Clinical trials stopped by Covid-19

Benjamin Gregory Carlisle PhD

Charité – Universitätsmedizin Berlin, Germany
Berliner Institut für Gesundheitsforschung (BIG) / Berlin Institute of Health (BIH)
QUEST – Quality | Ethics | Open Science | Translation

The Covid-19 outbreak that became a global pandemic in 2020 has disrupted lives, families, industries and entire nations. This project is a weekly-updated "living paper" that aims to quantify some of the effects of Covid-19 on the enterprise of human research.

The following table contains all registry entries from ClinicalTrials.gov whose overall status changed to Terminated, Suspended or Withdrawn since 2019-12-01. Investigator-provided reasons that explicitly mention Covid-19 are highlighted in green. Click a row of the table for more details about the trial.

To date, 2043 clinical trials have been stopped for reasons that explicitly cite Covid-19.

These data and figures are available to be downloaded under a Creative Commons By-Attribution Non-Commercial license. This data set was last updated 2021-01-29.

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Covid-19 arm per-trial data set TSV
Comparator arm per-trial data set TSV
Drugs and biologics in stopped trials TSV
NCT ID Overall status Brief title Phase Study type Why stopped Enrollment
NCT04729088 Withdrawn Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy Subjects Phase 1 Interventional The sponsor will no longer develop the experimental drug. Actual 0
NCT00520624 Withdrawn Treatment of Exercise-induced Laryngomalacia in Elite Athletes N/A Interventional No patients willing to join Actual 0
NCT03055312 Terminated Bicalutamide in Treatment of Androgen Receptor (AR) Positive Metastatic Triple Negative Breast Cancer Phase 3 Interventional Actual 36
NCT03260465 Suspended Clinical Study With the seleXys PC and the RM Pressfit Vitamys Cup N/A Interventional The study has been transferred to the University Hospital Basel; 18.12.2020 (Prof. Karl Stoffel, Principal Investigator; Ilona Ahlborn, Study Coordinator) Anticipated 60
NCT03540147 Terminated The Impact of Blood Flow Restriction (BFR) on Exercise and Hemodynamic Responses N/A Interventional The number of subjects in this study was overestimated in the initial assessment. Actual 20
NCT03540225 Withdrawn Vaginal Progesterone for the Prevention of Preterm Birth in Twins Phase 3 Interventional Fail to sort out the logistics of study drugs due to funding problems Actual 0
NCT04035317 Withdrawn Aesculus Hippocastanum L. on Fontan Circulation Phase 2 Interventional The graduate student quit. Actual 0
NCT04037631 Terminated Compare Visual Outcomes Using a New Diagnostic Device Observational recruitment Actual 24
NCT04139837 Suspended Frailty in Daily Practice: Screening, Consultation and Education Activities Observational COVID 19 pandemic Anticipated 15000
NCT04160429 Suspended Biospecimen Analysis in Detecting Chemical Concentrations in Patients With Chronic or Infectious Diseases Receiving Meditations Observational pending amendment approval Anticipated 100
NCT04165733 Suspended Professional Quality of Life in German Psychiatrists Observational Recruitment was suspended with the begin of the COVID-19 pandemic as this potentially has an incluence on our outcomes Anticipated 100
NCT04200300 Suspended Professional Quality of Life in German Mental Health Nursing Observational Recruitment was stopped with the begin of the COVID-19 pandemic as this potentially has an incluence on our outcomes Anticipated 100
NCT04216056 Suspended Evaluation of a Frailty Intervention Program in Hong Kong N/A Interventional COVID 19 pandemic Anticipated 152
NCT03773185 Suspended A Comparative Study of Brain Structure and Amyloid Load in MCI Patients Observational [Patient Registry] Low recruitment rate Anticipated 60
NCT03831594 Withdrawn Combining Physical Therapy With Vestibular Stimulation to Improve Postural Stability in Pusher's Syndrome N/A Interventional We were unable to recruit any suitable patients to this study Actual 0
NCT03909750 Suspended Use of Autologous Stem/Stromal Cells In Chronic Lung Disorders: Obstructive (COPD) & Restrictive (RLD) Phase 1 Interventional Withdrawn [COVID restrictions prevent patient enrollment or treatment. Clinical Trial facility is being closed due to viral limitations and loss of staff to perform] Anticipated 50
NCT04000750 Suspended Time-Restricted Eating and Muscle Hypertrophy N/A Interventional COVID-19 Anticipated 40
NCT04030910 Suspended 'LIFEView' Audiovisual Technology: Virtual Travel to Support Wellbeing and Quality of Life at the End of Life N/A Interventional Study on hold due to COVID-19 research restrictions for in-person research Anticipated 92
NCT04043468 Withdrawn Audit and Feedback Interventions With Primary Care Nursing Teams N/A Interventional COVID-19 Actual 0
NCT04156672 Withdrawn Real World Study Of The Clinical Profile And Treatment Outcomes Of Advanced Therapies For Ulcerative Colitis In Portugal Observational Study was cancelled due to reclassification of study design. No subjects enrolled in the study. Actual 0
NCT04288076 Withdrawn The Brain and Lung Interaction (BALI) Study N/A Interventional Low eligibility rate Actual 0
NCT04605926 Withdrawn A Study to Evaluate the Efficacy and Safety of Itolizumab in Subjects Hospitalized With COVID-19 Phase 3 Interventional Sponsor has currently elected to withhold study initiation Actual 0
NCT04613271 Suspended Efficacy and Safety of Favipiravir in Covid-19 Patients in Indonesia Phase 3 Interventional Study halted prematurely but potentially will resume, the protocol will be amended Anticipated 210
NCT02013167 Terminated Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) Phase 3 Interventional Actual 405
NCT02830724 Suspended Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers Phase 1/Phase 2 Interventional Requested by IRB Actual 2
NCT03190941 Suspended Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients Phase 1/Phase 2 Interventional Requested by IRB Actual 6
NCT03238157 Suspended Steroids for Early Treatment of Radiation Retinopathy Phase 2/Phase 3 Interventional Lack of funding Anticipated 90
NCT03959046 Suspended GIST in Hematopoietic Stem Cell Transplantation/Bone Marrow Transplantation N/A Interventional Temporarily paused due to COVID-19 and will resume based on guidance of public health authorities. This is not a suspension of IRB approval. Anticipated 133
NCT03745326 Suspended Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients Phase 1/Phase 2 Interventional Requested by IRB Actual 4
NCT04102436 Suspended Non-Viral TCR Gene Therapy Phase 2 Interventional Requested by IRB Anticipated 210
NCT04169360 Withdrawn Safety and Preliminary Efficacy of ANS-6637 to Reduce Drug Craving and Harm in People With Opioid Use Disorder Phase 2 Interventional The FDA determined that there is not adequate safety information to continue clinical investigations using ANS-6637 and Amygdala Neurosciences, the product company of ANS-6637, is no longer pursuing research with this compound. Actual 0
NCT04308954 Terminated Neuroimaging GABA Physiology in Fragile X Syndrome Phase 1 Interventional Difficulty with patient recruitment due to COVID-19 pandemic Actual 17
NCT04534140 Withdrawn Skin Hydration in Persons With Acne After Dietary Supplementation With Botanical Antioxidants N/A Interventional Contract not negotiated. Actual 0
NCT01442402 Terminated APOL1 Gene Variants in African American Kidney Transplant Recipients Observational Lack of funding/resources Actual 39
NCT02470533 Terminated Transarterial Chemoembolization Versus Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Phase 2 Interventional Low accrual Anticipated 100
NCT02939859 Suspended Use of Cellular Stromal Vascular Fraction in Multiple Sclerosis,Autoimmune, Inflammatory, Neurologic Conditions N/A Interventional Withdrawn [COVID restrictions prevent patient enrollment or treatment. Clinical Trial facility is being closed due to viral limitations and loss of staff to perform] Anticipated 100
NCT03088774 Withdrawn Comparing Satisfaction With a Participatory Driven Web-application and a Standard Website N/A Interventional The primary trial was stopped. Since, a feasibility study showed that recruitment was not feasible. We obtain a recruitment rate of 15 %. Actual 0
NCT03093948 Terminated Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest N/A Interventional Overlap with other RCT Actual 58
NCT03215355 Withdrawn Improving CBCT for Liver IG-SBRT Using Gadoxetate Disodium Phase 4 Interventional Not approved Actual 0
NCT03461419 Suspended Use of Stromal Vascular Fraction in Multiple Sclerosis N/A Interventional Withdrawn [COVID restrictions prevent patient enrollment or treatment. Clinical Trial facility is being closed due to viral limitations and loss of staff to perform] Anticipated 100
NCT04673175 Suspended Ceftolozane-Tazobactam for Directed Treatment of Pseudomonas Aeruginosa Bacteremia and Pneumonia in Patients With Hematological Malignancies and Hematopoietic Stem Cell Transplantation Phase 1/Phase 2 Interventional Voluntary global product recall of Zerbaxa (ceftolozane and tazobactam) for injection (1.5g). Anticipated 20
NCT03512405 Suspended Pembrolizumab and Blinatumomab in Treating Participants With Recurrent or Refractory Acute Lymphoblastic Leukemia Phase 1/Phase 2 Interventional pending intrim analysis Anticipated 36
NCT04536857 Suspended Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA) Observational [Patient Registry] The study has not been funded so far, but we will study it in the future. Anticipated 302
NCT01757223 Withdrawn Administration of AdVEGF-All6A+ to Myocardium of Individuals With Diffuse CAD Via Minimally Invasive Surgery Phase 1/Phase 2 Interventional Closure due to lack of funding. Actual 0
NCT02021734 Suspended Genetics of Mendelian Diseases in Qatar Observational Temporarily paused due to COVID-19 and will resume based on guidance of public health authorities. This is not a suspension of IRB approval. Anticipated 400
NCT00068003 Suspended Harvesting Cells for Experimental Cancer Treatments Observational Actual 2109
NCT02133196 Suspended T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer Phase 2 Interventional Actual 3
NCT02621021 Suspended A Prospective Randomized and Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab Phase 2 Interventional Actual 20
NCT03895359 Withdrawn Transarterial Chemoembolization (TACE) Versus TACE Plus Stereotactic Body Radiation Therapy (SBRT) in Liver Carcinoma Phase 3 Interventional Erroneously entered in ClinicalTrials.gov. Replacement submission has been approved. Actual 0
NCT04436120 Terminated Treatment Resistance Following Anti-cancer Therapies N/A Interventional COVID-19 pandemic related enrollment pause Actual 37
NCT04664543 Terminated Efficacy of Free Versus Low Residue Diet as Preparation for Screening Colonoscopy N/A Interventional Organization and logistic problems due to COVID19 pandemy Actual 100
NCT00578396 Withdrawn Phase I Biomarker Study of Dietary Grape-derived Low Dose Resveratrol for Colon Cancer Prevention Phase 1 Interventional Non applicable clinical trial Actual 0
NCT00579358 Withdrawn Molecular Basis of Congenital Heart Defects Observational Nonapplicable clinical trial Actual 0
NCT00580099 Withdrawn Assisted Exercise in Prematurity; Effects and Mechanisms N/A Interventional Non applicable clinical trial Actual 0
NCT00580697 Withdrawn Prevalence of Lower Urinary Tract Symptoms in Women With Gynecologic Malignancy Planning to Undergo Surgical Management Observational Nonapplicable clinical trial Actual 0
NCT00580918 Withdrawn Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients Observational Nonapplicable clinical trial Actual 0
NCT00585403 Withdrawn Exercise Changes to Peripheral Blood Mononuclear Cells in Children Observational Nonapplicable clinical trial Actual 0
NCT00703443 Withdrawn The Genetics of Cardiomyopathy and Heart Failure Observational Non applicable clinical trial Actual 0
NCT00824395 Withdrawn The Genetics of Diabetes in Southern California Chinese Americans Observational Non applicable clinical trial Actual 0
NCT00894491 Withdrawn Complementary and Alternative Medical Trends: A Patient Survey in a University Based Clinic Observational Nonapplicable clinical trial Actual 0
NCT01386190 Withdrawn Impact of Exercise on Body Composition in Premature Infants N/A Interventional Non applicable clinical trial Actual 0
NCT04723173 Suspended Quality Control of CE-Certified Phonak Hearing Aids - 2020_43 N/A Interventional Corona Anticipated 11
NCT01543802 Terminated Study of Preoperative Therapy With Pazopanib (Votrient®) to Treat High-risk Soft Tissue Sarcoma Phase 2 Interventional slow recruitment Actual 21
NCT02510911 Terminated Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy? N/A Interventional lack of effect at interims analysis Actual 60
NCT02614157 Terminated Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal Cancer N/A Interventional we can not recruit enough patients Actual 51
NCT03051035 Terminated First-in-Human Study of KO-947 in Non-Hematological Malignancies Phase 1 Interventional Due to a strategic business decision Kura has stopped development of KO-947. Neither safety nor efficacy reasons were the cause of study termination. Actual 62
NCT03221842 Terminated Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients Phase 3 Interventional The study was terminated early due to a business decision and not for safety reasons. Actual 63
NCT03684889 Suspended CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma Phase 1/Phase 2 Interventional Study halted pending review of safety event Anticipated 112
NCT04245696 Suspended Bipolar RF Microneedling for Improved Laxity and Lift of the Submental and Neck Tissue and Effect on Elastin N/A Interventional Study on hold, enrollment suspended at this time Anticipated 60
NCT04313465 Withdrawn T-MACS Decision Aid: a Randomized, Controlled Point of Care Trial N/A Interventional CI no longer wishes to complete this study due to Covid-19 Actual 0
NCT00581152 Withdrawn The Role of TBX3 in Human ES Cell Differentiation Observational IRB suspension Actual 0
NCT02664571 Withdrawn Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis N/A Interventional experimental drug prohibited by the ANSM (French competent authority) Actual 0
NCT02844582 Terminated Cabazitaxel and Prednisone in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Phase 2 Interventional Poor accrual of subjects onto study Actual 2
NCT02970435 Terminated Evaluating the Impact of Video Discharge Instructions for Mohs Surgery Post-Operative Care N/A Interventional Slow accrual Actual 14
NCT03247244 Terminated Safety and Efficacy of Cannabis in Tourette Syndrome Phase 2 Interventional Recruitment/enrollment took too long Actual 15
NCT03739476 Terminated Clinical Trial With Quetiapine Prophylaxis Postoperative Delirium in High Risk Surgical Patients Phase 3 Interventional Due to the crisis SARS-COV-2 pandemic: recruitment of patients for the trial is stopped, healthcare pressure generated, suspend the non-essential scheduled surgical activity and on June 30, 2020 medication expired, funding has been exhausted. Actual 50
NCT03879824 Terminated Radial Versus Femoral Secondary Access During TAVI N/A Interventional The PI and co-investigators would like to terminate the study given challenges with patient enrollment. Actual 15
NCT03901378 Withdrawn Pembrolizumab With Chemotherapy in Metastatic or Unresectable High Grade Gastroenteropancreatic or Lung Neuroendocrine Carcinoma Phase 2 Interventional Lack of accrual Actual 0
NCT04002622 Terminated Study of TQB2450 Injection in Subjects With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma Phase 2 Interventional The population of target indication is small and screening is difficult. Actual 1
NCT04052269 Suspended Phosphodiesterase Inhibitors in Glaucoma Study (PhiGS) Phase 3 Interventional suspended due to COVID Anticipated 30
NCT04124510 Terminated Efficacy and Safety of Flutiform K-haler in Patients With Uncontrolled Asthma Following Mid-dose ICS/LABA DPI Therapy Phase 3 Interventional The Contract of K-haler products had been terminated between Mundipharma and provider. Therefore, this clinical trial was terminated early. Actual 20
NCT04181632 Suspended Evaluation of Pain Alleviating Strategies During Allergy Shots N/A Interventional Due to the pandemic, enrollment was halted and patients were not coming to clinic. 40 of 100 patients were randomized. Anticipated 100
NCT04299802 Withdrawn Percutaneous Ultrasonic Tenotomy Versus Platelet Rich Plasma for Gluteal Tendinopathy N/A Interventional Study not being pursued Actual 0
NCT04369001 Withdrawn Program ACTIVE: Phase 2 N/A Interventional Due to covid-19 and social distancing, this study was terminated. Actual 0
NCT03910439 Terminated Avelumab in Combination With Hypofractionated Radiotherapy in Patients With Relapsed Refractory Multiple Myeloma Phase 2 Interventional Slow/Insufficient accrual. Actual 4
NCT04456088 Withdrawn Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (CANADA Trial) Phase 2 Interventional Terminated (halted prematurely) Actual 0
NCT04724512 Suspended Randomised Controlled Trial to Compare Tissue Reactions and Scarring With Polypropylene vs Polyglactin 910 Sutures in Periocular Skin: SUSY Study (SUture StudY) Phase 4 Interventional setup activities were suspended due to COVID Anticipated 44
NCT00738777 Suspended Pre-operative Hormonal Treatment for Hormone Receptor Positive Breast Cancer Phase 2 Interventional in preparation for an amendment Anticipated 250
NCT03284203 Terminated Feasibility of SpiroPD N/A Interventional The aims represented in this study are also included in another, larger study of at-home COPD care. There was insufficient research team support to complete both protocols and the work would have been duplicative. Thus, we have terminated this study. Actual 15
