included Actual 11
NCT01984866 Terminated CPR Prediction After Neoadjuvant Using Excisional Biopsy By Radiofrequency In Breast Cancer From II-III UICC Stages. Observational Recruitment was very low. Actual 13
NCT02728284 Suspended Evaluation of Cardiac Function With Cardio-respiratory Synchronized MRI N/A Interventional COVID-19 Anticipated 100
NCT02728336 Suspended MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT) N/A Interventional COVID-19 Anticipated 110
NCT02741180 Suspended Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias N/A Interventional COVID-19 Anticipated 135
NCT03324828 Terminated Presurgery Anxiolysis in Children Treated With Hydroxyzine Versus Non-pharmacological Intervention (Distractoria Technique Clown) Phase 4 Interventional COVID-19 Actual 170
NCT03809039 Terminated A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-6345 in Healthy Subjects Phase 1 Interventional Preclinical finding Actual 52
NCT04063228 Terminated High Level Mobility Training in Ambulatory Patients With Acquired Non-progressive Central Neurological Injury N/A Interventional Lack of resources Actual 28
NCT04354389 Withdrawn DAS181 for STOP COVID-19 Phase 2/Phase 3 Interventional No COVID-19 in EU countries - Sponsor withdraw in regulatory stage Actual 0
NCT04415073 Suspended A Phase 2 Study to Evaluate Axatilimab for Hospitalized Patients With Respiratory Involvement Secondary to COVID-19 Phase 2 Interventional Given enrollment challenges, partly attributable to the constantly changing COVID-19 treatment landscape, the trial has been suspended. Anticipated 186
NCT04370834 Suspended Tocilizumab for Patients With Cancer and COVID-19 Disease Phase 2 Interventional pending evaluation of data from other trial Anticipated 217
NCT04504591 Terminated Validation Of A New S-ICD Algorithm To Reduce Oversensing Of Dynamic T-Waves In Patients With Brugada Syndrome Observational Early termination due to COVID19; preliminary data can be considered significant Actual 126
NCT01569438 Terminated The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005) Phase 2 Interventional Actual 107
NCT02459054 Terminated Syncardia 50cc TAH-t as a Bridge to Transplant N/A Interventional 50cc TAH-t received FDA approval March 5, 2020. Actual 16
NCT03117530 Suspended Measuring Brain Inflammation in Autism Phase 1 Interventional COVID Anticipated 30
NCT03150797 Terminated Melatonin for Adolescent Migraine Prevention Study Phase 2 Interventional Insufficient Fund Actual 72
NCT03449524 Terminated PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH) Phase 2 Interventional LOE Actual 69
NCT03738293 Withdrawn Continuous Glucose Monitoring of Late Preterm Birth After Corticosteroids Observational Study was not started at site. Actual 0
NCT04074577 Suspended Computer Aided Detection, Tandem Colonoscopy Study N/A Interventional suspended due to COVID-19, will resume Anticipated 196
NCT04076566 Withdrawn Malignant Ascites Alfapump® Study Observational Update to clinical strategy - COVID impact Actual 0
NCT04265898 Withdrawn Validating the Digital Virginia Tech Carilion Cognitive Examination Observational The study did not receive IRB approval and was withdrawn by the PI on April 9, 2020. Actual 0
NCT04336774 Withdrawn CAPTION AI to Minimize Risk of COVID Exposure N/A Interventional Technology was approved by FDA before study enrolled subjects Actual 0
NCT03558672 Terminated A Registry to Evaluate the Flexitouch System and Flexitouch Plus for Treatment of Head and Neck Lymphedema Observational [Patient Registry] Low enrollment numbers Actual 24
NCT04507100 Suspended Comprehensive Analysis of the Program:Salud Escolar N/A Interventional Schools are in lockdown due to COVID-19 pandemic Anticipated 1200
NCT02661087 Withdrawn Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility N/A Interventional Principal investigator departure Actual 0
NCT02859298 Withdrawn Feasibility Study and Predictive Value of the Uterine Cervix Polarimetric Imaging for the Management of the Threat of Premature Delivery. N/A Interventional Lack of human ressources Actual 0
NCT03115593 Withdrawn Compare the Performance of Targeted Biopsy Versus Aspiration Biopsy With a Pipette for the Diagnosis of Endometrial Cancer N/A Interventional Lack of human ressources Actual 0
NCT04039477 Withdrawn A Phase 2 Study to Evaluate the Safety and Efficacy of KZR-616 in Patients With AIHA and ITP Phase 2 Interventional Clinical trial activity slowdown due to COVID-19 pandemic, high screen fail rate, and lack of enrollment led to the decision to withdraw the MARINA study. Actual 0
NCT04236661 Withdrawn Reports on Sleep Quality and Thermoregulation Among Veterans N/A Interventional study team unable to start up study at this time Actual 0
NCT04327401 Terminated COVID-19-associated ARDS Treated With Dexamethasone: Alliance Covid-19 Brasil III Phase 3 Interventional The Data Monitoring Committee recommended to stop the trial based on the Recovery Trial results, which was accepted by the CoDEX Steering Committee. Actual 299
NCT03989752 Suspended Overground Walking Program With Robotic Exoskeleton in Long-term Manual Wheelchair Users With Spinal Cord Injury N/A Interventional COVID-19 - To resume most likely in 2021 Anticipated 20
NCT01876264 Withdrawn Crohn's Extent of Resection Trial N/A Interventional Study abandoned Actual 0
NCT02489448 Suspended Neoadjuvant MEDI4736 Concomitant With Weekly Nab-paclitaxel and Dose-dense AC for Stage I-III Triple Negative Breast Cancer Phase 1/Phase 2 Interventional Suspended due to COVID-19 Anticipated 71
NCT02730884 Terminated Single-Arm Study of the Efficacy and Safety of Oral Rigosertib in Patients With Myelofibrosis (MF) and Anemia Phase 2 Interventional Terminated Per PIs request due to low accrual Actual 3
NCT02910648 Suspended Healthy Behaviors Learning Task and Sleep N/A Interventional COVID-19; unable to continue to enroll due to pandemic Anticipated 110
NCT03259568 Suspended Effects of rTMS on Human Brain Activity Measured With EEG and fMRI N/A Interventional Covid-19 Anticipated 264
NCT03405727 Withdrawn Improvement of Sarcopenia in Patients Following Two Different Diets N/A Interventional Lack of human ressources Actual 0
NCT03449212 Suspended SOD1 Kinetics Measurements in ALS Patients Observational COVID-19 pandemic Anticipated 86
NCT03805360 Terminated The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients Phase 1 Interventional Insufficient enrollment Actual 4
NCT04038502 Suspended BRcA Deficient Prostate Cancer Treated With Carboplatin or Docetaxel Phase 2 Interventional Currently Suspended during modification of study drugs due to change in standard of care. Anticipated 40
NCT03328598 Terminated A Community-based Resilience Program of Only-child Loss Parents N/A Interventional Don't have enough funding to finish the project. Actual 144
NCT03517969 Suspended M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Phase 2 Interventional Scheduled Interim Monitoring Anticipated 130
NCT04123808 Withdrawn IpsiHand System for Rehabilitation of the Arm and Hand After Stroke N/A Interventional Closed by sponsor Actual 0
NCT00575328 Terminated Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in Females Phase 3 Interventional Only N=10 enrolled; funding ran out; too few subjects to yield useful data. Actual 10
NCT02767323 Suspended Using TMS to Increase Executive Function in Older Adults N/A Interventional Covid-19 Anticipated 350
NCT02932176 Suspended Machine Learning for Handheld Vascular Studies Observational COVID-19 Anticipated 100
NCT03053518 Terminated Validation of Machine Learning Based Personalized Nutrition Algorithm to Reduce Postprandial Glycemic Excursions Among North American Individuals With Newly Diagnosed Type 2 Diabetes N/A Interventional Withdrawal of Funding Actual 22
NCT03311828 Suspended Copper 64Cu-DOTA-Daratumumab Positron Emission Tomography in Diagnosing Patients With Relapsed Multiple Myeloma Phase 1 Interventional To determine if met the optimal imaging dose or if need to further escalate Anticipated 21
NCT03710421 Suspended CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma Phase 1 Interventional FDA Clinical Hold Anticipated 30
NCT03797144 Terminated Fenestrated Screw Study N/A Interventional Delay in enrollment as compared to plan (impacted by COVID-19 pandemic) and availability of data from alternative data sources to support the products in scope. Actual 27
NCT04005079 Suspended Pilocarpine After Combined Cataract/Trabectome Surgery Phase 3 Interventional not performing Trabectomes Anticipated 140
NCT04022720 Withdrawn Platelet-Rich Fibrin in Intraoral Soft Tissue Regeneration N/A Interventional No patients enrolled. Also, impacted of COVID on enrolling subjects hindered recruitment. Actual 0
NCT04176406 Suspended Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub) N/A Interventional Covid-19 Anticipated 60
NCT04232306 Suspended Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section Phase 4 Interventional Decision was made to suspend enrollment until further notice. Anticipated 144
NCT00527709 Withdrawn Hold Parameters on Likely Cardiovascular Depressant Medications Observational The study was a retrospective chart review and was mistakenly registered in ClinicalTrials.gov Actual 0
NCT03245970 Withdrawn Impedance Cardiography to Decrease the Risk of Preeclampsia Early Phase 1 Interventional Investigator retired. Other investigators did not want to continue study. Actual 0
NCT03371914 Terminated Costs, Efficiency and the Role of Management in HIV Prevention Interventions for Female Sex Workers in Nigeria N/A Interventional Due to defunding of USAID project that supported the majority of the sites selected in the randomization. Actual 32
NCT03395353 Terminated A Study of Duloxetine (LY248686) in the Treatment of Japanese Children and Adolescents With Depressive Disorder Phase 3 Interventional Business decision Actual 151
NCT03420456 Terminated Transcranial Pulse Near-Infrared Light in Generalized Anxiety Disorder: a Placebo-Controlled Study N/A Interventional Sponsor withdrew funding for reasons unrelated to safety or efficacy Actual 17
NCT03529552 Terminated Evaluation After Reconstruction of the Anterior Cruciate Ligament of the Knee Using the Bioresorbable Interference Screw (SMS): Resorbability, Per- and Post-operative Complications and Articular Functional Recovery. N/A Interventional The Dm production has been stopped Actual 40
NCT03587129 Terminated Clinical Study of Apatinib in the Treatment of Platinum Resistant Recurrent Ovarian Cancer Phase 2 Interventional No patient enter this study. Actual 1
NCT03638336 Withdrawn Evaluation of the Performance of a Robotic Flexible Ureteroscopy (ILY) in Laser Treatment of Nephrolithiasis N/A Interventional No actual DM Actual 0
NCT03650660 Terminated Concordance Between Echocardiographic Assessment Performed in the Initial Phase of Decompensated Cirrhosis With Edema and Ascites by an Expert Intensive Care Physician and a Non-expert Gastroenterologist Observational departure of the principal recruiter in the study Actual 55
NCT03727165 Suspended Nocturnal Cyclic Enteral Nutrition Infusion Versus Continuous Infusion of Enteral Nutrition N/A Interventional Covid pandemia. Is one temporal decision. Anticipated 260
NCT04008550 Terminated Prognostic Impact of the Evolution of PAH 3 Months After TAVI (HTP-TAVI) N/A Interventional - Delay in enrolment (24% at 1 year) - Lower than estimated prevalence of PAH (15% instead of 50%) - Refusal of patients with PAH to participate Actual 101
NCT04295616 Terminated Additional Effect of Intrapulmonary Percussive Ventilation (IPV) on Respiration in People With Multiple Sclerosis (MS). N/A Interventional Due to COVID-19 situation IPV is no longer allowed in the center Actual 5
NCT04408391 Withdrawn Brain MRI Imaging in Patients With SARS-Cov2 (COVID-19) Infection With or Without Anosmia Observational No Inclusion potentiel Actual 0
NCT02756013 Terminated Weight-based Dosing for Dense Weekly Paclitaxel and Carboplatin in Overweight Patients w/ Body Surface Area (BSA) > 2.0 Phase 2 Interventional Lack of accrual - terminated Actual 3
NCT02758899 Terminated Diabetes and Glycosylation in Cervical Spondylosis Observational Actual 21
NCT03642457 Terminated Efficacy Between Serratus Plane Block And Local Infiltration In Vats Phase 4 Interventional PI left institution and unable to find new PI Actual 65
NCT01961804 Terminated PREVACT : Preventive REversal of Vitamine K Antagonist in Minor Craniocerebral Trauma Phase 3 Interventional Actual 202
NCT02952586 Terminated Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100) Phase 3 Interventional Actual 697
NCT04501211 Withdrawn Open Label Transdermal Granisetron to Relieve Chronic Nausea and Emesis Phase 2 Interventional Abandoned due to limited resources Actual 0
NCT03163459 Suspended Short-duration Selective Brain Cooling for Patients Undergoing Mechanical Thrombectomy Phase 2/Phase 3 Interventional Interim analysis Anticipated 120
NCT04287543 Withdrawn Melatonin on Clock Genes in Parkinson's Disease Phase 2/Phase 3 Interventional Due to the COVID-19 pandemic, we were unable to begin the study Actual 0
NCT04321850 Terminated Impact of the Use of Zinc in the Prevention of Oral Mucositis in Pediatric Patients With Lymphoblastic Acute Leukemia. N/A Interventional Health restrictions due to the COVID-19 pandemic Actual 21
NCT04353505 Withdrawn Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache Phase 1 Interventional PI closed the study before any enrollment Actual 0
NCT04424537 Suspended SOAR-2: Intervening in Obesity Through Reduction of Dietary Branched Chain Amino Acids Early Phase 1 Interventional Suspended due to lack of funding Anticipated 132
NCT03073759 Terminated Effect of Transcranial Direct Current Stimulation on Peripheral Neuropathy N/A Interventional Not enough participants Actual 4
NCT00156429 Terminated Genetic Predictors of Outcome in HCM Patients Observational Preliminary analyses did not reveal significant associations. Actual 98
NCT02799836 Withdrawn The Effect of Light Deprivation on Visual Functions in Adult Amblyopes N/A Interventional This study never started, did not receive IRB approval and was closed administratively at the site. Therefore, no subjects were recruited or enrolled. Actual 0
NCT03313076 Terminated Vitamin D and n-3 PUFAs to Prevent Chronic Pain Following Major Thermal Burn Injury Phase 2 Interventional COVID-19 global pandemic, and study funding period ended 7/31/2020. Actual 24
NCT03583931 Suspended Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication N/A Interventional Lack of study personnel Anticipated 36
NCT03839485 Suspended Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic Phase 3 Interventional Follow-ups paused temporarily since March 16th, 2020 due to COVID-19 Actual 98
NCT03949530 Terminated A Study of Safety & Blood Levels of IDL-2965 in Healthy Subjects and Patients With a Special Type of Pulmonary Fibrosis Phase 1 Interventional Due to development challenges associated with the SARS-CoV-2 pandemic and emerging nonclinical data Actual 6
NCT04260360 Withdrawn Trial of NanoDoce Intratumoral Injection in Renal Cell Carcinoma Phase 1 Interventional Not initiated Actual 0
NCT02828098 Terminated Exploratory Study of BO-112 in Adult Patients With Aggressive Solid Tumors Phase 1 Interventional Actual 44
NCT03294200 Terminated Clinical Trial Evaluation of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System N/A Interventional As per sponsor Actual 18
NCT03632967 Terminated Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System N/A Interventional as per sponsor Actual 7
NCT03662009 Suspended Multi-limb Dual-task Control in Parkinson's Disease Observational Temporary Restrictions on in-person contact due to COVID-19 Anticipated 60
NCT00714272 Terminated Granulocytapheresis in Psoriasis N/A Interventional Primary outcome not achieved. Actual 4
NCT02436135 Terminated Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Idelalisib in Adults Receiving Ruxolitinib as Therapy for Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis With Progressive or Relapsed Disease Phase 1 Interventional Actual 10
NCT02151019 Terminated Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer Phase 1/Phase 2 Interventional Actual 94
NCT02424955 Suspended Feasibility 3D Perfusion Ultrasound for Liver Cancer SABR Planning and Response Evaluation N/A Interventional Suspended due to Covid Anticipated 20
NCT02834481 Terminated Assessment of Pain Monitoring With ANI/NIPE Monitor Program in Pediatric Cardiac Surgery Postoperative. N/A Interventional too complicated recruitment Actual 20
NCT03303235 Withdrawn Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections Early Phase 1 Interventional Collaborators left the institution. Actual 0
NCT03381677 Suspended Pedicle Osteotomy for Stenosis Trial N/A Interventional In light of the ongoing COVID-19 pandemic and its impact on clinical trials Anticipated 344
NCT03762681 Terminated A Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection Phase 1 Interventional The study was terminated due to program discontinuation. Actual 55
NCT03784963 Terminated Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD Phase 1/Phase 2 Interventional Low enrollment Actual 35
NCT04264052 Suspended Characterisation of Large Airway Collapse During Exercise (LACE) Observational Due to COVID-19 Royal Brompton Hospital's internal imposed restrictions Anticipated 40
NCT04418934 Withdrawn Clinical Investigation to Evaluate the Hemanext® Red Blood Cell Processing System for Extended Storage of Leukoreduced Red Blood Cells Phase 2 Interventional Grant application for study was rejected Actual 0
NCT03465735 Terminated Vascular Boot Warming Program After Acute Deep Vein Thrombosis (DVT) ± Pulmonary Embolism (PE) N/A Interventional Due to lack of recruitment of eligible participants Actual 15
NCT01387477 Withdrawn Lactate to Treat Hypoglycemia Phase 4 Interventional Actual 0
NCT01794559 Suspended Study to Evaluate the Safety and Efficacy of PEER Interactive Versus Treatment as Usual in Subjects With a Primary Diagnosis of Depression N/A Interventional No site recruitment due to Covid-19 Anticipated 1922
NCT02021721 Terminated Next Generation DNA Sequencing in Patients With Idiopathic Male Infertility Observational Lack of funding Actual 5
NCT02229175 Withdrawn Laser vs Bevacizumab Injection Alone in Treatment of Diabetic Macular Edema Phase 2/Phase 3 Interventional Study not feasible with current resources. Actual 0
NCT02679560 Terminated Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures Phase 2 Interventional Poor recruitment Actual 1
NCT02685111 Terminated Intermittent G-CSF in Patients With Breast Cancer Receiving Adjuvant Docetaxel, Doxorubicin, and Cyclophosphamide (TAC) Phase 2 Interventional Actual 22
NCT02762318 Terminated Identification and Characterization of Bone-related Genetic Variants in Families Observational Lack of funding Actual 5
NCT03059615 Withdrawn A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS Phase 2 Interventional No recruitment since initiation Actual 0
NCT03113617 Suspended 68Ga-RM2 PET/CT in Detecting Regional Nodal and Distant Metastases in Patients With Intermediate or High-Risk Prostate Cancer Phase 2 Interventional Suspended due to Covid Anticipated 90
NCT03854214 Suspended Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury Early Phase 1 Interventional Patient recruitment is temporarily suspended due to COVID-19. Anticipated 48
NCT04220892 Withdrawn Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma Early Phase 1 Interventional One of the study drugs will no longer be supplied by manufacturer and the pembrolizumab + abemaciclib study arm is removed due to toxicity seen in other trials. Actual 0
NCT04316598 Terminated Cannabis Effects on Electroencephalography Phase 1 Interventional Terminated by the sponsor in the context of COVID-19 pandemia Actual 16
NCT04335552 Terminated Pragmatic Factorial Trial of Hydroxychloroquine, Azithromycin, or Both for Treatment of Severe SARS-CoV-2 Infection Phase 2 Interventional Poor recruitment, strong evidence from larger trials of no therapeutic benefit Actual 11
NCT04412252 Withdrawn Safety and Efficacy of Tofacitinib in Hospitalized Participants With COVID-19 Pneumonia Who Are Receiving Standard of Care Therapy Phase 2 Interventional Due to the pursuit of other SARS-CoV-2-related research including alternative trials with tofacitinib, this trial was canceled prior to subject enrollment. Actual 0
NCT00616642 Terminated Rosiglitazone in Treating Patients With Pituitary Tumors Phase 2 Interventional low patient recruitment Actual 1
NCT01548339 Terminated Laparoscopic Cholecystectomy for Acute Cholecystitis After 72 Hours of Symptoms N/A Interventional Intermediary analysis showing increased morbidity in the delayed group Actual 86
NCT02258464 Terminated Study of Radium-223 Dichloride Versus Placebo and Hormonal Treatment as Background Therapy in Subjects With Bone Predominant HER2 (Human Epidermal Growth Factor Receptor 2) Negative Hormone Receptor Positive Metastatic Breast Cancer Phase 2 Interventional Due to lower than expected recruitment since the start of study Actual 99
NCT02665143 Suspended A Randomized Trial of a Combination of Nintedanib/Placebo in Combination With Induction Chemotherapy for Patients With Refractory or First Relapse Acute Myeloid Leukemia Phase 1/Phase 2 Interventional Anticipated 60
NCT00983528 Terminated Alemtuzumab and Clofarabine for Relapsed or Refractory Acute Lymphoblastic Leukemia Phase 1/Phase 2 Interventional Support withdrawn due to slow accrual Actual 6
NCT04493528 Suspended Needle-free Dental Anesthesia N/A Interventional COVID-19 Anticipated 30
NCT00889083 Withdrawn Hepatic Mitochondrial Function in Sepsis Observational no patients to include Actual 0
NCT01199211 Terminated Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism Observational IRB approval expired Actual 187
NCT03907813 Withdrawn Liposomal Bupivacaine After Cesarean Delivery Phase 4 Interventional change in design Actual 0
NCT02394106 Terminated Ofatumumab in Children With Drug Resistant Idiopathic Nephrotic Syndrome Phase 2 Interventional Actual 13
NCT02648971 Terminated Controlled Trial to Compare Single Versus Two Portal Knee Arthroscopy Techniques N/A Interventional Actual 37
NCT04249180 Withdrawn Eye Rubbing and Keratoconus in Montpellier CHU Observational CPP Actual 0
NCT04419493 Suspended A Study in Healthy Men to Compare 2 Different Formulations of Alteplase Phase 1 Interventional The study was put on hold after observation of unexpected laboratory findings. Root cause analysis is ongoing. Anticipated 60
NCT01498445 Terminated An Open-Label, Phase I/II Study of Two Different Schedules of Dasatinib (Sprycel) and Decitabine (Dacogen) Used in Combination for Patients With Accelerated or Blastic Phase Chronic Myelogenous Leukemia (Protocol CA180357) Phase 1/Phase 2 Interventional Terminated per memo from PI/study team Actual 33
NCT01974154 Terminated COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function Observational Lack of funding. Actual 206
NCT02514252 Terminated Sublingual Fentanyl for the Management of Breakthrough Pain Phase 2 Interventional Actual 6
NCT02693717 Terminated Pemetrexed Disodium in Treating Patients With Previously Treated Metastatic Urothelial Cancer Phase 2 Interventional The trial was closed due to the changing efficacy of treatments for metastatic urothelial cancer. Actual 7
NCT02737202 Terminated Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis Phase 2 Interventional Actual 28
NCT02740114 Terminated Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway Phase 3 Interventional Per PIs request Actual 105
NCT02765165 Terminated Phase 1/2 Study of USL311 Alone and in Combination With Lomustine in Subjects With Advanced Solid Tumors and Relapsed/Recurrent Glioblastoma Multiforme (GBM) Phase 1/Phase 2 Interventional Business reasons not related to safety Actual 26
NCT03135470 Terminated Pain Medication After Ambulatory Surgery Observational Phase II recruitment unsuccesful, phase III lacking personnel resources Actual 146
NCT03345953 Terminated Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome Phase 2 Interventional Study facing recruitment difficulties related to stringent eligibility criteria Actual 29
NCT03448874 Withdrawn Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study] N/A Interventional The company will design a new study Actual 0
NCT03505606 Suspended New Visual Acuity and Crowding Tests for Better Detection of Amblyopia N/A Interventional Clinic building closed due to COVID pandemic. Anticipated 48
NCT03736642 Withdrawn Study of the Microbiological Profile of Stool in Patients With Anorexia Nervosa Observational never started Actual 0
NCT03847389 Terminated Clobetasol Topical Oil for Children With Moderate to Severe Atopic Dermatitis Phase 1/Phase 2 Interventional Difficulty in enrollment and COVID-19 pandemic. Actual 8
NCT03886753 Terminated Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products Observational Feasibility Actual 10
NCT04021797 Terminated Autonomic Mechanisms of Sleep-dependent Memory Consolidation N/A Interventional Study stopped due to COVID-19 Actual 12
NCT04267315 Suspended Trigger Point Injections for Post-Mastectomy Pain Syndrome Phase 2 Interventional COVID pandemic Anticipated 120
NCT02926248 Suspended Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement Phase 4 Interventional Continuing IRB review was not submitted. Study was inactivated with the institutional IRB. Anticipated 112
NCT02654704 Terminated Vaccination Responses in Young and Older Adults Observational There was insufficient enrollment of subjects. Actual 61
NCT03511222 Terminated Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors Phase 1 Interventional Low accrual Actual 16
NCT00293215 Terminated Biodistribution Study of CMD-193 in Patients With Advanced Tumours Expressing the Lewis-Y Antigen Phase 1 Interventional Abnormal distribution and lack of tumor targeting were observed. Actual 9
NCT03750773 Withdrawn Gabapentin for Relief of Immediate Postoperative Pain Phase 1/Phase 2 Interventional Lack of funding Actual 0
NCT03809130 Terminated Effectiveness of an Online Intervention Targeting Cancer-related Fatigue N/A Interventional Terminated Per PI Actual 27
NCT03876132 Terminated Perception of the Risks of Alcohol and Individual Vulnerabilities in Young Adults Observational The number of patients is suffisant to answer to the primary outcome Actual 23
NCT03881007 Terminated A Trial to Compare Antibacterial vs. Placebo Mouthwash to Reduce the Incidence of STIs in MSM Taking HIV PrEP N/A Interventional An interim analysis, planned because of the influence of the COVID-lockdown, showed the LCM mouthwash did not affect the incidence of Ng, Ct and syphilis. Actual 343
NCT03947437 Withdrawn Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients Phase 1/Phase 2 Interventional Finances Actual 0
NCT04013373 Suspended Home-Based Fluid Status Monitoring in Heart Failure Patients Observational Covid-19 pandemic Anticipated 200
NCT04038424 Suspended The Effect of Art Therapy on Patients With Stroke N/A Interventional Due to the Pandemic of COVID-19 Anticipated 60
NCT04248959 Suspended Prehabilitation to Improve Cancer Surgery Outcomes in AYA Patients With Extremity Sarcomas N/A Interventional COVID-19 Anticipated 30
NCT04290832 Terminated Developing and Testing Interventions to Address Conscientious Objection to Abortion Care in Mexico and South Africa N/A Interventional The study was stopped prematurely due to the COVID-19 pandemic Actual 317
NCT01715571 Terminated Assessment of Penile Vibratory Stimulation Using the Viberect in Men With Mild-Moderate ED N/A Interventional Unable to obtain adequate recruitment Actual 7
NCT02507232 Terminated Study of NovoTTF-200A Alone and With Temozolomide in Patients With Low-Grade Gliomas Early Phase 1 Interventional low enrollment Actual 2
NCT03013608 Terminated Children's Nail Bed Injuries : Study of the Efficacy of the Simple Relocation of Nail Plate N/A Interventional recruitment difficulty Actual 7
NCT03170583 Terminated SJM Brady MRI Post Approval Study Observational Abbott received FDA approval to transition the ongoing Brady MRI PAS study to EP a new EP-Passion Real World Evidence methodology Actual 1768
NCT03287180 Withdrawn Adolescent Community Reinforcement Approach in Combination With Buprenorphine/Naloxone for Severe Opioid Use N/A Interventional unable to enroll any participants Actual 0
NCT03698370 Suspended Gallium Ga 68 DOTA-NeoBOMB1 and Gallium Ga 68 PSMA-R2 PET/MRI in Diagnosing Participants With Recurrent Prostate Cancer Phase 2 Interventional Due to Covid-19 issues Anticipated 50
NCT03831711 Suspended 68-Ga-RM2 PET/MRI in Imaging Patients With Estrogen Receptor-Positive Breast Cancer Phase 1/Phase 2 Interventional Due to Covid issues Anticipated 20
NCT03949517 Suspended A Pilot Study of 68-Ga PSMA 11 PET/MRI and 68-Ga RM2 PET/MRI for Evaluation of Prostate Cancer Response to HIFU or HDR Therapy Phase 1/Phase 2 Interventional Due to Covid Anticipated 10
NCT04105842 Suspended Refitting Daily Disposable Contact Lens Wearers With Dry Eye Disease With A Different Daily Disposable Lens Type N/A Interventional COVID-19 Anticipated 43
NCT04159935 Suspended Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease Phase 4 Interventional COVID-19 Anticipated 52
NCT04201639 Suspended Evaluating the Performance of Precision1 Daily Disposable Contact Lens in a Group of Heavy Digital Device Users N/A Interventional COVID-19 Anticipated 35
NCT04205162 Suspended Evaluating the Initial Lens Handling Experience of Neophyte Contact Lens Wearers Fitted With Precision1 and 1-Day Acuvue Moist Contact Lenses N/A Interventional COVID-19 Anticipated 60
NCT04209530 Suspended Impact of CCH Treatment of Buttock and Thigh Cellulite in Adult Women Phase 2 Interventional Study temporarily suspended due to COVID-19 related disruptions Anticipated 19
NCT04264208 Suspended HDR Brachytherapy 68-Ga-RM2 PET, 68-Ga-PSMA-11 PET &Multi Parametric MRI in Prostate Cancer Phase 2 Interventional Due to Covid Issues Anticipated 100
NCT04322903 Withdrawn Passport to Freedom: Health and Housing N/A Interventional Due to COVID 19 restrictions and protocol could not to be implemented safely for participants and researchers. Actual 0
NCT04490863 Suspended Noninvasive Hemoglobin Repeatability and Reproducibility in a Blood Donation Setting N/A Interventional Enrollment paused due to Covid-19 pandemic Anticipated 26
NCT02904876 Terminated Evaluation of Early Changes Visible to the Diffusion MRI in Response to Two Years of Treatment With Tysabri in Patients With Multiple Sclerosis Phase 4 Interventional Actual 70
NCT04114019 Withdrawn The Effect of Pelvic Floor Physiotherapy on Vaginal Elasticity Observational The study device became unavailable for use. Actual 0
NCT04140539 Suspended A Clinical Study to Enable Process Validation of Commercial Grade OTL-101 Phase 2/Phase 3 Interventional Recruitment on hold for business reasons Anticipated 3
NCT02269345 Terminated Auricular Acupuncture in Ureteral Stent Pain N/A Interventional Unworkable. This study had several PIs and attempted several avenues of recruitment. Still were only able to recruit 34 out of the 120 needed. Actual 34
NCT02608307 Terminated Medical Treatment Decision Making Using Adaptive Conjoint Analysis Observational Slow accrual and COVID-19 restrictions Actual 14
NCT02678351 Suspended 68Ga-PSMA-11 PET/MRI in Finding Tumors in Patients With Intermediate or High-Risk Prostate Cancer Undergoing Surgery Phase 2/Phase 3 Interventional Due to Covid-19 Anticipated 200
NCT02722512 Terminated Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Phase 1 Interventional Lack of substantial evidence for immune responses in response to vaccination. Actual 10
NCT01341730 Terminated The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Phase 4 Interventional Actual 41
NCT02749526 Terminated Endostar Combined With MPFC Adjuvant Treatment of Esophageal Cancer Clinical Trial Phase 2 Interventional low accrual rate Anticipated 70
NCT02959411 Terminated Tolvaptan for Advanced or Refractory Heart Failure Phase 4 Interventional Low accrual rate Actual 9
NCT03115840 Suspended Measuring Outcomes of Activity in Intensive Care Observational Study enrollment halted due to COVID-19 Anticipated 312
NCT03978390 Withdrawn Improving Children's Cooperation During Dental Injection N/A Interventional Change in research direction Actual 0
NCT04040127 Withdrawn Residual Dental Pulp Tissue and Cord Blood Stem Cells Phase 2 Interventional Did not obtain IRB approval Actual 0
NCT01798043 Terminated Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance N/A Interventional Due to slow enrolment Actual 29
NCT04136847 Withdrawn Study to Evaluate the Efficacy and Tolerability of the SkinPen on Male and Female Subjects' Dorsal Hands as a Treatment for Signs of Hand Aging N/A Interventional Due to COVID 19 the Study did not start enrolling Actual 0
NCT04285749 Withdrawn Prevention of Recurrence and Metastasis in Genetically High-Risk Melanomas Early Phase 1 Interventional PI moving to new institution prior to study activation Actual 0
NCT02727127 Terminated Brain Ion Homeostasis, Lithium and Bipolar Disorder Observational Lost funding due to low enrollment Actual 26
NCT02911467 Terminated Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in Castration-Resistant Prostate Cancer Phase 1 Interventional Low Accrual Actual 8
NCT03198156 Terminated Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy N/A Interventional Funding Stopped Actual 39
NCT03216538 Terminated Safety and Efficacy of AS101 1% Oral Solution in Patients With Neovascular Age-Related Macular Degeneration (AMD) Phase 1/Phase 2 Interventional Sponsor's decision. Actual 20
NCT03651531 Terminated Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus Phase 3 Interventional Trial halted early due to limited ability to recruit participants Actual 1
NCT03822195 Withdrawn Lectine Pathway in Unstable Carotid Plaque Observational PI changed Institution Actual 0
NCT03839940 Suspended Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer Phase 3 Interventional New drug distribution process Anticipated 279
NCT03879044 Terminated Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD) N/A Interventional Funding stopped Actual 16
NCT04034914 Terminated Yoga Intervention in Supporting Children With Cancer and Their Parents During Chemotherapy Infusion N/A Interventional Funding unavailable Actual 10
NCT01982149 Terminated Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer Observational Lack of funding Actual 27
NCT04487548 Suspended Perioperative Smoking Cessation BUndle in Tertiary Care - Can Timing Improve OUTcomes? N/A Interventional COVID19 changed the workflow within the department and the study is no longer feasible Anticipated 214
NCT02188511 Terminated Effects of Electronic Cigarettes on Lung Biology N/A Interventional Lack of funding Actual 13
NCT02247648 Terminated Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy Phase 2 Interventional Actual 100
NCT02531295 Suspended Immunologic Response to Kansui in Treated HIV+ Individuals: a Dose Escalation Study Phase 1 Interventional Temporary pause on non-COVID clinical trial recruitment at study site Anticipated 9
NCT02675218 Terminated Bone MicroArchitecture Abatacept (BMA2) Observational No more inclusion Actual 13
NCT02687477 Terminated PADN to Treat Severe Obstructive Sleep Apnea N/A Interventional Lack of patients meeting the criteria for admission Actual 1
NCT03390413 Withdrawn Robot-assisted Surgical Resection vs. Cryoablation of Localised Renal Cancer Phase 3 Interventional Logistics and lack of funding Actual 0
NCT03393117 Withdrawn Bupivacaine Versus Liposomal Bupivacaine For Breast Pain Management After Breast Recontruction Phase 2 Interventional No accrual Actual 0
NCT01652157 Terminated Long-term Study in US Cystic Fibrosis Patients Receiving Digestive Enzyme Supplements to Assess Narrowing of the Large Intestine Causing Adverse Intestinal Symptoms (Fibrosing Colonopathy) Observational Strategic considerations Actual 17
NCT02075047 Terminated Efficacy and Safety Trial of Flexible Doses of Oral Ziprasidone in Children and Adolescents With Bipolar I Disorder Phase 3 Interventional Based on recent input from FDA, the pre-specified final analysis will be performed at the current enrollment using a re-estimation of the sample size. Anticipated 194
NCT02180152 Withdrawn Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial N/A Interventional Actual 0
NCT02717650 Suspended The Alfred Step Test Exercise Protocol (A-STEP), for Adults With Cystic Fibrosis. N/A Interventional Validation study suspended due to Covid-19 restrictions-will resume when able Anticipated 30
NCT02864355 Terminated Does Perioperative Goal Directed Therapy Using Flotrac Improve Outcomes in Esophagectomy Patients N/A Interventional Minimally invasive surgical methods have ceased enrollment Actual 35
NCT03067480 Terminated Comparison of 3 Versus 6-Month Use of CGMS in Non-Insulin Using T2DM Patients N/A Interventional Low enrollment Actual 12
NCT03128580 Terminated Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles Observational After an interim analysis, it was decided to discontinue the study after a stochastic curtailment analysis. Actual 40
NCT03324516 Withdrawn The Effect of Temporal Muscle Suspension of Temporal Hollowing N/A Interventional Due to limited support staff and time, study was unable to get started Actual 0
NCT03331666 Terminated Impact of LDL-cholesterol Lowering on Platelet Activation Phase 4 Interventional Terminated Prematurely due to COVID-19 Actual 4
NCT03341143 Suspended Fecal Microbiota Transplant (FMT) in Melanoma Patients Phase 2 Interventional Study suspended due to COVID 19. Study recruitment estimated to resume by September, 2020. Anticipated 20
NCT03586778 Suspended Dry Needling for Patients With Back Pain N/A Interventional COVID-19 Anticipated 48
NCT03730896 Terminated Effectiveness of Dry Needling of the Sternocleidomastoid in Patients With Cervicogenic Headaches N/A Interventional Not enough viable subjects Actual 17
NCT03930225 Suspended Effectiveness of A Stigma Directed Interventional Program in Schizophrenia N/A Interventional Covid 19 Break has caused the research to stop temporarily for safety of participants and conductors Anticipated 160
NCT03993379 Terminated PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors Phase 2 Interventional Sponsor's Decision Actual 3
NCT04059653 Terminated Evaluation of a New Technology for the Treatment of Bladder Leakage in Women N/A Interventional COVID19 pandemic. Cannot recruit from primary care during pandemic Actual 86
NCT04199481 Withdrawn Univation XM France Observational Study stopped due to product discontinuation by manufacturer Actual 0
NCT02662634 Withdrawn A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer Phase 2 Interventional Actual 0
NCT03304990 Withdrawn Panomics Relationships in the Epidemiology of Cancer Through In Silico Expression (PRECISE) Observational [Patient Registry] PI has left our Inst. Actual 0
NCT03513458 Withdrawn Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation Phase 1/Phase 2 Interventional [The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic. Actual 0
NCT03513471 Withdrawn Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation Phase 1/Phase 2 Interventional The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic. Actual 0
NCT03652298 Terminated Effects of a Neuroscience-based Technique on Cancer Patients Announced of a Palliative Disease Progression and Partners Phase 2 Interventional Lack of recruitment and of study staff Actual 19
NCT03663790 Suspended Effects of Gait Retraining on Lower Extremity Biomechanics N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 51
NCT03676712 Terminated The Effect of Flexible Thoracolumbar Brace on Idiopathic Scoliosis, Prospective, Randomized, Open-label Trial N/A Interventional Recruitment of subjects was not successful. Actual 17
NCT03687476 Withdrawn Safety and Tolerability Study of VTS-270 in Pediatric Participants With Niemann-Pick Type C (NPC) Disease Phase 2 Interventional Business decision to Cancel Actual 0
NCT03776864 Suspended Umbralisib and Pembrolizumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma Phase 2 Interventional Unacceptable Toxicity Anticipated 20
NCT03864393 Suspended Effect of Multimodal Exercise Training on Walking Economy in Individuals With Parkinson's Disease N/A Interventional Paused due to COVID-19. Expected to resume. Not a suspension of IRB approval. Anticipated 30
NCT03872336 Terminated Acute Labetalol Use in Preeclampsia Phase 4 Interventional Slow enrollment Actual 15
NCT03877692 Terminated Acute Control of Chronic Hypertension Phase 4 Interventional Slow enrollment Actual 10
NCT04023721 Terminated Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic, Hepatitis B e Antigen-negative Subjects Infected With HBV Virus and Receiving or Stopping Treatment With a NUC Inhibitor Phase 2 Interventional Safety Actual 64
NCT04248361 Suspended TEM-PCR™ Prospective Clinical Utility Study Phase 4 Interventional COVID-19 Anticipated 314
NCT03239951 Terminated Study to Assess the Efficacy, Safety and Tolerability of (iTind) N/A Interventional Due to the COVID-19 outbreak and the overall low recruitment Actual 5
NCT03588936 Terminated Nivolumab and Tocilizumab for Relapsed Hematological Malignancy Post-allogeneic Transplant Phase 1 Interventional Halted for convenience due to COVID19 challenges. Actual 2
NCT03955718 Withdrawn Developing and Testing Motherly App: a Smartphone Application to Promote Mothers' Mental Health N/A Interventional The study stopped because of delays in the development of the smartphone app intervention Actual 0
NCT03234387 Suspended A CFit Study - Baseline Observational Poor recruitment Anticipated 45
NCT03237767 Suspended A CFit Study - Acute Exercise N/A Interventional Poor recruitment Anticipated 16
NCT02651116 Terminated Dextromethorphan Pediatric Acute Cough Study Phase 4 Interventional The study was prematurely discontinued due to slow enrollment during the 2019/2020 cold season. No safety or efficacy concerns led to the decision to terminate Actual 131
NCT03545165 Terminated 177Lu−J591 and 177Lu−PSMA−617 Combination for mCRPC Phase 1/Phase 2 Interventional Sponsor withdrawal Actual 6
NCT03586934 Terminated Multimodal Analgesia in Shoulder Arthroplasty Phase 3 Interventional Difficult to enroll patients for the study Actual 18
NCT03607864 Terminated Coral Bone Graft Verses Xenograft With Immediate Implant in Maxillary Anterior Esthetic Zone N/A Interventional because bone osteointegration is completed Actual 18
NCT03978416 Terminated Development of Novel Behavioral Intervention for Sustainable Weight Loss in Hispanic Adults With Obesity N/A Interventional The study was terminated due to the SARS-CoV-2 pandemic. Aim 1 was completed. Actual 23
NCT04277442 Suspended Testing Nivolumab in Combination With Decitabine and Venetoclax in Patients With Newly Diagnosed TP53 Gene Mutated Acute Myeloid Leukemia Phase 1 Interventional Other - Pending amendment to address FDA comments Anticipated 13
NCT04439305 Withdrawn Testing Dasatinib as a Potential Targeted Treatment in Cancers With DDR2 Genetic Changes (MATCH-Subprotocol X) Phase 2 Interventional zero accrual Actual 0
NCT02781961 Terminated Identification of In-vivo Probe Based Confocal Laser Endomicroscopy Cellular Characteristics in Obese Women Observational Actual 10
NCT03632954 Terminated Cytal® Wound Matrix and MicroMatrix® Wound Study Observational Sponsor Decision Actual 39
NCT04475861 Withdrawn Metabolomics and Wound Healing in Diabetes N/A Interventional no participants enrolled Actual 0
NCT00388739 Withdrawn Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department N/A Interventional Different study was designed Actual 0
NCT03008980 Withdrawn The Analysis of WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) Increased Yield of Barrett's Esophagus and Esophageal Dysplasia Observational Study halted prematurely, prior to enrollment of first participant. Actual 0
NCT03214809 Terminated The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams N/A Interventional Slow inclusion rate (partly due to Covid-19) Actual 100
NCT03214835 Withdrawn CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions N/A Interventional Study halted prematurely, prior to enrollment of first participant. Actual 0
NCT03399097 Withdrawn Characterizing the Intestinal Hormonal Secretion in Non-obese, Obese and Non-obese Patients After Bariatric Surgery Observational change sites Actual 0
NCT03414112 Suspended The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa Early Phase 1 Interventional Recruitment is suspended due to COVID-19. Anticipated 40
NCT04043520 Suspended Bioenergetic Effects of Aging and Menopause (BEAM) Phase 4 Interventional COVID-19 Closure Anticipated 95
NCT04231188 Terminated User Experience of a Mobile Application Observational Delay in recruitment due to corona virus pandemic resulted in a newer version of mobile app made available and testing on the old version will be redundant. Actual 6
NCT04298814 Withdrawn Safety Related Factors of Endotracheal Intubation in Patients With Severe Covid-19 Pneumonia Observational It was repeated with other studies in the same department Actual 0
NCT04477642 Withdrawn Abatacept for Patients With COVID-19 and Respiratory Distress Phase 1/Phase 2 Interventional Funding Actual 0
NCT02798939 Terminated Evaluation of Lactoferrin, Procalcitonin and Aution® Urine Dipsticks for the Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Observational investigator choice Actual 123
NCT02819544 Withdrawn Evaluation of the Interest of the Instillation of Saline Intraperitoneally (INSI ) Versus Instillation of Naropin the Surgical Site Versus Lung Recruitment Maneuvers ( PVM ) in the Management of Pain After Laparoscopic Cholecystectomy in Ambulatory Care Phase 3 Interventional investigator choice Actual 0
NCT02828800 Terminated Cartography of Allodynic and Hypoasthetic Territories Following TKA Observational investigator choice Actual 38
NCT03132818 Withdrawn Impact of the Assumption in Charge of Medical Aid to the Procreation With Donation of Gametes on the Sexuality of the Couple Observational investigator choice Actual 0
NCT03145870 Withdrawn Prevalence of Asymptomatic Thrombosis in Multiple Myeloma N/A Interventional investigator choice Actual 0
NCT03149952 Withdrawn A Pilot Study of the Feasibility of Setting up a Logbook for Allogeneic Haematopoietic Stem Cell Patients at the University Hospital of Amiens N/A Interventional investigator choice Actual 0
NCT02845336 Terminated Celecoxib for Thyroid Eye Disease Phase 2 Interventional Poor enrollment Actual 7
NCT03295656 Withdrawn Contrast-Enhanced Ultrasound Diagnosis of Acute Appendicitis Phase 1 Interventional Unanticipated delays. Actual 0
NCT03342638 Terminated Maximizing Outcome of Multiple Sclerosis Transplantation Phase 3 Interventional PI Sabbatical Actual 66
NCT03167151 Terminated Pembrolizumab in Intermediate Risk Recurrent Non-muscle Invasive Bladder Cancer (NMIBC) Phase 1/Phase 2 Interventional The study failed to recruit within the permitted timeframe Actual 6
NCT03537521 Withdrawn Reversal Agent Use in Patients Treated With Direct Oral Anticoagulants or Vitamin K Antagonists (RADOA). Focus on New Antidots Observational [Patient Registry] due to corona pandemic crisis Actual 0
NCT03696901 Terminated Xydalba Utilization Registry in Germany Observational Terminated Actual 16
NCT03797430 Withdrawn Determination of Normal Values for the Star Excursion Balance Test (SEBT) in Handball Players Observational NO PARTICIPANTS ENROLLED Actual 0
NCT03983486 Withdrawn Rationale for Cytogenetic Risk Stratification by Imaging Flow Cytometry in Multiple Myeloma Observational technical problem Actual 0
NCT04192513 Suspended Observer-Blinded Dose Escalating, Single Dose to Study Safety and Antimicrobial Efficacy of Gel vs. Placebo Phase 2 Interventional Covid-19 has shut the clinic indefinitely Anticipated 12
NCT04315051 Suspended A Trial of Safety/Efficacy of Test Article in Patients With Interdigital T. Pedis Phase 2 Interventional Covid- 19 has shut the clinic Anticipated 80
NCT04345614 Suspended A Study of Auxora in Patients With Severe COVID-19 Pneumonia Phase 2 Interventional FDA strongly recommended transitioning to blinded, placebo-controlled RCT. Anticipated 400
NCT02032784 Terminated Prophylactic Octreotide to Prevent Post Duodenal EMR and Ampullectomy Bleeding Phase 4 Interventional Difficult to enroll subjects Actual 33
NCT03809650 Terminated A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Phase 3 Interventional Due to a change in the development strategy Actual 9
NCT03910790 Withdrawn Liver Biopsy Using a 19 Gauge Fine Needle Biopsy Needle N/A Interventional A competing study made it challenging to enroll subjects. Actual 0
NCT02333409 Terminated Acupuncture for Pain Control in Patients With Inoperable Pancreatic Cancer N/A Interventional Expertise resigned Actual 1
NCT03303690 Terminated AS: Ankle Spacer for Talar Osteochondral Defects N/A Interventional Arthrex stopped manufacturing the device Actual 2
NCT03676725 Suspended Assessing the Frequency of Lidocaine Ineffectiveness in the General Population Early Phase 1 Interventional Pandemic (Covid-19) Anticipated 100
NCT04167189 Suspended Assessing the Frequency of Lidocaine Ineffectiveness in ADHD Early Phase 1 Interventional Pandemic (Covid 19) Anticipated 40
NCT04411134 Withdrawn E7 TCR T Cell Immunotherapy for High-Grade Cervical Intraepithelial Neoplasia Phase 1 Interventional Closed based on the lack of perceived clinical activity observed from a different study treating a similar patient population with same study agent. Actual 0
NCT00992030 Terminated R-ABVD vs ABVD-RT in Early Stage Hodgkin's Lymphoma Phase 3 Interventional Low recruitment and difficulty in having study data Actual 112
NCT01113567 Suspended Effect of Lactose in Patients With Chronic Liver Disease and Minimal Hepatic Encephalopathy N/A Interventional The hospital was converte to attend only COVID19 patiens Actual 18
NCT01518959 Terminated The Effect of 25-OH-Vitamin-D3 Substitution in Patients With Malignant and Immune-hematologic Diseases Phase 3 Interventional Insufficient recruitment rate; technical issues with sample storage Actual 31
NCT02439307 Suspended Effycacy of Rifaximin on Reverse Minimal Hepatic Encephalopathy and Elimation Small Intestinal Bacterial N/A Interventional The hospital was converted to attend only covid19 patients Anticipated 46
NCT02547948 Withdrawn CD19-targeting CAR T Cells for B Cell Lymphoma Phase 1/Phase 2 Interventional Actual 0
NCT02547961 Withdrawn Chimeric Antigen Receptor-Modified T Cells for Breast Cancer Phase 1/Phase 2 Interventional Project terminated due to revision of local regulations Actual 0
NCT02565901 Terminated Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Phase 1/Phase 2 Interventional Terminated due to insufficient funding Actual 28
NCT02575261 Withdrawn CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients Phase 1/Phase 2 Interventional Actual 0
NCT02712905 Terminated An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies Phase 1/Phase 2 Interventional Strategic Business Decision Actual 116
NCT02723942 Withdrawn CAR-T Cell Immunotherapy for HCC Targeting GPC3 Phase 1/Phase 2 Interventional Project terminated due to revision of local regulations Actual 0
NCT02732015 Terminated Rolapitant Hydrochloride in Preventing Nausea/Vomiting in Patients With Sarcoma Receiving Chemotherapy Phase 2 Interventional Terminated per PI's request Actual 37
NCT03252171 Withdrawn CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients Phase 1/Phase 2 Interventional Project terminated due to revision of local regulations Actual 0
NCT03259659 Terminated Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Observational [Patient Registry] Principal Investigator was leaving the institution. Actual 20
NCT03439150 Terminated Resistance STEMI Study N/A Interventional slow enrolment Actual 5
NCT03445663 Terminated Study Evaluating AMG 424 in Subjects With Multiple Myeloma Phase 1 Interventional Sponsor business decision not to proceed with the AMG 424 asset. Actual 27
NCT03514407 Terminated A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma Phase 1 Interventional Strategic Business Decision Actual 25
NCT03621124 Suspended Maladaptive Adipose Tissue Activity in Cancer N/A Interventional Pause due to COVID-19 Pandemic Anticipated 36
NCT03669549 Terminated Nevanimibe HCl for the Treatment of Classic CAH Phase 2 Interventional Following an interim data review, further investment in nevanimibe has been discontinued Actual 15
NCT03755960 Suspended ACUpuncture in Diabetic Peripheral Neuropathy N/A Interventional due to the pandemic clin.research was suspended from 04/2020 on- tbc in 09/2020 Anticipated 110
NCT03862846 Terminated A Study of the Safety of REN001 in Patients With Primary Mitochondrial Myopathy Phase 1 Interventional COVID-19 Pandemic sufficient data gathered to achieve the study objective Actual 23
NCT04088032 Withdrawn Neoadjuvant Study of Abemaciclib, Durvalumab, and an Aromatase Inhibitor Early Stage Breast Cancer Early Phase 1 Interventional Per sponsor Actual 0
NCT04135768 Withdrawn A Study Examining The Effect Of Wrist Joint Haematoma Washout As An Adjunct Procedure To Plating Of The Distal Radius In Fractures Of The Distal Radius Involving The Wrist Joint N/A Interventional COVID19 pandemic: national lockdown imposed and study centre diverted all trauma cases to surrounding hospitals Actual 0
NCT04176978 Suspended PsA T2T Statin Trial on Carotid and Coronary Atherosclerosis N/A Interventional Lack of funding Anticipated 142
NCT04476693 Suspended Metabolic Responses to Breakfast in Adolescent Girls N/A Interventional Unable to recruit due to school closures in response to Covid-19 Anticipated 18
NCT02894086 Withdrawn A Retrospective Study of the Feasibility of Ambulatory Appendicectomy for Acute Appendicitis (Based on Data From the PMSI French National Hospital Information System) in the Adults Hospitalized Between December 2013 and December 2014 Observational Investigator choice Actual 0
NCT02973009 Withdrawn Impact of the Systematic Closure of the Epigastric Trocar on Postoperative Incisional Hernia After Sleeve Gastrectomy Rate of First Intention. Monocentric Study, Before / After Prospective. Observational investigator choice Actual 0
NCT03004482 Suspended Analysis of Video Imaging in Newborns Observational lack of Funding Anticipated 80
NCT03027934 Withdrawn A Single Center Study to Evaluate Ticagrelor Mechanism of Action in Inhibiting Juvenile Platelet ADP Response Phase 4 Interventional Study population difficult to recruit Actual 0
NCT03079661 Terminated Impact of Air Quality on Exacerbations of COPD in the Somme Observational investigator choice Actual 179
NCT03107390 Terminated Evaluation of NT-proBNP in Chronic Inflammatory Bowel Disease N/A Interventional investigator choice Actual 159
NCT03115138 Terminated Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas. N/A Interventional investigator choice Actual 19
NCT03139825 Withdrawn Connectivity and Social Cognition in Adolescent Girls With Borderline Personality Disorder, a Pilot Study N/A Interventional Not accepted Actual 0
NCT03144661 Terminated An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies Phase 1 Interventional Strategic Business Decision Actual 25
NCT03311074 Withdrawn Retroviral Insertion Site Methodology Study Phase 4 Interventional Replaced with new observational study design Actual 0
NCT03407976 Terminated Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies Phase 1 Interventional Funding source withdrew financial support prior to start of Phase II portion of study Actual 5
NCT03602872 Withdrawn Safety of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells in Subjects With Osteoarthritis Phase 1 Interventional Sponsor to start with different protocol, postponed due to COVID Actual 0
NCT03647085 Suspended Data Collection Atrial Fibrillation Exploratory Study Observational Due to COVID-19 Anticipated 50
NCT03698227 Terminated OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma Patients Phase 2 Interventional Lack of efficacy on olaratumab Actual 2
NCT03721393 Suspended Data Collection - Of Syncope Tilt Table Testing Study Observational Due to COVID-19, part of the budget used to fund the COST3 trial has been eliminated. The study will start again in the near future. Anticipated 50
NCT03847675 Suspended Reach Out and Read Arabic to Promote Arabic Literacy in Toddlers N/A Interventional Awaiting IRB approval of amendment Anticipated 206
NCT04049682 Withdrawn Start Times and Restful Sleep Observational Study never recruited subjects Actual 0
NCT04101890 Suspended The Healthy Baby Bottoms Study Phase 4 Interventional Pandemic preventing recruitment due to regulations limiting personnel in clinical spaces. Anticipated 100
NCT04150666 Withdrawn The Water Intake Trail and Primary Aldosteronism Postoperation(WIT-PAP) N/A Interventional No subjects are willing to participating. Actual 0
NCT04272645 Withdrawn Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate Cancer Phase 2 Interventional Coordinating site change Actual 0