NCT03394196 Terminated RESIST-2: 2nd-line ART for HIV-2 Infection N/A Interventional COVID-19 and Funding Actual 152
NCT03149679 Terminated The p53 Colorectal Cancer Trial Phase 2 Interventional The study was discontinued after the first pre-planned interim analysis due to insufficient response rates. Actual 12
NCT03405142 Suspended Panitumumab-IRDye800 Compared to Sentinel Node Biopsy and (Selective) Neck Dissection in Identifying Metastatic Lymph Nodes in Patients With Head&Neck Cancer Phase 2 Interventional Business decision Anticipated 20
NCT03617146 Terminated Coaching and Education for Diabetes Distress N/A Interventional Recruitment challenges. Actual 19
NCT03630120 Terminated Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer Phase 2 Interventional Lack of efficacy Actual 6
NCT03944369 Terminated VITORA: Clinical Study to Evaluate the Effect of KB109 on the Gut Microbiome in Subjects Whose Gastrointestinal Tracts Are Colonized With Multiple Drug-resistant Organisms N/A Interventional COVID-19 pandemic Actual 3
NCT03951662 Withdrawn Immunology of HIV and Alcoholic Hepatitis Observational Funding ended Actual 0
NCT03977675 Terminated The Role of HNKs in the Antidepressant Effect of Ketamine Phase 1 Interventional PI left the institution Actual 8
NCT04112017 Terminated A Study of YVOIRE Y-Solution 360 for Hand Augmentation to Correct Volume Loss N/A Interventional Sponsor's decision Actual 116
NCT04142359 Terminated PK Sub-Study of QUILT-3.032 (CA ALT-803-01-16) and of QUILT-2.005 (CA ALT-803-01-14) Observational Study was closed due to the recent pandemic and enrollment challenges. Actual 1
NCT04184037 Terminated iMeditate at Home for Older Adults With Mild Cognitive Impairment and Caregivers N/A Interventional Study recruitment was suspended due to interruption of in-person testing after the start of the COVID19 pandemic in March 2020. The current study's protocol is being revised to be delivered fully remotely. Actual 9
NCT04721171 Suspended Effectiveness of Electrical Neurostimulation in Cyclic Vomiting Syndrome. N/A Interventional Due to COVID-19 Actual 3
NCT02520557 Terminated An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Observational The study was not terminated for safety reasons. The sponsor was released from the postmarketing requirement to conduct the study Actual 121
NCT02602210 Terminated Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis Phase 3 Interventional low inclusion rate Actual 100
NCT02807753 Terminated The Hemophilia Ultrasound Project Observational Sponsor funding ended Actual 18
NCT02899650 Terminated Rates of Recovery From Strenuous Exercise in Physically Active Older Adults N/A Interventional This was a research project that was conducted by a visiting scholar and his time for departure came earlier than the study completion. Actual 60
NCT03433755 Terminated Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia Phase 3 Interventional Prematurely Discontinued Amgen decision Amgen Decision Actual 259
NCT03573336 Terminated Assess Safety and Efficacy of Vilaprisan in Subjects With Endometriosis Phase 2 Interventional Due to a change in the development program, the study was closed prematurely. Actual 8
NCT03646916 Withdrawn Intraoperative Dexamethasone and Its Effect on Hyperglycemia Phase 4 Interventional Lack of patients Actual 0
NCT03684668 Terminated Psychoeduc Interv. Through Meta-universes on Condom's Use Self - Efficacy and Sexual Behavior in Students of UAChile N/A Interventional Data collection could not be completed in time and it has not been possible to continue due to the pandemic. Since it is not yet known when the face-to-face classes will resume, we moved on to the data analysis phase with the existing data. Actual 90
NCT03976557 Terminated BIP CVC in Access Center at Danderyd Hospital, Stockholm, Sweden N/A Interventional Due to Corona/Covid19 pandemic Actual 19
NCT04028921 Withdrawn Activity, Adiposity, and Appetite in Adolescents 2 Observational Study Withdrawn Actual 0
NCT04493203 Suspended Nivolumab Plus Axitinib in Patients With Anti-PD1 Refractory Advanced Melanoma Phase 2 Interventional Study to resume after FDA review Anticipated 31
NCT04720742 Suspended Immune Therapy and Analytical Treatment Interruption in HIV+ Participants Who Received an Allogeneic Stem Cell Transplantation Phase 2 Interventional Due to the COVID-19 pandemic the financial sponsor of the trial suspended the study funding due to funding limitations and based on various considerations, including the uncertainties of conducting the study in the volatile scenario of this pandemic. Anticipated 5
NCT00144443 Terminated Kansas City Community Environmental Remediation And Training (KC CERT) N/A Interventional Not completed 200
NCT02684617 Terminated Study of Pembrolizumab (MK-3475) in Combination With Dinaciclib (MK-7965) in Hematologic Malignancies (MK-3475-155) Phase 1 Interventional Business Reasons Actual 75
NCT01794572 Terminated Phase 1-2 Study of Total Bone Marrow Irradiation With Helicoidal Tomotherapy in 1st Myeloma Relapse Phase 1/Phase 2 Interventional Low patient recruitement rate and modification of the therapeutic standard Actual 13
NCT03299231 Suspended Oscillating Positive Expiratory Pressure Devices and Acute Exacerbation of Chronic Obstructive Pulmonary Disease N/A Interventional COVID 19 consequences Anticipated 160
NCT03718325 Suspended Burst Spinal Cord Stimulation (Burst-SCS) Study N/A Interventional Enrollment and interactions/interventions are temporarily paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 20
NCT04115644 Suspended Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial Phase 4 Interventional Covid-19 and we failed to submit annual report for 2017 and 2018 Anticipated 400
NCT04197453 Terminated The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS) Observational [Patient Registry] Business decision Actual 752
NCT04473521 Withdrawn A Clinical Study to Assess Force Required to Dislodge Upper Denture With and Without Use of a Novel Denture Adhesive Phase 3 Interventional Study objectives no longer met business need Actual 0
NCT04653168 Suspended A Study of LY3041658 in Healthy Participants Phase 1 Interventional Enrollment on hold due to COVID-19 pandemic. Anticipated 16
NCT02485652 Terminated Phase II Trial of HM61713 for the Treatment of ≥2nd Line T790M Mutation Positive Adenocarcinoma of the Lung Phase 2 Interventional Study termination by the Sponsor Actual 162
NCT03228654 Terminated Electrosurgical Unipolar Vessel Sealing in Vaginal Hysterectomy Phase 4 Interventional No available device in the hospital to complete study Actual 10
NCT03270722 Withdrawn Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing N/A Interventional We did not enroll any patients for logistic reasons. Actual 0
NCT02309515 Terminated Lenalidomide in Improving Immune Response to Vaccine Therapy in Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Monoclonal B Cell Lymphocytosis Phase 2 Interventional Slow Accrual Actual 12
NCT02505204 Suspended PVB With vs. Without Clonidine for Ventral Hernia Repair N/A Interventional Anticipated 60
NCT02292121 Terminated Intestinal Permeability in Obesity N/A Interventional lack of surgical controls Actual 80
NCT02523768 Terminated Prevention in Recipients With Primary IgA Nephropathy of Recurrence After Kidney Transplantation: ATG-F Versus Basiliximab as Induction Immunosuppressive Treatment Phase 4 Interventional Difficulties for recruting patients Actual 117
NCT02667717 Terminated Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy N/A Interventional difficulties in including patients Actual 34
NCT02866916 Withdrawn Study of SXL01 in Patients With Metastatic Castration-Resistant Prostate Cancer (PROSTIRNA) Phase 1 Interventional Study cancelled Actual 0
NCT02911220 Terminated Genetic Study of Familial Forms of Non-atopic Asthma N/A Interventional not enough available families to get significant genetic results Actual 2
NCT03547063 Suspended Responses to Appetite and Taste in the Brain Circuits That Control Eating Behaviour Observational COVID-19 Anticipated 75
NCT03806335 Suspended The Effectiveness of Local Infiltration Technique in Adult Tonsillectomy N/A Interventional Lack of patients Anticipated 60
NCT04243694 Withdrawn Sustainable Mindfulness and Resilience Training (SMART) N/A Interventional Reduction in funding. Actual 0
NCT03359174 Terminated An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing Cholangitis Phase 2 Interventional low recruitment Actual 2
NCT03707418 Withdrawn Bivalirudin vs Heparin in ECMO Patients Phase 1 Interventional unable to secure funding Actual 0
NCT03751423 Suspended Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion Phase 3 Interventional Study on-hold due to COVID-19 pandemic restrictions. Will resume when possible. Anticipated 123
NCT03809663 Terminated A Dose Ranging Placebo-Controlled Double-Blind Study to Evaluate the Safety and Efficacy of Tezepelumab in Atopic Dermatitis Phase 2 Interventional Tezepelumab as a monotherapy in atopic dermatitis did not reach the targeted efficacy level pre-established for this patient population. Actual 251
NCT03861182 Terminated Contribution of PRF in CDH in Children With Prothetic Patch Closure Phase 3 Interventional Lack of staff Actual 30
NCT03927625 Withdrawn Evaluation of Ascorbate-Meglumine Therapeutic for SRS Phase 1 Interventional IRB determination Actual 0
NCT04205071 Withdrawn Lorcaserin in Treating Chemotherapy-Induced Peripheral Neuropathy in Patients With Stage I-IV Gastrointestinal or Breast Cancer Phase 1 Interventional PI decision Actual 0
NCT04406064 Withdrawn Viral Specific T-cells for Treatment of COVID-19 Phase 2 Interventional The use of steroids to treat COVID prevents the use of VSTs for these patients. The Principal Investigator does not feel the study had an expectation of enrolling patients as the treatment options for COVID have evolved. Actual 0
NCT04713306 Withdrawn Gender Differences in Parkinsonian Patients- a Swedish Register Study Observational [Patient Registry] Actual 0
NCT04585932 Withdrawn Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the Treatment of Biochemically Recurrent Prostate Cancer, RESTART Study Phase 2 Interventional At the request of the ad interim Department Chairman due to PI is no longer at institution. Actual 0
NCT01939431 Terminated Genetic and Other Aspects of Podoconiosis Observational Slow/Insufficient accrual Actual 76
NCT03478904 Terminated Study to Compare Capsule and Liquid Formulations of Enzalutamide After Single Dose Administration Under Fasting Conditions in Prostate Cancer Phase 1 Interventional Study drug is now commercially available in tablet format Actual 1
NCT03854786 Terminated Aerobic Fitness in Overweight and Obese Individuals N/A Interventional Due to Covid - 19 pandemic Actual 11
NCT03978156 Suspended Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease Phase 1 Interventional covid-19 Covid-19. Anticipated 30
NCT02235545 Terminated Optisure Lead Post Approval Study Observational Abbott received FDA approval to transition the ongoing Optisure PAS to EP a new EP-PASSION Real World Evidence methodology Actual 1735
NCT03038750 Suspended Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers Observational Study suspended as a precautionary measure, due to COVID-19, as the outbreak poses an increased risk to participants, due to potential exposure to the virus through attendance for study visits. Anticipated 220
NCT03040804 Terminated Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa N/A Interventional Infeasibility to continue study. Actual 2
NCT03277586 Terminated Effects of Probiotics on Symptoms of Depression Phase 3 Interventional COVID-19 Actual 28
NCT03722459 Suspended Novel MRI Sequence- MR Fingerprinting N/A Interventional Study suspended due to COVID-19 restrictions. Study will be resumed once plans for appropriate social distancing are in place. Anticipated 105
NCT03760614 Withdrawn A Study of Entinostat and FOLFOX in Subjects With Pancreatic Adenocarcinoma Phase 1 Interventional Lack of Funding Actual 0
NCT03779828 Terminated Evaluating the Effectiveness of Telemonitoring System in the Management of Patients With CIDP Observational Due to logistical concerns Actual 11
NCT03808532 Withdrawn Moisturizer to Prevent Atopic Dermatitis Phase 2 Interventional Lack of funding Actual 0
NCT03852420 Withdrawn Boston Scientific's Single Shot LUMINIZE RF Balloon Catheter in the Treatment of Symptomatic, Drug Refractory Paroxysmal Atrial Fibrillation N/A Interventional Sponsor discretion Actual 0
NCT03927365 Suspended Muco-ciliary Cleansing of Lungs in COPD With and Without a Salt Particle Inhaler N/A Interventional COVID-19 Pandemic Anticipated 35
NCT03943407 Withdrawn Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch N/A Interventional The Imiquimod 3.75% was ineffective Actual 0
NCT04097353 Suspended Improving Health Behaviors for Pediatric Cancer Survivors N/A Interventional Study recruitment of new participants was suspended during 2020 due to the Covid-19 pandemic. Anticipated 75
NCT04218383 Suspended Transcranial Direct Current Stimulation for Impulsivity and Food-related Impulsivity in Obesity N/A Interventional Coronavirus pandemic Anticipated 30
NCT04243824 Withdrawn Ga-68 MAA Distribution in PAE Patients Early Phase 1 Interventional Lack of funding Actual 0
NCT04373083 Withdrawn Anti-PD-1 Antibody Treatment With Cemiplimab and Radiotherapy in Early-stage Classical Hodgkin Lymphoma Phase 2 Interventional Business Decision Actual 0
NCT04408872 Withdrawn EUS vs EGD in Emergency Room Patients Referred for EGD N/A Interventional Study was not approved by the institution's scientific committee. Actual 0
NCT04426357 Terminated A Study to Evaluate the Effect of Renal Impairment on JNJ-64417184 and Its Two Minor Metabolites JNJ-68294291 and JNJ-65201526 in Adult Participants Phase 1 Interventional company decision Actual 6
NCT04477954 Terminated Hyperbaric Oxygen as an Adjuvant Treatment for Patients With Covid-19 Severe Hypoxemia Phase 2 Interventional Investigators and Ethic Committee endorsed early suspension of the protocol because of superiority and safety. For the interim analysys, the statistical methodology presented by Pocock was followed. Actual 40
NCT04574973 Terminated Optimizing Transcranial Direct Current Stimulation for Motor Recovery From Severe Post-stroke Hemiparesis N/A Interventional Relocation of PI Actual 4
NCT04586777 Terminated Effects of Transvertebral Direct Current Stimulation in Humans N/A Interventional Relocation of PI Actual 27
NCT03798678 Suspended CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma Phase 1 Interventional DLT evaluation of the current dose level Anticipated 36
NCT04707638 Withdrawn Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation Observational [Patient Registry] Ethics application has not been completed yet Actual 0
NCT02519738 Terminated Granulation Tissue Treatment: Silver Nitrate vs Kenalog vs Washcloth Abrasion Phase 3 Interventional enrollment difficulties Actual 52
NCT02543957 Withdrawn Factors Associated With Increased Risk of Bacteremia and Cholangitis in ERCP With Cholangioscopy Observational Funding not received. Actual 0
NCT02992340 Terminated Varlitinib in Combination With Gemcitabine and Cisplatin for Treatment naïve Advanced or Metastatic BTC Phase 1/Phase 2 Interventional Sponsor decided to terminate the study and not proceed to Phase 2. Anticipated 204
NCT03334227 Terminated High Flow Nasal Cannula in Severe Sepsis N/A Interventional low recruitment Actual 39
NCT03346577 Terminated Endovascular Treatment of Peripheral Artery Disease Observational [Patient Registry] Termination of collaboration Actual 60
NCT03397173 Suspended TET2 Mutations in Myelodysplastic Syndromes and Acute Myeloid Leukemia With Azacitidine + Ascorbic Acid Phase 2 Interventional Administrative hold Anticipated 28
NCT03519061 Withdrawn Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates Phase 2/Phase 3 Interventional Unable to obtain FDA exemption Actual 0
NCT03555656 Terminated Repeated Educational Intervention for the Prevention of Diabetic Foot Ulcers in High-risk Patients N/A Interventional Futility analysis suggested termination Actual 89
NCT02495103 Terminated Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma Phase 1/Phase 2 Interventional Vandetanib is no longer available as Sanofi has decided not to provide additional drug. All subjects are off-study. Actual 7
NCT03728205 Withdrawn Yoga for Solid Tumor N/A Interventional Covid-19 Actual 0
NCT03787147 Withdrawn Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Adult Patients for Pain Control During Spinal Injections (SI) Phase 2 Interventional Never started the study cause of the lack of funding Actual 0
NCT04085679 Terminated Multidisciplinary Mobile Unit for Preventing Hospitalization of Nursing Home Residents Observational The local Healthcare authorities extended the planned intervention to all nursing homes of the district after the emergence of multiple outbreaks of severe COVID-19 in several nursing homes. Actual 13
NCT04123756 Terminated Predicting Outcome Following Standardized Exercise Therapy in Knee Osteoarthritis Patients Observational Recruitment issues due to the corona virus and lack of funding to continue Actual 12
NCT04134143 Terminated Multiple Applications of ExpressGraft-C9T1 Skin Tissue as a Treatment for Diabetic Foot Ulcers Phase 1 Interventional Business decision - not related to product quality or safety concerns Actual 6
NCT04144634 Terminated Feasibility of Additional Physiotherapy for Patients Aged 75 and Older Phase 2 Interventional Terminated due to COVID-19 Actual 15
NCT04189991 Suspended Oxygen Titration Protocol for Exertion of COPD Patients by an Automated Adjustment Device N/A Interventional Recruitment has not started yet due to COVID pandemic. Anticipated 25