NCT04293172 Withdrawn Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease. Phase 3 Interventional Study halted prematurely, prior to enrolment of first patient. Actual 0
NCT04331834 Suspended Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic Phase 3 Interventional The study has been suspended until a new epidemic curve occurs. Anticipated 440
NCT04474652 Suspended Guide for Prioritisation of Patients for Referral to Breast Clinics Observational COVID-19 Anticipated 4000
NCT04474795 Suspended Clinic to Community Connections N/A Interventional due to COVID-19 Anticipated 115
NCT02193152 Terminated Pazopanib in Molecularly Selected Patients With Advanced NSCLC Phase 2 Interventional Terminated by sponsor Actual 16
NCT03090126 Withdrawn Assessment of Therapeutic Education About Non Invasive Ventilation in Patients With Chronic Respiratory Failure (QoVNI) Observational No possibility to recruit. Actual 0
NCT03285165 Suspended Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU Patients Phase 2/Phase 3 Interventional NO AVAILABLE FUND Anticipated 60
NCT02050607 Withdrawn Fecal Microbiota Transplantation for the Treatment of Metabolic Syndrome Phase 2 Interventional Actual 0
NCT02078934 Withdrawn Endoscopic Gastric Plication for Weight Loss in Morbidly Obese Patients Prior to Incisional Hernia Repair N/A Interventional Did not receive funding for recruitment. Actual 0
NCT02418039 Suspended High Protein Diet Versus Normal Protein Diet in Treating Patients With Minimal Hepatic Encephalopathy N/A Interventional The hospital was convert to attend only COVID19 Anticipated 80
NCT02752230 Withdrawn Comparison of Exparel to Marcaine in Post-Surgical Analgesia in Bariatrics Phase 4 Interventional Attending physician left network Actual 0
NCT02814344 Terminated Comparative Study of the Propagation of Uterine Electrical Activity (EHG) in Pregnant Women During Pregnancy and During Labour Observational Investigator choice Actual 27
NCT02815501 Withdrawn Thyroid Dysfunction and Obstetric Complications Observational Investigator choice Actual 0
NCT02848508 Withdrawn Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Phase 2 Interventional Investigator choice Actual 0
NCT02281994 Terminated Odontoid Fracture Study Treated With Pulsed Electromagnetic Fields N/A Interventional Anticipated 360
NCT02436590 Terminated Efficacy and Safety of an Active Pulsed Electromagnetic Field for the Treatment of Osteoarthritis of the Knee N/A Interventional Anticipated 150
NCT02453490 Terminated Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis Phase 3 Interventional difficultly recruiting Anticipated 360
NCT03253679 Suspended AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification Phase 2 Interventional Other - Protocol amendment required for expansion Anticipated 32
NCT04272034 Withdrawn Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors Phase 1 Interventional Business Decision Actual 0
NCT03686176 Terminated Virtual Reality During Procedures in Pediatric Patients N/A Interventional Coronavirus (COVID-19)-related pause on all clinical research studies. Actual 64
NCT04471857 Terminated Hypnosis for Children Undergoing Anorectal Manometry N/A Interventional Due to COVID-19 recruitement stopped since intended sample size was an estimation and not based on power calculation Actual 34
NCT04472520 Withdrawn Use of AliveCor ECG Monitoring to Replicate ECG Lead Recording N/A Interventional lack of enrollment Actual 0
NCT02903407 Terminated Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU Phase 4 Interventional All enrolled participants completed the study protocol but the study was terminated prior to the goal number of participants due to low recruitment Actual 7
NCT04265014 Withdrawn Comparison of Goal-directed and Liberal Fluid Management N/A Interventional we didn't have any patient Actual 0
NCT04468373 Terminated Study of WA-NG (NG-IMT) Telescope Prosthesis in Patients With End-stage Age-related Macular Degeneration N/A Interventional Development of next-generation device Actual 9
NCT04468854 Terminated Influence of Luteolin on Memory in Healthy Subjects N/A Interventional Corona-Virus Lockdown (16th March in Switzerland) Actual 40
NCT00003086 Terminated Repeated Bone Marrow Transplantation in Treating Women With Advanced Breast Cancer Phase 1/Phase 2 Interventional no participants enrolled in a three year period Anticipated 12
NCT02527681 Terminated Pharmacokinetics and Safety of Ceftobiprole in Neonates and Infants up to 3 Months Treated With Systemic Antibiotics Phase 1 Interventional on 07Jul2020 due to slow enrollment; there were no safety concerns. Actual 15
NCT03225924 Terminated Study of Entospletinib (ENTO) in Newly Diagnosed DLBCL Patients With aaIPI>=1 Treated by Chemiotherapy Phase 1/Phase 2 Interventional Stop of drug development Actual 25
NCT03380091 Terminated Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial Phase 4 Interventional Recruitment challenges Actual 3
NCT03518320 Terminated Safety and Tolerability of TAR-200 and Nivolumab in Subjects With Muscle-Invasive Bladder Cancer Phase 1 Interventional Business objectives have changed Actual 13
NCT03661983 Terminated Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Subjects With Tourette's Disorder Phase 4 Interventional Lack of feasibility for completion of the trial within a reasonable time frame. Actual 36
NCT03672474 Terminated REGEnLIFE RGn530 - Feasibility Pilot N/A Interventional Covid19 sanitary crisis Actual 60
NCT03781089 Suspended Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients Phase 4 Interventional Covid-19 Anticipated 40
NCT04032483 Suspended A Survey of Financial Toxicity in Rural Cancer Patients Observational Study recruitment temporarily halted due to COVID-19. Anticipated 100
NCT04055012 Suspended Effects of Metformin on Low Back Pain Phase 2 Interventional FDA Recall of Metformin Anticipated 400
NCT04127695 Withdrawn A Study to Evaluate the Safety and Tolerability of ABBV-0805 in Patients With Parkinson's Disease Phase 1 Interventional Strategic considerations Actual 0
NCT04223011 Withdrawn Initiating Substance Use Disorder Treatment for Hospitalized Alcohol Use Disorder Patients N/A Interventional Due to COVID-19, recruitment was halted before we were able to enroll participants. Currently we are unable to resume recruitment due to study staff changes. Actual 0
NCT04392648 Withdrawn A Study to Evaluate the Safety, Tolerability and Efficacy of Intravenous TAK-573 as Part of Combination Therapy in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Phase 1 Interventional Business Decision (no enrollment) Actual 0
NCT02741505 Withdrawn Brain Sleep Deprivation MRI Effects (BEDTIME) N/A Interventional Funding was not obtained Actual 0
NCT02851056 Suspended Survivin Vaccine : Multiple Myeloma Autologous Hematopoietic Cell Transplant (HCT) Early Phase 1 Interventional Temporary lack of funding Anticipated 20
NCT03231527 Withdrawn Outcomes of Total Arterial Coronary Artery Bypass Grafting Observational research group's decision Actual 0
NCT03330834 Terminated CAR-T Cell Immunotherapy for Advanced Lung Cancer Phase 1 Interventional Serious adverse events Actual 1
NCT03461861 Suspended Network-Level Mechanisms for Preclinical Alzheimer's Disease Development Phase 2 Interventional COVID-19 Anticipated 50
NCT03797612 Withdrawn Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Knee Replacement in Patients With High PCS Scores Phase 2 Interventional Study initiation delayed due to COVID 19 Actual 0
NCT03878563 Terminated Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC) Observational Sponsor-PI left Switzerland Actual 26
NCT04104919 Withdrawn Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Mastectomy in Patients With High PCS Scores Phase 2 Interventional Study Initiation delayed due to COVID 19 Actual 0
NCT04138199 Terminated A Study to Assess Effectiveness and Safety of Fixed Dose Combination of Lopinavir/Ritonavir (LPV/r) in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Patients After Switching From Kaletra in the Routine Clinical Settings of Russian Federation Observational Strategic Considerations Actual 239
NCT04235621 Suspended A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN) Observational Sponsor decision for administrative reasons Anticipated 160
NCT04379947 Withdrawn Preoperative Use of Fractional Flow Reserve in CABG Use and Effectiveness of FFR-based CABG in Real-life Practice Observational research group's decision Actual 0
NCT00820716 Terminated Exercise Training in Asthma N/A Interventional Difficulties in recruiting patient Actual 2
NCT02050646 Suspended The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis N/A Interventional Study PI changed institutions Actual 20
NCT02056054 Suspended De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Observational Study PI has moved institutions Anticipated 180
NCT03361085 Terminated Modular Prevention Bundle for Non-ventilator-associated Hospital-acquired Pneumonia (nvHAP) N/A Interventional COVID-Epidemic with changes in patient mix, restructuring of wards/departments, new standard-precautions Actual 45000
NCT03653533 Terminated Evaluation of the Function "Stop Before Hypoglycemia" on External Insulin Pump N/A Interventional Difficulties for recruitment Actual 8
NCT01705080 Terminated IntErnational Long-term Follow-up Study of Patients With Uncontrolled HyperTensioN Observational Abbott made a decision to not further develop the RDN program. Actual 354
NCT03819933 Suspended Optimizing Family Counseling for Anticipated Extremely Preterm Delivery N/A Interventional Study has temporarily suspended enrollment due to the Covid-19 pandemic. Anticipated 460
NCT01988090 Terminated High Dose Vitamin D vs Standard Dose Vitamin D Study Phase 2 Interventional An interim analysis demonstrated no benefit of high dose vitamin D when compared to standard dose vitamin D in the reduction or prevention of arthralgia Actual 93
NCT02412371 Terminated A Study Evaluating the Efficacy and Tolerability of Veliparib in Combination With Paclitaxel/Carboplatin-Based Chemoradiotherapy Followed by Veliparib and Paclitaxel/Carboplatin Consolidation in Adults With Stage III Non-Small Cell Lung Cancer (NSCLC) Phase 1/Phase 2 Interventional Phase 2 was not conducted due to a change in the standard of care for newly diagnosed, unresectable Stage III NSCLC Actual 48
NCT04467632 Withdrawn Circadian & Homeostatic Synchronization Effect on Waking Mobility in Parkinson's Disease N/A Interventional The principal investigator left the hospital Actual 0
NCT02899156 Terminated Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Exposure Phase 4 Interventional A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis. Actual 22
NCT01757899 Withdrawn Effects and Safety of Infusion of Low-Doses of Methylprednisolone in Early ALI and ARDS in Children Phase 2 Interventional Technical problems Actual 0
NCT02174770 Terminated Blood Flow Restriction Training in Rehabilitation Patients N/A Interventional Lack of resources Actual 10
NCT02227134 Withdrawn Ultrasound to Predict a Pediatric Difficult Airway and Obstructive Sleep Apnea Syndrome in Children N/A Interventional Unable to perform the ultrasound. Actual 0
NCT02323477 Terminated Human Umbilical Cord Stroma MSC in Myocardial Infarction Phase 1/Phase 2 Interventional Due to budget limitations as allocated for a given period. Actual 46
NCT02610608 Terminated Medical Assistance for the Procreation and Risk of Thrombosis. Observational RECRUITMENT DIFFICULTIES Actual 129
NCT02717507 Suspended Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors Phase 2 Interventional Evaluation of currently enrolled patients Anticipated 250
NCT02840513 Terminated Smartphone App and CO Self-monitoring for Smoking Cessation Phase 4 Interventional Due to insufficient patient recruitment and lack of funding Actual 81
NCT02887118 Terminated Dense Red Blood Cells in Sickle Cell Children Observational The recruiting centre was no longer presenting new patients for inclusion Actual 82
NCT02901431 Terminated A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD) Phase 2 Interventional The 24-week analysis indicated no clinical or statistical benefit for the primary endpoint for the overall study population. No new safety concerns identified. Anticipated 340
NCT03002506 Terminated Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Burns Phase 4 Interventional Much slower recruitment than anticipated Actual 6
NCT03003728 Withdrawn 2015-10: Expanded Natural Killer Cells and Elotuzumab for High-Risk Myeloma Post- Autologous Stem Cell Transplant (ASCT) Phase 2 Interventional Withdrawal of study support Actual 0
NCT03321864 Suspended Capture of Prostatic Trans-rectal Ultrasound Scans for Research N/A Interventional PI has left Trust currently. Anticipated 150
NCT03430544 Suspended Cariprazine Effects on Brain and Behavior in Cocaine Use Disorder Phase 2 Interventional Suspended: Study halted prematurely but potentially will resume Anticipated 60
NCT03432572 Withdrawn Investigating Oral Agents for Urine Staining to Facilitate Intraoperative Observation of Ureteral Jets Early Phase 1 Interventional enrollment proved difficult Actual 0
NCT03573076 Terminated Treatment of Photodamaged Skin of the décolleté Phase 4 Interventional The second study arm including radio-frequency microneedling was withdrawn due to availability of newer treatment options. Actual 12
NCT03757351 Terminated Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis Phase 1 Interventional Due to change in Sanofi's development strategy for DNL747/SAR443060 - not due to any safety concerns Actual 15
NCT03881995 Terminated Effects of Insulin Glargine and Lixisenatide on the Brain Phase 4 Interventional insufficient recruitment Actual 1
NCT03904706 Terminated Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan N/A Interventional We were unable to continue field activities due to COVID-19 Actual 1871
NCT04085549 Suspended Effects of a Berry Oil Cream on Atopic Eczema and Skin N/A Interventional Study was suspended due to Covid-19 situation. Anticipated 90
NCT04090853 Terminated Subject Evaluation of a 1064nm Diode Laser/RF N/A Interventional Slow enrolment and Covid19 Actual 13
NCT04185155 Terminated Simple Cognitive Task After Trauma EKUT RCT N/A Interventional Halted prematurely - Covid-19 pandemic prevented recruitment/testing in ED Actual 16
NCT03444311 Terminated Combined Nutritional Therapies for the Treatment of Ulcerative Colitis N/A Interventional Low tolerability of fibers included in the product Actual 12
NCT04462341 Suspended Efficacy of an Oral Hygiene Implant Protocol N/A Interventional COVID-19 Anticipated 28
NCT01335113 Terminated A Scan Ultrasonography in the Evaluation of Retinopathy of Prematurity Observational Unable to get accurate measurements with existing technology Actual 1
NCT01551043 Terminated Allo CART-19 Protocol Phase 1 Interventional Administrative Reasons Actual 2
NCT01711307 Terminated Operative vs. Non-Operative Treatment of Acute Ruptures of the Achilles Tendon N/A Interventional Anticipated 220
NCT01823237 Suspended Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19 Anticipated 15
NCT02544503 Suspended Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 150
NCT02565199 Suspended Premotor Cortex: A New Target for Stroke Motor Rehabilitation N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 50
NCT03460964 Terminated Measuring Sweat Glucose of Patients With Diabetes - The ENGAGE Study N/A Interventional Could not perform accurate measures due to equipment and sensor issues. Actual 2
NCT03504917 Terminated A Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension Phase 3 Interventional A futility analysis assessed that the study is highly unlikely to meet the pre-defined primary objective of the study. No new safety concerns were identified. Actual 322
NCT03609502 Suspended Perceptual Learning and Memory Consolidation in Adults With and Without LI N/A Interventional research facilities temporarily closed due to COVID-19 Anticipated 100
NCT03628053 Withdrawn Tisagenlecleucel vs Blinatumomab or Inotuzumab for Patients With Relapsed/Refractory B-cell Precursor Acute Lymphoblastic Leukemia Phase 3 Interventional Novartis is no longer pursuing this study because of planned investigation of novel CAR-T therapies in this patient population. Actual 0
NCT03685773 Suspended The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients Phase 2 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 60
NCT03714867 Withdrawn Pre-Operative Pregabalin for Post-Operative Pain in Head and Neck Cancer Surgery Phase 4 Interventional Inability to recruit patients Actual 0
NCT03869814 Withdrawn Non-invasive Liquid Biopsy Analysis of Epigenomics Signatures in Multiple Cancer Types Observational Developing new protocol Actual 0
NCT01445821 Terminated Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial Phase 3 Interventional Developed a better regimen: DIAD. Cast. 2018 NCT03593902 Actual 44
NCT03948464 Suspended Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder Phase 3 Interventional Temporarily suspended due to COVID-19 precautions Anticipated 198
NCT04060329 Terminated Measuring and Improving Coproduction Using coopeRATE N/A Interventional Reasons associated with COVID-19 pandemic led to cancellation of Phase 2 Actual 280
NCT04468048 Withdrawn Music Utilization in Sedation and Induction in Colonoscopy Observational No participants Actual 0
NCT04090242 Terminated Impact of App Based Diabetes Training Program in Conjunction With the BD Nano Pen Needle in People With T2 Diabetes N/A Interventional Enrollment halted prematurely due to the Covid-19 pandemic Actual 57
NCT04465071 Suspended Lubricating Eye Drops After Routine Cataract Surgery N/A Interventional No active recruitment at present due to COVID-19 pandemic Anticipated 168
NCT03209869 Suspended Treatment of Relapsed or Refractory Neuroblastoma With Expanded Haploidentical NK Cells and Hu14.18-IL2 Phase 1 Interventional resources limited due to COVID-19 Anticipated 6
NCT03265717 Terminated DNA Plasmid Encoding a Modified Human Telomerase Reverse Transcriptase (hTERT), Invac-1 in Chronic Lymphocytic Leukemia Phase 2 Interventional sponsor decision Actual 26
NCT03281902 Suspended Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy Observational Budget Anticipated 250
NCT03586414 Suspended MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women N/A Interventional COVID-19 Anticipated 60
NCT03708380 Suspended Diabetes Prevention for Black Men N/A Interventional COVID-19 Anticipated 20
NCT03775915 Terminated Neurofeedback for Stroke Rehabilitation N/A Interventional COVID-19 lockdown and halt of clinical trials Actual 26
NCT04106505 Terminated Efficacy of a Novel App-based Migraine Treatment Platform - a Pilot Study N/A Interventional Recruitment terminated prematurely due to SARS-CoV-2 pandemic Actual 23
NCT02655861 Terminated A Multi-center, Prospective Evaluation of Infants and Children With Congenital Ichthyosis Observational Actual 21
NCT02695641 Withdrawn Reduction of Plasma Free VEGF-A Using Low-dose Bevacizumab in Hemodialysis Patients Early Phase 1 Interventional Unable to enroll patients for the trial. Actual 0
NCT02825446 Terminated Angioplasty of the Tibial Arteries Augmented Radio Frequency Denervation of the Popliteal Artery N/A Interventional a significant number of patients were not selected Actual 15
NCT02959502 Suspended Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression N/A Interventional temporarily suspended due to COVID-19 Anticipated 40
NCT04265235 Terminated EXerCise Intervention in cholesTatic LivEr Disease: The EXCITED Study N/A Interventional COVID pandemic. Recruited 31 out of target 40 patients. Actual 31
NCT04302350 Suspended Application of Nitrous Oxide in Inflation-deflation Process During Thoracoscopic Segmentectomy N/A Interventional because of the COVID-19 pandemic. Anticipated 100
NCT02994914 Terminated GEriatric Determinants of Curative RAdiotherapy Scheme Choice for Breast Cancer ELderly Patient Treatment Compliance and Tolerance N/A Interventional Low rythm of inclusions Actual 241
NCT02999152 Terminated Validation of Radio-induced Damage Biomarkers N/A Interventional Low rythm of inclusions, financial support terminated Actual 16
NCT03643679 Terminated Tobacco Cessation for Sexual Minorities N/A Interventional Covid-19 quarantines and closures prevented recruitment and assessment of participants. Actual 32
NCT03743961 Terminated Geriatric Intervention Contribution on Quality of Life of Elderly Patients With Metastatic Neoplasia Observational Low rythm of inclusions Actual 28
NCT04083469 Terminated Identifying Student Opinion Leaders to Lead E-cigarette Interventions N/A Interventional Covid-19 resulted in school closures. Actual 686
NCT04187378 Suspended Effect of Active Warming on Surgical Site Infections N/A Interventional Due to the COVID-19 pandemic, elective surgeries were temporarily delayed in our country. It's targeted to take cases again as of August 2020. Anticipated 48
NCT04236453 Terminated A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat When Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Co-administration of the Separate Agents Phase 1 Interventional COVID-19 pandemic impacted the BE assessment of the trial. The clinical team decided to terminate the trial in order to start a new pivotal BE trial Actual 16
NCT04322227 Terminated Study Investigating Effects of Foliglurax in Patients With Parkinson's Disease (PD) and Healthy Subjects Phase 1 Interventional Study termination due to efficacy results of another study Actual 6
NCT03588741 Terminated Evaluation of Safety Following Immune Tolerance Induction Treatment With Turoctocog Alfa in Patients With Haemophilia A Following Inhibitor Development in NN7170-4213 Trial Phase 3 Interventional The trial was terminated as the participant withdrew from the trial. Actual 1
NCT02700191 Terminated Cardiovascular Diagnosis Using µ-Cor - an Interventional Pilot Trial N/A Interventional Lack of interest Actual 8
NCT03390335 Suspended Decompression Tables for Diving at Altitude N/A Interventional COVID-19 research suspension Anticipated 72
NCT03628976 Suspended Noninvasive VNS for Neuromotor Adaptations N/A Interventional COVID-19 pandemic Anticipated 24
NCT03921359 Terminated SMARTfit Training for Parkinson's Disease N/A Interventional In compliance with research restrictions imposed due to the COVID-19 pandemic. Actual 9
NCT03931928 Suspended Genotype and Phenotype Guided Supplementation of TAMoxifen Standard Therapy With ENDOXifen in Breast Cancer Patients Phase 2 Interventional COVID-19 pandemic Anticipated 750
NCT03953209 Withdrawn Spironolactone for the Treatment of Melasma Phase 1 Interventional Conflict with funding Actual 0
NCT04174326 Suspended CBT Program for Pain Management for Children and Youth With CP (CBT=Cognitive Behavioral Therapy; CP= Cerebral Palsy) N/A Interventional COVID-19 restrictions Anticipated 16
NCT04207138 Withdrawn To Study the Association Among Labor Pain and Physical Parameters in Laboring Pregnant Women Observational change sponsor Actual 0
NCT04271839 Withdrawn Efficiency Control of Fluticasone/Formoterol K-haler (Medium Strength) vs ICS/LABA (High Strength) in Asthma Patients Phase 4 Interventional The trial has been terminated early due to the SARS-CoV-2 pandemic. Actual 0
NCT02530008 Suspended Breast Cancer 2-PREVENT Translational Center of Excellence (TCE) - Metastatic Markers of Recurrent Tumor Phenotype for Breast Cancer Observational Study is suspended due to Abramson Cancer Center suspension of Observational research studies due to the COVID-19 Pandemic. Anticipated 600
NCT03161158 Terminated PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure N/A Interventional Low recruitment Actual 48
NCT03492710 Withdrawn Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Phase 3 Interventional A change in sponsor's developmental strategy Actual 0
NCT03778528 Terminated Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome Observational researcher left the institution study will not continue Actual 1
NCT03890380 Terminated Safety and Performance Evaluation of the Magneto Wire N/A Interventional Sponsor's decision Actual 4
NCT03925155 Withdrawn RCT Investigating Pre-cesarean Vaginal Wash of Chlorhexidine vs Povidone-iodine for Patient With Ruptured Amniotic Membrane. Phase 3 Interventional The study was withdrawn from the IRB Actual 0
NCT04073160 Withdrawn TRIO Bladder: A Study of Durvalumab Plus Tremelimumab Followed by Concurrent Durvalumab Plus Bladder Radiation in Muscle-Invasive Bladder Cancer Phase 1 Interventional Study will not be completed. No participants were enrolled. Actual 0
NCT04455919 Terminated Yoga for Chronic Chikungunya N/A Interventional covid health crisis Actual 42
NCT02670083 Terminated A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD). Phase 3 Interventional This study was discontinued due to an interim analysis in this study, which indicated that Crenezumab was unlikely to meet its primary endpoint. Actual 813
NCT03114657 Terminated A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD) Phase 3 Interventional This study was discontinued due to an interim analysis in the BN29552 study, which indicated that Crenezumab was unlikely to meet its primary endpoint. Actual 806
NCT00915681 Terminated Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning Phase 2 Interventional Sponsor decision Actual 104
NCT02196051 Withdrawn Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver. N/A Interventional Study halted permanently participants are not being enrolled Actual 0
NCT02652702 Terminated Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of Colorectal Cancer Patients Phase 2 Interventional Not enough patients recruited Anticipated 60
NCT02742844 Terminated Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Phase 1/Phase 2 Interventional COVID-19 pandemic and patient recruitment issues Actual 13
NCT03169114 Terminated Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation N/A Interventional Poor recruitment and terminated during COVID-19 pandemic Actual 81
NCT04361461 Withdrawn Use of Hydroxychloroquine Alone or Associated for Inpatients With SARS-CoV2 Virus (COVID-19) Phase 3 Interventional This study was canceled before enrollment due to a decision by the Sponsor Actual 0
NCT02600429 Terminated Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Phase 3 Interventional Business decision Actual 18
NCT03017105 Terminated Cross-education for Proximal Humerus Fracture Rehabilitation Phase 1/Phase 2 Interventional Logistical difficulties leading to an extremely slow recruitment rate Anticipated 40
NCT03023813 Suspended Individualizing Disease Prevention for Middle-Aged Adults N/A Interventional Enrollment is temporarily paused due to COVID-19; interactions/interventions with current participants continue. This is not a suspension of IRB approval. Anticipated 130
NCT03076710 Withdrawn Post-Operative Pain Management Following Spine Surgery Observational No participants were identified per inclusion/exclusion criteria Actual 0
NCT04457427 Withdrawn Randomized Study to Investigate the Safety and Performance of Diaphragm Stimulation Coupled With Mechanical Ventilation N/A Interventional Study not started Actual 0
NCT03376399 Withdrawn Potential Benefits of Sleeve Gastrectomy Surgery on Diabetic Gastroparesis Symptoms Observational No participants enrolled. Study terminated at PI's discretion Actual 0
NCT03598907 Terminated Point-of-care Management of Coagulopathy in Lung Transplantation Observational After interim statistical analysis, a statistician reccommended to stop study, because results are significant and in favour of POC approach. Actual 67
NCT03684187 Suspended Mindfulness - Based Intervention in the Treatment of Fatigue in Patients With Primary Biliary Cholangitis N/A Interventional Covid - 19, will resume when able. Anticipated 20
NCT03707457 Terminated Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma Phase 1 Interventional Funding/material support withdrawn Actual 3
NCT03890198 Terminated A Phase 1 Study of LCAR-C182A Cells in the Treatment of Advanced Gastric Cancer and Pancreatic Ductal Adenocarcinoma Early Phase 1 Interventional the Preliminary data, progress of this study and the adjustment of the pipeline and strategy . Actual 2
NCT03902275 Terminated Validation of a Quantra Supported Hemotherapy Algorithm in Cardiac Surgery N/A Interventional SARS-CoV-2 Pandemic Actual 20
NCT04051996 Suspended GLAD-AML - Glasdegib (Pf-04449913) With Two Standard Decitabine Regimens for Older Patients With Poor-risk Acute Myeloid Leukemia Phase 2 Interventional Temporary Recruitment Hold due to COVID-19 Anticipated 46
NCT04125030 Suspended Convergent and Concurrent Validity Between Clinical Recovery and Personal-civic Recovery in Mental Health Observational [Patient Registry] COVID-19 pandemic Anticipated 200
NCT04132700 Withdrawn Longitudinal Evaluation of Energy Expenditure in ICU Patients From Admission to Discharge Using A Novel Indirect Calorimeter: LEEP-Forward Trial N/A Interventional LEEP-COVID study (NCT04350073) initiation enables inclusion of COVID-positive subjects Actual 0
NCT04395118 Withdrawn STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention for Elevated LFTs N/A Interventional Study will not be conducted as a RCT due to limited project timeline. Actual 0
NCT02624700 Terminated 2nd Line Treatment With Pemetrexed and Sorafenib for Recurrent or Metastatic Triple Negative Breast Cancer Phase 2 Interventional Actual 13
NCT03923348 Terminated Pelvic Floor Muscle Training With Leva System for Urge Incontinence N/A Interventional Slow Recruitment and Re-prioritizing of Sponsor-funding Actual 5
NCT03339921 Terminated Botulinum for Chronic Exertional Compartment Syndrome Phase 2/Phase 3 Interventional This study is being closed because it is unworkable. Actual 3
NCT01089374 Suspended Phyllodes Tumor Partial Breast Radiation Study N/A Interventional continuing review Anticipated 50
NCT02387125 Terminated Phase 1b Safety Study of CMB305 in Patients With Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1 Phase 1 Interventional This study did not meet the efficacy objective Actual 79
NCT02485990 Terminated Study of Tremelimumab Alone or Combined With Olaparib for Patients With Persistent EOC (Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma) Phase 1/Phase 2 Interventional Withdrawal of sponsor support Actual 24
NCT02826967 Terminated Feasibility and Effectiveness of Colonic Irrigation N/A Interventional COVID-19 institutional restrictions on screening colonoscopies Actual 36
NCT02847130 Suspended Identifying, Understanding, and Overcoming Barriers to the Use of Clinical Practice Guidelines in Pediatric Oncology Observational Reviewing enrolled patients Anticipated 694
NCT03471559 Terminated Cannabidiol - an in Vivo Innovative Drug Delivery Study Phase 1 Interventional Two step study, step two was not feasible based on results from phase one. Actual 8
NCT04078438 Terminated Neurofeedback In Treatment Resistant Depression N/A Interventional Because of researcher foreign training Actual 70
NCT04146012 Suspended BEACH Trial: Bovine Early Access, Compatibility and Hemostasis Trial Phase 3 Interventional Company was sold and clinical trial was suspended Anticipated 75
NCT03791008 Suspended Assessment of Feasibility and Acceptability of Personalized Breast Cancer Screening N/A Interventional Recrutiment was suspended on March 12, 2020 due to the coronavirus pandemic Anticipated 385
NCT04323631 Withdrawn Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death Early Phase 1 Interventional Trial not started due to accumulating evidence against HCQ for COVID Actual 0
NCT04164082 Suspended Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer Phase 2 Interventional Other - Planned safety stopping Anticipated 163
NCT03846492 Suspended Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS N/A Interventional Suspended due to COVID-19 Anticipated 90
NCT00003060 Terminated Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Metastatic Melanoma Phase 1 Interventional lack of patient accrual Anticipated 6
NCT03396484 Withdrawn Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 Diabetes Phase 2 Interventional Study not begun due to continued laboratory work on the feasibility of outcome measures. Actual 0
NCT03944707 Terminated Study of Efficacy and Safety of LOU064 in Inadequately Controlled Asthma Patients Phase 2 Interventional Company decision Actual 76
NCT04020549 Withdrawn Single-Session Computerized Mental Health Intervention for Rural Indian Adolescents N/A Interventional In collaboration with community partners, we determined that the reading level required for the intervention did not make it suitable for the adolescents. Actual 0
NCT04160091 Terminated Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis Phase 2 Interventional The study was terminated prematurely due to the COVID-19 pandemic creating uncertainty impacting trial progress and costs. Actual 19
NCT04290637 Suspended The Galway Sea Swimmers Study N/A Interventional Unable to recruit during COVID-19 crisis Anticipated 150
NCT04330300 Suspended Coronavirus (COVID-19) ACEi/ARB Investigation Phase 4 Interventional Challenges with funding and very low incidence of COVID-19 at Irish study site Anticipated 2414
NCT02609984 Terminated Study to Compare the Safety and Efficacy of CMB305 With Atezolizumab to Atezolizumab Alone in Participants With Sarcoma (IMDZ-C232/V943A-002) Phase 2 Interventional This study did not meet the efficacy objective Actual 89
NCT01510691 Withdrawn Vitrectomy Retinal Oxygenation Observational Difficulties in recruiting participants Actual 0
NCT02477124 Suspended A See and Treat Paradigm for Cervical Pre-cancer N/A Interventional COVID-19 Anticipated 200
NCT02673021 Terminated MARK 1A Series: Percutaneous Microwave Ablation for Patients With Lung Tumor(s) N/A Interventional Funding suspended prior to completing enrollment of all participants. Actual 6
NCT03323645 Terminated Prosthetics Registry and Outcomes in Urology at Duke Observational change of study structure and resource allocation Actual 190
NCT03339973 Terminated Allogeneic ABCB5-positive Stem Cells for Treatment of PAOD Phase 1/Phase 2 Interventional Very slow recruitment of patients and the current COVID-19 pandemic situation. Actual 24
NCT03457818 Terminated Therapy of the Skeletal Disease of Type 2 Diabetes With Denosumab Phase 2 Interventional Due to enrollment difficulties compounded by the COVID pandemic. Actual 8
NCT04409483 Withdrawn Evaluation of Additional Treatments for COVID-19: a Randomized Trial in Niger Phase 3 Interventional Epidemic dynamics Actual 0
NCT02753595 Terminated Study of Eribulin Mesylate in Combination With PEGylated Recombinant Human Hyaluronidase (PEGPH20) Versus Eribulin Mesylate Alone in Subjects With Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, High-Hyaluronan (HA) Metastatic Breast Cancer (MBC) Phase 1/Phase 2 Interventional evolving standard of care and difficulties of enrolling participants Actual 25
NCT03491150 Terminated An Open-Label Crenezumab Study in Participants With Alzheimer's Disease Phase 3 Interventional This study was discontinued due to an interim analysis in the BN29552 study, which indicated that Crenezumab was unlikely to meet its primary endpoint. Actual 149
NCT04451382 Terminated PTNS vs Botox of Refractory OAB Observational Low recruitment Actual 150
NCT03143985 Suspended Vactosertib in Combination w/ Pomalidomide in Relapsed or Relapsed and Refractory Multiple Myeloma Phase 1 Interventional Major revisions due Anticipated 18
NCT02985554 Terminated Phase I Study to Assess the Tolerability and Efficacy of Nivolumab in Patients With Hematologic Malignancies Phase 1 Interventional Study stopped early due to slow accrual and safety concerns. Actual 3
NCT01301482 Terminated Ear Acupuncture for Acute Sore Throat in Patients Unable to Take Non-steroidal Anti-inflammatory Agents (NSAIDs) N/A Interventional Study is no longer necessary (outmoded, outdated, science has changed) Actual 2
NCT03020264 Terminated Frequency of Hypoglycemia in Patients With Type 2 Diabetes Under Insulin Therapy Older Than 75 Years in Real Life N/A Interventional COVID-19 Actual 161
NCT03475043 Suspended Neuroplasticity in Auditory Aging_Project 2 N/A Interventional coronavirus pandemic, no human subjects research at UMD Anticipated 405
NCT03868436 Suspended PENTHROX™ in the Canadian Emergency Department (ED) Phase 4 Interventional Recruitment is complete however study suspended due to COVID 19 Actual 99
NCT03910322 Terminated The Effect of a Probiotic Strain on Aspirin-induced GI Damage N/A Interventional Decision made by Sponsor Actual 30
NCT04231682 Withdrawn A Study to Evaluate Efficacy and Safety of Denosumab for Prevention and Treatment of Osteoporosis in 1st Time Liver Transplant Recipients. Phase 2 Interventional Grant support was withdrawn from Amgen Pharmaceuticals Actual 0
NCT04259190 Withdrawn A Comparison of Treatment Rationales on Willingness to Tolerate Distress in Interoceptive Exposure N/A Interventional Halted due to COVID-19. Actual 0
NCT04329403 Withdrawn Clinical Endpoint Bioequivalence Study of Adapalene Gel 0.1% Phase 3 Interventional Market reasons Actual 0
NCT03051698 Terminated C1-inhibitor in Allergic ASThma Patients Phase 4 Interventional Interim analysis showed no differences between groups Actual 37
NCT00839787 Withdrawn The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision N/A Interventional Unable to enroll more patients Actual 0
NCT01785069 Terminated Safety and Effectiveness of NATRELLE® 410 Highly Cohesive, Anatomically Shaped, Silicone-filled X-Style and L-Style Breast Implants N/A Interventional There was no indication that long-term follow-up would differ between any of the studies that have evaluated devices within the 410 Style Matrix. Actual 355
NCT03255213 Suspended Lingual Muscle Training in Late-Onset Pompe Disease (LOPD) N/A Interventional Due to COVID19 restrictions Anticipated 5
NCT03488147 Suspended Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery Phase 2 Interventional Change in Investigational Drug Service policies resulting in the need to change the operational design of the overall protocol. Anticipated 500
NCT03567291 Terminated Evaluation of Safety and Tolerability of Long-term TEV-50717 (Deutetrabenazine) for Treatment of Tourette Syndrome in Children and Adolescents Phase 3 Interventional The parent trials did not meet the primary endpoints of reduction in motor and phonic tics. Actual 228
NCT03836885 Withdrawn Apremilast - Oral Lichen Planus Trial Phase 2 Interventional Study was terminated due to delay in enrollment. Actual 0
NCT03890861 Suspended Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)" N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 200
NCT04020926 Terminated Impact of Hyponatremia on Muscle Strength, Gait and Cognitive Function Observational Study was stopped due to COVID-19 pandemic. Actual 8
NCT04162145 Terminated BRIDGE Device for Treatment of Opioid Withdrawal N/A Interventional Due to COVID-19 pandemic Actual 12
NCT04177459 Terminated Rehabilitation of Adolescents Living With Chronic Fatigue N/A Interventional Covid-19 Actual 3
NCT04285008 Withdrawn Randomized Controlled Study Comparing Colon Evaluation With The Pure-Vu System To A Standard Colonoscopy In Patients Who Are High Risk For Inadequate Bowel Preparation N/A Interventional Sponsor has terminated study due to COVID-19 related concerns Actual 0
NCT04354441 Withdrawn Effect of Hydroxychloroquine in COVID-19 Positive Pregnant Women Phase 2 Interventional Not started Actual 0
NCT03128931 Terminated SedLine Engineering Data Collection Study in Pediatric Patients Undergoing General Anesthesia or Sedation N/A Interventional Study was terminated as enrollment rate did not meet the requirement of the Sponsor. Actual 45
NCT03728673 Suspended A Study Utilizing Escitalopram in Glioma Patients Phase 2 Interventional COVID-19 safety precautions Anticipated 20
NCT04449445 Suspended Perioperative Nutritional Optimization in Head and Neck Cancer Patients N/A Interventional COVID-19 Anticipated 300
NCT02351869 Terminated Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder Phase 2 Interventional This study was terminated due to COVID-19 pandemic-related halting of recruitment in the context of an upcoming replacement of the study MRI scanner. Actual 25
NCT02362191 Terminated Targeting Inter-Hemispheric Alpha Coherence With tACS To Treat PMDD N/A Interventional The study was terminated because the dense treatment schedule precluded successful recruitment of study participants. Actual 13
NCT03082612 Suspended Overcoming Psychological Distress Through Hymns N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Actual 12
NCT03135262 Terminated A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL) Phase 1/Phase 2 Interventional Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2. Actual 29
NCT03375606 Terminated Assessing the Safety and Tolerability of CSL730 in Healthy Caucasian and Japanese Adults Phase 1 Interventional The Sponsor decided to terminate this study in favor of development of subcutaneous administration. Actual 26
NCT03540043 Terminated Thykamine Safety and Efficacy Study in Mild-to-Moderate Atopic Dermatitis Phase 2 Interventional Reached required analyzable sample size; COVID-19 recruitment challenges Actual 162
NCT04202718 Withdrawn VitalConnect VitalPatch ECG Interpretation/Arrhythmia Detection N/A Interventional Study never started due to COVID-19 pandemic Actual 0
NCT01832727 Terminated Phase 1b/2, Multicenter, Open-label Study of Oprozomib and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma Phase 1/Phase 2 Interventional Enrollment halted during phase 2 to reformulate the investigational product Actual 65
NCT02996448 Terminated Safety, Tolerability, and Immunogenicity of One Dose of NDV 3A Vaccine in People With STAT3-Mutated Hyper-IgE Syndrome Phase 2 Interventional Safety concerns led to early termination. Actual 3
NCT03982537 Withdrawn Effect of N-Acetyl Cysteine (NAC) on the Oral Microbiome Phase 2 Interventional Concept is withdrawn and a different concept will be submitted the near future. Actual 0
NCT04190069 Withdrawn Effects of Behavioral Interventions on Weight Loss and Weight Maintenance N/A Interventional IRB recommended change to registry study or quality improvement project status Actual 0
NCT00263562 Terminated Steroid Treatment for Sickle Cell Pain Crisis Phase 3 Interventional poor enrollment, availability of more effective medications Actual 18
NCT02395627 Terminated Reversing Therapy Resistance With Epigenetic-Immune Modification Phase 2 Interventional Insufficient efficacy in an unselected patient population Actual 38
NCT02352155 Terminated Second-look Endoscopy in High Risk Patients After Endoscopic Hemostasis to Their Bleeding Peptic Ulcers Improves Their Outcomes N/A Interventional Actual 157
NCT02899481 Terminated Role of Intrapartum Ultrasound in Instrumental Delivery N/A Interventional Data Safety Monitoring Committee recommended stopping the trial due to futility. Actual 222
NCT02953119 Terminated Prehabilitation for Elective Major Abdominal Surgery N/A Interventional Difficulty recruiting patients Actual 20
NCT03064152 Terminated Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery N/A Interventional slow enrollment, outcome measures collected but actual enrollment is below target enrollment Actual 49
NCT03736421 Suspended Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients Observational Enrollment and other trial activities have temporarily paused due to COVID-19 and are expected to resume in the future; This is not a suspension of IRB approval Anticipated 280
NCT04140591 Terminated Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis Phase 2/Phase 3 Interventional 1. Most patients with liver cirrhosis already use PPI and NSBB 2. 90 % Peptic ulcer size is smaller than 5cm Actual 10
NCT04251182 Suspended Clinical Study Evaluating Efficacy and Safety of T3D-959 in Mild-to-moderate AD Subjects Phase 2 Interventional COVID-19 Panemic Anticipated 256
NCT03136900 Terminated Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of With Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation,After Surgery for Congenital Heart Disease, in Infants. N/A Interventional Recuitment to slow Actual 41
NCT02708849 Terminated The Sustained Effects of Ketamine Phase 1 Interventional Actual 3
NCT01803984 Terminated MIBRAIN - Migraine and the Brain: Consequences, Causes, and Vascular Interaction Observational Actual 166
NCT02501473 Terminated Study of Intratumoral G100 With Or Without Pembrolizumab or Rituximab In Patients With Follicular Non-Hodgkin's Lymphoma (MK-3475-174/IMDZ-G142) Phase 1/Phase 2 Interventional Business reasons Actual 52
NCT02702518 Terminated rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host Disease Phase 1/Phase 2 Interventional The DSMB committee recommended closing the trial because of the COVID-19 risk in this "at-risk" oGVHD population if they came for study visits. Actual 58
NCT03532009 Terminated Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure Phase 2 Interventional Study stopped early due to the COVID-19 pandemic Actual 182
NCT03732196 Terminated Food Frequency Questionnaire for Chinese Pregnant Women Observational Unable to recruit enough participants Actual 68
NCT03925493 Suspended Exercise Prescription in Cardiac Rehabilitation N/A Interventional The COVID-19 pandemic has caused us to suspend recruitment. Anticipated 60
NCT04225078 Suspended A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants Phase 1 Interventional Trial was put On Hold due to COVID-19. The Site will not start recruiting activities until further notice Anticipated 52
NCT04232878 Terminated A Single Ascending Dose Trial of CVL-936 in Healthy Subjects Phase 1 Interventional Sufficient data has been obtained to meet current objectives Actual 10
NCT04346355 Terminated Efficacy of Early Administration of Tocilizumab in COVID-19 Patients Phase 2 Interventional Based on interim analysis for futility and given an enrolment rate almost nil Actual 126
NCT04363203 Suspended VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL) Phase 3 Interventional concerns related to study drug Anticipated 300
NCT04416178 Suspended Sickle Cell Disease and the Genomic Needs of Parent and Pediatric Stakeholders Observational Temporary Enrollment Hold due to COVID-19 Anticipated 300
NCT04390386 Withdrawn Controlled Study of IC14 for Treatment of ALS Phase 2 Interventional contract not yet signed Actual 0
NCT01697293 Terminated Triciribine Phosphate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer Phase 1/Phase 2 Interventional criteria for continuing enrollment in Phase 2 portion was not met Actual 34
NCT02069431 Terminated Oxytocin Aging Study Phase 1 Interventional This study was halted prematurely due to the COVID-19 pandemic, resulting in the inability to enroll participants. Funding for this project has also ended. Actual 153
NCT02070666 Terminated Preventive Strategies in Acute Respiratory Distress Syndrome (ARDS) N/A Interventional Low recruitment and published data with no benefit Actual 98
NCT03051282 Suspended Genetic Determinants of ACEI Prodrug Activation Phase 4 Interventional Enrollment and interactions/interventions are paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 36
NCT03326804 Suspended H1 Hip Resurfacing Arthroplasty Observational awaiting data points for data analysis Anticipated 250
NCT03894579 Withdrawn Autologous Natural Killer Cells in Subjects With Plaque Psoriasis Phase 1 Interventional Study withdrawn per NKMax America Actual 0
NCT03978936 Suspended Medication Adherence With Telehealthcare Medication Therapy Management Phase 3 Interventional Study recruitment temporarily suspended due to COVID-19 pandemic. Anticipated 300
NCT03998514 Suspended A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease Phase 1 Interventional COVID-19 related delay Anticipated 86
NCT04240158 Terminated IW-6463 Safety Study in Healthy Elderly Subjects Phase 1 Interventional Some subjects could not complete the second crossover period due to COVID-19-related site closure. The study was closed to allow analysis of all collected data. Actual 24
NCT04362332 Terminated Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19 Phase 4 Interventional Currently, almost no patients admitted to Dutch hospitals. If any effect of HCQ is to be expected we need more than 1000 inclusions Actual 25
NCT04369742 Suspended Treating COVID-19 With Hydroxychloroquine (TEACH) Phase 2 Interventional Investigator decision Anticipated 626
NCT03790683 Suspended Intraoperative Warming During Major Surgical Procedures Using the Esophageal Temperature Management System N/A Interventional Sponsor funding limitations Anticipated 48
NCT03234153 Terminated Neoadjuvant Immunotherapy With Durvalumab and Tremelimumab for Bladder Cancer Patients Ineligible for Cisplatin Phase 2 Interventional low accrual Actual 6
NCT04361552 Withdrawn Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection) Phase 3 Interventional Study abandoned due to drug billing issues Actual 0
NCT03502954 Terminated A Study to Investigate the Safety, Tolerability and Pharmacokinetics of ABY-039 Phase 1 Interventional Halted prematurely Actual 66
NCT02220790 Suspended BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia Observational [Patient Registry] Final enrollment on hold due to COVID-19 restrictions Anticipated 515
NCT02419105 Terminated Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors Phase 3 Interventional Delayed recruitment mainly due to a screening to inclusion rate much lower than expected. Due to the delayed recruitment IMP reached the end of its shelf life. Actual 91
NCT02565511 Terminated A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease Phase 2/Phase 3 Interventional Study was terminated by Novartis after a planned review by DMC of unblinded data identified worsening in some measures of cognitive function Actual 480
NCT02733614 Suspended Proof-of-concept Study to Assess the Efficacy and Safety of SRX246 in Adults With PTSD Phase 2 Interventional COVID-19 Anticipated 52
NCT02868827 Terminated Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency. Phase 2/Phase 3 Interventional The initial plan was 2 years but due to slow recruitment. We were able to screen 635 patients in 4 years and recruited only 127 patients. Actual 127
NCT03132428 Terminated Registry to Evaluate INOmax in Newborn Babies With Pulmonary Hypertension Observational Positive results at interim analysis Actual 140
NCT03246919 Terminated Ideal Time of Oxytocin Infusion During Cesarean Section Phase 4 Interventional PI left Loyola and Sub-I graduated. Actual 68
NCT03472924 Terminated The Effects of Kinesio Tape® on Arthrogenic Muscle Inhibition and Rate of Torque Development N/A Interventional Insufficient recruitment and enrollment. Reduction in study personnel capacity. Actual 6
NCT03475602 Terminated Membranous Nephropathy-associated Serological Antibody Predict the Prognosis of Idiopathic Membranous Nephropathy Observational [Patient Registry] Our center had adopted a new detection method for anti-PLA2R antibodies in all membranous nephropathy patients. Actual 85
NCT03543033 Withdrawn Preoperative Corticosteroid Epidural Injection and Lumbar Decompression Surgery Outcomes N/A Interventional The study was closed by the investigators due to lack of study population to enroll. Actual 0
NCT03598036 Terminated Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosis Phase 2 Interventional Low recruitment rate Actual 5
NCT03718338 Suspended Mechanisms of Metabolic and Hormone Action on Plaque Formation in Brain and Carotid Vessels in Prostate Adenocarcinoma Observational COVID19 Suspension Anticipated 30
NCT03850509 Terminated Efficacy and Safety of Oral OPS-2071 in Subjects With Crohn's Disease Showing Symptoms of Active Inflammation Phase 2 Interventional Sponsor Decision Actual 3
NCT02193282 Suspended Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) Phase 3 Interventional Other - Modifications to MCF Anticipated 450
NCT04175132 Terminated Binding of Foliglurax to Regions in the Brain in Healthy Participants and in Patients With Parkinson's Disease (PD) Phase 1 Interventional New efficacy data from another study Actual 6
NCT04242966 Withdrawn The Effect of Higher Protein Dosing in Critically Ill Patients Ultrasound a Sub-study Phase 3 Interventional Study never started. Operational issues prevented study from rolling out Actual 0
NCT04282798 Withdrawn Racial Variation in Response to Music Interventions for People With Alzheimer's Dementia N/A Interventional COVID delay and subsequent unavailability of staff. Actual 0
NCT03127124 Suspended QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer Phase 1/Phase 2 Interventional IRB Recommendation Anticipated 64
NCT03418649 Suspended Eplerenone as a Supplement to Epidural Steroid Injections Phase 4 Interventional Unable to recruit during COVID-19 epidemic restrictions on associated clinical practice Anticipated 40
NCT04436770 Suspended Medical Recovery and Social Reintegration for Post-stroke Patients Using Virtual Reality N/A Interventional Due to the COVID-19 pandemic Actual 52
NCT03906448 Terminated FORWARD Optune and Adjuvant TMZ in Grade II/III Astrocytoma Phase 2 Interventional The study was terminated because the Study Chair/IDE Sponsor and Novocure determined that conducting this trial was not feasible without CMS approval. Actual 2
NCT03957278 Suspended A Study to Evaluate the DAISe System During Neurointervention for Acute Ischemic Stroke N/A Interventional Device modifications Anticipated 120
NCT03987750 Withdrawn Safinamide for Levodopa-induced Dyskinesia (PD-LID) Phase 3 Interventional drug development plan has been updated Actual 0
NCT04329611 Suspended ALBERTA HOPE COVID-19 for the Prevention of Severe COVID19 Disease Phase 3 Interventional Enrolment was suspended on 22may2020, after Mehra et al (Lancet 2020) suggested excess toxicity of HCQ. Anticipated 1660
NCT03707600 Withdrawn State and Trait Mediated Response to TMS in Substance Use Disorder N/A Interventional PI closing his lab Actual 0
NCT04434378 Terminated Tamsulosin to Prevent Postoperative Urinary Retention in Laparoscopic Inguinal Hernia Repair Phase 4 Interventional Significant difference not reached on interim analysis Actual 170
NCT02925988 Terminated Combined Amplitude-integrated and Conventional EEG Monitoring in High-risk Critically Ill Neonates N/A Interventional Actual 4
NCT04434872 Terminated Fecal Microbiota Transplantation as a Treatment for Ulcerative Colitis Phase 2 Interventional Lack of budget Actual 80
NCT00855907 Terminated Fatty Liver in Inflammatory Bowel Disease (IBD) Patients Observational Lack of budget Actual 100
NCT03940287 Terminated Muscle Energy Technique and Kinesiotaping in Mechanical Sacroiliac Joint Dysfunction N/A Interventional Due to COVID-19 lockdown Actual 30
NCT03940339 Terminated Suboccipitalis Myofascial Release in Hamstring Tightness in Patients With Anterolisthesis N/A Interventional Due to COVID-19 lockdown Actual 32
NCT03974009 Terminated Calcaneal Taping on Balance, Gait and Range of Motion in Chronic Stroke Survivors N/A Interventional Due to COVID-19 lockdown Actual 18
NCT04129489 Terminated A Phase 2a Study to Evaluate the Safety and Efficacy of Cannabidiol Only as Maintenance Therapy and Steroid Sparing in Patients With Stable Autoimmune Hepatitis Phase 2 Interventional low recruitment Actual 2
NCT04247308 Suspended Multi Modal Stimulations in Pre-term Neonates N/A Interventional Due to COVID-19 lockdown Anticipated 56
NCT02825043 Terminated HFNC Effect on BCSS in Patients With COPD N/A Interventional Slow enrollment and unable to meet enrollment targets Actual 6
NCT02178566 Terminated Pulmonary Rehab in Chronic Obstructive Pulmonary Disease (COPD): Response to Tyvaso Phase 2 Interventional Unable to enroll Actual 4
NCT03269968 Terminated Use of Negative Pressure Wound Therapy in Morbidly Obese Women After Cesarean Delivery N/A Interventional Recruitment difficulty Actual 25
NCT03738228 Suspended Atezolizumab Before and/or With Chemoradiotherapy in Immune System Activation in Patients With Node Positive Stage IB2, II, IIIB, or IVA Cervical Cancer Phase 1 Interventional Scheduled Interim Monitoring Anticipated 40
NCT03774784 Terminated A Study of the Natural History of Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Disease Observational The study was terminated due to the impacts of COVID-19 on patient safety and enrollment. Actual 26
NCT04044209 Suspended A Study of the IDH1 Inhibitor AG-120 in Combination With the Checkpoint Blockade Inhibitor, Nivolumab, for Patients With IDH1 Mutated Relapsed/Refractory AML and High Risk MDS Phase 2 Interventional COVID-19 temporary suspension Anticipated 45
NCT04285190 Withdrawn The Effect of T89 on Improving Oxygen Saturation and Clinical Symptoms in Patients With COVID-19 N/A Interventional The COVID-19 pandemic in China has ended completely. As a result, patient recruiting is impossible in China. Actual 0
NCT04285268 Withdrawn Rituximab, Venetoclax, and Bortezomib for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma Phase 2 Interventional funding available Actual 0
NCT04287491 Withdrawn Use Of Virtual Reality For Pain Control in Dermatological Bedside Procedures N/A Interventional Lack of funding Actual 0