NCT04386447 Withdrawn Phase II RCT to Assess Efficacy of Intravenous Administration of Oxytocin in Patients Affected by COVID-19 Phase 2 Interventional The study was not approved by the Italian Medicines Agency (AIFA). Actual 0
NCT04656704 Withdrawn Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease Early Phase 1 Interventional PI no longer pursuing clinical trial Actual 0
NCT03421106 Terminated A Multilevel Intervention in the Hunger Relief Network to Improve Diet Among Adults Experiencing Food Insecurity N/A Interventional Data collection was halted prematurely due to COVID-19. Actual 504
NCT04170959 Terminated The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC Phase 2 Interventional Loss of external funding Actual 3
NCT04349930 Withdrawn The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC) Phase 1 Interventional Need to obtain IND approval. Actual 0
NCT04351516 Withdrawn Test and Treat COVID 65plus+ Phase 2/Phase 3 Interventional No Patients enrolled Actual 0
NCT03582046 Terminated Targeting Abdominal Perfusion Pressure in Septic Shock N/A Interventional Lack of Enrollment Actual 12
NCT03817281 Withdrawn Collective Accuryn Physiologic Signals and Signatures Observational [Patient Registry] Lack of Enrollment Actual 0
NCT04194528 Terminated S1916 Digital Medicine Program for Pain Control in Cancer Patients N/A Interventional Study sponsor withdrew support. Actual 2
NCT04690868 Suspended A Study to Compare PK, PD and Safety of the AD-213-A and AD-2131 Phase 1 Interventional Rescheduled Study Anticipated 40
NCT01324908 Terminated Biomarkers in Predicting Response in Patients With Graft-Versus-Host Disease Undergoing Extracorporeal Photophoresis N/A Interventional Low accrual Actual 85
NCT03154710 Suspended Relevance of a Web-mediated Follow up in Patients Having a Lymphoma With a High Risk of Relapse in Complete or Partial Response N/A Interventional Negative interim analysis Actual 52
NCT03597347 Terminated Trial of Inhaled Molgramostim in CF Subjects With NTM Infection Phase 2 Interventional Recruitment for trial stopped early due to limitations from COVID-19, additionally changes in the standard of care for CF patients during the study period resulted in confounding of the primary endpoint. Actual 14
NCT04060225 Terminated Effects of High Caffeine Content Coffee on Blood Pressure in Young Adults N/A Interventional not possible to enroll during COVID pandemic Actual 1
NCT04264156 Suspended A Safety and Efficacy Study of Lucinactant for Inhalation in Preterm Neonates 26 to 32 Weeks GA Phase 2 Interventional Corporate business reasons Actual 12
NCT04372940 Suspended Tranexamic Acid in Gender Mastectomy Phase 4 Interventional Suspended due to COVID Anticipated 50
NCT04373603 Suspended Use of Tranexamic Acid in Facial Fillers Phase 4 Interventional Suspended due to COVID Anticipated 40
NCT01507506 Terminated Phase III Study Comparing 2 Brain Conformational Radiotherapy in Combination With Chemotherapy in the Treatment of Glioblastoma Phase 3 Interventional Actual 180
NCT03420976 Withdrawn Novel Supplement-based Therapy for the Treatment of Small Intestinal Bacterial Overgrowth Early Phase 1 Interventional PI no longer in practice. Actual 0
NCT01824823 Terminated Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence Phase 2 Interventional Slow accrual Actual 3
NCT04131322 Terminated Loss of Response of Adalimumab Biosimilar vs Adalimumab Original, in Inflammatory Bowel Disease. Phase 4 Interventional Sponsor cancellation Actual 24
NCT04589572 Suspended Extreme Lateral Interbody FusionFUSION (XLIF) Versus Posterior Lumbar Interbody Fusion (PLIF) N/A Interventional Because of COVID-19 Anticipated 40
NCT01939691 Terminated Macular Edema Nepafenac vs. Difluprednate Uveitis Trial Phase 4 Interventional Difficulty enrolling Actual 9
NCT02111382 Suspended Electroencephalography Activity in Individuals With Nonspecific Chronic Low Back Pain After Cranial Osteopathic Manipulative Treatment N/A Interventional The pilot study demonsttated some new concerns about methodology. So we decided to suspended temporarily to added new settings to study design. Anticipated 81
NCT02943837 Withdrawn EUS-guided Fine Needle Aspiration (EUS-FNA) Versus EUS-guided Fine Needle Biopsy (EUS-FNB) for Diagnosis of Subepithelial Tumors N/A Interventional Funding issues Actual 0
NCT03087097 Terminated Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition Phase 1 Interventional COVID-19 pandemic and resource constraints Actual 5
NCT02195024 Terminated Cardiac MRI After Pacemaker Replacement Phase 4 Interventional PI changed affiliation not beening allowed to continue the trial in further cooperation. The sub-investigators did not see any option to continue the trial and made the decision to terminate the study. Actual 23
NCT02961114 Withdrawn Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy Phase 1/Phase 2 Interventional COVID restrictions prevent patient enrollment or treatment. Clinical Trial facility is being closed due to viral limitations and loss of staff to perform Actual 0
NCT04008303 Withdrawn Outcomes of Migraine Surgery Observational No participants enrolled since this study open. The Primary research member (medical school student) is no longer available to do this study Actual 0
NCT00794339 Terminated Phase II Trial of 64Cu-ATSM PET/CT in Cervical Cancer Phase 2 Interventional transfer of funding Actual 73
NCT02591173 Terminated Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure Early Phase 1 Interventional Difficulty recruiting Actual 7
NCT03011671 Suspended Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma Phase 1 Interventional Initial enrollment goal met. Pending funding to expand study. Anticipated 24
NCT03028740 Terminated AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH Phase 3 Interventional Study stopped due to lack of efficacy. Actual 1779
NCT03059446 Terminated Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis Phase 2 Interventional Study stopped due to lack of efficacy Actual 187
NCT03329378 Suspended Neoadjuvant Dose-Dense For Early Her2Neu Positive Breast Cancer Phase 2 Interventional Data Safety Monitoring Board is in agreement with the study findings so far and the stopping rule has been met, which suspends the study treatment arms. Anticipated 75
NCT04017910 Suspended Automated 3D Ultrasound-based Surveillance of Arteriovenous Fistula Maturation for Post-operative Hemodialysis Patients Observational to address inquiry. Anticipated 100
NCT04086927 Withdrawn Unna Boots for Ankle Fracture Swelling N/A Interventional no funding Actual 0
NCT04281238 Suspended The Effects of Yoga Training in Ankylosing Spondylitis Patients N/A Interventional Because of Covid-19 Anticipated 60
NCT04283526 Withdrawn Study of Select Combinations in Adults With Myelofibrosis Phase 1 Interventional Sponsor Decision Actual 0
NCT03789487 Terminated Electrical Optimization of Cardiac Resynchronization Therapy in Non-responder Patients N/A Interventional the end of inclusion period Actual 27
NCT02212015 Terminated Evaluation of Votrient in Angiosarcoma Phase 2 Interventional Due to interim analysis' results and definitions fixed in protocol Actual 26
NCT02336984 Withdrawn A Phase I/II Trial of HER-2/Neu Pulsed DC1 Vaccine Combined With Trastuzumab for Patients With DCIS Phase 1/Phase 2 Interventional PI left Abramson Cancer Center and study never opened at Moffitt Cancer Center. Actual 0
NCT03516903 Terminated Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI Phase 2/Phase 3 Interventional Due to the COVID-19 pandemic. With a second wave just beginning, and considering that we are testing an immunosuppressant in patients with high risk for COVID-19 complications, we would not be able to re-start recruitment safely in the near future. Actual 35
NCT03942276 Terminated Effects of Different Exercises Interventions in Post-menopausal Women N/A Interventional Participants constantly reported knee pain. Actual 60
NCT04259840 Terminated Clinical Outcomes of Resective Surgical Treatment of Peri-Implantitis With or Without Implantoplasty Observational COVID-19 pandemic Actual 41
NCT04474626 Withdrawn Isoquercetin in Sickle Cell Anemia Phase 2 Interventional Trial did not activate Actual 0
NCT04483687 Withdrawn Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Have an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drug Therapy Phase 3 Interventional Development program terminated Actual 0
NCT04483700 Withdrawn Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Are Naive to Biologic Disease-Modifying Antirheumatic Drug Therapy Phase 3 Interventional Development program terminated Actual 0
NCT01217047 Terminated Study on Functional Electrical Stimulation (FES) Cycling Following Spinal Cord Injury Phase 2/Phase 3 Interventional Lack of funding Actual 11
NCT01695473 Terminated Neoadjuvant BKM120 in High-risk Prostate Cancer Phase 2 Interventional Lack of Accrual Actual 11
NCT03062553 Withdrawn Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation N/A Interventional Testing for this study remained in the pilot stages due to optimization of the tACS equipment. There are no clinical results to report. Actual 0
NCT03585062 Terminated Trial of Neoadjuvant Chemotherapy With S1 Plus Paclitaxel-albumin on Pancreatic Cancer Phase 2 Interventional The paclitaxel-albumin halt production. Actual 40
NCT03929601 Suspended Rituximab and Abatacept for Prevention or Reversal of Type 1 Diabetes Phase 2 Interventional Enrollment suspended by Sponsor. Anticipated 36
NCT04002635 Withdrawn Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS) Phase 4 Interventional Practical issues Actual 0
NCT04300881 Terminated Treatment of Post-Ocriplasmin Therapy Vitreolysis Induced Subretinal Fluid With Eplerenone (Mineralocorticoid Antagonists) Phase 2 Interventional Enrollment Actual 2
NCT04454398 Withdrawn Study to Evaluate STI-1499 (COVI-GUARD) in Patients With Moderate COVID-19 Phase 1 Interventional Difficulty recruiting Actual 0
NCT04702230 Terminated Value of Functional Magnetic Resonance Imaging of Hepatocellular Carcinoma After Transarterial Chemoembolization or Transarterial Radioembolization Observational Treatment practice unexpectedly changed during the course of the study. Majority of follow-up MRI performed in external institutions. Consequently, the planned number of participants could not be reached. Actual 32
NCT00358657 Terminated Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited Disorders Phase 2 Interventional Low accrual Actual 14
NCT03091478 Terminated Pembrolizumab in Patients With Leptomeningeal Disease Phase 2 Interventional Low Accrual Actual 13
NCT01569035 Terminated Warfarine in Unexplained Oligohydramnios Phase 4 Interventional Actual 200
NCT01688284 Terminated The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage N/A Interventional Actual 500
NCT03412734 Terminated Vaginal Preparation Prior to Hysterectomy Phase 4 Interventional The institutional review board recommended the study stop enrollment prior to achieving its initial sample size for patient safety. Actual 94
NCT02601391 Withdrawn An Evaluation of an Adapted STEPPS Group Within Forensic Services N/A Interventional Not able to run research in the service. Research terminated. Actual 0
NCT03367195 Terminated Efficacy and Safety of DLBS2411 in the Management of GERD Phase 3 Interventional Very low recruitment rate. The Study Site classifies as tertiary referral hospital. Therefore, GERD Patients being referred to the site are mostly those with comorbidities included in the exclusion criteria. Actual 32
NCT03700723 Terminated Comparison of the Efficacy & Safety of Resusix With FP24 in Patients With Acquired Coagulopathy Phase 2 Interventional Convenience of Government Funding Sponsor Actual 4
NCT03713684 Terminated Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Alone or in Combination With Oral Antidiabetic Drug(s) Phase 3 Interventional Sponsor decision to cancel TRIAL, not related to safety concern Actual 370
NCT03770728 Terminated Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone or in Combination With Sulfonylurea Phase 3 Interventional Sponsor decision to cancel TRIAL, not related to safety concern Actual 312
NCT03829007 Terminated PD-L1 ImagiNg to prediCt Durvalumab Treatment Response in HNSCC Phase 1/Phase 2 Interventional Hampering patient enrolment after registration of first line pembrolizumab Actual 33
NCT01679561 Withdrawn Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial Phase 4 Interventional Actual 0
NCT01718340 Withdrawn Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia Phase 4 Interventional Actual 0
NCT02591953 Terminated Prospective Clinical Analysis of Ultrasound-guided Biceps Corticosteroid Injections N/A Interventional Unable to meet enrollment and follow up criteria Actual 25
NCT00279851 Withdrawn Blood Sugars in Children With Idiopathic Seizures. Observational Actual 0
NCT00484172 Withdrawn Genomic Search for Childhood Obesity Genes-A Pilot Study Observational Study Withdrawn due to Investigator leaving Actual 0
NCT02402829 Terminated A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipuncture Observational lack of participation or interest in other sites. Actual 3
NCT03093935 Terminated StimRouter™ for Pain Management in Post-stroke Shoulder Pain N/A Interventional Lack of subject participation Actual 6
NCT00766142 Terminated Chemotherapy and Cetuximab in Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer Phase 2 Interventional In 2008, new data highlighted that Cetuximab had no efficacy in case of KRAS mutation. As such, eligibility criteria were revised and limited to KRAS wild-type. Inclusions were thus slown down considerably, and the trial was stopped. Actual 18
NCT00867789 Terminated Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department N/A Interventional Slow enrollment due to subjects not meeting inclusion/exclusion criteria Actual 140
NCT03327662 Terminated Utilising CTC Counts to Optimize Systemic Therapy of Metastatic Prostate Cancer Phase 3 Interventional Underrecruitment Actual 12
NCT03730571 Terminated The AbsorbaSeal Vascular Closure Device Trial N/A Interventional Insufficient closure Actual 9
NCT04340843 Suspended Testing the Combination of Belinostat and SGI-110 (Guadecitabine) for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma Phase 2 Interventional Scheduled Interim Monitoring Anticipated 26
NCT04441164 Withdrawn VERARE : Effectiveness of Virtual Motor Actions for Improving Walking in Patients With Post-resuscitation Muscle Weakness N/A Interventional Submitted, denied (too much steps; project to be cut in several projects) Actual 0
NCT00809692 Withdrawn In Vivo Assessment of Histamine Pharmacodynamics N/A Interventional Study withdrawn and combined with a new protocol Actual 0
NCT02389517 Suspended Lenalidomide With or Without Ixazomib Citrate and Dexamethasone in Treating Patients With Residual Multiple Myeloma After Donor Stem Cell Transplant Phase 2 Interventional Enrollment on hold due to funding. Anticipated 86
NCT02734589 Terminated Fecal Transplantation Using a Diet for Donor and Recipient in Refractory Colitis N/A Interventional DSMB recommendation of stopping the trial after reviewing the interim data Actual 54
NCT02771795 Terminated A Long-term Follow-up Study for Cardiac Safety in the Patients With HER2 (+) Breast Cancer Who Have Completed the SB3-G31-BC Observational Considering the life-threatening risk posed by COVID-19 disease to a fragile population, the Sponsor concluded that the benefit of continuing the study does not outweigh the risk to the safety of patients & site staffs. Actual 549
NCT03115190 Terminated Improving the Referral of Patients With Chest Pain N/A Interventional The Philips Minicare has been taken off the market due to financial company issues that have nothing to do with the safety of the Minicare or the URGENT trial. Actual 40
NCT03391791 Terminated Long Term Follow up of Subjects Exposed to Genetically Engineered T Cell Receptors Observational terminated after participants were enrolled Actual 2
NCT03496298 Terminated Effect of Efpeglenatide on Cardiovascular Outcomes Phase 3 Interventional Sponsor decision to cancel TRIAL, not related to safety concern Actual 4077
NCT03864367 Withdrawn Mobile Weight-Support Therapy (MWeST) for Mobility After Geriatric Fracture Observational PI decided to end the study Actual 0
NCT03926598 Terminated Guide To Goals: A Novel Care Coordination Tool for Children With Type Two Diabetes (T2D) Observational This study did not complete enrollment due to COVID-19. Institutional constraints prevented this study from continuing and the study team no longer wishes to pursue this project. Actual 6
NCT04037319 Suspended Atrial Fibrillation After Surgery for Colorectal Cancer Observational Study recruitment has been halted due to the Pandemic. It is anticipated that recruitment will restart in March 2021. Anticipated 720
NCT04197011 Suspended Advanced Prosthetic Devices for Lower Limb Amputees Observational Recruitment not currently possible owing to current ongoing COVID-19 pandemic. Actual 19
NCT04253665 Suspended Nursing Discharge Teaching for Multimorbid Inpatients N/A Interventional Due to the COVID-19, the study has been suspended since November 2020 Anticipated 180
NCT04699552 Withdrawn Effect of Laser Settings on Postoperative Voiding Symptoms in Patients Undergoing Holmium Laser Enucleation of the Prostate N/A Interventional PI does not wish to move forward with the Study Actual 0
NCT00202930 Terminated Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma Phase 2 Interventional Closed early due to low accrual. Actual 4
NCT02931851 Suspended Family Information Management in the Intensive Care Unit N/A Interventional Actual 75
NCT03719898 Withdrawn Brigatinib in Relapsed or Refractory ALK-Positive Anaplastic Large Cell Lymphoma Phase 2 Interventional Slow accrual Actual 0
NCT02570438 Terminated Improving Surgical Safety of Seniors Through Preoperative Cognitive Screening Observational This study was terminated prior to its planned enrollment due to low recruitment rates at the time that the funding for the study was completed. Actual 500