NCT04333914 Suspended Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection Phase 2 Interventional Potential recrutment related to the epidemic context. Anticipated 384
NCT04432415 Suspended Comparison of Silver Diamine Fluoride and Sodium Fluoride Varnish to Prevent and Arrest Root Caries in Older Adults N/A Interventional Coronavirus Pandemic Actual 90
NCT03026166 Terminated A Study of Rovalpituzumab Tesirine Administered in Combination With Nivolumab and With or Without Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer Phase 1/Phase 2 Interventional Enrollment was stopped after the dose-limiting toxicity (DLT) evaluation phase of Cohort 2. Actual 42
NCT02997228 Suspended Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study Phase 3 Interventional Other - Study requires an approved DTL template Anticipated 200
NCT01003769 Terminated Lenalidomide and AT-101 in Treating Patients With Relapsed B-Cell Chronic Lymphocytic Leukemia Phase 1/Phase 2 Interventional Lack of funding Actual 5
NCT02119312 Suspended Malaria Clinical Trials Center General Screening Observational [Patient Registry] COVID19 safety measures-institutional policy to suspend non-covid related studies Anticipated 3500
NCT02521870 Terminated A Trial of Intratumoral Injections of SD-101 in Combination With Pembrolizumab in Patients With Metastatic Melanoma or Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Phase 1/Phase 2 Interventional A strategic restructuring including the planned conclusion of clinical oncology development programs and no further sponsoring of the development of SD-101. Actual 241
NCT02764086 Terminated INTENSE: A Phase I/II Study of INhomogeneous Targeted Dose Escalation in Non-Small CEll Lung Cancer Phase 1/Phase 2 Interventional Accrual lower than anticipated and not expected to improve Actual 6
NCT03731117 Suspended FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU Phase 4 Interventional Study with inclusions suspended due to COVID-19 since 18th march 2020 Anticipated 70
NCT04284462 Terminated Liking Adaptation to Beverages of Varying Sweetness Levels After Prolonged Exposure N/A Interventional Sponsor decision to stop study due to COVID-19 pandemic Actual 170
NCT04431232 Suspended Endo-Band: Endoscopic Band Ligation for Weight Loss N/A Interventional Due to COVID-19 pandemic Anticipated 5
NCT02357004 Withdrawn Mechanisms of Refractory Hypertension (Carvedilol) N/A Interventional Actual 0
NCT02357017 Withdrawn Mechanisms of Refractory Hypertension (High and Low Salt Diet) N/A Interventional Actual 0
NCT03403751 Terminated Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury Phase 3 Interventional Very slow enrollment of target patient population Actual 58
NCT03489512 Withdrawn Comparison Trial for Chloraprep Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia Phase 4 Interventional Administrative issues Actual 0
NCT03053050 Terminated Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis Phase 3 Interventional This study was terminated early due to lack of efficacy based on the results of the Week 48 analysis as prespecified in the clinical study protocol. Actual 808
NCT04106700 Suspended Prophylaxis With Apixaban in Transplant Eligible Patients With Multiple Myeloma Receiving Induction Therapy With IMiDs Phase 2 Interventional Low recruitment Anticipated 60
NCT04428762 Withdrawn Glycemic Control and Quality of Life With i- Port Advance in Pediatric T1DM N/A Interventional we decided to change the protocol completely to an RCT. Actual 0
NCT00230308 Suspended Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer Observational Suspended due to Covid-19 Anticipated 500
NCT02568917 Suspended Effectiveness of ART and Conventional Treatment - Practice-based Clinical Trial N/A Interventional There was a problem with the municipality and they have choose to suspend it. Anticipated 800
NCT03054636 Terminated Short-term Perfusion Angiography Pilot Study (SPA) Observational After data review of enrolled pts, it was determined that initial study objectives would not be met w/ continuation of enrollment Actual 38
NCT03292536 Terminated Merestinib on Bone Metastases in Subjects With Breast Cancer Phase 1 Interventional Enrollment incomplete by the end of the contracted enrollment period Actual 2
NCT03724253 Terminated [68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR) Phase 2 Interventional Recruitment was stopped before the target sample size was achieved. Actual 19
NCT03745196 Terminated The Effect of PC945 on Aspergillus or Candida Lung Infections in Patients With Asthma or Chronic Respiratory Diseases Phase 2 Interventional The study is being terminated early as a result of the coronavirus (COVID-19) outbreak. Actual 13
NCT03785730 Suspended Ultraconservative Caries Treatment in Anterior Cavitated Caries Lesion of Primary Teeth N/A Interventional Outbreak of COVID-19. Anticipated 196
NCT03785769 Suspended Pre-etching of Dentin Before Restorations With High Viscosity Glass Ionomer Cement N/A Interventional The Outbreak of COVID-19. Anticipated 192
NCT03827889 Suspended Efficacy of Two Protocols for Applying Fluorine Varnish to Deciduous Teeth N/A Interventional Outbreak of COVID-19. Anticipated 168
NCT03870841 Terminated The Effect of PC945 on Aspergillus Fumigatus Lung Infection in Patients With Cystic Fibrosis Phase 2 Interventional The study is being terminated early as a result of the coronavirus (COVID-19) outbreak. Actual 4
NCT03905447 Terminated The Effect of Early Treatment of PC945 on Aspergillus Fumigatus Lung Infection in Lung Transplant Patients. Phase 2 Interventional The study is being terminated early as a result of the coronavirus (COVID-19) outbreak. Actual 2
NCT03908944 Withdrawn Postoperative Pain and Headache After Craniotomy Phase 2 Interventional PI- Dr. Jellish passed away. The study was terminated with the IRB Actual 0
NCT03966300 Suspended Improving the School Vaccination Experience: What CARDs Are You Going to Play? N/A Interventional Study suspended because of Covid-19 - no vaccinations are occurring in schools Anticipated 1400
NCT03966391 Suspended Effectiveness of CARD for Improving School-Based Immunizations N/A Interventional Study suspended because of Covid-19 - there are no vaccinations in schools Anticipated 7800
NCT04344379 Suspended Prevention of SARS-CoV-2 in Hospital Workers s Exposed to the Virus Phase 3 Interventional suspension of clinical trials with hydroxychloroquine by health authorities Actual 122
NCT04393597 Withdrawn Effects of Food on the Pharmacokinetics of DWJ1458 in Healthy Adults Phase 1 Interventional We decided to discontinue this particular clinical study through internal discussion. Actual 0
NCT02212730 Terminated A Study Evaluating the Effect of Pembrolizumab (MK-3475) in Participants With Renal Cell Cancer (MK-3475-031) Phase 1 Interventional Terminated early due to low enrollment Actual 10
NCT02328287 Terminated Study on Allogeneic Osteoblastic Cells Implantation in Rescue Interbody Fusion Phase 2 Interventional Actual 6
NCT02501265 Suspended Adaptive Pharmacotherapy for Smoking Cessation Phase 2 Interventional Enrollment suspended due to COVID-19 Anticipated 188
NCT02665988 Terminated Adjunctive Transcranial Direct Current Stimulation N/A Interventional We terminated the study because the Pain Management Program closed in January 2018. Actual 4
NCT03079102 Terminated Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest Phase 2 Interventional Slow enrollment and planned change of institution by PI Actual 57
NCT03186937 Suspended A Window of Opportunity Study of Methionine Deprivation in Triple Negative Breast Cancer Phase 2 Interventional due to COVID-19 Anticipated 25
NCT03277222 Terminated Intranasal Treatment of HIV-associated Neurocognitive Disorders Phase 2 Interventional Unable to find further eligible participants Actual 4
NCT03318757 Withdrawn Bupivacaine Liposomal Injectable Suspension, Pain and Narcotic Use After Elective Orthognathic Surgery Phase 4 Interventional The research could not be conducted as it was denied by the IRB. Actual 0
NCT03819686 Suspended Reducing Disparities in Living Donor Transplant Among African Americans N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 850
NCT03914079 Suspended Evaluation of the CAD-det System, a Novel Non-Invasive Acoustic Diagnostic for the Diagnosis of Coronary Artery Disease Observational [Patient Registry] Sponsor due to COVID-19 Anticipated 2000
NCT03988582 Withdrawn Safety and Effectiveness of EBV-specific Cytotoxic T Cells for the Treatment for EBV Lymphomas or Other EBV-associated Malignancies Phase 2 Interventional Lack of accrual Actual 0
NCT03995966 Suspended A Clinical Trial for Self-Injurious Behavior N/A Interventional Paused due to COVID-19 and expected to resume; Not a suspension of IRB approval. Anticipated 30
NCT04149444 Withdrawn A Study of Trifluridine/Tipiracil in Triple Negative Metastatic Breast Cancer Phase 2 Interventional Sponsor withdrew support Actual 0
NCT04257214 Suspended Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder N/A Interventional COVID-19 Anticipated 440
NCT04428242 Withdrawn Study Evaluating Retinal Health Monitoring System Thickness Module Observational COVD-19 Actual 0
NCT01926301 Withdrawn Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy Observational Actual 0
NCT01978509 Terminated The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies N/A Interventional Lack of enrollment Actual 32
NCT02173470 Terminated Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery N/A Interventional Expected futility in reaching the primary endpoint Actual 866
NCT02317302 Terminated FDG Tumor Heterogeneity During Chemoradiation as a Predictor of Response in Patients With Cervical Cancer Phase 1 Interventional Insufficient funding Actual 48
NCT02462200 Terminated Shave Margins in Breast Conservation Therapy Phase 2 Interventional Insufficient funding Actual 81
NCT02542241 Terminated Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control Phase 4 Interventional lack of funds to continue recruitment Actual 52
NCT02887248 Terminated Nab-paclitaxel Plus Gemcitabine as First-line Therapy for Cisplatin-ineligible or Cisplatin-incurable Advanced Urothelial Carcinoma Phase 2 Interventional Enrollment issues Actual 3
NCT03138083 Terminated OMO-1 in Solid Malignancies Phase 1/Phase 2 Interventional strategic reasons (not due to lack of efficacy or safety issues) Actual 40
NCT03300609 Terminated 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab Phase 3 Interventional Insufficient Accrual Actual 4
NCT03726905 Suspended Complex Exercises of the Respiratory Muscles Plus Aerobic Training vs. Aerobic Training in Patients With СHF N/A Interventional Study suspended because of COVID 19 Anticipated 60
NCT03856580 Suspended Long-acting Biomedical HIV Prevention in Transgender Women N/A Interventional Due to COVID-19 pandemic Anticipated 45
NCT03864328 Terminated A Phase 2b Study of Inhaled RVT-1601 for the Treatment of Persistent Cough in IPF Phase 2 Interventional COVID-19 Pandemic Actual 108
NCT03929068 Suspended Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis Phase 1 Interventional COVID-19 Pandemic Anticipated 15
NCT04090879 Suspended Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders Phase 2 Interventional COVID19 pandemic Anticipated 232
NCT04092101 Suspended Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder Phase 2 Interventional COVID19 pandemic Anticipated 310
NCT04092387 Suspended Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age Phase 2 Interventional COVID19 pandemic Anticipated 246
NCT04345861 Terminated Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for COVID-19 Pneumonia (COVIDOC Trial) Phase 2/Phase 3 Interventional halted prematurely. Actual 7
NCT01850108 Suspended Non-Myeloablative Conditioning and Bone Marrow Transplantation N/A Interventional COVID-19 response Anticipated 25
NCT03794024 Terminated Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome Observational Manufacturer of the device filed for bankruptcy Actual 3
NCT04424576 Suspended Ovarian Morphology in Girls Observational Suspended due to COVID-19. No suspension of IRB approval. Anticipated 60
NCT01973881 Suspended Quantitative MRI for Myelofibrosis Observational Enrollment paused due to COVID-19 and will resume in the future. This is not a suspension of IRB approval. Anticipated 120
NCT03023449 Suspended Diffuse Optical Monitoring With Inhaled Nitric Oxide Phase 2 Interventional Enrollment in this study has been temporarily suspended due to the COVID-19 pandemic. Anticipated 40
NCT03161964 Terminated Propranolol in Treating Hypoglycemia Unawareness Phase 2 Interventional Statistical power could not be achieved due to low enrollment. Actual 2
NCT03224546 Suspended Cocaine Use Reduction and Health N/A Interventional COVID-19 Anticipated 250
NCT03445767 Withdrawn Structured Polypharmacy Management Before Elective Non-cardiac Surgery in Frail and Elderly People N/A Interventional Did not receive full funding to proceed Actual 0
NCT03496077 Suspended Addictive Potential of LCCs in Dual Users N/A Interventional COVID outbreak Anticipated 125
NCT03786783 Suspended Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant Phase 2 Interventional Other - Pending evaluation of patients on study currently Anticipated 45
NCT03877198 Terminated Comparison of Oxygen Controllers in Preterm InfanTs N/A Interventional As a result of a slower inclusion rate than expected, competence of medical staff to work with the AVEA ventilator could no longer be guaranteed. Actual 15
NCT03895853 Terminated Early Metabolic Resuscitation for Septic Shock Phase 2 Interventional At the request of the PI Actual 2
NCT03937986 Suspended Suvorexant and Cocaine Early Phase 1 Interventional COVID-19 Anticipated 20
NCT03954938 Suspended Behavioral Effects of Drugs (Inpatient): 38 Early Phase 1 Interventional COVID-19 Anticipated 30
NCT03960606 Suspended Study in Adult Asthmatic Patients With Allergic Bronchopulmonary Aspergillosis Phase 2 Interventional COVID-19 Pandemic Anticipated 64
NCT04203511 Withdrawn INCMGA00012 in Combination With Chemoradiation in Participants With Stage III Non-Small Cell Lung Cancer (POD1UM-301) Phase 3 Interventional Sponsor Strategic/Business Decision Actual 0
NCT04420247 Suspended Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19 Phase 3 Interventional WHO has recommended Chloroquine studies to be suspended for lack of efficacy. Actual 54
NCT00001219 Terminated Comparing Magnetic Resonance Imaging/Spectroscopy Techniques Observational protocol has not been used for many years and has outlived it utility Actual 49946
NCT03243058 Suspended Low-dose IL-2 in Established T1D - The "PROREG" Study Phase 1/Phase 2 Interventional Funding withdrawal and COVID-19 environment. Anticipated 60
NCT03343613 Terminated A Study of LY3381916 Alone or in Combination With LY3300054 in Participants With Solid Tumors Phase 1 Interventional Study terminated due to strategic business decision by Eli Lilly and Company. Actual 60
NCT02506114 Terminated Neoadjuvant PROSTVAC-VF With or Without Ipilimumab for Prostate Cancer Phase 2 Interventional Low Accrual Actual 15
NCT02812407 Withdrawn HRIM vs Mucosal Impedance in GERD Participants N/A Interventional No linger a clinically relevant research question Actual 0
NCT03349840 Terminated Randomised Open Label Study of Insulin Degludec Versus Insulin Glargine U100 in Ramadan Phase 4 Interventional The study was terminated by the IRB and the Institutional Official after the MOPH and WCMQ audits Actual 273
NCT03613259 Withdrawn Fluorothymidine F-18 PET in Diagnosing Patients With Intermediate or High Grade Soft Tissue Sarcoma Early Phase 1 Interventional Funding expired Actual 0
NCT03810183 Terminated A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia Phase 2 Interventional Company decision Actual 9
NCT03916146 Suspended Behavioral Parent Training for Families With Deaf and Hard of Hearing Preschoolers N/A Interventional Research activity paused for COVID-19 Anticipated 300
NCT03944551 Terminated Bubble Continuous Positive Airway Pressure for Children With Severe Pneumonia in Mali, Africa N/A Interventional Participant mortality rates were higher than expected. Actual 13
NCT04186689 Suspended Relationship Between Food Insecurity and Child Dental Anxiety Observational COVID -19 pandemic Anticipated 300
NCT04419792 Suspended 'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy' Observational Recruitment for study has been suspended due to Covid-19. Anticipated 70
NCT00985907 Terminated Doxil® + Melphalan + Velcade (DMV) in Relapsed/Refractory Multiple Myeloma Phase 1/Phase 2 Interventional Low Accrual Actual 13
NCT00393224 Terminated Defining the Clinical Utility of EBV Antibody Screening to Identify Individuals Susceptible to Nasopharyngeal Carcinoma (NPC) Within High-Risk, Multiplex NPC Families Observational Determined not to be human subject reseach Actual 952
NCT01257100 Terminated Environmental and Genetic Determinants of NPC Observational Determined not to be Human Subject Research Actual 3500
NCT02512237 Terminated A Dose-escalation Study of ARX788, IV Administered in Subjects With Advanced Cancers With HER2 Expression Phase 1 Interventional Replace with a new trial Actual 9
NCT02767934 Terminated Pembrolizumab in Treating Minimal Residual Disease in Patients With Acute Lymphoblastic Leukemia Phase 2 Interventional Terminated due to lack of efficacy Actual 12
NCT02974673 Terminated Pilot Study of Ejaculatory Dyssynergia by Electronic Microsensors of Sphincters N/A Interventional lack of recruitment Actual 11
NCT03301636 Terminated A Study of Indoximod or Placebo Plus Pembrolizumab or Nivolumab for Subjects With Unresectable or Metastatic Melanoma Phase 2 Interventional Sponsor termination, not related to efficacy, safety or feasibility. Actual 21
NCT03448133 Withdrawn rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial N/A Interventional Because of the expiration of the previous ethical approval documents Actual 0
NCT03537547 Terminated Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder Phase 4 Interventional Per sponsor and PI institution discussions Actual 6
NCT03571646 Terminated LIFEGUARD Study - Continuous Respiratory Monitoring on the General Ward N/A Interventional Poor recruitment rate due to difficulties in identifying suitable patients Actual 6
NCT03579758 Withdrawn Chemotherapy Before & After Surgery in Patients With Resectable Gallbladder Cancer Phase 3 Interventional This trial will open as an NCTN trial. Actual 0
NCT03735160 Withdrawn Pressure Over Nasotracheal Intubation Related Nasal Alar Injury Observational Technical problem Actual 0
NCT03822689 Withdrawn Comparison of Ventilation Tubes Among Anesthetized Pediatrics N/A Interventional Institutional Review Board did not approve Actual 0
NCT03869372 Suspended Cerebral Cortical Influences on Autonomic Function N/A Interventional Covid-19 Anticipated 96
NCT03918499 Suspended IRX-2, Cyclophosphamide, and Pembrolizumab in Treating Participants With Recurrent or Metastatic Gastric or Gastroesophageal Junction Cancer Phase 1/Phase 2 Interventional Temporary on hold Anticipated 20
NCT03952143 Suspended A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 Diabetes Phase 3 Interventional Enrollment on hold due to COVID-19 pandemic. Anticipated 564
NCT04084665 Withdrawn Biomarkers in Participants With Hidradenitis Suppurativa Receiving Guselkumab. Early Phase 1 Interventional COVID-19 Pandemic Actual 0
NCT04097431 Suspended Identifying Precursors to Severe Problem Behavior N/A Interventional Temporarily paused due to COVID-19 and expected to resume; not a suspension of IRB approval. Anticipated 60
NCT04118036 Suspended Abemaciclib + Pembrolizumab In Glioblastoma Phase 2 Interventional Safety concerns Anticipated 47
NCT04144127 Suspended Prostate Cancer Soccer N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 40
NCT01870869 Terminated NATRELLE® 410 X-Style and L-Style Breast Implants Continued Access Study N/A Interventional There was no indication that long-term follow-up would differ between any of the studies that have evaluated devices within the 410 Style Matrix. Actual 1951
NCT02083939 Terminated Prophylactic Antibiotic Treatment for Laparoscopic Inguinal Hernia Mesh Repair: Necessary or Not? Observational Recruitment failed Actual 5
NCT03284476 Withdrawn Post Surgically Treated Peritonitis Complications Observational No inclusion Actual 0
NCT03284489 Withdrawn Post Pancreatitis Complications Study (Based on a Prospective Data Base) Observational No inclusion Actual 0
NCT03407287 Suspended Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status Observational interim analysis Anticipated 180
NCT03744598 Terminated Self-monitoring of Spirometry & Symptoms Via patientMpower App in Idiopathic Pulmonary Fibrosis Observational Clinic visits stopped due to COVID19 Actual 21
NCT03862690 Withdrawn A Research Study, Looking at How NovoMix® Works in People With Type 2 Diabetes in Local Clinical Practice in Algeria Observational Sponsor decision Actual 0
NCT03867240 Suspended Gabapentin and Chronic Post Surgical Pain Phase 3 Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 100
NCT04001231 Withdrawn Study of Exenatide Once-Weekly Suspension in Chinese Patients With Type 2 Diabetes Mellitus Phase 1 Interventional The study is stopped based upon strategic considerations impacting the clinical development of exenatide once-weekly suspension in China Actual 0
NCT04417816 Terminated Ultrasound-induced Adipose Tissue Cavitation and Training in Obesity N/A Interventional At the request of the Ethical Committee Actual 28
NCT04140877 Withdrawn Choroidal Changes Post Short Term Exposure To Virtual Reality Devices N/A Interventional Strategy change Actual 0
NCT04239534 Suspended CONVERGE CAP Study-For The Treatment Of Symptomatic Persistent or Long-standing Persistent AF N/A Interventional Start-up and enrolling activities have been temporatily suspended due to the COVID-19 pandemic. Anticipated 170
NCT04333654 Suspended Hydroxychloroquine in Outpatient Adults With COVID-19 Phase 1 Interventional Sponsor decision pending further evaluation of information related to benefit-risk Anticipated 210
NCT04347512 Withdrawn EVALUATION OF THE EFFICACY OF THE HYDROXYCHLOROQUINE-AZITHROMYCIN COMBINATION IN THE IN THE PREVENTION OF COVID-19 RELATED SDRA Phase 3 Interventional In view of the notices concerning hydroxychloroquine issued by the regulatory authorities, we withdraw the protocol Actual 0
NCT01210027 Suspended A Study of Radiation Toxicity in the Liver Using MRI-Based Perfusion Observational Enrollment and/or interactions/interventions temporarily paused due to COVID-19 and expected to resume in the future. This is not a suspension of IRB approval. Anticipated 140
NCT02045381 Suspended Optimization of MRI for Radiation Therapy Observational Enrollment and/or interactions/interventions temporarily paused due to COVID-19 and expected to resume in the future. This is not a suspension of IRB approval. Anticipated 432
NCT02250924 Withdrawn Caffeinated Gum to Prevent Post-Operative Ileus: A Prospective, Randomized, Placebo-controlled Trial N/A Interventional Investigator decision - clinical practice change Actual 0
NCT02303392 Suspended Selinexor and Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Aggressive Non-Hodgkin Lymphoma Phase 1 Interventional pending amendment Anticipated 92
NCT02748746 Withdrawn Early Detection of Lymphedema With Bio-Electrical Impedance Analysis in Patients After Breast Cancer Surgery N/A Interventional Unable to achieve device(s) which will be used in this study. Actual 0
NCT03115320 Terminated Frozen-thawed Embryo Transfer in a Naturally Stimulated Cycle: Does hCG Triggering Bring Any Advantage in Comparison to Testing LH Surge With Home Tests? Phase 4 Interventional High cancellation rate in LH test group in interim analysis Actual 62
NCT03287063 Suspended Study Using Genomic, Histologic and Radiomic Analysis to Evaluate Regional Tumor Heterogeneity in Patients Undergoing Surgery for Newly Diagnosed Glioblastoma Observational Enrollment and/or interactions/interventions temporarily paused due to COVID-19 and expected to resume in the future. This is not a suspension of IRB approval. Anticipated 20
NCT03325114 Terminated Safety and Efficacy of Chlorthalidone in Type 1 Diabetes Phase 2 Interventional COVID restrictions prohibit further study activies Actual 1
NCT03941717 Suspended Testing the Effectiveness of a Parent and Child Mindfulness-Based Intervention for Child Venipuncture N/A Interventional COVID-19 restrictions Anticipated 150
NCT03970109 Suspended HLAB-002 of ANS-6637 for Alcohol Use Disorder Phase 2 Interventional Clinical Hold for Safety Anticipated 81
NCT04086342 Withdrawn CHI-902 for Treatment of Social Anxiety Disorder Phase 2 Interventional Changes in pipeline Actual 0
NCT04100629 Terminated Digital Support Intervention on Newly Licensed Nurses N/A Interventional Lack of enrollment (and due to pandemic) Actual 23
NCT04139980 Suspended Virtual Reality Device for Rehabilitation of Stroke Patients N/A Interventional staffing resources Anticipated 100
NCT04189315 Withdrawn Relieving Burden of Hypophosphatasia in Adults With Functional Impairment Due to Chronic Disease Phase 4 Interventional R&D portfolio review and in light of the global impact of the COVID-19 pandemic Actual 0
NCT04332081 Terminated Hyperbaric Oxygen for COVID-19 Patients N/A Interventional The IRB has determined that the design of this trial should be changed to a randomized controlled trial. A new record will be created for the redesigned study. Actual 20
NCT04341727 Suspended Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection Phase 3 Interventional DSMB recommended study suspension slow accrual Anticipated 500
NCT04371926 Withdrawn Prophylactic Benefit of Hydroxychloroquine in COVID-19 Cases With Mild to Moderate Symptoms and in Healthcare Workers With High Exposure Risk N/A Interventional Concerned about the adverse effects of HCQ Actual 0
NCT03536338 Terminated Spinal Stimulation Sit-to-Stand Training After Spinal Cord Injury N/A Interventional COVID-19 pandemic Actual 9
NCT04003519 Withdrawn Study to Predict Lanreotide-induced Disease Activity Normalization in Acromegaly Observational Study timeline delay, low site feasibility and delay concerns due to COVID-19. Actual 0
NCT03933930 Withdrawn Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy. N/A Interventional No patient wants to be recruited. Actual 0
NCT04411121 Suspended Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-risk Head and Neck Cancer Phase 2/Phase 3 Interventional Scheduled Interim Monitoring Anticipated 613
NCT02842125 Terminated Safety and Efficacy of Intra-Arterial and Intra-Tumoral Ad-p53 With Capecitabine (Xeloda) or Anti-PD-1 in Liver Metastases of Solid Tumors and Recurrent Head and Neck Squamous Cell Cancer Phase 1/Phase 2 Interventional Arm C rolled into parallel study; Arms A and B halted for greater efficacy in Arm C Actual 4
NCT03610763 Suspended Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 347
NCT03637023 Suspended Virtual Reality for Parkinson's Disease N/A Interventional due to COVID-19 outbreak Anticipated 30
NCT04032158 Terminated Study of Evobrutinib in Participants With Relapsing Multiple Sclerosis (RMS) Phase 3 Interventional Administrative reason by Sponsor. Actual 3
NCT02125331 Terminated Measurement of NonInvasive Blood Pressure in Neonates Through Adults and Special Populations Observational Data collection requirment complete Actual 83
NCT04164069 Suspended Dasatinib in Preventing Oxaliplatin-Induced Peripheral Neuropathy in Patients With Colorectal Cancer Receiving FOLFOX and Bevacizumab Phase 1 Interventional PI Decision Anticipated 20
NCT04184518 Withdrawn Durvalumab (MEDI4736) Plus Cediranib in Patients With Metastatic Uveal Melanoma Phase 2 Interventional The Cediranib producer laboratory decided to stop the development of this product. Actual 0
NCT04235270 Suspended A Study of Macitentan and Tadalafil as a Fixed Dose Combination and the Free Combination in Healthy Adult Participants Phase 1 Interventional Occurrence of COVID-19 pandemic Anticipated 62
NCT04300413 Suspended Patient-Centered, Interprofessional Approach to Improve Functional Outcomes in a Skilled Nursing Facility N/A Interventional On hold due to COVID-19 outbreak Anticipated 53
NCT03010137 Terminated Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial N/A Interventional Lack of staff resources to properly consent and enroll patients into the study. Actual 30
NCT00001651 Terminated Use of Labeled Glucose to Study Lymphocyte Replication and Survival in HIV-Infected Patients N/A Interventional Slow/Insufficient accrual Actual 54
NCT02353000 Terminated Whole Brain Radiotherapy (WBRT) Versus Stereotactic Radiosurgery (SRS) for 4 Upto 10 Brain Metastases N/A Interventional Unable to achieve accrural within anticipated timeframe Actual 31
NCT02625376 Terminated Resveratrol for Exudative Age-Related Macular Degeneration N/A Interventional Actual 25
NCT03256331 Terminated Evaluate the Safety of BEL-X-HG in Advanced Cancer Patients Phase 1 Interventional In the light of the on-going COVID-19 pandemic and the resulted difficulty in patient recruitment. Actual 23
NCT03393806 Terminated Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD) Phase 2 Interventional Recruitment was terminated early before meeting target enrolment due to a high screen failure rate and the feasibility of completing the study in a timely way Actual 18
NCT02281877 Suspended Alterations in Muscle After Total Knee Arthroplasty N/A Interventional On hold due to COVID-19 outbreak Anticipated 20
NCT02898753 Terminated VAL-1221 Delivered Intravenously in Ambulatory and Ventilator-free Participants With Late-Onset Pompe Disease Phase 1/Phase 2 Interventional Company closure due to lack of funding Actual 12
NCT03054961 Suspended Cerebral Oxygen Saturation and Cytochrome Oxidase REDOX State in Children With Epilepsy: A Pilot Study Observational Protocol Amendment in process, pending reengineering of intruments Anticipated 40
NCT03274817 Terminated A Proof of Concept Study of the Prevention of Mild Cognitive Impairment and Eventual Alzheimer's Disease Using F18 Flutemetamol Phase 1 Interventional Insufficient Enrollment Actual 5
NCT03410056 Terminated Safety and Efficacy of AMG 592 in Subjects With Active Rheumatoid Arthritis Phase 1/Phase 2 Interventional Amgen made a business decision not to proceed with Phase 2. Actual 36
NCT04415372 Suspended Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis Observational Suspended due to COVID-19 Anticipated 50
NCT03629249 Terminated Systemic Corticosteroids Avoidance Study in Severe Asthma Patients Phase 3 Interventional Company decision Actual 609
NCT03713099 Withdrawn NEUWAVE Flexible Probe Study #2 N/A Interventional Changed study design prior to any patients enrolled. Actual 0
NCT04017637 Withdrawn Resistance Training Intervention to Promote Lean Mass in Youth With IBD N/A Interventional Study cancelled Actual 0
NCT04002882 Suspended Role of Body Fat Distribution in Metabolic and Pulmonary Decline in Cystic Fibrosis (ORBIT-CF) Observational Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 90
NCT04116229 Suspended Cognition and Magnetic Resonance Imaging of Brain Inflammation in Obesity Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 20
NCT02872935 Terminated Minimizing Nausea and Vomiting During Spinals for CS Phase 4 Interventional Actual 22
NCT00933829 Terminated Comparison of Cosmetic Outcomes of Lacerations Repaired Using Absorbable Versus Non-absorbable Sutures N/A Interventional Actual 160
NCT01126853 Withdrawn Combination Hepatitis A and B Vaccine to Induce Immunity in Non-responders Phase 4 Interventional Actual 0
NCT02765516 Terminated Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol Intervention N/A Interventional Inability to recruit Actual 43
NCT03165968 Suspended Test and Evaluation of Non-Invasive Neuro-Assessment Devices (NINAD): NeuroKinetics, Inc, iPAS Observational COVID19 epidemic, and institutional guidelines for halt of recruitment during epidemic Anticipated 150
NCT03357042 Withdrawn Evaluation of a Physical Intervention for Persistent Post-Concussive Symptoms N/A Interventional researchers did not find participants to meet the inclusion and exclusion criteria for the testing protocols Actual 0
NCT03790865 Terminated Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome Phase 2/Phase 3 Interventional Livoletide did not result in a statistically significant improvement in hyperphagia and food-related behaviors Actual 158
NCT03953521 Terminated Neuronavigated TBS in Depression N/A Interventional Interim analysis indicated no statistical difference between treatment arms. Actual 37
NCT04032171 Terminated Study of Evobrutinib in Participants With Relapsing Multiple Sclerosis Phase 3 Interventional Administrative reason by Sponsor. Actual 1
NCT04092257 Suspended HPV-Based Screen-and-Treat Demonstration Project in Lilongwe N/A Interventional The study was about to start recruiting but in response to COVID-19, screening and enrollment has been put on hold. Anticipated 625
NCT04114630 Withdrawn Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab Phase 3 Interventional No patients were enrolled and global prioritization of pipeline and research strategy Actual 0
NCT02766478 Suspended Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer Phase 2 Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 24
NCT04174794 Terminated Investigating Reduction of aCute heArt Failure Readmission With Lung UltraSound-preliminary Trial Observational COVID-19 Pandemic Actual 43
NCT02813668 Suspended Worksite Lifestyle Program for Reducing Diabetes and Cardiovascular Risk in India N/A Interventional Study activities involving participants are suspended due to COVID-19 Actual 2065
NCT04198844 Withdrawn The Effectiveness and Safety of Apixaban in NVAF Patients With History of Osteoporosis and/or Fracture: A Nation-wide Population Based Study Observational Interaction term analysis result was not significant and thus comparative effectiveness for primary and secondary outcomes could not be considered per protocol. Actual 0
NCT04205890 Withdrawn Intravenous Ketamine Effects on Functional Neuroanatomy Phase 1 Interventional Sponsor is no longer interested in funding the study Actual 0
NCT04332549 Withdrawn To Assess the Bioavailability and Safety of Paclitaxel Injection Concentrate for Suspension in Subjects With Locally Recurrent or Metastatic Breast Cancer Phase 1 Interventional After meeting with the FDA, SPARC concludes a BE study will not be required Actual 0
NCT04334967 Suspended Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care Phase 4 Interventional suspected unfavorable risk/benefit assessment Actual 13
NCT03307057 Suspended Promoting Transactional Supports to Optimize Social Communication Outcomes for Infants and Their Families N/A Interventional The study activities are on hold due to COVID Anticipated 250
NCT02946437 Withdrawn Sevoflurane in Subarachnoidal Haemorrhage Phase 2 Interventional Patients failed to be enrolled because of tight exclusion criteria. Actual 0
NCT03595748 Suspended Peer Mentorship to Improve Outcomes in Patients on Maintenance Hemodialysis N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval Anticipated 200
NCT04413487 Withdrawn Early Detection of Heart Problems in Cancer Patients Receiving Chemotherapy Observational Study never started due to change in standard of care guideline Actual 0
NCT03999190 Withdrawn Imaging Dopamine D2 Agonist Binding Sites in Schizophrenia Observational investigational radiotracer was not approved Actual 0
NCT04003935 Terminated Juice Plus Inflammaging and Cardiovascular Disease Prevention Study Observational One of the 2 nutritional products is reformulated and withdrawn from the market Actual 22
NCT04041596 Withdrawn Degree of Benefit From Low-Frequency Acoustic Amplification Using the Advanced Bionics Acoustic Earhook Phase 4 Interventional Due to a lack of enrollment Actual 0
NCT04162431 Suspended DOLPHIN-VIVO: Diagnosis Of LymPHoma IN Vivo (Ex Vivo Phase) Observational Covid19 Anticipated 250
NCT04213014 Suspended Guys/Girls Opt for Activities for Life Trial (GOAL) to Increase Young Adolescents' Physical Activity and Healthy Eating Phase 3 Interventional Recruitment halted due to COVID19 Anticipated 1760
NCT04289883 Withdrawn Food Structure and Satiety N/A Interventional The Covid-19 pandemic that made it impossible to conduct within the timeframe. Actual 0
NCT04407832 Withdrawn Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy N/A Interventional Actual 0
NCT03235986 Terminated A Study To InvestigateThe Safety, Tolerability And Efficacy Of Nebulised Curosurf® In Preterm Neonates With Respiratory Distress Syndrome (RDS) Phase 2 Interventional Change in the benefit-risk balance Actual 166
NCT03654755 Terminated Study to Evaluate Long-Term Safety of ASN002 in Subjects With Moderate to Severe Atopic Dermatitis Phase 2 Interventional Phase 2 study results Actual 168
NCT03728504 Terminated Study to Evaluate ASN002 in Subjects With Moderate To Severe Chronic Hand Eczema Phase 2 Interventional Primary Endpoint completed and continuing visit schedule complications due to COVID-19 Actual 19
NCT03770299 Withdrawn An Investigational Immuno-therapy Study of Nivolumab Given After Surgery in Non-Small Cell Lung Cancer (NSCLC) Participants With Minimal Residual Disease Phase 2 Interventional Business objectives have changed Actual 0
NCT02281344 Terminated MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Participants Phase 1 Interventional Inconsistent and unpredictable exposures were observed. Drug needed to be reformulated. Actual 6
NCT02667327 Terminated A Study of Granexin Gel in the Treatment of Diabetic Foot Ulcer Phase 3 Interventional Sponsor Decision (No safety or efficacy concerns) Actual 124
NCT02744612 Suspended Ibrutinib and Brentuximab Vedotin in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma Phase 2 Interventional Anticipated 39
NCT02860078 Suspended Epidural Injection of Corticosteroids Under USG (EICUS) N/A Interventional Not started Anticipated 30
NCT02924389 Suspended Dolutegravir in Reservoirs N/A Interventional Enrollment and study visits are temporarily suspended due to COVID-19. Anticipated 40
NCT02975128 Terminated Minimal Invasive Breast Cancer Excision Using the Breast Lesion Excision System Under Ultrasound Guidance N/A Interventional Needle production stopped Actual 22
NCT03318107 Terminated Ultrasound and Photoacoustic Imaging for Cervical Cancer N/A Interventional Low accrual Actual 2
NCT03335020 Withdrawn Using Ultrasonography, Shear Wave Elastography, Strain Imaging, and 3-D Volume Ultrasonography on Cardiovascular Disease Phase 1 Interventional Closed by Investigator Actual 0
NCT03342911 Suspended Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery Phase 2 Interventional COVID-19 Anticipated 37
NCT03418532 Terminated MP0250 DARPin® Protein Plus Osimertinib in Patients With EGFR-mutated NSCLC Phase 1/Phase 2 Interventional Sponsor's decision Actual 8
NCT03457025 Withdrawn Effect of Adjuvant Hyperbaric Oxygen Therapy on Bells Palsy Outcome Early Phase 1 Interventional lack of enrollment Actual 0
NCT03492138 Terminated Ixazomib, ONC201, and Dexamethasone in Relapsed/Refractory Multiple Myeloma Phase 1/Phase 2 Interventional Low enrollment Actual 5
NCT03551119 Suspended Physical Activity in Renal Disease (PAIRED): The Effect on Hypertension Phase 3 Interventional Covid-19 pandemic Anticipated 160
NCT03648216 Suspended The Effect of Experimentally Increasing Sedentary Behaviour on Subjective Well-being N/A Interventional Recruitment and study progress halted by COVID-19 Anticipated 46
NCT03968835 Withdrawn A Comparison of the Outcomes of Distal Fingertip Amputations Treated With Either Artificial (Xeroform) or Biological Dressings Observational lack of enrollment Actual 0
NCT03970356 Suspended Improving Antibiotic Prescribing for Urinary Tract Infections in Frail Elderly N/A Interventional Study paused due to Covid-19 outbreak Anticipated 680
NCT02149823 Suspended Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations Phase 1 Interventional COVID-19 Anticipated 165
NCT02532517 Terminated Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device N/A Interventional No safety issues; change in innovation strategy Anticipated 320
NCT02694341 Withdrawn Bakri Balloon in Placenta Previa N/A Interventional No participants shared Actual 0
NCT02866279 Suspended Immediate Postpartum Contraceptive Implant Placement and Breastfeeding Success in Women at Risk for Low Milk Supply: A Non-inferiority Trial N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 375
NCT02923986 Withdrawn Clinical Trial of BP1001 (Liposomal Grb2 Antisense Oligonucleotide) in Combination With Dasatinib in Patients With Ph + CML Who Have Failed TKI, Ph+ AML, Ph+ MDS Phase 1/Phase 2 Interventional No enrollment Actual 0
NCT03036319 Suspended Patient-Centered NeuroRehabilitation (PCN) N/A Interventional Enrollment and interactions/interventions are temporarily paused due to COVID-19 and are expected to resume in the future. Anticipated 500
NCT03451851 Suspended A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants Phase 3 Interventional Enrollment Hold due to COVID-19 Anticipated 125
NCT03341000 Terminated Pilot Study to Examine the Feasibility of the Dynamic Interferential Spinal Cord Stimulation System™ (DISCSS™) N/A Interventional Sponsor Decision Actual 18
NCT03395119 Suspended Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects Phase 1 Interventional Suspended due to COVID-19 risks Anticipated 60
NCT03517995 Withdrawn Randomized, Phase II Clinical Trial of Sulforaphane in Bladder Cancer Chemoprevention Phase 2 Interventional Grant not approved Actual 0
NCT03520309 Suspended Clinical Criteria for the Evaluation of Caries Lesions Around Restorations in Primary Teeth (CARDEC-03) N/A Interventional Follow-ups paused temporarily since March 16th due to COVID-19 Actual 163
NCT04016116 Withdrawn Dual PD-1 and JAK2 Inhibition in Hematological Malignancies Phase 2 Interventional PI left the institution Actual 0
NCT03630367 Suspended Effects of L‑Carnitine Supplementation on Respiratory Distress Syndrome Phase 4 Interventional Unavailability of the medication Anticipated 300
NCT03717532 Terminated Blood Flow Restriction Therapy in Patellofemoral Pain Syndrome N/A Interventional Inadequate/low enrollment Actual 1
NCT03729310 Withdrawn Comparison of Two Steroid Nasal Implants Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis Early Phase 1 Interventional No participants enrolled Actual 0
NCT04404348 Suspended Cognitive Rehabilitation for Opioid Abuse-related Cognitive Impairment N/A Interventional Study halted due to Covid-19 precautions Anticipated 50
NCT04056637 Terminated Choice of Modality of Follow up for Medication Abortion N/A Interventional COVID-19 Impacted Service Delivery and Research Infrastructure Actual 26
NCT04074304 Suspended Developing and Piloting a Multi-component Technology-based Care Intervention to Address Patient Symptoms and Caregiver Burden in Home Hospice. Phase 1. N/A Interventional Temporarily paused due to COVID-19 and will resume based on guidance of public health authorities. This is not a suspension of IRB approval Anticipated 30
NCT04123197 Suspended Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis N/A Interventional The study activities are suspended due to COVID Anticipated 300
NCT02515669 Terminated Study of an Investigational Drug, RO7239361 (BMS-986089), in Ambulatory Boys With DMD Phase 1/Phase 2 Interventional A pre-planned futility analysis indicated lack of efficacy. Actual 43
NCT04179721 Suspended Reducing Behavioral and Psychological Symptoms of Dementia N/A Interventional COVID-19; study will resume when restrictions are lifted. Anticipated 158
NCT04230720 Suspended Effect of Artificial Tears on Biometry Phase 4 Interventional Temporarily paused due to COVID-19 and will resume based on guidance of public health authorities. This is not a suspension of IRB approval. Anticipated 30
NCT04404790 Suspended Antiplatelet Thrombolysin (Anfibatide) Phase 1 Clinical Trial in Healthy Volunteers Phase 1 Interventional Optimization of protocol Anticipated 50
NCT04409314 Suspended Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy Observational Drug Supply Anticipated 30
NCT01263652 Withdrawn Patient Preferences, Analgesic Delivery Method and Pain Reduction in Spine Patients N/A Interventional inability to complete recruitment as planned Actual 0
NCT03132064 Suspended The Association Between Pre-operative Pain Psychology and Hypersensitivity With Poor Functional Outcome After Knee Replacement. Observational COVID-19 Anticipated 50
NCT03611296 Suspended Translational Investigation of Growth and Everyday Routines in Kids (TIGER Kids) Fitness Ancillary Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Actual 30
NCT04341610 Withdrawn ASC Therapy for Patients With Severe Respiratory COVID-19 Phase 1/Phase 2 Interventional Not approved by ethical committee Actual 0
NCT02430649 Withdrawn Irreversible Electroporation(IRE) For Unresectable Prostatic Neoplasms N/A Interventional Actual 0
NCT03699644 Suspended Multimodal Ocular Imaging in Neurodegeneration N/A Interventional Enrollment/interactions/interventions are temporarily paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 50
NCT04402775 Terminated Brachiocephalic Arteriovenous Fistulae: Two Different Techniques of Bloodless Surgery and Their Effect on Fistula Stenosis. N/A Interventional Due to a low inclusion rate Actual 25
NCT04406610 Terminated CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients Phase 1/Phase 2 Interventional Actual 2
NCT02557529 Terminated Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy N/A Interventional Slow recruition Actual 50
NCT02897713 Suspended Feasibility, Safety, and Outcomes of Intensive Enteral Nutrition in Patients With Mechanical Ventilation N/A Interventional Similar study has been published. Anticipated 400
NCT04128436 Terminated The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates N/A Interventional With the interim analysis, a marked decrease in ongoing pregnancy rate was noted in patients with a drop in serum progesterone level from OPU+3 day to OPU+5 day Actual 126
NCT04402294 Suspended Individualized Closed Loop TMS for Working Memory Enhancement N/A Interventional COVID-19 Restrictions Anticipated 38
NCT03495427 Suspended PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men w/ High Decipher Test Scores Phase 2/Phase 3 Interventional Compounding facility to submit quality update before they can manufacture 18F-DCFPyL Anticipated 60
NCT02545283 Terminated A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) Phase 3 Interventional The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed. Actual 447
NCT03551717 Terminated Retinal Microvascularization and Cardiovascular Disease Observational Lack of inclusion Actual 155
NCT03575507 Withdrawn Non-invasive Improvement of Buttocks With Magnetic Device N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03812341 Withdrawn SINGLE PATIENT EXPANDED ACCESS OF A PROSPECTIVE, MULTICENTER CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND PROBABLE BENEFIT OF THE KERAKLEAR NON-PENETRATING KERATOPROSTHESIS IN SUBJECTS WITH CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT N/A Interventional No enrollment Actual 0
NCT03946774 Suspended Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 20
NCT04069260 Terminated A Phase 2 Study of ELX-02 in Patients With Nephropathic Cystinosis Phase 2 Interventional Due to study design limitations, this study has been discontinued and will not proceed with the 2nd cohort as contemplated in the original protocol. Actual 3
NCT04141046 Suspended LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE N/A Interventional Suspended due to COVID-19 risks Anticipated 72
NCT04207905 Suspended Evaluation of the Healthy Michigan Plan Section 1115 Community Engagement Requirement Waiver Observational On 3/4/20 a federal judge ruled the HMP work requirement unlawful, thereby ending it and suspending implementation of this RCT. This is not an IRB suspension. Anticipated 229000
NCT04306861 Suspended Novel MRI Techniques for Pancreatic Cancer Observational Enrollment and other trial activities have temporarily paused due to COVID-19 and are expected to resume in the future; This is not a suspension of IRB approval Anticipated 20
NCT04350450 Withdrawn Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore Phase 2 Interventional PI withdrew the submission to the IRB Actual 0
NCT04377737 Withdrawn Incidence of Covid-19 in School Children N/A Interventional Human Subjects Protection Review: submitted, denied Actual 0
NCT01805973 Terminated Surviving Aneurysm Surgery: A Pilot Study on Exercise Training in Abdominal Aortic Aneurysm Patients N/A Interventional Anticipated 100
NCT02636387 Terminated Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease Observational Low recruitment Actual 14
NCT02816437 Withdrawn FMT for MDRO Colonization in Solid Organ Transplant Phase 1 Interventional safety Actual 0
NCT03115151 Suspended Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery Phase 4 Interventional COVID-19 policy Anticipated 58
NCT03348280 Suspended Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics Observational temporarily paused due to Covid-19 and expected to to resume, this is not a suspension of IRB approval. Anticipated 40
NCT03438435 Suspended Fluorescence QRH-882260 Peptide Imaging in the Bile Duct Phase 1 Interventional Enrollment and interactions/interventions temporarily paused due to COVID-19 & may resume in the future. No suspension of IRB approval. Anticipated 12
NCT03453658 Suspended Mechanized Instrumentation for Endodontic Treatment of Primary Teeth N/A Interventional Follow-ups paused temporarily since March 16th, 2020 due to COVID-19. Anticipated 150
NCT03579147 Withdrawn Non-invasive Buttock Lifting Induced by Magnetic Device - Multicentric Study N/A Interventional It was not possible to recruit any patients at that time. Actual 0
NCT03610347 Terminated Paclitaxel Eluting Balloon After Bare Metal Stent Implantation vs. Drug-Eluting Stent in St Elevation Myocardial Infarction N/A Interventional Low recruitment Actual 199
NCT03844750 Suspended Pembrolizumab After Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and Who Are Undergoing Liver Surgery Phase 2 Interventional Pending Amendment Anticipated 19
NCT03852576 Suspended Phase 1B Study of KSP/QRH Dimer for Detection of Neoplasia in the Esophagus Phase 1 Interventional Enrollment and interactions/interventions temporarily paused due to COVID-19 & will resume in the future. No suspension of IRB approval. Anticipated 50
NCT03856125 Withdrawn Percutaneous Electrical Stimulation on Radial Nerve in Patients With Lateral Epicondylalgia N/A Interventional Covid19 locked down Actual 0
NCT03896477 Suspended Phase 3 Study of 10-valent Pneumococcal Conjugate Vaccine (PNEUMOSIL) Administered in a 2+1 Schedule to Healthy Infants Phase 3 Interventional Temporarily halted some in-person research activities due to COVID-19 pandemic Actual 660
NCT04044391 Terminated Use of Magnetocardiography in Evaluation of Patients Going for Cardiac Catheterization Observational Study was defunded. Actual 101
NCT04114656 Suspended Effects of Intravenous GSK3858279 on a Battery of Evoked Pain Tests in Healthy Volunteers Phase 1 Interventional Due to the COVID-19 pandemic, this study has temporarily suspended recruitment activities. Other elements of the study are ongoing. Anticipated 24
NCT04175600 Suspended A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension Phase 3 Interventional Due to COVID-19 pandemic, a decision was made on 01Apr2020 to temporarily suspend further screening Anticipated 237
NCT04009850 Suspended Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior N/A Interventional Temporarily suspended due to COVID-19 pandemic. Anticipated 50
NCT04117607 Terminated Safety and Pharmacokinetics of Rezafungin Phase 1 Interventional Stopped due to the formation of injection site skin nodules. Actual 14
NCT04241159 Withdrawn Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults Early Phase 1 Interventional Protocol required revisions and application was withdrawn from the IRB. Actual 0
NCT02608229 Terminated BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer Phase 1 Interventional Adverse events Actual 18
NCT04399291 Suspended Vitamin D Status and Bone Health of Older Adults in Care Facilities Observational COVID-19, study status being reviewed on an ongoing basis. Anticipated 200
NCT02940457 Withdrawn Cognitive Ability Training for Seniors With Mild Cognitive Impairment N/A Interventional The employe for the study quit and a new grant proposal was not financed Actual 0
NCT03779802 Terminated Prospective Multicentric Study Comparing the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization Therapy Recipients N/A Interventional With the current health situation, we do not anticipate a significant resumption of recruitment for several months. Actual 50
NCT04010448 Suspended A Trial to Assess the Safety, Immunogenicity and Efficacy of a Trivalent Rotavirus P2-VP8 Subunit Vaccine in Prevention of Severe Rotavirus Gastroenteritis in Healthy Infants in Africa and India Phase 3 Interventional temporarily halted due to COVID-19 Anticipated 8200
NCT04248335 Suspended Effect of Obesity on Proton Pump Inhibitors Phase 4 Interventional Suspended due to COVID-19; No suspension of IRB approval Anticipated 150
NCT04307693 Terminated Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19) Phase 2 Interventional Terminated early because no patients were further enrolled since mid-Apr 2020. Actual 65
NCT03354637 Terminated A Study of ATI-50002 Topical Solution for the Treatment of Alopecia Areata Phase 2 Interventional The double-blind primary endpoint was not met. Open Label Extension period halted as a result. Actual 129
NCT02931110 Suspended Study of IV CBL0137 in Previously Treated Hematological Subjects Phase 1 Interventional Business reasons Anticipated 230
NCT03137199 Terminated Allogeneic Human Cells (hMSC) Via Intravenous Delivery in Patients With Mild Asthma Phase 1 Interventional First cohort completed. Per sponsor decision. Actual 3
NCT03479905 Suspended The Use of High Flow Nasal Cannula, Standard Face Mask and Standard Nasal Cannula in Morbidly Obese Patients N/A Interventional COVID-19 policy Anticipated 216
NCT03716466 Suspended Evaluation of Prophylactic Endotracheal Intubation Observational Suspended due to covid-19 policy Anticipated 100
NCT04020042 Suspended Epidural Placement Using Handheld Ultrasound Device vs. Traditional Landmark Palpation N/A Interventional COVID-19 policy Anticipated 300
NCT04247009 Suspended Postprandial Inflammation in Rheumatoid Arthritis N/A Interventional Due to risk for covid-19 spreading, the study was suspended 12 march 2020. Anticipated 80
NCT04328350 Suspended Social Experiences of Adolescents and Young Adults With Cancer Observational Required COVID-19 related change Anticipated 200
NCT04354714 Withdrawn Ruxolitinib to Combat COVID-19 Phase 2 Interventional Could not make FDA required changes Actual 0
NCT03624192 Terminated RES Prepared With RECELL® Compared to Conventional Care for Healing of Donor Sites in Ages 1-16 Years N/A Interventional Study closed in response to COVID-19 and overall program objectives. Actual 3
NCT04093648 Withdrawn T Cells co- Expressing a Second Generation Glypican 3-specific Chimeric Antigen Receptor With Cytokines Interleukin-21 and 15 as Immunotherapy for Patients With Liver Cancer (TEGAR) Phase 1 Interventional The key elements of this study were incorporated into another study. Actual 0
NCT02830438 Terminated Shear Wave Elastography in Native Kidney Disease N/A Interventional Not enough participants recruited Actual 8
NCT00601939 Suspended Effectiveness of Empowerment Group Sessions for Treating Suicidal African American Women in Abusive Relationships N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 397
NCT01490827 Terminated Argus® II Retinal Prosthesis System Post-Market Surveillance Study Observational Sponsor discontinued the Argus II product Actual 52
NCT01574664 Withdrawn Evaluation of RFID Localization System for Marking and Retrieving Breast Lesions Observational Not required to be registered Actual 0
NCT01627301 Suspended Sympathetic Overactivity in Post-traumatic Stress Disorder N/A Interventional The study activities are suspended due to COVID-19 Anticipated 100
NCT01947673 Suspended Mechanisms of Intradialytic Hypertension N/A Interventional Study activities are suspended due to COVID-19 Anticipated 100
NCT02204904 Terminated Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD) Observational Sufficient enrollment for Month 24 safety and efficacy endpoints Actual 59
NCT02411773 Suspended Sympatholysis in Chronic Kidney Disease Phase 2 Interventional Study activities are temporarily suspended due to COVID-19. Anticipated 110
NCT02562092 Suspended The Georgia Latino AIDS/HIV Diagnosis and Linkage in Youth (GLADLY) Project N/A Interventional Enrollment and study visits are temporarily suspended due to COVID-19. Anticipated 112