NCT03205046 Terminated A Study of Acalabrutinib and Vistusertib in Subjects With Relapsed/Refractory B-cell Malignancies Phase 1/Phase 2 Interventional Sponsor's decision not to pursue further development of the combination in DLBCL Actual 25
NCT03342365 Terminated Evaluation of Intestinal Bacterial and Fungal Translocation and Intestinal Microbiota in Febrile Neutropenic Patients in Pediatric Onco-hematology Observational 10 patients inclued instead of 50 Actual 10
NCT03620149 Terminated Reduced Dose-density of Denosumab for Unresectable GCTB Phase 2 Interventional Poor accrual Actual 2
NCT04132739 Terminated Piloting Diet and Exercise Interventions in Older Hispanics With Diabetes N/A Interventional COVID-19 Actual 39
NCT04187612 Suspended Association of Body Fluid Distribution With Obstructive Sleep Apnea in Pregnant Women With Body Mass Index ≥ 40 kg/m2 Observational Virtual/telephone appointments for patients due to Covid restrictions have halted this research. We may resume when we have the resources, however the current plan is to publish the data we have so far. Anticipated 52
NCT02272348 Terminated Self-management of Type 1 Diabetes Under Functional Insulin Therapy N/A Interventional Change in methodology too important - end of randomization Actual 13
NCT02528071 Terminated Prognostic Value of a Diaphragmatic Endurance Test in Patients With Amyotrophic Lateral Sclerosis Observational lack of inclusion Actual 136
NCT02853162 Terminated Ablative tReatment of Inoperable REnal Cell Carcinoma Using STereotactic Body Radiotherapy (ARREST-study) Phase 2 Interventional Slow inclusion Anticipated 30
NCT02446886 Terminated Adrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MS Phase 4 Interventional Slow enrollment Actual 15
NCT03219372 Terminated Pravastatin Intervention to Delay Hepatocellular Carcinoma Recurrence Phase 2 Interventional Study discontinued due to low accrual. Actual 1
NCT00127543 Withdrawn Kid Cards: Teaching Kids About Medicines N/A Interventional Not completed Actual 0
NCT01895881 Withdrawn Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Phase 2 Interventional Unable to Recruit Participants Actual 0
NCT03327324 Suspended Improving Sleep Using Mentored Behavioral and Environmental Restructuring N/A Interventional Due to the COVID19 pandemic, as of March 14, 2020, all nursing homes in New York were on lockdown, as a result, all of the recruitment efforts have been on pause until further notice. Anticipated 120
NCT03936595 Terminated Recovery of Performance, Muscle Damage and Neuromuscular Fatigue Following Muscle Power Training N/A Interventional There was a high drop-out rate and we were unable to recruit new subjects. Actual 10
NCT04001738 Terminated Evaluation of Direct Transfer to Angiography Suite vs. Computed Tomography Suite in Endovascular Treatment: Randomized Clinical Trial (ANGIOCAT) N/A Interventional Intermediate analysis Actual 174
NCT04124783 Withdrawn Study to Evaluate the Effects of the Cooling Bolero in Women With Menopause Symptoms N/A Interventional The company no longer provided the device. Actual 0
NCT01174121 Suspended Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer Phase 2 Interventional Actual 91
NCT03818542 Terminated A Study to Assess the Effects of Multiple Study Drug Regimens in Subjects With Newly Diagnosed Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 1 Interventional Strategic considerations Actual 3
NCT04692246 Terminated Effect of Essential Oils as Adjutants on the Treatment of Subjects With Periodontitis: Assessment of Metabolic Variables as Effect Modifiers N/A Interventional Due to COVID-19 Pandemic Actual 60
NCT03084510 Withdrawn REPRISE China - Clinical Evaluation in China N/A Interventional study device was recalled. Actual 0
NCT03412877 Suspended Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in People With Metastatic Cancer Phase 2 Interventional Action taken by IRBO Anticipated 270
NCT04034745 Withdrawn Open Label Study to Analyze the Effect of Telotristat Ethyl on Weight Regulation/Gain Observational lack of funding Actual 0
NCT03063359 Terminated Intranasal Fentanyl Versus Oral Morphine Sulfate in the Treatment of Pain in Pediatric Trauma Phase 3 Interventional The new pain protocols imposed by the HAS make it difficult to include new patients in the study Actual 22
NCT03327974 Terminated Evolution of Dark Ideas When Introducing or Switching an Antidepressant N/A Interventional Problem on the app, questioned the feasability of the study Actual 38
NCT03729063 Terminated Impact of Twice-daily Measurement of Expired CO During Hospitalization on Smoking N/A Interventional Difficulty in recruiting, many patients with exclusion criteria Actual 67
NCT04508868 Terminated Treatment of Depressive Symptoms in Older Individuals in Isolation During Covid-19 N/A Interventional Study terminated due to changes in government restrictions. Collected data to be presented as a pilot study. Actual 41
NCT04691726 Suspended Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia Phase 4 Interventional Pandemia of the Covid-19 Anticipated 150
NCT03808012 Withdrawn Predictability of the Ability to Perform an Emergency Stop After Surgery for Inguinal Hernia N/A Interventional Unsuccessful recruitment Actual 0
NCT04370938 Withdrawn Provider Burnout During COVID-19 N/A Interventional No participants were enrolled and the study was never initiated. Actual 0
NCT03253289 Suspended Meclizine for Hepatocellular Carcinoma Phase 1 Interventional This study has been temporarily suspended to accrual by the Data Review Committee due to a protocol violation that recently occurred. The study will resume to accrual after the protocol has been amended and approved by the IRB and DRC. Anticipated 13
NCT03964376 Suspended Nasal High Flow Therapy in Surgical Patients With Unrecognized Obstructive Sleep Apnea N/A Interventional due to COVID-19 Anticipated 190
NCT04531397 Withdrawn Efficacy and Safety of Dapagliflozin in Children With Proteinuric Chronic Kidney Disease Phase 4 Interventional lack of funding Actual 0
NCT03920878 Withdrawn Cataract DME - Peri vs. Intraop Phase 2 Interventional The study team was unable to secure sufficient funding and administrative support. Actual 0
NCT04464525 Withdrawn Omecamtiv Mecarbil Post-trial Access Study Phase 3 Interventional Sponsor decision Actual 0
NCT03641430 Withdrawn The Effects of Over-the-Counter Products on the Skin N/A Interventional The study design will need to be changed completely becasue of the change of research interest. We have decided to withdraw the study. Actual 0
NCT03641677 Suspended Increasing Lung Transplant Availability Using Normothermic Ex Vivo Lung Perfusion (EVLP) at a Dedicated EVLP Facility N/A Interventional Data Monitoring Committee review triggered by protocol Halting Rule. Anticipated 186
NCT00904345 Terminated Study of Radiation (RT) Concurrent With Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (SCC) Phase 2 Interventional Stopped early for funding and efficacy reasons. Actual 23
NCT04258410 Suspended Quercetin for Cardio-Skeletal Muscle Health and Estrogen Deficiency Phase 4 Interventional Investigator is revising protocol. Anticipated 24
NCT01849783 Terminated Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma Phase 2 Interventional Principal Investgator leaving institution Actual 41
NCT03026127 Suspended A Novel Cognitive Reappraisal Intervention for Suicide Prevention N/A Interventional Temporarily paused due to COVID-19 and will resume based on guidance of public health authorities. This is not a suspension of IRB approval. Anticipated 90
NCT03158116 Terminated The Use of Inhaled Aztreonam in Children With a Tracheostomy Tube and Pseudomonas Phase 4 Interventional IRB application expired. Actual 6
NCT03161821 Suspended Circulating Tumor Cells in Solid Tumors Observational New enrollment and collection of blood samples paused while IRB reviews use of the investigational assay involved. Anticipated 500
NCT03334578 Withdrawn The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients. Phase 4 Interventional Lack of recruitment Actual 0
NCT03615989 Suspended The Combined Effect of Dairy and/or Creatine and Exercise on Bone and Inflammation N/A Interventional COVID-19 Anticipated 15
NCT04060251 Suspended Is There an Alternative to Immediate Home Physical Therapy Following Total Knee Arthroplasty N/A Interventional COVID-19 limitations on recruitment Anticipated 87
NCT04230564 Withdrawn Acute Myeloid Leukemia Real World Treatment Patterns Observational Not pursued Actual 0
NCT04570449 Withdrawn Fluoxetine to Reduce Hospitalization From COVID-19 Infection (FloR COVID-19) Early Phase 1 Interventional Study timeline is not feasible Actual 0
NCT02156674 Terminated Naglazyme After Allo Transplant for Maroteaux-Lamy Syndrome N/A Interventional Slow accrual Actual 1
NCT04681027 Suspended Safety, Tolerability, Effectiveness, and Pharmacokinetic Data in Opioid-experienced Children Phase 3 Interventional Study Suspended 06Feb2020 per FDA Request Actual 15
NCT03672370 Terminated PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip Arthroplasty Observational Study terminated as CE marks of the devices used have not been renewed. Actual 100
NCT00256776 Terminated MMVAR - Velcade: Study of Velcade for the Treatment of Myeloma Patients After Autologous Transplantation Phase 3 Interventional Actual 269
NCT03552692 Terminated Use of Venetoclax as Single Agent in Patients With Relapsed/Refractory BCL-2 Positive Peripheral T Cell Lymphoma Phase 2 Interventional efficacy lower than expected Actual 22
NCT01984268 Terminated ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate Phase 2 Interventional Actual 15
NCT02177838 Terminated Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer N/A Interventional Slow accrual Actual 8
NCT00700154 Terminated Insulin Infusion Diabetes Ulcer N/A Interventional participants are no longer being examined or receiving intervention Actual 40
NCT02818764 Terminated Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty Observational COVID related limitations Actual 3
NCT03534219 Withdrawn Efficacy of the EarPopper Device in Children With Recurrent Otitis Media N/A Interventional No participants enrolled Actual 0
NCT03795623 Suspended Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation Phase 2/Phase 3 Interventional Only recruitment temporarily paused due to Covid-19 Anticipated 354
NCT03966989 Suspended Improving Quality & Equity of Emergency Care Decisions (IQED) N/A Interventional Suspended due to COVID-19 pandemic Anticipated 80
NCT04552262 Suspended Study to Learn More About the Effect of a New Drug Called BAY2327949 on the Blood Flow Through Kidneys in Adult Participants With Moderate Chronic Kidney Disease Phase 1 Interventional Temporary on hold. Anticipated 22
NCT03761836 Withdrawn Evaluation and Adverse Event Surveillance for Initial Implementation of ShangRing Circumcision in Mozambique N/A Interventional Funding no longer available Actual 0
NCT04403646 Terminated Tannin Specific Natural Extract for COVID-19 Infection N/A Interventional low rate of covid patients Actual 124
NCT02916472 Suspended CyberCycling to Reduce Therapeutic Side Effects and Improve Quality of Life in AYA Cancers N/A Interventional COVID-19 Anticipated 20
NCT03096340 Terminated Safety and Pharmacokinetic Study of IT-141 in Monotherapy in Patients With Advanced Cancer Phase 1 Interventional Terminated by sponsor. Actual 10
NCT03162562 Terminated The Safety and Antitumor Activity of the Combination of Oregovomab and Hiltonol in Recurrent Advanced Ovarian Cancer Phase 1 Interventional Sponsor Decision to discontinue long-term follow-up Actual 10
NCT03782363 Withdrawn Study of Adoptive Immunotherapy in Relapsed and Non-resectable Sarcomas After Multimodal Treatment. Phase 1 Interventional Initial version of the protocol not submitted and new version approved has a new sponsor and it has been added into Clinicaltrials by the new sponsor Actual 0
NCT04209179 Suspended A Clinical Study Investigating the Safety, Tolerability, PK and PD of PCO371 in Patients With Hypoparathyroidism Phase 1 Interventional Temporary halt due to adverse events Anticipated 24
NCT04357028 Suspended Measles Vaccine in HCW Phase 3 Interventional Failure of subject recruitment Anticipated 200
NCT00637767 Terminated High-Dose Melphalan With or Without Radiolabeled Monoclonal Antibody in Treating Patients With Multiple Myeloma Undergoing an Autologous Stem Cell Transplant Phase 2 Interventional Low recruitment Actual 25
NCT04267679 Withdrawn Cannabidiol for Anxiety Phase 2 Interventional Stopped due to COVID-19 pandemic. Actual 0
NCT03090932 Suspended Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS Observational Enrollment is temporarily paused due to COVID-19; interactions/interventions with current participants continue. This is not a suspension of IRB approval. Anticipated 250
NCT03134027 Suspended Reconstitution of a Human Immune System in a Patient Derived Xenograft (PDX) Model of Genitourinary (GU) Cancers Observational Suspended due to COVID-19. Anticipated 30
NCT03802214 Terminated Ulcerative Colitis - Vedolizumab- With/Without Prior Exposure to Anti-TNF(Tumor Necrosis Factor)Therapy Observational Funding discontinued Actual 1
NCT03969940 Withdrawn Thermotherapy of Buruli Ulcer at Community Level in the Health District of Akonolinga Observational Lack of supply of comparator drug in country Actual 0
NCT04026334 Terminated Evaluation of V.A.C. VERAFLO CLEANSE CHOICE™ Dressing Using Normal Saline to Promote Increased Healthy Wound Bed Tissue N/A Interventional Insufficient subject accrual rate Actual 8
NCT04279665 Suspended Virtual Reality to Reduce Intra-procedural Anxiety and Sedation Needs During Procedures N/A Interventional Equipment changed Anticipated 20
NCT04338906 Withdrawn Combination Therapy With Camostat Mesilate + Hydroxychloroquine for COVID-19 Phase 4 Interventional lack of public funding; planned control arm with Hydroxychloroquine treatment showed out as not being standard of care anymore as time evolved. Actual 0
NCT04341441 Terminated Will Hydroxychloroquine Impede or Prevent COVID-19 Phase 3 Interventional Interim analysis did not reveal any safety concerns by the DSMB, but unblinded data did not provide support to continue. Event rate did not meet projected magnitude; given low recruitment potential, it is unlikely that a positive result will occur. Actual 624
NCT04609800 Withdrawn Study on the Utilization of Cabozantinib in Adult Patients With Advanced or Metastatic Renal Cell Carcinoma (RCC) in 2nd Line Treatment Following Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Therapy Under Real-real Life Clinical Setting in France. Observational Unfavorable opinion of IRB/IEC Actual 0
NCT04675086 Withdrawn Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection Phase 3 Interventional Administrative Decision Actual 0
NCT03442985 Terminated An Efficacy and Safety Study of Palovarotene for the Treatment of MO Phase 2 Interventional Trial was terminated early to analyze the accumulated data and evaluate the efficacy, safety and future of palovarotene in MO. Actual 194
NCT03431740 Suspended FENO, Extended NO Analysis and NO/CO Diffusing Capacity in Thoracic Radiation Therapy Observational Study recruitment paused due to Corona-Pandemic Anticipated 38
NCT02730793 Terminated Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease Phase 2 Interventional terminated due to an inability to recruit study subjects Actual 5
NCT02647762 Terminated CF101 Therapy Compared to Methotrexate Therapy for Active Rheumatoid Arthritis Phase 3 Interventional Interim analysis results Actual 244
NCT03344562 Terminated Cranial Electrical Stimulation (CES) as Treatment for Insomnia in Patients With Subacute Stroke N/A Interventional Due to lack of resources (insufficient personnel) and due to technical problems with measurement of primary and secondary outcomes. Actual 19
NCT03508219 Suspended POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI) N/A Interventional COVID-19 Anticipated 260
NCT03824704 Terminated A Study to Evaluate Rucaparib in Combination With Nivolumab in Patients With Selected Solid Tumors (ARIES) Phase 2 Interventional Sponsor made a business decision to discontinue the study due to low accrual. Actual 1
NCT03939897 Suspended Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer Phase 1/Phase 2 Interventional Other - Pending amendment Anticipated 194
NCT04366791 Suspended Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19 Phase 1/Phase 2 Interventional per PI: temporarily hold throughout month of Dec. Anticipated 10
NCT04216316 Suspended Testing the Addition of an Anti-cancer Drug, M6620, to the Usual Treatments (Carboplatin and Gemcitabine) and to Avelumab for Non-small Cell Lung Cancer Phase 1/Phase 2 Interventional Other - to reevaluate primary endpoint Anticipated 106
NCT03516084 Terminated A Study of Niraparib as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Patients With Extensive Stage Small Cell Lung Cancer Phase 3 Interventional As the treatment model of extensive-stage small cell lung cancer changed rapidly and the enrollment speed significantly lower than expected, ZaiLab decided to terminate this study Actual 185
NCT01117779 Terminated Tracking Renal Tumors After Cryoablation Evaluation Observational Boston Scientific acquisition of BTG/Galil Medical - business decision made to stop follow-up early Actual 250
NCT03279068 Terminated Electronic Fetal Monitoring With and Without Pattern Interpretation Observational Civil unrest in region/country of study Actual 637
NCT03943706 Withdrawn E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users Observational The investigator moved to another institution, therefore the study was never initiated. Actual 0