NCT02624258 Terminated Pilot Study of Non-Viral, RNA-Redirected Autologous T Cells in Patients With Refractory or Relapsed Hodgkin Lymphoma Early Phase 1 Interventional Principal Investigator decision to stop trial Actual 2
NCT02641509 Terminated Accuracy in Resection of Non-pedunculated Colonic Lesions 5-20 mm With/Without Using NBI N/A Interventional Actual 113
NCT02818959 Terminated First in Man Study of the JenaValve TAVI Plus System Transfemoral N/A Interventional Due to inability to recruit sufficient sample size in reasonable time frame. Actual 7
NCT02947750 Suspended Neurovascular Transduction During Exercise in Chronic Kidney Disease Phase 2 Interventional Study activities are temporarily suspended due to COVID-19. Anticipated 150
NCT03074695 Suspended DPE Technique in Labor Epidural for Morbidly Obese Women Phase 4 Interventional COVID 19 Pandemic Anticipated 130
NCT03265249 Suspended BRIDGE Device for Post-operative Pain Control N/A Interventional COVID-19 Restrictions Anticipated 50
NCT03565406 Terminated A Phase 1b Study of the Selective HDAC Inhibitor Mocetinostat in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV Melanoma Phase 1 Interventional recruiting or enrolling participants has halted prematurely and will not resume; participants are no longer being examined or treated Actual 11
NCT03677284 Suspended Managing Time With Dementia: Effects of Time Assistive Products in People With Dementia N/A Interventional Due to the situation of virus Covid-19, recruitment is paused from 7th April. Anticipated 74
NCT03783650 Suspended Boosting Primary Care Awareness and Treatment of Childhood Hypertension N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 64
NCT03805438 Suspended ED90 of 3% Chloroprocaine for Cervical Cerclage Phase 4 Interventional COVID 19 Pandemic Anticipated 40
NCT03890419 Suspended Opioid Sparing Potential of Light-Induced Analgesia N/A Interventional COVID-19 restrictions Anticipated 90
NCT04040751 Suspended Carepartner Collaborative Integrated Therapy in Sub-Acute Stroke N/A Interventional Enrollment is suspended due to COVID-19, prescreening continues for future enrollment. Anticipated 36
NCT04068272 Suspended Safety of Bosentan in Type II Diabetic Patients Phase 1 Interventional Covid 19 general restrictions in Spain - Will eventually be resumed Anticipated 22
NCT04072367 Withdrawn FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial N/A Interventional The study was withdrawn due to a change in company strategy. Actual 0
NCT00900575 Suspended Cervical Cancer Detection Using Optical Spectroscopy N/A Interventional COVID-19 Anticipated 350
NCT02469129 Suspended PET Imaging of PARP Activity in Cancer Early Phase 1 Interventional Suspended due to COVID19 Anticipated 50
NCT02604277 Suspended Suicidal Behavior in Patients Diagnosed With Bipolar Disorder N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 130
NCT02720185 Suspended Window of Opportunity Trial of Dasatinib in Operable Triple Negative Breast Cancers With nEGFR Phase 2 Interventional Recruitment suspended due to COVID-19 Anticipated 19
NCT02788214 Terminated Helicobacter Pylori Genome Project Observational research determined not to be human subject research Actual 821
NCT03078192 Suspended Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging Phase 2 Interventional suspended for this protocol due to the pandemic Anticipated 127
NCT03138564 Suspended An Effectiveness-Implementation Trial of SPIRIT in ESRD N/A Interventional Enrollment is temporarily suspended due to COVID-19. Anticipated 800
NCT03206125 Terminated NCI UNC Project ESCC Observational determined not to be human subjects research Actual 648
NCT03342157 Terminated Docusate/Senna for the Treatment of Diabetic Gastroparesis Phase 2 Interventional low enrollment Actual 2
NCT03342235 Withdrawn Excimer Laser Surgery for Anisometropic Amblyopia N/A Interventional Study not started due to lack of recruitment potential. Actual 0
NCT03367312 Suspended Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI Phase 2 Interventional suspended for this protocol due to the pandemic, Anticipated 12
NCT03415022 Suspended Computer-Based Treatment for Social Anxiety Disorder N/A Interventional Due to COVID19 Pandemic Anticipated 40
NCT03506620 Withdrawn The Role of Nerve Blocks in Hip Arthroscopy Phase 4 Interventional Unforeseen cost restrictions of the drug halted the execution of this study altogether. Actual 0
NCT03533465 Suspended Understanding the Role of Sleep in Complicated Grief N/A Interventional Due to funding limitations Anticipated 10
NCT03574792 Suspended Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy N/A Interventional Temporarily Suspended due to COVID-19 Anticipated 60
NCT03631680 Suspended The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause Observational Temporarily paused due to COVID-19 and expected to resume. Anticipated 10
NCT03650881 Withdrawn The Comparative Efficacy of an Over the Counter Light Therapy Mask vs Over the Counter Topical Benzoyl Peroxide 2.5% and Used in Combination With Over the Counter Adapalene Gel 0.1% for Mild to Moderate Acne N/A Interventional no eligible subjects were enrolled Actual 0
NCT03651869 Suspended Effects of Nicotine in Tobacco Smokers Phase 1 Interventional Study recruitment temporarily suspended due to COVID-19 pandemic. Anticipated 220
NCT03686813 Suspended Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention Phase 2 Interventional Due to COVID-19 pandemic research stoppage Anticipated 20
NCT03742817 Suspended Effects of e-Cigarettes on Perceptions and Behavior N/A Interventional Study recruitment temporarily suspended due to COVID-19 pandemic. Anticipated 40
NCT03751358 Terminated ESP Volunteer LA Spread Controlled by MRI N/A Interventional Problem with MRI interpretation Actual 8
NCT03781388 Suspended ED90 for Hyperbaric Bupivacaine in Super Obese Parturients Phase 4 Interventional COVID 19 Pandemic Anticipated 40
NCT03856268 Suspended Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause Observational Temporarily paused due to COVID-19 and expected to resume. Anticipated 12
NCT03933956 Suspended Metabolic Effects of the SGLT-2 Inhibitor Empagliflozin in Patients With Diabetic Nephropathy (MEDiaN) Phase 3 Interventional The study will be temporarily suspended due to the COVID-19 situation. Anticipated 40
NCT03966144 Withdrawn RoboHear™ Device: Advanced Haptic Technology That Allows the Deaf to Understand Speech N/A Interventional Company discontinued study and closed. No participants were enrolled. Actual 0
NCT04013880 Suspended ASTX727 and FT-2102 in Treating IDH1-Mutated Recurrent/Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia Phase 1/Phase 2 Interventional Paused for COVID 19 Response Anticipated 80
NCT04053452 Suspended Peripheral Nerve Ultrasound for Diagnosis and Prognosis of Guillain-Barre Syndrome N/A Interventional Due to COVID-19 restrictions Anticipated 50
NCT04107181 Suspended Pilot Study for Speculum Free Cervical Cancer Screening N/A Interventional COVID-19 Anticipated 305
NCT04333498 Suspended Use of Antiretroviral (ARV) Drug Levels in Dried Blood Spots (DBS) to Assess and Manage ART Adherence in South Africa N/A Interventional Due to COVID19 Pandemic Anticipated 60
NCT04399031 Suspended Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1 N/A Interventional Study recruitment temporarily suspended due to COVID-19 pandemic. Anticipated 200
NCT04395638 Suspended Replenishing and Maintaining Vitamin D Status in Older Adults in Residential Care Facilities in NI N/A Interventional COVID-19 study status being reviewed on an ongoing basis. Anticipated 40
NCT03588806 Terminated Use of Xtampza ER to Overcome Difficulties in Swallowing Opioid Pills Phase 4 Interventional Study halted permanently and will not resume; participants are no longer being examined or receiving intervention. Actual 11
NCT02687165 Terminated Uncovering Neural and Immune Mechanisms of Chronic Pain in Post Treatment Lyme Syndrome N/A Interventional Slow recruitment due to strict inclusion/exclusion criteria Actual 4
NCT01796470 Terminated Entospletinib in Combination With Idelalisib in Adults With Relapsed or Refractory Hematologic Malignancies Phase 2 Interventional Study was terminated due to safety measures. Actual 66
NCT03610048 Terminated A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD) Phase 3 Interventional Sponsor Decision Actual 175
NCT04066790 Terminated Pyrotinib or Trastuzumab Plus Nab-paclitaxel as Neoadjuvant Therapy in HER2-positive Breast Cancer Phase 2 Interventional We terminated this trial and initiated a new one including pertuzumab. Actual 12
NCT04249596 Suspended Tianeptine for Treatment Resistant Depression Phase 4 Interventional Due to COVID-19 Pandemic Anticipated 75
NCT04396834 Terminated Mechanisms of Lorcaserin for Smoking Cessation Phase 2 Interventional Medication removed from the U.S. market by the The Food and Drug Administration Actual 3
NCT04396847 Terminated Laboratory Screening of Lorcaserin for Alcohol Use Disorder Phase 2 Interventional Medication removed from the U.S. market by the The Food and Drug Administration Actual 5
NCT00903266 Suspended Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia Phase 3 Interventional Covid-19 Pandemie Anticipated 30
NCT02201355 Suspended Hypofractionated Reduced-Volume Chemoradiation for T1/2N0-2 SCC Head and Neck Phase 1 Interventional PI LEFT THE DEPARTMENT Anticipated 60
NCT03104335 Withdrawn Apatinib for Advanced Soft Tissue Sarcoma Patients: a Phase 2, Multicenter Trial Phase 2 Interventional Not enough patients Actual 0
NCT03150420 Terminated A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients Phase 3 Interventional Inability to accrue subjects that met the exclusion criterion "Any prior (within the past 30 days) or current Sodium Thiosulfate treatment". Actual 29
NCT03342300 Withdrawn Pegylated Liposomal Doxorubicin Versus Pirarubicin Plus Ifosfamide, Dacarbazine in Locally Advanced, Unresectable or Metastatic Soft-tissue Sarcoma Phase 2/Phase 3 Interventional No participants enrolled Actual 0
NCT03440008 Suspended Improving the Detection, Classification and Treatment of Misaligned Arthritic Ankles Observational ORD hold on non-treatment participant visits re: COVID19 Anticipated 110
NCT03476642 Suspended Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks Phase 4 Interventional Temporarily suspended due to Pandemic. Anticipated 24
NCT03655119 Suspended PES Family Support and Follow-Up Program N/A Interventional Enrollment and interventions are temporarily paused due to COVID-19 and are expected to resume in the future.This is not a suspension of IRB approval. Actual 229
NCT03694197 Terminated Long Term Safety Study of PRALUENT Phase 4 Interventional The primary objective (to evaluate the long-term safety of Praluent) was adequately evaluated in other studies. Actual 1389
NCT03694548 Suspended Acceptability, Feasibility and Safety of a Yoga Program for Chronic Pain in Sickle Cell Disease N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 20
NCT03788070 Terminated Prevalence of Preoperative Dehydration in Major Elective Urologic Surgery and Its Impact on Postoperative Outcome Observational Due to COVID-19 study inclusion was halted on March 16, 2020 after 309 days. Actual 188
NCT03805711 Terminated HLT Meridian Valve CE Mark Trial N/A Interventional Sponsor decision to stop enrollment. Actual 1
NCT03814382 Terminated Acupuncture to Reduce Anxiety in Alzheimer's Disease (AD) and AD Related Dementias N/A Interventional Termination of study funding Actual 9
NCT04044378 Withdrawn Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced Osteosarcoma Phase 1/Phase 2 Interventional toxicity Actual 0
NCT04139694 Withdrawn Improving Insulin Resistance in Gynecological Cancer Patients N/A Interventional unable to procure supplement for clinical trial use Actual 0
NCT04393831 Suspended A Prospective Trial on Nerve Sparing Techniques Performed in Radical Prostatectomy N/A Interventional Temporarily paused due to COVID-19 and will resume based on guidance of public health authorities. This is not a suspension of IRB approval. Anticipated 112
NCT04394312 Suspended Parent PLAYSHOP: A Physical Literacy Training Workshop for Parents N/A Interventional COVID-19 physical distancing protocols and closures Anticipated 100
NCT04394832 Terminated Reducing Intrusive Memories in Refugees and Asylum Seekers With PTSD: A Pilot Study N/A Interventional Covid-19 Actual 4
NCT04277624 Suspended A Study to Assess Bioequivalence of Fezolinetant Formulations in Healthy Postmenopausal Female Participants Phase 1 Interventional Due to COVID-19. Anticipated 22
NCT01880073 Terminated FemVue and Tubal Patency N/A Interventional Slow recruitment Actual 24
NCT04394962 Suspended Virtual Reality Use in Assisted Reproductive Technology N/A Interventional Due to COVID-19 situation Anticipated 350
NCT00181220 Withdrawn Valproic Acid in the Induction of EBV Lytic Cycle Antigen Expression in Nasopharyngeal Carcinoma Phase 1 Interventional PI left JHU and is not able to be reached for updates Actual 0
NCT00358241 Withdrawn Effects of Nerve Block on Knee Function After Knee Replacement N/A Interventional PI left JHU and is not able to be reached for updates Actual 0
NCT00367718 Withdrawn Trial of VELCADE in Patients With Metastatic or Locally Recurrent Nasopharyngeal Carcinoma Phase 2 Interventional PI left JHU and is not able to be reached for updates Actual 0
NCT01493258 Withdrawn Comprehensive Informatics Framework for Comparative Effectiveness Research (CER) Dissemination N/A Interventional PI left JHU and is not able to be reached for updates Actual 0
NCT02015650 Terminated Cetuximab Compared to Mitomycin-C and 5-Fluorouracil for Locally Advanced Squamous Cell Carcinomas of the Head and Neck Phase 4 Interventional Low Recruitment rate Actual 4
NCT02232568 Terminated Trial of Feedback on Blood Use N/A Interventional Insufficient numbers of participating sites and hip surgery cases. Actual 426
NCT02536170 Suspended Arginine Therapy for Sickle Cell Disease Pain Phase 2 Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 114
NCT02657356 Terminated Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST Phase 3 Interventional Exposure of these high-risk patients to clinic or in-person visits during the pandemic presented an unacceptable risk to their health Actual 202
NCT02658916 Terminated Extension Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PSP) Who Participated in CN002003 Phase 1 Interventional 251PP301(NCT03068468) primary endpoint was not met;further development of Gosuranemab BIIB092 in progressive supranuclear palsy will not be pursued. Actual 47
NCT02993354 Suspended Noninvasive Monitoring of Uterine Electrical Activity and Fetal Heart Rate: A New External Monitoring Device Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 55
NCT03054038 Suspended Afatinib and Necitumumab in Patients With EGFR Mutation Positive Advanced or Metastatic Non-small Cell Lung Cancer Phase 1 Interventional Pause for COVID-19 Response Anticipated 60
NCT03154827 Terminated A Phase Ib/II, Multicenter, Single Arm, Open-Label Study, To Evaluate the Safety, Tolerability and Efficacy of the BL-8040 and Atezolizumab Combination for Maintenance Treatment in Subjects With Acute Myeloid Leukemia Who Are 60 Years or Older - The BATTLE Study Phase 1/Phase 2 Interventional Due to lack of enrollment Actual 1
NCT03394664 Suspended FB4 (Framingham, Boston, Bloomington, Birmingham, and Baylor) N/A Interventional In light of COVID-19, the FB4 trial is indefinitely on hold. Anticipated 125
NCT03662074 Suspended Subsequent Line Gemcitabine and Nivolumab in Treating Participants With Metastatic Small Cell Lung Cancer Phase 2 Interventional Interim analysis per protocol Anticipated 29
NCT03706872 Terminated Efficacy of an App for Monitoring Physical Activity and Weight of Obese Pregnant Women (Pas&Pes) N/A Interventional Women`s confinement for COVID-19 pandemic and changes on prenatal care. Actual 123
NCT04093349 Suspended A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE) Phase 1/Phase 2 Interventional Due to the COVID-19 pandemic, enrollment has been suspended until further notice Anticipated 20
NCT04099056 Suspended Brain Stimulation and Decision-making N/A Interventional Enrollment is temporarily suspended due to COVID-19 Anticipated 100
NCT04116606 Suspended Antidepressant Trial With P2X7 Antagonist JNJ-54175446 Phase 2 Interventional Due to currect Covid-19 pandemic. Anticipated 142
NCT04208698 Terminated A Scintigraphy Study in Adults With Diabetic Gastroparesis Phase 2 Interventional Trial was terminated due to the impact of COVID-19 on trial activities. Actual 2
NCT04261582 Suspended Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD) Observational On hold due to COVID-19 outbreak Anticipated 245
NCT04264637 Suspended Study to Find Out How Long it Takes Azelastine Hydrochloride 0.15% Nasal Spray to Relieve Symptoms in Patients Suffering From Allergic Rhinitis Phase 3 Interventional Covid-19 pandemic Anticipated 80
NCT03309033 Terminated Fifteen-year Immunologic Follow-up of Women Who Received One, Two and Three Doses of the Bivalent HPV Vaccine in the Costa Rica HPV-16/18 Vaccine Trial (CVT): Generating Durability Data: The ESCUDDO-CVT Study Observational NIH is not engaged in human subjects research Actual 869
NCT03204539 Terminated INdividualized ITI Based on Fviii(ATE) Protection by VWF Phase 4 Interventional Termination of funding from sponsor. Actual 1
NCT03781609 Suspended Motor Learning Approach for Manual Wheelchair Users N/A Interventional Temporarily paused due to COVID-19, expected to resume, IRB not suspended. Anticipated 48
NCT03941600 Suspended Feasibility of Exercise and Spinal Cord Injury N/A Interventional Temporarily paused due to COVID-19, expected to resume, IRB not suspended. Anticipated 40
NCT03957057 Suspended Intravenous Iron Carboxymaltose, Isomaltoside and Oral Iron Sulphate for Postpartum Anemia Phase 3 Interventional Covid-19 Anticipated 300
NCT04077879 Suspended Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP1617 in Healthy Adult Non-Asian and Japanese Subjects Including Assessment of a Food Effect Phase 1 Interventional Due to COVID-19 Anticipated 97
NCT04184895 Suspended A Study to Assess the Safety, Tolerability and Immunological Response of ASP2390 in Adult Subjects Allergic to House Dust Mites Phase 1 Interventional Due to COVID-19 Anticipated 28
NCT02479906 Terminated A Safety & Efficacy Study With Deep Transcranial Magnetic Stimulation for the Treatment of Post-Traumatic Stress Disorder (PTSD) N/A Interventional The results did not demonstrate sufficient clinical benefit induced specifically by the active treatment to justify continuation of the trial. Actual 203
NCT03032042 Withdrawn Intestinal Microbiome Post-Azythromycin/Albendazole Treatment Phase 4 Interventional We were not able to secure IRB approval in the timeline necessary to do this study. Actual 0
NCT03040024 Terminated Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) Patients Phase 4 Interventional Halted due to COVID 19; we believe we have adequate data for analysis Actual 93
NCT03435380 Suspended Promoting Breast Cancer Screening in Women Who Survived Childhood Cancer N/A Interventional Covid-19 Anticipated 291
NCT03841357 Suspended Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA) Phase 3 Interventional Covid-19 Pandemic Anticipated 306
NCT04221594 Suspended Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery Observational The study activities are suspended due to COVID Anticipated 108
NCT02642562 Suspended Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN Phase 4 Interventional COVID-19 Pandemic Anticipated 1300
NCT02890368 Terminated Trial of Intratumoral Injections of TTI-621 in Subjects With Relapsed and Refractory Solid Tumors and Mycosis Fungoides Phase 1 Interventional Actual 56
NCT03039686 Terminated Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of RO7239361 in Ambulatory Boys With Duchenne Muscular Dystrophy Phase 2/Phase 3 Interventional A pre-planned futility analysis indicated lack of efficacy Actual 166
NCT03079882 Suspended VisR Ultrasound for Noninvasively Monitoring Renal Allograft Health Observational Suspended due to COVID-19 risks Anticipated 100
NCT03258541 Terminated Organ-sparing With TraceIT® for Rectal Cancer Radiotherapy N/A Interventional Surgical access not facilitated- residues of hydrogel. Actual 2
NCT04391699 Withdrawn Evaluation of Prophylactic Heated Humidification on Obstructive Sleep Apnea (OSA) Patient Short Term Compliance to CPAP Therapy N/A Interventional cancelled before initiation Actual 0
NCT03277742 Withdrawn Joint Management of DM2 and Pulmonary TB in Orizaba, Veracruz N/A Interventional Due to safety reasons. The region was considered too dangerous. Actual 0
NCT03508453 Withdrawn IC14 for Treatment of Amyotrophic Lateral Sclerosis Phase 2 Interventional Study will not be conducted due to lack of funding Actual 0
NCT03617874 Suspended PC4PrEP: Integrating PrEP Into Primary Care N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 219
NCT03691376 Suspended Genetically Engineered Cells (NY-ESO-1 TCR Engineered T Cells and HSCs) After Melphalan Conditioning Regimen in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Phase 1 Interventional Temporarily Suspended due to COVID-19 Anticipated 18
NCT03937999 Suspended Bezlotoxumab as Secondary Prophylaxis for C. Difficile in High-risk Hospitalized Patients Exposed to Antibiotics. Phase 4 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval Anticipated 50
NCT04007315 Suspended SaeboGlove Therapy for Severe Upper Limb Disability and Severe Hand Impairment After Stroke N/A Interventional COVID-19 Anticipated 110
NCT04049578 Terminated A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Balovaptan in Children With Autism Spectrum Disorder Phase 1 Interventional Recent analysis of Phase II balovaptan data in paediatric ASD did not support the continuation of this study. No new safety concerns were identified. Actual 2
NCT04063709 Suspended Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk N/A Interventional Suspended due to COVID-19 risks Anticipated 80
NCT02465034 Suspended Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 75
NCT02682082 Terminated EUS Guided Neurolysis Celiac Block w/wo Bupivacaine in Patient Being Treated Palliatively for Pancreatic Cancer N/A Interventional Closed by CHUM REB for incomplete documentation of research activities. Actual 22
NCT02685332 Suspended Phase I Dose Escalation of Single Fraction Adjuvant Stereotactic Body Partial Breast Irradiation Early Stage Breast CA Phase 1 Interventional Due to COVID-19 Anticipated 75
NCT02694965 Suspended Understanding Immunotherapy Resistance Mechanisms in Advanced Melanoma Observational COVID-19; enrollment will resume when local guidance is updated Anticipated 100
NCT02788019 Terminated Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques? Phase 4 Interventional Unable to complete the sample size needed for 80% power due to changes in surgical approach to adductor block usage. Anticipated 68
NCT02834754 Withdrawn Vedolizumab Post Op Study Phase 2 Interventional Limited time for enrollment of required number of subjects Actual 0
NCT02944578 Suspended Topical Curcumin for Precancer Cervical Lesions Phase 2 Interventional The study activities are on hold due to COVID-19 Anticipated 40
NCT03079297 Suspended Rapid Antidepressant Effects of Leucine Phase 2 Interventional Covid-19 Anticipated 40
NCT03353272 Suspended The Influence of a Cognitive Behavioral Approach on Changing Patient Expectations in Shoulder Pain N/A Interventional COVID-19 institutional policy Actual 33
NCT03433261 Suspended Ketogenic Diet for Reduction of CNS Oxygen Toxicity in Working Divers N/A Interventional Due to COVID-19 temporary suspension of in-person, non-essential research at Duke Anticipated 60
NCT03466398 Withdrawn Effects of a Remote Patient Monitoring Protocol on Glycemic Control in Adolescents With Type 1 Diabetes N/A Interventional Technical limitations encountered with the remote monitoring platform Actual 0
NCT03554278 Suspended Alteration of Stool Microbiota in Preterm Infants With Anemia Observational Covid-19 Anticipated 70
NCT03555981 Terminated Early Kangaroo Mother Care in Gambian Hospitalised Unstable Neonates N/A Interventional In response to COVID pandemic Actual 279
NCT03559634 Suspended Contraception Initiation Feasibility in the Pediatric ED N/A Interventional COVID Anticipated 400
NCT03599206 Suspended ONES Grant: CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability Early Phase 1 Interventional COVID 19 Anticipated 100
NCT03646877 Suspended Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis Phase 1 Interventional COVID 19 Anticipated 70
NCT03647761 Suspended Does Wearing Tetra-Grip Improve Arm Function in Children Diagnosed With Neonatal Brachial Plexus Palsy? N/A Interventional Covid19 Actual 24
NCT03661645 Suspended Post-operative Methylprednisolone Taper Course for Orthopedic Surgery Phase 4 Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 1000
NCT03667781 Suspended Therapeutic Drug Monitoring of Cardiac Medications Observational Covid-19 Anticipated 60
NCT03727893 Suspended Exercise Training and Manual Wheelchair Users With SCI N/A Interventional Temporarily paused due to COVID-19, expected to resume, IRB not suspended. Anticipated 30
NCT03748277 Terminated Comparison of Open and Minimally Invasive Surgical Techniques in the Treatment of Degenerative One-level Stenosis of Lumbar Spine N/A Interventional Recruitment terminated, all follow-up visits were canceled due to quarantine Actual 132
NCT03761498 Suspended Is There a Microbiome Associated With Poor Growth in Preterm Infants? Observational Covid-19 Anticipated 100
NCT03806556 Suspended A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia Phase 1/Phase 2 Interventional Enrollment suspended for COVID-19 related reasons Anticipated 20
NCT03834779 Suspended HIV+ Substance Users Released From Jail N/A Interventional Covid 19 Anticipated 85
NCT03857490 Suspended Heat Therapy in Older Hypertensive Women N/A Interventional Covid-19 Anticipated 200
NCT03924245 Suspended Olaparib and Entinostat in Patients With Recurrent, Platinum-Refractory, Resistant Ovarian, Primary Peritoneal, Fallopian Tube Cancers Phase 1/Phase 2 Interventional Pending site logistics Anticipated 73
NCT03976219 Suspended Measuring Evoked Potentials From the Spinal Cord and Dorsal Root Ganglion N/A Interventional Enrollment and in-person study activity suspended due to COVID-19 Anticipated 30
NCT03981835 Suspended Management of Antiplatelet Regimen During Surgical Procedures Observational [Patient Registry] Covid-19 Anticipated 1492
NCT03989635 Withdrawn Mechanistic Study of Anti-inflammatory Effects of Fevipiprant in Patients With Eosinophilic Asthma. Phase 2 Interventional Company Decision Actual 0
NCT03990740 Withdrawn Myofibroblastic Transformation Secondary to Epithelial-stromal Interactions in the Keratoconus Observational Logistical difficulties : protocol never finalized nor submitted Actual 0
NCT03999879 Suspended PhosphoRus, Proton Imaging and Amyloid BuRdEn (PREPARE) ON AMYLOID BURDEN AND COGNITION Observational Due to COVID 19 Anticipated 45
NCT04038099 Suspended Lessons on Urethral Lidocaine in Urodynamics Phase 4 Interventional Covid-19 Anticipated 70
NCT04061018 Suspended The Genetic, Protein, and Lipid Basis of Variation in Cholesterol Efflux Observational The study is temporarily suspended due to covid-19 policy. Anticipated 180
NCT04067505 Suspended Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study Phase 3 Interventional Adjustment of study protocol. Anticipated 240
NCT04106011 Suspended Cognitive Changes With Gabapentin Treatment Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 42
NCT04138953 Suspended Cortical Contributions to Motor Sequence Learning N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 60
NCT04156399 Terminated Acupuncture for Adults With Sickle Cell Disease (SCD): A Feasibility Study N/A Interventional COVID-19 pandemic Actual 6
NCT04156997 Suspended Extreme Lipids Repository Observational [Patient Registry] The study is temporarily suspended due to covid-19 policy. Anticipated 250
NCT04164732 Suspended Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy Phase 2 Interventional Only recruitment temporarily paused due to COVID-19 Anticipated 44
NCT04226833 Suspended A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function Phase 1 Interventional Recruitment is currently on hold due to COVID-19 pandemic Anticipated 24
NCT04254185 Suspended Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow N/A Interventional Enrollment and interventions are temporarily paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 378