NCT03804164 Withdrawn Psycho-Educational Cognition Intervention in Patients With Blood and Lymph Cancer N/A Interventional Feasibility Actual 0
NCT03987347 Withdrawn Health Condition of Cannabis Consumers in the Canadian Population Observational No authorization from CLSA database scientific committee Actual 0
NCT03997981 Suspended Chemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY) Observational Enrollment on hold due to COVID-19 pandemic. Anticipated 200
NCT04153838 Suspended Estimating Premorbid Intellectual Functioning in Children and Measuring Change in Cognitive Functioning as Children Develop Observational Due to covid-19 restrictions on recruiting Anticipated 100
NCT04209556 Withdrawn A Study To Evaluate The Safety And Efficacy Of PF-06826647 In Participants With Moderate To Severe Ulcerative Colitis Phase 2 Interventional The study was withdrawn following a strategic portfolio re-prioritization. Actual 0
NCT04513782 Suspended The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss Observational On Hold due to COVID-19 outbreak Anticipated 200
NCT04549584 Terminated Neoadjuvant Chemotherapy Response in Metaplastic Carcinoma of Triple Negative Breast Cancer Observational [Patient Registry] due to poor enrolled patients Actual 3
NCT04576208 Withdrawn A Study to Evaluate the Impact of Management Strategies on Gastrointestinal-Related Adverse Events in Participants With Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations Receiving TAK-788 Phase 2 Interventional Business Decision (no safety or efficacy concerns) Actual 0
NCT00285363 Withdrawn Quality of Life Among Children and Adolescents With Cancer Observational Unable to reconcile record due to age Actual 0
NCT00777218 Withdrawn Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine N/A Interventional Enrollment criteria was too challenging and Investigators changed Institutions Actual 0
NCT00844740 Withdrawn Calcimimetics in Hypophosphatemic Rickets N/A Interventional Actual 0
NCT01051544 Withdrawn Study of First TIME Immunotolerance Induction in Severe Hemophilia A Patients With Inhibitor at High Risk of Failure: Comparison With FVIII Concentrates With or Without Von Willebrand Factor - RES.I.S.T. Naive N/A Interventional complete per PI Actual 0
NCT02481960 Terminated Study of Intraparenchymal Therapy With Irinotecan Drug Eluting Beads as Adjunct to Recurrent Surgically Resectable High Grade Glioma Phase 1/Phase 2 Interventional The decision to terminate the trial was based on the slow rate of recruitment across the programme of studies] Actual 5
NCT02834455 Terminated Rational Approach to a Unilateral Pleural Effusion2 N/A Interventional Patient inclusion cannot be reached within timelimits Actual 200
NCT02994953 Terminated A Phase Ib Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of Avelumab in Combination With M9241(NHS-IL12) (JAVELIN IL-12) Phase 1 Interventional The study got discontinued due to lack of efficacy Actual 52
NCT03042897 Withdrawn Exercise and Diet Intervention in Promoting Weight Loss in Obese Patients With Stage I Endometrial Cancer N/A Interventional PI left institution Actual 0
NCT03120390 Withdrawn Physical Activity in Reducing Metabolic Dysregulation (MetD) in Obese Latina Breast Cancer Survivors N/A Interventional PI left institution Actual 0
NCT03272087 Terminated Rational Approach to a Unilateral Pleural Effusion N/A Interventional Patient inclusion cannot be completed within time limits Actual 120
NCT03449095 Suspended Understanding Alcohol Reward in Social Context N/A Interventional COVID-19 Anticipated 600
NCT03647722 Terminated Assessing the Induction of Long-term Immune Regulation Following Treatment With Lemtrada® (Alemtuzumab). Observational Study funding was terminated. Actual 97
NCT03739606 Withdrawn Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood Cancer Phase 2 Interventional RSS recommendation Actual 0
NCT03763929 Terminated Efficacy and Safety of Trans Sodium Crocetinate (TSC) for Treatment of Suspected Stroke Phase 2 Interventional The study was stopped due to lack of meaningful enrollment due to the COVID-19 pandemic. Actual 6
NCT04027270 Withdrawn Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients Undergoing Prostatectomy N/A Interventional Covid Actual 0
NCT04042051 Terminated Copanlisib in Combination With T-DM1 in Pretreated Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer Phase 1 Interventional Accrual rate to date was too low to finish the trial in a reasonable timeframe Actual 2
NCT04049487 Terminated Impact of Exercise on Diastasis Rectus Abdominus N/A Interventional Covid Actual 6
NCT04063943 Terminated Long Term Sidus PMCF N/A Interventional Sponsor has decided there is not a business need for this study and is not required to complete. Actual 11
NCT03512353 Terminated A Study of Carfilzomib Plus Dexamethasone in Adults With Relapsed or Refractory Multiple Myeloma at US Community Oncology Centers Phase 2 Interventional Sponsor Decision Actual 7
NCT04212650 Terminated Losartan to Improve Hip Microfracture Phase 1/Phase 2 Interventional redesigned trial using another placebo controlled drug Actual 1
NCT04240327 Suspended Marker Driven Selection of Patients for Prostate Biopsy and Management Observational Temporarily closed to accrual due to pending amendment. Anticipated 300
NCT04522817 Withdrawn CLBS119 for Repair of COVID-19 Induced Pulmonary Damage Phase 1 Interventional Acute COVID-19 treatments have improved significantly leading to decreased use of ventilatory support. This, coupled with approval of a vaccine, has changed the profile/prognosis of patients and led to a lack of patients with long-term hypoxia. Actual 0
NCT04536181 Withdrawn Study of Initial Steroid Treatment in Young Children With Nephrotic Syndrome Phase 3 Interventional lack of funding Actual 0
NCT02977286 Terminated Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids Phase 4 Interventional Poor enrollment Actual 12
NCT03754166 Terminated Feasibility of Constraint-induced Therapy Combined With Visual-spatial Cueing Strategy in Patients With Acute Stroke N/A Interventional Study non feasible following changes in organisation of service Actual 8
NCT03807843 Suspended Chikungunya Vaccine Study in Previously Exposed Adults Phase 2 Interventional Further screening, enrollment, and dosing of subjects was suspended due to a clinical stock recovery action. Anticipated 60
NCT03993977 Withdrawn ROTEM-guided Transfusion Protocol in Attempt to Reduce Blood Transfusions in Major Oncological Surgery N/A Interventional Due to changes in the surgical technique, no potential subjects anymore Actual 0
NCT04667871 Withdrawn Effect of Cataract Hyperemulsification Surgery on Meibomian Gland Morphology and Function Observational An six-month follow-up was completed after the treatment Actual 0
NCT03170115 Terminated Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer Phase 2 Interventional Aspirin added to chemoradiotherapy was safe but did not improve response to total neoadjuvant treatment. The study was closed due absence of benefit. Actual 25
NCT03360708 Suspended Vaccine Therapy in Treating Patients With Recurrent Glioblastoma Early Phase 1 Interventional protocol design Anticipated 20
NCT03561090 Terminated A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors Phase 3 Interventional Parallel IW-3718 Phase III trial did not meet pre-specified criteria. Actual 495
NCT03610581 Terminated Safety, Reactogenicity and Immunogenicity of Adenovirus Serotype 26 (Ad26)- and Modified Vaccinia Ankara (MVA)-Vectored Vaccine Components in Otherwise Healthy Women With HPV16 or HPV18 Infection of the Cervix Phase 1/Phase 2 Interventional Low enrolment and increasing COVID restrictions, following an earlier enrolment pause in April made it clear that completion of the study would not be feasible Actual 9
NCT04511975 Suspended A Study Evaluating the Safety and Efficacy of IBI188 in Combination With AZA in Subjects With Newly Diagnosed MDS Phase 1 Interventional Clinical hold Anticipated 32
NCT03263390 Terminated Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Observational Study terminated by study partners Actual 6
NCT03674190 Withdrawn A Study Comparing the Outcome of Anterior Lumbar Fusion and Total Lumbar Disc Replacement N/A Interventional Difficult to find patients that accepted the study Actual 0
NCT03280121 Terminated Hernia Reduction Prior to Scheduled TIF Completion N/A Interventional Slow enrollment and Covid-19 Actual 14
NCT04673435 Withdrawn Permeaderm Versus Homograft for Full-thickness Burns N/A Interventional Protocol was withdrawn and closed by IRB in April, 2018 prior to enrollment of first patient Actual 0
NCT04055168 Terminated A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD6615 in Healthy Subjects Phase 1 Interventional It was decided to not run the Japanese cohorts in the study. Actual 24
NCT04324021 Terminated Efficacy and Safety of Emapalumab and Anakinra in Reducing Hyperinflammation and Respiratory Distress in Patients With COVID-19 Infection. Phase 2/Phase 3 Interventional Standard of care evolved during the timeframe of the study and had critical impact on recruitment. Early termination is not based on safety reasons but because of recruitment issues. Patients ongoing will be completed. Planned LPLV 25Jan2021 Actual 16
NCT04490382 Withdrawn Spinal Cord Stimulation (SCS) for Amputees N/A Interventional Funding Actual 0
NCT00470249 Terminated Carboplatin and Gemcitabine in Treating Patients With Locally Advanced or Metastatic Breast Cancer Phase 2 Interventional Due to difficulty in recruitment Actual 5
NCT03587831 Suspended Vertical Sleeve Gastrectomy and Lifestyle Modification for the Treatment of Non-Alcoholic Steatohepatitis N/A Interventional Recruitment has been halted until further funding is secured. Anticipated 60
NCT03967587 Suspended Evaluation of Intravascular Monitoring of Partial PRessure of Oxygen for Neonatal intensiVE Care Patients N/A Interventional Suspended due to a Device Deficiency, an obstruction at the position under the suture thread. Before resuming the clinical investigation, a protective action must be implemented to avoid the catheter from kinking at the site of the suture. Anticipated 50
NCT04215900 Suspended High-Speed Yoga and Executive Function N/A Interventional COVID-19 Anticipated 90
NCT04389229 Withdrawn OVSTAR TIL Trial (OVarian Cancer Co-STimulatory Antigen Receptor TIL Trial) Phase 1/Phase 2 Interventional Sponsor decision Actual 0
NCT04531865 Withdrawn Randomized Trial Evaluating Mycophenolate Mofetil in Children With Nephrotic Syndrome After Rituximab Treatment Phase 3 Interventional To Whom it may concern, we are writing to terminate the trial due to lack of funding. No participant was enrolled. We are sorry for any inconvenience caused. Please let me know if this is suitable.Thank you and best regards. Actual 0
NCT04577131 Suspended Improving Adherence to Home Blood Pressure Monitoring With Pharmacist Support N/A Interventional App has been discontinued. Waiting on IRB approval for an amendment Anticipated 50
NCT04671420 Withdrawn Evaluate the Efficacy and Safety of HLX01 Versus Mabthera in Patients With Low Tumour Burden Follicular Lymphoma. Phase 3 Interventional sponsor strategy decision Actual 0
NCT00114712 Terminated The Ribavirin Pregnancy Registry Observational [Patient Registry] Per the Division of Project Management, Office of Regulatory Operations, Office of Generic Drugs, FDA there is no regulatory requirement to continue this Registry. Actual 477
NCT00823290 Terminated Sorafenib and LBH589 in Hepatocellular Carcinoma (HCC) Phase 1 Interventional Investigator left site Actual 2
NCT01524120 Withdrawn Endoscopy and Endomicroscopy for Assessment of Mucosal Healing in Inflammatory Bowel Disease (IBD) Observational Actual 0
NCT02597465 Withdrawn A Randomized, Open-Label, Comparative, Parallel-Group, Multicenter Study of SPARC1507 Phase 3 Interventional Sponsor decided not to initiate the study for alternate commercial strategy Actual 0
NCT03519126 Terminated Electrostimulation in the Treatment of Idiopathic Overactive Bladder N/A Interventional Due to the covid-19 pandemic Actual 67
NCT03563352 Withdrawn Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in Participants With Breast, Colorectal, Upper Gastrointestinal, or Prostate Cancer Observational Zero accrual Actual 0
NCT03713320 Terminated SOLAR: Efficacy and Safety of Cobomarsen (MRG-106) vs. Active Comparator in Subjects With Mycosis Fungoides Phase 2 Interventional The study was terminated early for business reasons, and not due to concerns regarding safety or lack of efficacy. Actual 37
NCT03720392 Terminated Fecal Microbiota Transplantation (FMT) in Recipients After Allogeneic Hematopoietic Cell Transplantation (HCT) Phase 2 Interventional Terminated due to sponsor decision Actual 8
NCT03868891 Suspended Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate N/A Interventional All study procedures have been suspended since March 20, 2020 due to Coronavirus Disease 2019. Anticipated 30
NCT03881553 Terminated Interventions to Help Infants Recover in the Hospital N/A Interventional Covid halt in March; PI subsequently moved to another Institution Actual 14
NCT03881748 Suspended Clinical Trial of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy N/A Interventional Insufficient staff Anticipated 20
NCT04109092 Withdrawn A Study of Stimulator of Interferon Genes (STING) Agonist E7766 in Non-muscle Invasive Bladder Cancer (NMIBC) Including Participants Unresponsive to Bacillus Calmette-Guerin (BCG) Therapy, INPUT-102 Phase 1 Interventional There was no enrolment of participants.Unscheduled Clinical Study Closure - Eisai Network Company Decision, November 12, 2020. Actual 0
NCT04369599 Suspended Trans Thoracic Manipulation of Ventilation/Perfusion: the V/Q Vest for COVID-19 N/A Interventional Enrollment temporarily suspended pending protocol updates. Anticipated 24
NCT04388722 Withdrawn Monitoring Noninvasively for Infusion and Transfusion Optimization N/A Interventional Sponsor's decision to withdraw study. Actual 0
NCT04537975 Withdrawn C2Rx Hemofiltration Treatment in Severe or Critically Ill Adults With COVID-19 N/A Interventional Withdrawn (Study was withdrawn by Sponsor because of change in regulatory strategy.) Actual 0
NCT03514277 Terminated A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Phase 4 Interventional PI decision to close study early Actual 19
NCT03472755 Withdrawn Comparison of Direct Anterior and Posterior Surgical Approaches in Regards to the Patient' Physical Characteristics N/A Interventional difficulty in setting up the study in the investigator site Actual 0
NCT03773172 Terminated Study to Evaluate the Effects of MEDI6012 on Apolipoprotein B100 Metabolism Phase 2 Interventional Early termination due to COVID-19 Actual 7
NCT03901079 Terminated Trial for A Novel Facilitated Antegrade Steering Technique in Revascularization of Coronary Chronic Total Occlusions Observational HGRAC approval letter had expired. The enrollment speed of FAST CTO is much slower than planning and the scientific value becomes limited due to the delayed data readout anticipation. Actual 20
NCT04194840 Suspended Transplant Wellness Clinic for Elderly or High Risk Patients Undergoing BMT N/A Interventional COVID-19 Anticipated 20
NCT04397393 Terminated Does Camel Milk Consumption Decrease The Efficacy Of Midazolam For Sedation Observational insufficient data Actual 26
NCT04665310 Withdrawn Evaluation of Anti-rejection Drug, Tacrolimus, in African-Americans With Kidney Transplant Phase 4 Interventional Study not started, funding Actual 0
NCT01805037 Terminated Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Phase 1/Phase 2 Interventional Lack of funding Actual 20
NCT02282514 Terminated Stem Cell Transplantation for Stiff Person Syndrome (SPS) Phase 1/Phase 2 Interventional Could not predict who would respond, relapse or go into remission Actual 23
NCT02213757 Terminated Effect of Vaginal Estrogen on Asymptomatic Microhematuria (AMH) Phase 4 Interventional Low Enrollment Actual 27
NCT04663269 Terminated Regional Erector Spinae Analgesic Block vs Standard of Care Undergoing Percutaneous Nephrolithotomy Phase 4 Interventional Drop out from surgeons from 3 to 1. It will take too long to feasibly accrue with only one provider. Actual 5
NCT04668859 Terminated Midodrine as Novel Treatment of Post-Cardiopulmonary Bypass Vasoplegic Syndrome Phase 4 Interventional PI relocated Actual 10
NCT02893176 Withdrawn Macitentan in the Treatment of Organ Rejection After Lung Transplantation Phase 4 Interventional Actual 0
NCT03715400 Suspended Mobile Virtual Positive Experiences for Anhedonia N/A Interventional COVID-19 Restrictions for in-person study procedures Anticipated 74
NCT04309825 Withdrawn Transgastrostomal Endoscopies N/A Interventional no IRB approval Actual 0
NCT04433546 Terminated Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Phase 2 Interventional Company no longer pursing indication Actual 54
NCT04137107 Suspended Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer Phase 2/Phase 3 Interventional Protocol-specified safety stopping rule Anticipated 327
NCT01842282 Suspended Amlexanox for Type 2 Diabetes and Obesity Phase 2 Interventional Funding struggles, may resume recruitment if funding problems resolve Anticipated 15
NCT01906073 Withdrawn Nasal Fentanyl for Chronic Cancer Pain Phase 3 Interventional Actual 0
NCT03323190 Withdrawn An Educational Intervention to Improve Disease Management Knowledge of Hospitalized Patients With COPD N/A Interventional Withdrawn due to low feasibility. Actual 0
NCT03353896 Withdrawn NovoTTF-200A Device in Treating Patients With Newly Diagnosed High Risk Oligodendroglioma N/A Interventional Insufficient accrual Actual 0
NCT03420521 Terminated Nivolumab With Ipilimumab in Subjects With Neuroendocrine Tumors Phase 2 Interventional Loss of funding Actual 9
NCT02681809 Terminated A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR Phase 2 Interventional Slow recruitment rate Actual 48
NCT03631654 Withdrawn Ivabradine in Stage D Heart Failure Patients on Chronic Inotropes Phase 4 Interventional Unable to obtain funding Actual 0
NCT03922477 Terminated A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in Combination With Hu5F9-G4 to Patients With Relapsed and/or Refractory Acute Myeloid Leukemia Phase 1 Interventional F. Hoffmann-La Roche has decided to terminate enrollment and close the study prior to planned due to a lack of continued strategic fit. Actual 13
NCT04077372 Suspended Assessment of a Serious Illness Conversation Guide (SICG) in Advanced Gastro-Intestinal Cancers N/A Interventional Covid-19 Anticipated 68
NCT04329923 Terminated The PATCH Trial (Prevention And Treatment of COVID-19 With Hydroxychloroquine) Phase 2 Interventional Cohort 1: slow accrual Cohort 2: Other studies showed no benefit Cohort 3: Study met pre-specificied futility analysis at planned second interim analysis Actual 173
NCT04603690 Withdrawn Study to Investigate the Benefits of Colchicine in Patients With COVID-19 Phase 3 Interventional No funding available Actual 0
NCT02745210 Terminated Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy. N/A Interventional The acquisition sequence was incompatible with MRI hardware Actual 9
NCT02598674 Withdrawn Severe Sepsis in Children - IMPRESS-C Observational Expired IRB Actual 0
NCT03123783 Terminated CD40 Agonistic Antibody APX005M in Combination With Nivolumab Phase 1/Phase 2 Interventional Sponsor business reasons Actual 400
NCT03348735 Terminated Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment Phase 4 Interventional Low inclusion rate Actual 33
NCT03720210 Terminated Radiofrequency Ablation for Amiodarone-induced Thyrotoxicosis N/A Interventional Very low enrollment Actual 1
NCT04139382 Suspended Using Telemedicine to Improve Early Medical Abortion at Home N/A Interventional Suspended during COVID-19 outbreak, aim to re-start 2021 Anticipated 1222
NCT04198168 Terminated The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance Observational Due to the COVID-19 situation, it was not feasible to complete the study in our ICU. Actual 2
NCT00634972 Terminated Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity Phase 4 Interventional The study could not be completed as the company producing this product interrupted their supply of this medication Actual 83
NCT01121120 Terminated Acceleration of Platelet Recovery Following Autologous Peripheral Blood Stem Cell Transplant (PBSC) in Hodgkin, Non-Hodgkin Lymphoma or Multiple Myeloma Patients Phase 2 Interventional Actual 75
NCT01300611 Terminated TXA127 in Enhancement of Engraftment in Adult Double Cord Blood Transplantation Phase 1 Interventional Anticipated 20
NCT04664803 Terminated Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis Phase 4 Interventional Actual 284
NCT03537612 Suspended Sensorial and Physiological Mechanism-based Assessments of Perioperative Pain Phase 3 Interventional Do to our inability to meet recruitment targets - Sponsor stopped funding. Looking for new sponsor and protocol modifications Anticipated 150
NCT02382588 Terminated Comparison of Topical 0.15% Gancyclovir Gel Versus 0.3% Hypromellose Gel for the Treatment of Herpes Zoster Keratitis Phase 2 Interventional There were difficulties meeting the enrollment goal within stipulated time frames. Actual 7
NCT02401074 Withdrawn Airway Temperature Phase 1 Interventional Study was withdrawn prior to patient enrollment due to COVID-19, funding termination and lack of eligible study participants. Actual 0
NCT00760929 Terminated A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on Progression-Free Survival in Patients With Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC). Phase 2 Interventional The study was terminated due to the termination of the clinical development program. Actual 171
NCT04656808 Terminated Guilt Focused Psychological Intervention N/A Interventional COVID-19 Actual 110
NCT02607228 Terminated Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 (Alobresib) as a Single Agent and In Combination With Enzalutamide in Participants With Metastatic Castrate-Resistant Prostate Cancer Phase 1/Phase 2 Interventional Actual 31
NCT02803632 Terminated Clinical and Actigraphic Profile of Young Patients Admitted for Attempted Suicide N/A Interventional recruitment problem Actual 98
NCT02905279 Terminated Spider Phobia Opposite Action Treatment Study N/A Interventional Doctoral student running the study left for internship and did not finish the study Actual 44
NCT03240003 Suspended A Novel Computer-Based Therapy for Social Anxiety N/A Interventional funding unavailable Anticipated 60
NCT03794960 Withdrawn Diabetes AutoimmunitY Withdrawn in Established Patients (DAY) Phase 2 Interventional Modification to Clinical Development Plan Actual 0
NCT03794973 Withdrawn Diabetes Autoimmunity Withdrawn in New Onset Patients (DAWN) Phase 2 Interventional Modification to Clinical Development Plan Actual 0
NCT03993314 Terminated Optimizing Anesthesia for Post Partum Tubal Ligations Phase 2 Interventional Lack of recruitment due to COVID-19 pandemic; chloroprocaine shortage Actual 17
NCT04031066 Withdrawn Interventional Study to Assess Efficacy and Safety of Velmanase Alfa in Patients With Alpha Mannosidosis Phase 3 Interventional Big delay on study activation (approval procedures by IRBs, hospitals contract negotiation) and on enrolment deadline due to CoViD-19; Placebo stock expires November 2021 and new batch not be available for at least one year Actual 0
NCT04185727 Terminated Training Intervention in the Treatment of Anorexia Nervosa N/A Interventional Corona. Actual 5
NCT04186598 Suspended Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema N/A Interventional Due to COVID-19 with temporary closure of recruitment sites Anticipated 264
NCT04410354 Terminated Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19 Phase 2 Interventional Failure to meet primary endpoint Actual 44
NCT04437953 Withdrawn Avatrombopag for Thrombocytopenia in People With Cancer Phase 2 Interventional Lack of accrual Actual 0
NCT04498598 Suspended Structural Modification In Supraglottic Airway Device N/A Interventional The manufacturer of the device has pending modifications to the device. Enrollment will resume once the revised devices are received at the site Anticipated 100
NCT02926521 Suspended Assessing Current Peripheral Nerve Block Catheter Fixation and Dressing Strategies: An Equivalence Study N/A Interventional COVID 19 RELATED FACTORS Anticipated 800
NCT03295695 Withdrawn PET-CT Imaging Using FDG-labeled Human Erythrocytes in Breast Cancer Patient Early Phase 1 Interventional closure of radiolaboratory Actual 0
NCT03354962 Terminated Induction of Immune-mediated aBscOpal Effect thrOugh STEreotactic Radiation Therapy in Metastatic Melanoma Patients Treated by PD-1 + CTLA-4 Inhibitors (BOOSTER MELANOMA) Phase 1/Phase 2 Interventional Slow recruitment rate Actual 6
NCT03543969 Suspended Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma Early Phase 1 Interventional pending amendment Anticipated 20
NCT03904199 Suspended Prospective Study of Personalized Approach to Inpatient Patients With Hyperglycemia Phase 4 Interventional pending amendment Anticipated 576
NCT03909295 Terminated An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan. Phase 3 Interventional This study was terminated early because the primary endpoint of PARAGON-HF was not met. Actual 52
NCT04092764 Suspended Feasibility Study for Electroacupuncture for Chemotherapy- Induced Peripheral Neuropathy (CIPN) N/A Interventional acupuncturist unavailable Actual 5
NCT00272987 Terminated ErbB2 Over-expressing Metastatic Breast Cancer Study Using Paclitaxel, Trastuzumab, and Lapatinib Phase 3 Interventional Enrollment was closed after the open label stage due to poor recruitment rate (randomized stage never opened). Actual 63
NCT01714817 Terminated Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis Phase 3 Interventional Inability to meet protocol objectives. Actual 695
NCT00701077 Terminated DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome Phase 3 Interventional recruitments issues Actual 5
NCT01101581 Withdrawn Study of Veltuzumab and 90Y-Epratuzumab in Relapsed/Refractory, Aggressive NHL Phase 1/Phase 2 Interventional No subjects enrolled Actual 0
NCT01510561 Withdrawn A Study of Fractionated 90Y-hPAM4 Plus Gemcitabine in Pancreatic Cancer Patients Receiving at Least 2 Prior Therapies. Phase 1 Interventional no subjects enrolled Actual 0
NCT01915472 Withdrawn A Phase II Study of IMMU 130 in Patients With Metastatic Colorectal Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03068130 Terminated Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER Phase 3 Interventional The company determined that continued exposure of these high-risk PH patients to clinic or in-person visits during the COVID pandemic presented an unacceptable risk. Actual 261
NCT03452202 Suspended Using tDCS in Speech-based Stroke Rehabilitation N/A Interventional COVID-19: protocol requires a large number (20+) of specifically timed visits. Because a mistimed visit would disqualify a participant, we have suspended until travel and data collection can be assured. Anticipated 12
NCT03563911 Withdrawn Brief Mindfulness and Nutrition-Based Interventions for Chronic Pain: Strategies to Ease Pain N/A Interventional COVID pandemic Actual 0
NCT03691415 Terminated Evaluation of the Safety and Effectiveness of BELKYRA® Inj. for the Treatment of Patients With Submental Fullness Due to Submental Fat: A Postmarketing Surveillance Study in Korea Observational Study discontinued due to business decisions. Actual 71
NCT03844646 Suspended Continuous Glucose Monitoring to Aid Weight Loss in Prediabetes N/A Interventional COVID-19 Anticipated 20
NCT03996252 Terminated Combination Topical Therapy for Treatment of Scalp Actinic Keratoses Early Phase 1 Interventional The study team was not able to start the study and they never completed the IRB submission, so the study was terminated. Actual 15
NCT04125745 Terminated Oral CXA-10 in Pulmonary Arterial Hypertension Phase 2 Interventional negative study outcome from Complexa's multicenter clinical trial; no safety concerns Actual 2
NCT04245852 Terminated Does a Video-based Education Tool Related to Strengthening Result in Different Functional Outcomes Compared to Traditional Physical Therapy Education for Patients? N/A Interventional COVID pandemic disrupted subject recruitment and primary investigator no longer with our university; no additional interest in continuing the study. Actual 5
NCT04287179 Withdrawn SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes Phase 3 Interventional COVID19 impact on this trial was evaluated and a delay of at least 6-9 months was expected. In parallel, the development of a new type of pen injector, which was an important part of the trial, was ceased and thus this trial was cancelled. Actual 0
NCT04355676 Withdrawn Evaluation of Activity and Safety of Two Regimens of Low Dose Oral Selinexor in Participants With Moderate or Severe COVID-19 Phase 2 Interventional No participants enrolled Actual 0
NCT04394104 Terminated COVID-19 Wellness Survey Observational Study has concluded. Actual 593
NCT04558216 Suspended Evaluation of Effect of Rifampin on the Pharmacokinetics of Vonoprazan in Healthy Participants Phase 1 Interventional Currently suspended due to ongoing FDA evaluation of rifampin products Anticipated 16
NCT02663934 Terminated Exercise Training to Improve Brain Health in Older HIV+ Individuals N/A Interventional COVID-19 Risk Actual 75
NCT02776709 Withdrawn Feasibility of a Single-operator Peroral Cholangiopancreatioscopy System (SpyGlass) Observational [Patient Registry] Actual 0
NCT03024424 Suspended Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD N/A Interventional Anticipated 200
NCT03058146 Terminated Independent Walking for Brain Health N/A Interventional COVID-19 Actual 55
NCT03257332 Withdrawn Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After Surgery for Rectal Cancer. Observational [Patient Registry] Not possible to include participants Actual 0
NCT03660657 Suspended Ozone Therapy in Refractory Ischemic Heart Disease. Phase 2/Phase 3 Interventional Very low recruitment. During COVID-19 pandemic these are patients of high risk. Anticipated 18
NCT03800069 Terminated Validation of Point of Care Liver Function Tests Observational scheduling complexities Actual 68
NCT04066192 Suspended Brexpiprazole in Alcohol Use Disorder Phase 2 Interventional Recruitment temporarily paused due to Level Red COVID numbers and restrictions. Anticipated 250
NCT02576977 Terminated Study of Pomalidomide and Low Dose Dexamethasone With or Without Pembrolizumab (MK-3475) in Refractory or Relapsed and Refractory Multiple Myeloma (rrMM) (MK-3475-183/KEYNOTE-183) Phase 3 Interventional The study was terminated early due to business reasons Actual 251
NCT04069910 Terminated Stereotactic Radiation Therapy Before Surgery for the Treatment of Resectable Brain Metastases N/A Interventional slow enrollment Actual 1
NCT02579863 Terminated Study of Lenalidomide and Dexamethasone With or Without Pembrolizumab (MK-3475) in Participants With Newly Diagnosed Treatment Naive Multiple Myeloma (MK-3475-185/KEYNOTE-185) Phase 3 Interventional The study was terminated early due to business reasons Actual 310
NCT04253457 Suspended The SToICAL Study - The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study Phase 3 Interventional COVID-19 Anticipated 100
NCT04338997 Withdrawn PK Study in Patients With Parkinson's Disease With IZD174 Phase 1 Interventional Strategic decision by Sponsor Actual 0
NCT04659694 Withdrawn Effect of an Intervention on Health in Older Care Home Residents N/A Interventional Withdrawal of PhD Actual 0
NCT01861028 Terminated Study Comparing Fit of the iTotal Versus Standard Total Knee Implants Observational Not enough patient volume to continue the study. Actual 44
NCT02046135 Terminated Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery Phase 2 Interventional Statistical analysis at interim analysis determined futility in continuing. Actual 51
NCT03041116 Terminated Efficacy and Safety Study of Fosmetpantotenate (RE-024) in PKAN Participants Phase 3 Interventional The study was terminated since fosmetpantotenate did not show statistically significant effects or clinical benefits during the double-blind period. Actual 84
NCT04151225 Withdrawn Study to Evaluate Safety, Tolerability and Efficacy of GSK2330811 in Crohn's Disease Phase 2 Interventional Internal sponsor decision to terminate project in Crohn's disease due to potential narrow therapeutic window. No subjects were enrolled Actual 0
NCT04368000 Terminated Prone Positioning in Awake Patients With COVID-19 Requiring Hospitalization N/A Interventional Study was terminated due to lack of adherence to the protocol in the intervention arm. Actual 30
NCT04460729 Withdrawn A Phase II, Open-Label, Multicenter Study of Capmatinib in Subjects With MET Exon 14 Skipping Mutation Positive, Advanced, NSCLC With Brain Metastases Phase 2 Interventional company decision Actual 0
NCT01268059 Terminated A Study of Carboplatin and Paclitaxel With or Without MEDI-575 in Untreated, Advanced Non-Small Cell Lung Cancer Phase 1/Phase 2 Interventional In conjunction with the overall risk-benefit assessment, study was terminated prematurely due to safety concerns. Actual 99
NCT04497948 Terminated Acalabrutinib Study With Best Supportive Care in Participants Hospitalized With COVID-19 Phase 1 Interventional Data from the CALAVI Phase II trials for Acalabrutinib in patients hospitalized with COVID-19 did not meet their primary efficacy endpoints. Based on this higher management made the decision to prematurely terminate the D822FC00005 PK study. Actual 8
NCT02693444 Withdrawn Comparison of Strength and Constant Score Pre- and Post-Subacromial Injection for Full Thickness Rotator Cuff Tears N/A Interventional Low pool of subjects Actual 0
NCT03145779 Withdrawn Evaluation of Phenotypic Variability in Fabry Disease Observational Funding Actual 0
NCT03353610 Terminated The PSVT Place Registry.Paroxysmal Supraventricular Tachycardia (PSVT) Registry. Observational Termination due to lack of adequate enrollment Actual 354
NCT03666429 Withdrawn Effectiveness of the NoseFrida Compared With Bulb Suction at Relieving Objective Signs of Nasal Obstruction and Reducing Return Visits in Pediatric Patients Presenting to the Emergency Department N/A Interventional PI left institution Actual 0
NCT03785392 Terminated Out of Plane Approach for Interscalene N/A Interventional Primary investigator left the Institution Actual 30
NCT03843320 Suspended Impact of SAVR and TAVR on Patient's Activity and Mobility Observational Reassessing study feasibility Anticipated 340
NCT02862535 Terminated Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Anti-Cancer Agents in Japanese Participants With Gastric or Gastroesophageal Junction Adenocarcinoma Phase 1 Interventional Study was terminated due to sponsor's decision to not pursue further development of andecaliximab in oncology Actual 36
NCT03137693 Terminated Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer N/A Interventional no responders/lack of efficacy Actual 20
NCT00023868 Terminated Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655) Phase 3 Interventional redesign 0
NCT01002209 Withdrawn Postoperative Hyperbaric Oxygen Treatments to Reduce Complications in Diabetic Patients Undergoing Vascular Surgery Phase 2/Phase 3 Interventional Changes in the organisation Actual 0
NCT03686423 Suspended Reversing Diabetic Peripheral Neuropathy Through Exercise Observational patient cohort consists of diabetic patients, which is a co-risk factor for covid-19 Anticipated 40
NCT03805464 Suspended Walking Gait Biomechanics Following Knee Joint Effusion N/A Interventional This study is suspended secondary to staffing/PI availability until February 2021. Anticipated 25