NCT01318590 Terminated Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis Phase 3 Interventional Closed by CHUM REB for incomplete documentation of research activities. Actual 2
NCT04359901 Suspended Sarilumab for Patients With Moderate COVID-19 Disease Phase 2 Interventional Enrollment paused while protocol changes are pending review. Anticipated 120
NCT02026232 Suspended Metabolic Effects of Hydroxychloroquine N/A Interventional COVID-19 Anticipated 30
NCT02122666 Suspended Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome Observational COVID-19 Anticipated 100
NCT02617979 Terminated Improving Mental and Physical Health and Decreasing Hospital Readmission After Pancreatectomy Through Enhanced Patient and Caregiver Education and Engagement N/A Interventional Patients are receiving detailed packet from department and do not feel they need to go online for additional support. Actual 91
NCT03432208 Terminated A Pilot Study to Assess the Value of EUS vs EGD in Emergency Room Patients Referred for EGD N/A Interventional Closed by CHUM REB for lack of documentation related to the recruitment of participants. Actual 2
NCT03492177 Suspended A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension Phase 2 Interventional Screening on hold due to covid-19 measures Anticipated 60
NCT04392336 Suspended Tracking and Improving Trust/Respect N/A Interventional COVID-19 Anticipated 180
NCT03689244 Suspended A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery and/or International Treatment Phase 3 Interventional Screening is temporarily halted due to COVID-19 Anticipated 280
NCT00992303 Suspended Collecting Tissue Samples From Patients With Cancer Undergoing Radiation Therapy Observational Due to CO-VID-19 Anticipated 10000
NCT02762604 Suspended Motor Imagery Intervention for Improving Gait and Cognition in the Elderly N/A Interventional Temporarily paused due to COVID-19. Expected to resume. Not a suspension of IRB Anticipated 48
NCT03540758 Suspended Regulation of Endogenous Glucose Production by Central KATP Channels Phase 2 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 45
NCT03566511 Suspended Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide Phase 2 Interventional Temporarily paused while we develop newer study techniques. We expect to resume; this is not a suspension of IRB approval. Anticipated 30
NCT03608163 Suspended Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) Phase 4 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 45
NCT04160702 Suspended Using VR to Assess the Efficacy of a Motivational Interviewing Intervention to Increase Bystander Behaviors N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 140
NCT04384276 Suspended Weigh Easy: Simplifying Home Weight Monitoring for Infants N/A Interventional suspended due to COVID-19; no suspension of IRB Anticipated 325
NCT01201850 Terminated The Role of Bevacizumab in the Treatment of Radiation Necrosis in Children With Central Nervous System Tumors N/A Interventional Poor accrual Actual 8
NCT01486134 Terminated Major RF Ablations of Hepatomas Under MR Thermometry Monitoring N/A Interventional For technical reasons Actual 15
NCT04388371 Suspended Glutamine PET Imaging in LAM Phase 1 Interventional Due to COVID 19 Pandemic Anticipated 5
NCT01977417 Terminated Inflammation Inhibition in Prediabetic Humans Phase 2 Interventional No funding Actual 21
NCT02002507 Withdrawn Jugular Venous Flow Neurosurgical Patients Observational We faced technical problem before conducting this study Actual 0
NCT02109237 Withdrawn Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3 N/A Interventional no funding Actual 0
NCT03058068 Withdrawn Human MesenchymAl Stem Cells Infusion in Patients With Cystic Fibrosis Phase 1 Interventional PI left the institution Actual 0
NCT03066596 Suspended Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 512
NCT03122912 Suspended Explore Effects of Dietary Fish Oil in Human Skin Phase 1 Interventional Enrollment and interactions/interventions paused due to COVID-19. Expected to resume in the future. This is not a suspension of IRB approval Anticipated 46
NCT03291340 Suspended Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI) Observational Recruitment temporarily suspended due to COVID-19 pandemic. Anticipated 42
NCT03128086 Terminated Weaning From Mechanical Ventilation in Neurological Patients N/A Interventional Because the principal investigator has moved to another hospital Actual 94
NCT03533400 Withdrawn Effectiveness of Jamboxx Respiratory Therapy Device: Study 1 N/A Interventional NHLBI has suggested the company focus on the other two ongoing trials Actual 0
NCT03582384 Withdrawn Use of Tocofersolan (Vedrop®) to Prevent or Treat Refractive Vitamin E Deficiency in Infants and Children Phase 2 Interventional Study never started Actual 0
NCT03361228 Terminated A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of INCB001158 Plus Epacadostat, With or Without Pembrolizumab, in Advanced Solid Tumors Phase 1/Phase 2 Interventional Study was terminated early based on emerging data with epacadostat and pembrolizumab. Actual 5
NCT03722238 Suspended Actual Use and Compliance Study Of Ibuprofen 600 Mg Immediate Release/Extended Release Tablets In At-Risk OTC Consumers Phase 3 Interventional Management decision to temporarily suspend enrollment while the program is reassessed Anticipated 820
NCT03728569 Suspended Skin Barrier Dysfunction and the Role of Skin Barrier Restoration Early Phase 1 Interventional Enrollment and interactions/interventions paused due to COVID-19. Expected to resume in the future. This is not a suspension of IRB approval Anticipated 45
NCT03767491 Withdrawn Waitlist-Control Trial of Smartphone CBT for Obsessive-Compulsive Disorder (OCD) N/A Interventional Study must be registered under the sponsor instead of the site, so we have created a new posting in the sponsor's account. Actual 0
NCT03769350 Withdrawn Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD) N/A Interventional Study must be registered under the sponsor instead of the site, so we have created a new posting in the sponsor's account. Actual 0
NCT03769363 Withdrawn Waitlist-Control Trial of Smartphone CBT for Social Anxiety Disorder (SAD) N/A Interventional Study must be registered under the sponsor instead of the site, so we have created a new posting in the sponsor's account. Actual 0
NCT03861611 Suspended A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain. Phase 4 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 198
NCT04102254 Suspended Thalamic Stimulation for Epilepsy Study N/A Interventional Lead acquisition from company & COVID-19 restrictions Anticipated 15
NCT04106973 Suspended Mesothelioma Early Detection by VOCs Observational Recruitment suspended secondary to social distancing directive associated with Covid-19 Anticipated 300
NCT04203238 Suspended Potato Research for Enhancing Metabolic Outcomes N/A Interventional Due to the SARS CoV2 pandemic Anticipated 36
NCT04244682 Suspended rTMS Brain Stimulation and Cognition N/A Interventional Enrollment is suspended due to COVID-19. Anticipated 80
NCT04252417 Terminated HI Study to Assess and Compare the Pharmacokinetic Parameters of MD1003 in Hepatic Impaired Patients and Healthy Subjects Phase 1 Interventional Due to other Phase 3 trial failure to meet primary endpoint Actual 15
NCT04252430 Terminated RI Study to Assess and Compare the Pharmacokinetic Parameters of MD1003 in Renal Impaired Patients and Healthy Subjects Phase 1 Interventional Due to other phase 3 trial failure to meet primary endpoint Actual 24
NCT04256148 Suspended ALXN1830 in Patients With Warm Autoimmune Hemolytic Anemia Phase 2 Interventional Study is stopped due to the COVID-19 pandemic as WAIHA patients may be at higher risk of contracting disease based on SOC treatments. Anticipated 32
NCT02824848 Terminated Perception-Action Approach vs. Passive Stretching for Infants With Congenital Muscular Torticollis N/A Interventional Study stopped due to COVID-19 pandemic and will not resume. Actual 32
NCT03055585 Terminated Applying Wolbachia to Eliminate Dengue N/A Interventional Distancing and movement restrictions of the COVID-19 emergency response made continuation of clinic-based and field entomological trial activities infeasible Actual 8173
NCT04004845 Suspended Labor Protocol Study Observational Temporarily paused due to COVID19, expected to resume. This is not a suspension of IRB approval Anticipated 740
NCT04266262 Suspended High-Intensity Training for Men With Prostate Cancer on Active Surveillance: A Feasibility Study N/A Interventional All research activities were suspended as a result of COVID-19. Anticipated 36
NCT03247231 Suspended Banding Without Resection in Small Subepithelial Tumours Observational [Patient Registry] Due to SARS-CoV2 (Covid-19) pandemia Anticipated 157
NCT03284346 Terminated Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors N/A Interventional PI left Actual 23
NCT01059513 Withdrawn Hypo-fractionated Stereotactic Body Radiotherapy for Localized Prostate Cancer Observational No participants enrolled Actual 0
NCT01605318 Withdrawn Dose Finding Study of Once or Twice Weekly IMMU-130 in Metastatic Colorectal Cancer Phase 1/Phase 2 Interventional No patients are enrolled in any studies conducted under this IND Actual 0
NCT02645487 Suspended Stereotactic Radiosurgery (SRS) for Brain Metastasis N/A Interventional Failed Audit; it was due to safety concerns after annual DSMC review, specifically safety assessments not being performed per protocol Anticipated 180
NCT02802293 Suspended Treatment of Depression With Connectivity Guided Robotically Delivered rTMS N/A Interventional Study temporarily suspended due to COVID-19 pandemic Anticipated 150
NCT03052517 Terminated Study of Safety of QAW039 in Patients With Asthma Inadequately Controlled on Standard-of-care Asthma Treatment Phase 3 Interventional Company Decision Actual 2541
NCT03171545 Suspended Enhancing the Cardiovascular Safety of Hemodialysis Care (Dialysafe) N/A Interventional Enrollment is temporarily paused due to COVID-19 and is expected to resume in the future. This is not a suspension of IRB approval. Anticipated 2100
NCT03304821 Suspended Granulocyte-Macrophage Stimulating Factor (GM-CSF) in Peripheral Arterial Disease Phase 2 Interventional Enrollment is temporarily suspended due to COVID-19 Anticipated 176
NCT03335878 Suspended Brain Health and Development With T1DM Observational Due to COVID 19. Anticipated 200
NCT03557502 Suspended Heat Therapy Versus Exercise Training in Hypertension N/A Interventional All Clinical Trials at Univ Oregon halted due to COVID-19 pandemic Anticipated 50
NCT03594994 Suspended Metabolic Effects of Sleep Extension in People With Obesity N/A Interventional Suspended due to Covid-19 Anticipated 40
NCT03646669 Suspended Symptom Perception N/A Interventional COVID-19 Anticipated 80
NCT03701828 Suspended Liver Health and Metabolic Function in People With Obesity N/A Interventional Suspended due to Covid-19 Anticipated 30
NCT03764488 Suspended A Study to Evaluate Safety, Tolerability, and Distribution of a Microdose of Radiolabeled BIIB067 (99mTc-MAG3-BIIB067) Co-administered With BIIB067 to Healthy Adults Phase 1 Interventional Healthy volunteer enrollment on hold at site due to COVID-19 pandemic. Anticipated 20
NCT04079855 Suspended Monell USDA Taste Test Study N/A Interventional corona virus Anticipated 128
NCT04259385 Suspended Effects of Sugary Drink Warning Labels on Parent Choices N/A Interventional Coronavirus stay-at-home orders prevent in-person data collection Anticipated 810
NCT04286243 Suspended Prevention of Cervical Cancer Through an HPV-based Screen-and-treat Strategy in Malawi N/A Interventional In response to COVID-19, implementation has been put on hold at sites that had already launched. Anticipated 9200
NCT02052921 Terminated Observation Versus Surgical Resection in Patients With Rectal Cancer Who Achieved Complete Clinical Response After Neoadjuvant Chemoradiotherapy N/A Interventional During the execution time foreseen in the project, the expected number of patients was not reached. Actual 13
NCT02417688 Suspended PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis Phase 1 Interventional temp suspend due to covid Anticipated 22
NCT02567110 Suspended Magnetic Resonance Spectroscopy (MRS) in Midlife Depression Observational Enrollment is temporarily suspended due to COVID-19. Anticipated 145
NCT02741648 Suspended RBC Irradiation, Anemia and Gut Injury Observational Enrollment is temporarily suspended due to COVID-19; follow up for current participants is continuing. Anticipated 220
NCT02784509 Suspended Translational Investigation of Growth and Everyday Routines in Kids Observational Temporary suspension due to COVID-19 stay-at-home order; will resume when clinic re-opens Anticipated 342
NCT02796144 Terminated MEtformin and Lorcaserin for WeighT Loss in Schizophrenia Phase 4 Interventional The FDA advised of a possible health risk associated with lorcaserin and the drug is being withdrawn. Actual 71
NCT02945644 Suspended Trazodone Dose Tolerance and APAP Adherence Phase 1 Interventional COVID19 pandemic Anticipated 45
NCT03176134 Suspended A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to <12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018) Phase 3 Interventional COVID-19 Anticipated 120
NCT03281499 Suspended Transoral Robotic Surgery and Tailored Radiotherapy in Unknown Primary and Small Squamous Cell Head and Neck Cancer N/A Interventional The study accrual is currently on hold until further notice due to the COVID-19 Pandemic. Anticipated 25
NCT03408340 Suspended Paravertebral Nerve Blocks in Neonates Phase 4 Interventional The study activities are suspended due to COVID-19 Anticipated 30
NCT03546335 Suspended Zr-89 Cimzia PET Imaging Rheumatoid Arthritis Phase 1 Interventional Lapse in study funding. Anticipated 10
NCT03660098 Suspended Mirror Box Therapy as a Treatment Option for Functional Movement Disorders Observational Due to COVID-19 virus Actual 14
NCT03840486 Suspended Pre-oxygenation With Real Time End-tidal Oxygen Measurements Versus Single Breath Measurements Phase 4 Interventional Study is temporarily suspended due to COVID-19. Anticipated 116
NCT03951363 Suspended iControl Chronic Kidney Disease N/A Interventional Suspended due to COVID-19 restrictions (funding and in-person visits) Anticipated 40
NCT03975491 Suspended The Exercise And Colon Cancer Treatment Trial N/A Interventional Temporarily suspended due to COVID-19. The study is planned to re-open. Suspension does not relate to withdrawal of IRB approval. Anticipated 60
NCT04096482 Suspended Safety and Effectiveness of the Peregrine Drivable ENT Scope for Endoscopy of the Paranasal Sinuses N/A Interventional Study is temporarily on hold pending updates and supplies from the sponsor. Anticipated 30
NCT04180540 Suspended Comparison of Percutaneous Closure to Manual Compression for Hemostasis N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 130
NCT04246567 Suspended Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant Levels and HIF 1 Levels N/A Interventional Ethics approval is expected from the pharmaceutical institution for the study which has received the local ethics committee approval. Actual 60
NCT04278963 Suspended Yinhu Qingwen Decoction for the Treatment of Mild / Common CoVID-19 Phase 2/Phase 3 Interventional There were no eligible patients in the paticipated centers. Anticipated 300
NCT04310865 Suspended Yinhu Qingwen Granula for the Treatment of Severe CoVID-19 Phase 2/Phase 3 Interventional There were no eligible patients with CoVID-19 in the paticipated centers. Anticipated 116
NCT04382677 Suspended Families Together: Intervention for Reunified Families N/A Interventional COVID-19 social distancing restrictions--temp halt of recruitment & intervention Anticipated 255
NCT02160288 Terminated Effects of Botox in Obstructed Defecation Syndrome Phase 2 Interventional Low recruitment Actual 1
NCT03437512 Suspended Non-invasive Brain Stimulation in Adults Who Stutter N/A Interventional Covid-19 paused human subjects research at study site Anticipated 50
NCT03629964 Withdrawn Study to Develop Head Stabilizer for Use During Brain Radiation Therapy N/A Interventional PI left site. Actual 0
NCT02260141 Terminated Treating Alzheimer's and Dementia With D-ribose N/A Interventional unable to get adequate enrollment Actual 3
NCT02886936 Suspended Immediate Fit Using Innovative Technology Transtibial Prosthesis N/A Interventional COVID 19 is causing us to suspend bringing patients into the hospital for safety reasons. Anticipated 20
NCT02888587 Suspended The Innervation of Human Gut Sensory Epithelial Cells Observational COVID-19 Restrictions Anticipated 50
NCT03081026 Suspended Transphyseal Vs. Physeal Sparing ACL Reconstruction in Skeletally Immature Patients: Risk of Subsequent Lower Extremity Growth Deformity Observational COVID19 Anticipated 100
NCT03179943 Suspended Atezolizumab + Guadecitabine in Patients With Checkpoint Inhibitor Refractory or Resistant Urothelial Carcinoma Phase 2 Interventional Pending Interim Analysis Anticipated 53
NCT03303950 Terminated Busulfan, Fludarabine, Donor Stem Cell Transplant, and Cyclophosphamide in Treating Patients With Multiple Myeloma or Myelofibrosis Phase 2 Interventional Original PI left institution, new PI decided to end study Actual 6
NCT03463395 Withdrawn Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux N/A Interventional Funding for this study has ended and we were unable to enroll any subjects Actual 0
NCT03630601 Suspended Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers N/A Interventional Suspended Temporarily due to COVID-19 Anticipated 90
NCT03650400 Terminated Pharmacokinetics, Safety and Tolerability of Fevipiprant Delivered Via a Once Daily Chewable Tablet in Children Aged 6 to < 12 Years With Asthma Phase 2 Interventional Company Decision Actual 12
NCT03657147 Suspended Improving African American Glaucoma Patient Involvement in Visits and Outcomes N/A Interventional Study halted prematurely due to COVID-19 but potentially will resume. Follow-up visits continue virtually. Anticipated 380
NCT03806192 Suspended Feasibility of Partners in Care Program for Caregivers of Patients With Acute Myeloid Leukemia N/A Interventional COVID19 Suspension Anticipated 40
NCT03881735 Suspended Enasidenib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia With an IDH2 Gene Mutation Phase 2 Interventional Temporarily Suspended due to COVID 19 Anticipated 86
NCT03956238 Suspended Alcohol Myopia, Objectification, and Sexual Assault N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 360
NCT04032717 Suspended Griffithsin-based Rectal Microbicide for PREvention of Viral ENTry (PREVENT) Phase 1 Interventional Due to the COVID-19 pandemic, study has been temporarily halted and will resume in the future Anticipated 21
NCT04037072 Suspended Efficacy of Topical Mitomycin C for Complex Benign Esophageal Anastomotic Strictures Phase 2 Interventional Due to COVID-19 Anticipated 82
NCT04048122 Suspended Feasibility and Effect of a Strategy-Based Cognitive Intervention for Parkinson Disease N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 60
NCT04199585 Terminated Safety and Tolerability of Lu AF95245 in Healthy Young Men Phase 1 Interventional new safety data from another study Actual 18
NCT04203186 Withdrawn A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI) N/A Interventional Funding was lost due to the COVID19 Pandemic Actual 0
NCT04357535 Terminated Prognosis of Coronavirus Disease 2019 (COVID-19) Patients Receiving Receiving Antihypertensives Observational We cannot meet number of subjects as recently published similar studies. Actual 17
NCT01864291 Terminated Auditory Brainstem Implant (ABI) in Pediatric Non-Neurofibromatosis Type 2 Subjects N/A Interventional Closed by IRB Actual 9
NCT04068532 Suspended A Study to Explore Pharmacodynamic Effects of BIIB104 on Brain Circuitry in Healthy Participants Phase 1 Interventional Healthy volunteer enrollment on hold at site due to COVID-19 pandemic. Anticipated 30
NCT04188301 Suspended Safety and Efficacy of IDA for Onchocerciasis Phase 2 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 201
NCT04230681 Suspended Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery Early Phase 1 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 300
NCT04246476 Suspended Sing for Your Saunter Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 60
NCT03519087 Terminated Nonarthritic Hip Disease Evaluation And Treatment N/A Interventional The planned 15-month recruitment period was completed. Actual 112
NCT04258670 Suspended Spontaneous Antigenemia in Loiasis Observational [Patient Registry] Study temporarily paused due to COVID-19 and expected to resume. Anticipated 60
NCT04258774 Suspended The Effect of Respiratory Challenge on the BOLD Signal N/A Interventional Temporarily halted due to COVID-19 Anticipated 48
NCT03637868 Withdrawn Eribulin in Brain Metastases From HER2-negative Breast Cancer Phase 2 Interventional no enrollment Actual 0
NCT03867045 Suspended Development of a Cabozantinib (Cabometyx) Symptom Management Application for Use in Patients With Renal Cancer N/A Interventional Study deemed non-essential under COVID pandemic, Anticipated 9
NCT04021914 Suspended Feasibility of EnChroma Use in the Emergency Department Setting N/A Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 10
NCT04376736 Suspended Home Visits for Patients at Risk for Appointment No-shows N/A Interventional Covid-19 Anticipated 400
NCT02447874 Suspended Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease Phase 1/Phase 2 Interventional Enrollment and study activities are temporarily suspended due to COVID-19. Anticipated 21
NCT02567448 Terminated Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA N/A Interventional Failed to accrue Actual 24
NCT02640209 Terminated Pilot Trial Of Autologous T Cells Engineered To Express Anti-CD19 Chimeric Antigen Receptor (CART19)In Combination With Ibrutinib In Patients With Relapsed Or Refractory CD19+ Chronic Lymphocytic Leukemia (CLL)Or Small Lymphocytic Lymphoma (SLL) Early Phase 1 Interventional Study is terminated due to administrative reasons. Actual 20
NCT02664337 Suspended Conjoint Analysis of Patient Preferences in Joint Interventions N/A Interventional Suspended due to COVID Anticipated 2310
NCT02918175 Suspended Mobile Health Behavioral Intervention in Patients With Heart Failure and Diabetes Mellitus N/A Interventional The study is halted due to COVID-19. Will update once enrollment resumes. Anticipated 200
NCT02978118 Suspended Exploring Relevant Immune-based Biomarkers and Circulating Tumor Cells During Treatment With Immune Checkpoint Inhibitors in Genitourinary Malignancies (CTC Immune Based Biomarkers) Observational study deemed non-essential under COVID-19 pandemic Anticipated 55
NCT03248765 Suspended Human Brain Adaptation to Chronic Pain and Its Effects on Opioid Use Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 60
NCT03253328 Suspended N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes N/A Interventional No one is currently receiving treatment and enrollment is of course on hold. Subjects being unblinded to perform interim analysis. Anticipated 50
NCT03352414 Terminated Trial Investigating Alvimopan for Enhanced Gastrointestinal Recovery After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Phase 2 Interventional stopped by sponsor Actual 58
NCT03399448 Terminated NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T Cells (NYCE T Cells) Phase 1 Interventional Sponsor has terminated trial to pursue other targets. Actual 3
NCT03577119 Suspended Full-fat Yogurt and Glucose Tolerance N/A Interventional Accrual on hold due to temporary pandemic research policy. Anticipated 32
NCT03612193 Suspended Role of the Gut Microbiome in Complex Regional Pain Syndrome Observational Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 140
NCT03670017 Suspended Glucose Time-In-Range Development Evaluation N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 50
NCT03697564 Suspended Nivolumab + Cabiralizumab + Gemcitabine in Patients With Stage IV Pancreatic Cancer Achieving Disease Control in Response to First-line Chemotherapy (GemCaN Trial). Phase 2 Interventional Working on getting accurate information for patients interested in the study. Anticipated 40
NCT03794258 Withdrawn Triple or Quadruple Combination DAAs Treatment for Subjects With HCV GT 1b Infection Phase 2 Interventional Can not recruit the patients due to the pandemic of COVID-19 Actual 0
NCT03881137 Suspended Improved Function and Quality of Life for Older Patients Receiving Radiotherapy, Part II N/A Interventional Enrolment stop 13.03.20 due to Corona pandemic. Continued suspension decided 28.04. Reopening estimated 01.10.20 Anticipated 162
NCT03926611 Suspended Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequately Controlled by H1-antihistamines Phase 2 Interventional COVID-19 Pandemic Anticipated 308
NCT03940651 Suspended Cardiac and Renal Biomarkers in Arthroplasty Surgery Phase 4 Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 140
NCT04006496 Suspended AML Expressive Writing N/A Interventional COVID-19 restrictions Anticipated 30
NCT04020887 Suspended Telemedicine Control Tower for the Post-Anesthesia Care Unit N/A Interventional Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. Anticipated 500
NCT04157179 Suspended Cerebral Oxygen Metabolism in Children N/A Interventional Temporarily halted due to COVID-19 Anticipated 350
NCT03382899 Terminated Study of Pegilodecakin (LY3500518) With Pembrolizumab Compared to Pembrolizumab Alone First-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer Phase 2 Interventional The CYPRESS-1 trial was closed early after the planned final analysis because the risk benefit ratio is unfavorable. Actual 99
NCT03382912 Terminated Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer Phase 2 Interventional The CYPRESS-2 trial was closed early after the planned final analysis because the risk benefit ratio is unfavorable. Actual 52
NCT03532490 Suspended Trial of Roflumilast in Asthma Management (TRIM) Phase 2 Interventional Suspended due to COVID-19 public health emergency. Anticipated 38
NCT03634397 Suspended Predicting Ipsilesional Motor Deficits in Stroke With Dynamic Dominance Model N/A Interventional Temporarily suspended due to Pandemic Actual 60
NCT03745781 Terminated Open-Label Placebo for Functional Dyspepsia Early Phase 1 Interventional low enrollment Actual 21
NCT03908827 Withdrawn BMAC in Severe Hip or Knee Osteoarthritis Awaiting Arthroplasty Phase 2/Phase 3 Interventional Change of study design Actual 0
NCT03938103 Suspended Evaluation of an Enhanced Delivery Model for Go NAPSACC N/A Interventional Temporarily halted as a precautionary measure due to COVID-19 pandemic. Anticipated 1189
NCT04129398 Suspended MK-8228 (Letermovir) in the Prevention of Human Cytomegalovirus (CMV) Infection and Disease in Adult Japanese Kidney Transplant Recipients (MK-8228-042) Phase 3 Interventional COVID-19 Anticipated 20
NCT04130295 Suspended Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injury N/A Interventional Covid-19 Anticipated 12
NCT04149600 Suspended Identification of Genetic Causes of Calcific Aortic Valve Disease Observational Enrollment and other trial activities have temporarily paused due to COVID-19 and are expected to resume in the future; This is not a suspension of IRB approval Anticipated 1000
NCT04203147 Suspended Home-based Diabetes-Modified Behavioral Activation Treatment for Low Income Seniors With T2DM N/A Interventional Due to COVID-19, a partial suspension of human subjects research was put into effect for research involving direct contact with human subjects. Anticipated 300
NCT04243811 Withdrawn Efficacy of Low Level Laser Therapy on İnjection Pain N/A Interventional Due to the technical problem in the laser device,it has not started. Actual 0
NCT04341870 Suspended Study of Immune Modulatory Drugs and Other Treatments in COVID-19 Patients: Sarilumab, Azithromycin, Hydroxychloroquine Trial - CORIMUNO-19 - VIRO Phase 2/Phase 3 Interventional DSMB recommendation (futility) Actual 27
NCT03454360 Terminated CHANGE Neo™ TA Registry With ACURATE Neo™ Aortic Bioprosthesis and ACURATE Neo™ TA Transapical Delivery System Observational Sponsor business decision unrelated to product safety or efficacy. Actual 106
NCT04063241 Suspended Parent Understanding of Discharge Instructions N/A Interventional Study suspended due to Covid-19 Anticipated 778
NCT04375189 Suspended High Risk Outpatient Intern-led Care (HeROIC) Clinic Initiative