NCT03809494 Terminated HemaTrate™ in the Treatment of Critical Limb Ischemia N/A Interventional The study has stopped early due to enrollment challenges related largely to the current pandemic Actual 2
NCT04004416 Suspended Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis Phase 4 Interventional Enrollment and interactions/interventions are temporarily paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 232
NCT04010461 Suspended Theta Burst Transcranial Magnetic Stimulation of Fronto-parietal Networks: Modulation by Mental State N/A Interventional Enrollment and interactions/interventions are temporarily paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval. Anticipated 48
NCT04052204 Terminated Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors Phase 2 Interventional The recruitment of new subjects has been stopped with no intention of restarting the study before reaching the protocol specified End of Trial. Actual 3
NCT04156204 Terminated Immunosuppressant Medication Dosed Daily After Kidney Transplant Early Phase 1 Interventional Discontinuation of study due to site staffing and resources available to conduct the study Actual 1
NCT01620216 Terminated Targeted Therapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia Phase 2 Interventional Unable to recruit enough eligible subjects Actual 13
NCT03904342 Withdrawn Sophie Pilot Implementation and Assessment N/A Interventional This study was not conducted due to concerns about collaboration with an outside vendor for the control condition. Actual 0
NCT04014569 Terminated Determination of Automated Multiple Insulin Dose Injections Settings Using the MDI/SMBG Advisor for Patients With Type 1 Diabetes -Data Collection, Observational & Proof of Concept Study N/A Interventional Investigators decision Actual 6
NCT02940223 Terminated Ethyl Icosapentate and Physical Activity in Treating Fatigue in Patients With Advanced Cancer Phase 2 Interventional PI is requesting termination (closure) of this study. Actual 2
NCT03990597 Withdrawn StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord Phase 1 Interventional Per PI Actual 0
NCT00626197 Terminated A Study to Evaluate Ocrelizumab in Patients With Nephritis Due to Systemic Lupus Erythematosus (BELONG) Phase 3 Interventional Study was terminated due to an imbalance of serious and opportunistic infections in the ocrelizumab treated patients versus the placebo arm. Actual 381
NCT02704403 Terminated Phase 3 Study to Evaluate the Efficacy and Safety of Elafibranor Versus Placebo in Patients With Nonalcoholic Steatohepatitis (NASH) Phase 3 Interventional Study did not meet the predefined primary surrogate efficacy endpoint, no safety issues identified Actual 2157
NCT02993094 Terminated Ixazomib (MLN9708) in Combination With Carboplatin in Pretreated Women With Advanced Triple Negative Breast Cancer Phase 1/Phase 2 Interventional Due to slow recruitment, the study had to be terminated prematurely. Actual 31
NCT03040453 Withdrawn Immunological Response After Ablative Therapy in the Liver N/A Interventional poor recruitment Actual 0
NCT03676543 Suspended Mutual Interactions Between Absence Epilepsy Seizures and the Integration of Sensory Stimuli N/A Interventional we arrived to the end of the inclusion and only 1 patient was recruited. We will submit an amendement Anticipated 20
NCT03873662 Terminated Biochemical Makers for Outcome After Pediatric out-of Hospital Cardiac Arrest Observational Low inclusion rate Actual 4
NCT04167345 Terminated Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype Phase 2 Interventional at Sponsor's discretion Actual 48
NCT04246034 Withdrawn Microvascular Breast Reconstruction With Lymph Node Transfer N/A Interventional surgery considered elective and cant be performed within corona restrictions Actual 0
NCT01602302 Terminated Ultrasound and Withdrawal of Biological DMARDs in Rheumatoid Arthritis Phase 4 Interventional low recruitment Actual 40
NCT03301701 Withdrawn Feasibility Trial in Men With Hormone Sensitive Oligometastatic Prostate Cancer N/A Interventional Lack of accruals Actual 0
NCT02452983 Terminated Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome Phase 1 Interventional This protocol is closed to further enrollment due to lack of study progress. Actual 14
NCT02838030 Suspended Efficacy of Aspirin and L-arginine in High Risk Preeclamptic Phase 2 Interventional COVID-19 pandemic Anticipated 82
NCT03397446 Terminated Lisdexamfetamine for Adults With Bulimia Nervosa Phase 2 Interventional Loss of resources due to COVID-19 resulted in insufficient funds to complete the trial as planned. However, sufficient data was collected to fulfill the aims of the trial. Discontinuation is not related to the drug, its use, or adverse events. Actual 23
NCT03482466 Terminated Neurofeedback for PTSD N/A Interventional Covid-19 Actual 8
NCT04148742 Suspended Assessing an Oral Bruton Tyrosine Kinase Inhibitor, DZD9008 in Patients Who Have Non-Hodgkin B-cell Lymphoma (WU-KONG3) Phase 1/Phase 2 Interventional Clinical development strategy adjustment, non-safety reason Anticipated 120
NCT00678002 Terminated Quality of Life in Pediatric Transplant Patients Observational Poor enrollment Actual 57
NCT04072874 Suspended Evaluation of the Safety and Clinical Activity of Curaleish in the Topical Treatment of Cutaneous Leishmaniasis. Phase 1/Phase 2 Interventional Tthe study is in the approval phase by local regulatory authorities Anticipated 50
NCT04273022 Suspended Effect of Exercise on Biomarkers in SCT N/A Interventional Due to the Covid-19 pandemic, Saint Louis University suspended human research studies that did not meet specific criteria, which this study did not meet. Anticipated 20
NCT02692768 Suspended The Effect of Music Therapy Intervention on Pain and Anxiety in Adult Patients Undergoing Total Shoulder Arthroplasty N/A Interventional as of 11/24/2020 indefinitely due to COVID-19 Anticipated 115
NCT03309098 Withdrawn Agreement Between Clinician and Instrumented Laxity Assessment Observational IRB's initial review of this study was not completed and study was withdrawn Actual 0
NCT03799380 Suspended DRIHNC - Dehydration Reduction in Head & Neck Cancer N/A Interventional Interim analysis Anticipated 155
NCT03880123 Withdrawn Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma Phase 1 Interventional Study will not proceed, no participants enrolled. Actual 0
NCT04139304 Suspended A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma Early Phase 1 Interventional Study contract changes Anticipated 15
NCT04140669 Terminated Automated Myocardial Performance Index Using Samsung HERA W10 Observational Sponsor support and funding was terminated due to pandemic Actual 7
NCT04258358 Suspended Evaluating the Community Areas of Sustainable Care and Dementia Excellence Model of Care N/A Interventional COVID-19 Interruption Anticipated 250
NCT04362124 Withdrawn Performance Evaluation of BCG Vaccination in Healthcare Personnel to Reduce the Severity of COVID-19 Infection. Phase 3 Interventional Study was stopped because Principal Investigator did not obtain sponsorship to carry it out Actual 0
NCT01225341 Terminated Botulinum Toxin A for Herpes Labialis N/A Interventional Too many patients withdrew/lost to follow up Actual 20
NCT03407482 Terminated An Extension Study of GDC-0853 in Participants With Moderate to Severe Active Systemic Lupus Erythematosus Phase 2 Interventional The study was ended early due to the lack of efficacy seen in the parent study GA30044. Actual 160
NCT00011492 Terminated Patient Evaluation for Head and Neck Surgery Branch Studies Observational Closed by Sponsor/Data Safety monitoring Board/IRB Actual 62
NCT01629095 Terminated Genetic Studies of Non-Alcoholic Fatty Liver Disease Observational Slow/insufficient accrual Actual 17
NCT03849079 Terminated Validation of the HYPONUT Product N/A Interventional All prick tests are positive Actual 6
NCT01683214 Terminated Brain Network Activation Analysis to Diagnose/Assess Treatment of Unipolar Major Depression and Bipolar I Depression Observational Actual 30
NCT03538795 Terminated Brain Stimulation and Rehabilitation for Adults With Chronic, Severe Arm Motor Impairment After Stroke N/A Interventional Ran out of funds Actual 3
NCT01433198 Withdrawn Aquatic Training in Patients With Severe Scarring N/A Interventional finances and feasibility Actual 0
NCT01522716 Terminated Mesenchymal Stromal Cells as Treatment of Chronic Graft-versus-host Disease Phase 1 Interventional New requirements for study approval with the Swedish Medical Products Agency Actual 11
NCT02311296 Withdrawn Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions Observational Study registered to wrong sponsor. Actual 0
NCT02435095 Terminated Antipsychotic Induced Structural and Functional Brain Changes Phase 4 Interventional slow patient recruitment, low patient-commpliance, high dropout rates, Actual 174
NCT02747784 Terminated Evaluation to Assess Cognitive Training for the Prevention of Post-operative Cognitive Decline N/A Interventional Lack of recruitment Actual 19
NCT02878694 Terminated Treatment of Ptosis to Muscular Dystrophy Oculopharyngeal by Myoblast Autologous Graft Phase 2/Phase 3 Interventional insufficient recruitment Actual 1
NCT03395652 Withdrawn Maternal Physical Activity and Pregnancy Outcome Observational technical problems Actual 0
NCT03409757 Terminated Velphoro and Impact on the Oral Cavity and Gut Microbiome Observational Insufficient Patient Recruitment Actual 22
NCT03875313 Terminated Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors Phase 1/Phase 2 Interventional Slow Enrollment Actual 33
NCT03928834 Withdrawn Sustainable Adherence and Prevention of HIV Drug Resistance in Adolescents N/A Interventional There was a delay in getting protocol approvals and hence the study would not be completed in time. Actual 0
NCT04195373 Withdrawn A Safety Study of TMV-018 in Patients With Tumors of the Gastrointestinal Tract Phase 1 Interventional Study not started, no subjects recruited. Actual 0
NCT02572570 Terminated Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth N/A Interventional Attrition rate complicated by COVID-19 led to termination. Actual 27
NCT01891643 Terminated PH III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Previously Untreated Multiple Myeloma (ELO 1 Substudy) Phase 3 Interventional Insufficient enrollment Actual 29
NCT02320292 Suspended Rituximab With or Without Yttrium Y-90 Ibritumomab Tiuxetan in Treating Patients With Untreated Follicular Lymphoma Phase 3 Interventional Anticipated 128
NCT02718196 Withdrawn Testing and Development of a Sleep Training Mobile Health Application N/A Interventional App stopped development before minimum viable product created Actual 0
NCT03592784 Terminated Food Order Intervention for Gestational Diabetes N/A Interventional Lack of enrollment during Covid pandemic, however sufficient data gathered for assessment of primary outcome Actual 28
NCT03159598 Withdrawn Drain-Less Abdominally Based Breast Reconstruction Using Lysine-Derived Urethane Adhesive N/A Interventional PI left institution, never submitted to IRB Actual 0
NCT03308734 Withdrawn Effects of 6 Week Reduced Exertion High Intensity Interval Training Protocol in Patients With Prostate Cancer N/A Interventional Lack of resource from collaborating organisation Actual 0
NCT03341676 Suspended Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) Phase 1 Interventional COVID Anticipated 30
NCT03352024 Withdrawn Impact of Hypno-analgesia on Pain During a Lumbar Puncture for Diagnosis of Alzheimer's Disease N/A Interventional internal organizational problem and dysfunction of study material Actual 0
NCT03361319 Withdrawn Combination Nab-paclitaxel (N-P) and Nintedanib or N-P and Placebo in Relapsed NSCLC Adenocarcinoma Phase 1/Phase 2 Interventional Withdrawal of financial support from funder Actual 0
NCT03400748 Terminated ANET Electrosurgery Applicator Pilot Evaluation Study N/A Interventional business reason Actual 6
NCT03684642 Terminated Efficacy and Safety of Efpeglenatide Versus Dulaglutide in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Phase 3 Interventional Sponsor decision to cancel TRIAL, not related to safety concern Actual 909
NCT04117438 Withdrawn Tell us Your Food Story Observational Due to COVID-19 pandemic, we will not be pursuing this study Actual 0
NCT04414904 Withdrawn Determining the Reproductive Health of Men Post-COVID-19 Infection Observational Unable to obtain approval Actual 0
NCT02951156 Terminated Avelumab In Combination Regimens That Include An Immune Agonist, Epigenetic Modulator, CD20 Antagonist and/or Conventional Chemotherapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) Phase 3 Interventional Study was terminated due to closure of study arms following futility analysis and difficulty in enrolling participants due to evolving treatment landscape Actual 29
NCT03363776 Terminated An Investigational Immuno-Therapy Study of Experimental Medication BMS-986277 Given Alone and in Combination With Nivolumab in Epithelial Cancers Phase 1/Phase 2 Interventional Business objectives have changed Actual 10
NCT01661387 Terminated A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI) Observational Takeda submitted 900 patient years Interim Analysis to PRAC and requested study to be closed since primary objective had been fulfilled. PRAC agreed and on 17Sep2020 approved closure of EU-AIR Registry. Takeda announced study closure on 31Oct2020. Actual 3258
NCT02131376 Terminated Investigating a Novel Modifiable Factor Affecting Renal Function After Partial Nephrectomy: Cortical Renorrhaphy N/A Interventional slow accrual, interim analysis showed no statistical significance Actual 26
NCT02154230 Suspended Sulphate-bicarbonate-calcium Water, Body Weight and Gut Microbiota N/A Interventional failure to enroll Anticipated 44
NCT02420795 Terminated Akt/ERK Inhibitor ONC201 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Phase 1/Phase 2 Interventional Per PI Request Actual 16
NCT02951572 Terminated Non-invasive Ventilation and Physical Activity N/A Interventional Recruitment problem Actual 8
NCT03014258 Suspended A Systems Biology Approach to Malaria Immunity Phase 1 Interventional Study is paused due to COVID-19. Anticipated 34
NCT03341273 Terminated Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level N/A Interventional Due to covid Actual 514
NCT03640338 Withdrawn The Efficacy of Continuous Cold-Therapy on Postoperative Pain and Narcotics Use Following Spinal Fusion N/A Interventional Limiting funding sources forced us to withdraw the study. Actual 0
NCT03917719 Terminated An Open-Label Extension Study of Edasalonexent in Boys With Duchenne Muscular Dystrophy Phase 3 Interventional The Phase 3 PolarisDMD trial did not meet the primary endpoint. As a result, activities related to the development of edasalonexent have stopped including the CAT-1004-302 Open-Label Study of Edasalonexent in Boys With Duchenne Muscular Dystrophy Actual 130
NCT03956550 Terminated A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee Phase 2 Interventional Regeneron has discontinued further clinical development of REGN5069, an antibody to GFRα3, which was previously being studied in osteoarthritis pain of the knee Actual 259
NCT04320524 Withdrawn TARA Working Prototype [Version 2]: Feasibility Study N/A Interventional Due to Covid, the study could not be initiated as planned. Actual 0
NCT04363853 Suspended Tocilizumab Treatment in Patients With COVID-19 Phase 2 Interventional Pending regulatory issues by Mexico´s health agency (CCINSHAE). Agency has requested further evidence for efficacy, therefore it was suggested that the study be temporarily suspended. Anticipated 200
NCT04371640 Suspended Sirolimus in COVID-19 Phase 1 Phase 1 Interventional Study population not regularly admitted to hospital Anticipated 40
NCT04386278 Terminated OrthoPulse Gen 2 Initial Device Evaluation and Assessment of Clinical Effectiveness (CA) N/A Interventional Study stopped because slow enrolment. Actual 56
NCT04566536 Suspended NoL Monitor Performances of Nociceptive and Non-nociceptive Stimuli Discrimination During Robotic Surgery Observational "Owing to the Covid-19 epidemics and in the application of guidelines, inclusions have been suspended in the ROBOTNOL research on November 2nd 2020 for an undetermined period of time." Anticipated 75
NCT04645264 Terminated Effect of Catheter on Postoperative Urinary Retention N/A Interventional PI initiated closure due to limited clinical resources and lack of participation. Actual 7
NCT01383044 Terminated Banding Ligation With Carvedilol Versus Carvedilol for the Prevention of First Bleeding Phase 4 Interventional slow enrollment Actual 65
NCT02633124 Terminated Preventing Catheter-related Bacteremia When Administering Injectable Medications in Premature Infants. N/A Interventional Actual 87
NCT02920710 Withdrawn ACTHAR Therapy for Central Nervous System Sarcoidosis Phase 4 Interventional Difficulty with recruitment Actual 0
NCT03910452 Suspended Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide Early Phase 1 Interventional On hold to reviewed data to determine how best to proceed as the patient's transplant course was complicated by engraftment syndrome and other conditions. Actual 1
NCT04638114 Withdrawn Mini- Open Direct-anterior Approach vs Hip Arthroscopy for Treatment of Femoroacetabular Impingement. N/A Interventional Investigator is no longer employed in study site Actual 0
NCT03553550 Terminated Role of Circulating Tumor DNA (ctDNA) From LIquid Biopsy in Early Stage NSCLC Resected Lung Tumor Investigation Observational Enrollment futility Actual 38
NCT04209621 Suspended Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Phase 2 Interventional On September 24, 2020 due to unexpected sudden death on study. Actual 3
NCT01097239 Withdrawn Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal Pelvic Cancer Phase 1/Phase 2 Interventional Failure to recruit. Actual 0
NCT01190241 Terminated Targeted Therapy Selection Based on Tumor Tissue Kinase Activity Profiles for Patients With Advanced Solid Malignancies, an Exploratory Study N/A Interventional Actual 45
NCT01691976 Withdrawn Mild Cognitive Impairment in Men Following Androgen Deprivation N/A Interventional No one recruited due to resource limitations. Issues with how complicated the study could be for patients so the study was later modified and turned into a different study. Actual 0
NCT02070887 Withdrawn Inhibiting COMT in Parkinson's Disease Observational Actual 0
NCT03063840 Withdrawn Microwave Ablation for the Treatment of Malignant Liver Tumors Closed to Intrahepatic Vessels N/A Interventional NO participants enrolled Actual 0
NCT03325101 Suspended Dendritic Cell Therapy After Cryosurgery in Combination With Pembrolizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Remove by Surgery Phase 1/Phase 2 Interventional pending protocol/funding review Anticipated 39
NCT03327272 Withdrawn Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Phase 3 Interventional Did not enroll, PI decided not to proceed. Actual 0
NCT03416816 Terminated A Study of DSP-0337 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile Phase 1 Interventional Alternate development strategy Actual 23
NCT03615495 Suspended Flourish™ Pediatric Esophageal Atresia Observational [Patient Registry] Study plan amendment Anticipated 20
NCT03901976 Terminated ZeroFall - Reliability Testing of Optical Sensor to Detect Bed Exit for Patients in Hospital N/A Interventional Not enough resources in place; COVID-19 pandemic impedes working on the project and travelling within the EU Actual 14
NCT03966547 Withdrawn Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714 N/A Interventional Main study concluded before enrollment Actual 0
NCT04267913 Withdrawn Testing of TAK228 (MLN0128, Sapanisertib) Plus Docetaxel to the Usual Standard of Care for Advanced Squamous Cell Lung Cancer (A Lung-MAP Treatment Trial) Phase 2 Interventional The pharmaceutical company sold the compound and pulled out. Actual 0
NCT04365231 Withdrawn Hydroxychloroquine Azithromycin COVID-19 Pregnancy Trial Phase 3 Interventional no authorization obtained Actual 0
NCT04418752 Withdrawn Narrative Exposure Therapy for Adults With Intellectual Disability N/A Interventional The study is no longer feasible due to the restrictions placed on access to potential participants during the COVID-19 pandemic. Actual 0
NCT04563559 Withdrawn PREFERENTIAL Study Phase 2/Phase 3 Interventional PI decided not to open study Actual 0
NCT03409237 Withdrawn Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension Observational No participant enrolled. The human resources to perform the study also due to the COBID emegency Actual 0
NCT03422757 Terminated Safety and Efficacy of Adaptive DBS Vs Conventional DBS in Patients With Parkinson's Disease N/A Interventional Company strategic decision Actual 6
NCT03837457 Terminated PRISM: Efficacy and Safety of Cobomarsen (MRG-106) in Subjects With Mycosis Fungoides Who Have Completed the SOLAR Study Phase 2 Interventional Study no longer needed because eligible subjects may receive treatment with cobomarsen in a crossover arm of the SOLAR clinical trial (NCT03713320) Actual 8
NCT03949673 Terminated Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip Phase 2 Interventional Lack of enrollment Actual 23
NCT04009486 Withdrawn Whole Body Vibration and the Brain in OSA N/A Interventional Not approved for funding Actual 0
NCT04178616 Terminated Assessment of the Prevalence of Olfactory Disorders in Systemic Scleroderma N/A Interventional Following the COVID-related health crisis, nasofibroscopic sampling could no longer be carried out Actual 59
NCT04304339 Suspended Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study Observational Covid19 pandemia Anticipated 500
NCT04343001 Withdrawn Coronavirus Response - Active Support for Hospitalised Covid-19 Patients Phase 3 Interventional Grant not obtained Actual 0
NCT04429464 Withdrawn AcQBlate Force Confirmatory Study for Atrial Arrhythmias (AcQBlate Force-PRA) N/A Interventional Due to restrictions related to COVID the sponsor has decided not to move forward with this study Actual 0
NCT02831933 Terminated Trial of Radiation and Gene Therapy Before Nivolumab for Metastatic Non-Small Cell Lung Carcinoma and Uveal Melanoma Phase 2 Interventional Lack of funding Actual 13
NCT04017624 Withdrawn Fresh Truck Pilot to Reduce Food Insecurity in a Medicaid ACO N/A Interventional The COVID-19 pandemic impacted study methods. Therefore, the study team opted not to conduct this study as written. The study never started and no participants were enrolled. Actual 0
NCT04044170 Terminated Poziotinib in Patients With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation Phase 2 Interventional Study termination by the Sponsor Actual 5
NCT04098419 Terminated Evaluation of a Two-tiered Cross-age Teaching Model for Food Literacy-based Education N/A Interventional Discontinuing the study because of COVID-19 Actual 24
NCT04201145 Withdrawn Pembrolizumab + Defactinib In Pleural Mesothelioma Phase 1 Interventional Funding complications coupled with competing scientific objectives Actual 0
NCT04226001 Withdrawn Impact of a Carrier (Infection, Colonization) of Highly Bacteria Resistance on the Patient's Quality of Life Hospital Environment Observational Coordinator departure Actual 0
NCT04633031 Withdrawn The Effect of Bracing on Sagittal Balance in Scoliosis Observational never approved Actual 0
NCT01474031 Terminated Prospective Study Deltamotion - DAA THA Study Observational Main investigator has left the department and therefore the study had ended Actual 29
NCT02529475 Terminated Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Phase 4 Interventional recruitment problem-covid- Actual 25
NCT02843932 Terminated Subjective Perception of Motor Control During Psychogenic Disorders N/A Interventional recruitment difficulties Actual 14
NCT02854397 Terminated Determination of Specific Biomarkers of Acute Attack of Angioedema Within Pediatric Population Observational Recruitment difficulties Actual 31
NCT03074318 Terminated Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery Phase 1/Phase 2 Interventional Terminated due to PI leaving institution Actual 35
NCT03370055 Withdrawn LeucoPatch® in Nonhealing Wounds With Exposed Bone or Tendon Study N/A Interventional Study was closed due to lack of participants Actual 0
NCT03454672 Terminated A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared With Laser N/A Interventional Delay in recruitment as per last protocol amendment due to Covid-19 Actual 68
NCT03976050 Terminated Phase I Study of HL-085 in Patients With Advanced Solid Tumors Phase 1 Interventional Study objective and design change Actual 4
NCT04271917 Suspended Analgesic Effects of Cannabidiol for Simple Tooth Extractions in Dental Patients Phase 3 Interventional COVID-19 Anticipated 120
NCT04347707 Terminated Building Regulation in Dual Generations N/A Interventional The trial was ended after one year due to the suspension of in-person research as a result of the COVID-19 pandemic. We have returned to the program development stage as we explore telehealth alternative options. Actual 28
NCT03271086 Withdrawn Relaxation Breathing Training for Children N/A Interventional The study was never started. Actual 0
NCT02842021 Terminated Efficacy and Safety of Product S2G6T-1in Patients With Symptomatic Inflammatory Interdigital Tinea Pedis Phase 2 Interventional Failed to meet success criteria Actual 283
NCT03173859 Withdrawn Efficacy of Rotations Between Abiraterone Acetate and Apalutamide in mCRPC Patients Phase 2 Interventional Delayed initiation Actual 0
NCT04041791 Suspended A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia Phase 3 Interventional Temporarily suspension due to the COVID19 pandemic and will resume once it is deemed safe. Anticipated 4392
NCT00820040 Terminated Feasibility of Permacol Use in Infected Fields Phase 2 Interventional Slow enrollment due to strict eligibility criteria Actual 10
NCT02957604 Terminated Evolocumab Pregnancy Exposure Registry Observational [Patient Registry] Actual 140
NCT03089463 Suspended Foot Assessment in People With Diabetes: A Quantitative Diagnostic Approach Observational The study has not managed to recruit adequate number of participants. Anticipated 153
NCT02457949 Terminated The Impact of Alternative Social Assistance Disbursement on Drug-related Harm N/A Interventional Interim analyses produced signal of intervention efficacy for primary outcomes and weaker signal of increased exposure to violence. Therefore, DSMC recommended stopping recruitment in May 2018. Enrolled participants completed intervention by Aug 2018 Actual 194
NCT02538913 Terminated Exercise Training for Rectal Cancer Patients N/A Interventional too slow recruitment; lack of resources Actual 25
NCT02596165 Terminated Validation of the Schiller BR-102 Plus PWA Device to Measure Central and Peripheral Hemodynamics N/A Interventional Stopp because of FDA concrns regarding recruitment. Actual 45
NCT03002467 Terminated Impact Analysis of Prognostic Stratification for Pulmonary Embolism N/A Interventional Low recruitment rate Actual 125
NCT03557970 Terminated JNJ-40346527 in Treating Participants With Relapsed or Refractory Acute Myeloid Leukemia Phase 2 Interventional Not enough enrollment to determine efficacy Actual 3
NCT04028635 Terminated Treating the Fear of Gaining Weight in Anorexia Nervosa N/A Interventional The study was terminated with a total of 35 patients finally enrolled, due to the Sars-Cov-2 (COVID-19) global pandemic breakout and the confinement measures considered. Actual 35
NCT00794417 Terminated A Study of Aflibercept Administered in Combination With Pemetrexed and Cisplatin in Participants With Advanced Carcinoma Phase 1/Phase 2 Interventional Actual 60
NCT04215549 Withdrawn The Cost of Obsessive-compulsive Disorder (OCD) in China Observational Because of COVID-19, we cann't carry out recruiting according to the original plan Actual 0
NCT04253067 Withdrawn A Single-Blind, Randomized Study to Compare fCO2 Laser Therapy Versus Sham for Treatment of SUI in Women N/A Interventional PI decided not to open study, following review of data collected in another study Actual 0
NCT04262375 Withdrawn A Phase 2 Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Multi-Cancer Populations With Correlation to Clinical, Molecular and Immunologic Parameters With DNA MethylaTION Phase 2 Interventional Overall clinical activity (ORR) for oleclumab + durvalumab is minimal across tumor types and does not support further evaluation of this doublet. Actual 0
NCT04262388 Withdrawn A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation Phase 2 Interventional Overall clinical activity (ORR) for oleclumab + durvalumab is minimal across tumor types and does not support further evaluation of this doublet. Actual 0
NCT04290442 Suspended Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery Phase 4 Interventional initially cessation due to covid, then fellow doing the study graduated with no time to complete the study; will take up again if a current fellow takes on the project Anticipated 70
NCT04345692 Terminated A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients Phase 3 Interventional RECOVERY Trial results - no efficacy Actual 17
NCT04349956 Terminated Long-Term Follow-Up Study of Patients With Osteoarthritis of the Knee Treated With UBX0101 or Placebo Observational Inability to achieve primary or secondary study objectives Actual 161
NCT02651272 Terminated Macitentan in Pulmonary Hypertension of Sickle Cell Disease Phase 2 Interventional Unable to enroll IRB approved sample of participants. Actual 4
NCT01543750 Withdrawn 4-Aminopyridine in Episodic Ataxia Type 2 Phase 2 Interventional Actual 0
NCT01843569 Withdrawn In Vitro Maturation (IVM) of Human Oocytes N/A Interventional Institutional approval of study has expired. Actual 0
NCT02053727 Withdrawn Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir Background N/A Interventional The study team did not enroll any patients due to difficulty with recruitment. Actual 0
NCT02331355 Withdrawn Hand Transplantation: Functional and Quality of Life Outcomes Observational unable to find appropriate candidates Actual 0
NCT02474888 Terminated Pharmacokinetic Study of Rituximab Induction Regimen in ANCA-associated Vasculitis Observational failure of recruit Actual 28
NCT02597660 Withdrawn A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy Phase 2 Interventional PI decided not to enroll Actual 0
NCT02718677 Withdrawn Patient-reported Outcomes in Subjects Treated With ReFacto AF Routine Prophylaxis Observational Company decision to not conduct study Actual 0
NCT03452540 Suspended Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis Phase 2 Interventional Company Decision Anticipated 120
NCT03592459 Withdrawn Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer N/A Interventional Study halted prematurely, prior to enrollment of first participant Actual 0
NCT03773055 Terminated Phase II Clinical Trial of NPC-06 in Patients With Neuropathic Pain in Cancer Phase 2 Interventional Low recruitment Actual 7
NCT03773991 Terminated Dyspnea Assessment in Hemodialysis Patients Observational Recruitment issues: Restrictions associated with the COVID-19 pandemic have made much of the research procedures unfeasible due to organizational and safety issues (for both staff and patient protection). Actual 7
NCT04435808 Terminated Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19 Phase 1/Phase 2 Interventional Stopped for futility by DSMB Actual 1
NCT04494178 Terminated G-PUR® for Reduced Dietary Fumonisin Bioavailability N/A Interventional Several analytical laboratories failed to develop and validate a suitable assay of urine fumonisin (the primary endpoint) up to date. Because of missing alternatives for an analytical laboratory the objective of the study cannot be met. Actual 7
NCT04540393 Suspended AZD1222 Vaccine for the Prevention of COVID-19 Phase 3 Interventional Study has been suspended due to the occurrence of SUSAR at University of Oxford sponsored Phase2/3 study. Study will continue to be on hold until Russian MOH approval is received. Anticipated 100
NCT04636372 Withdrawn Effect of Meibomian Gland Related Therapy on the Morphology of Meibomian Gland N/A Interventional An one-month follow-up was completed after the treatment. Actual 0
NCT02767570 Terminated Long-Term Effectiveness of Walking Training in Patients With Knee Osteoarthritis N/A Interventional Study data collection was terminated due to COVID-19 pandemic and will not resume. Actual 69
NCT03479463 Terminated Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy Observational [Patient Registry] Slow enrollment Actual 8
NCT04284787 Suspended BLAST MRD AML-2: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Azacitidine and Venetoclax as Frontline Therapy in Unfit Patients With Acute Myeloid Leukemia Phase 2 Interventional pending amendment approval Anticipated 76
NCT04628533 Withdrawn Exploring the Optimal Duration of a Group-based Online Behavioral Weight Loss Program N/A Interventional COVID-19. Recruitment never began. Actual 0
NCT02942485 Terminated Treatment of Giardia Lamblia Infections in Children Phase 4 Interventional Extremely slow enrollment Actual 8
NCT02205723 Withdrawn Smartphone-facilitated Asthma Control N/A Interventional Study was not initiated because we could not secure funding. Actual 0
NCT02234557 Suspended Tai Chi Training for Children With ADHD N/A Interventional Due to COVID-19, we have suspended enrollment for this study. Anticipated 40
NCT02431000 Withdrawn Male Fertility and Sperm Cryopreservation Observational PI is no longer at this University. Actual 0
NCT02443142 Withdrawn Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury Phase 2 Interventional Lack of study participants. Actual 0
NCT02458482 Withdrawn Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute Asthma Exacerbation in Children N/A Interventional The trainee for whom I designed the study did not begin enrollment and has left our institution. Actual 0
NCT02563561 Terminated A Study of Intravesical Apaziquone as a Surgical Adjuvant in Patient Undergoing TURBT Phase 3 Interventional Actual 62
NCT02587026 Terminated Biorepository for Precision Genomics Observational [Patient Registry] Study team has decided to close enrollment, and all subjects are being rolled into a different clinical trial: Total Cancer Care Actual 480
NCT02589860 Withdrawn Analysis of Oral Mucositis in Patient's Undergoing Melphalan Conditioning and Autologous Stem Cell Transplant Observational No accrual Actual 0
NCT02844933 Terminated Cannabidiol Oral Solution for the Treatment of Subjects With Prader-Willi Syndrome Phase 2 Interventional Insys Therapeutics filed Chapter 11 and terminated all studies. Actual 7
NCT03110484 Withdrawn Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study Phase 2 Interventional institution resource problem Actual 0
NCT03336242 Terminated Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures Phase 2 Interventional More patients in Cohort 1 than Cohort 2 demonstrated a clinically meaningful reduction of seizure count. Given this, enrollment of Cohort 3 was discontinued. Actual 20
NCT03355300 Terminated Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures Phase 2 Interventional Insys Therapeutics filed Chapter 11 and terminated all studies. Actual 6
NCT03421496 Terminated A Study to Assess the Efficacy, Safety, and Tolerability of Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms Phase 3 Interventional The study was terminated due to slow enrollment and failure to identify adequate patients that met entry criteria. Actual 2
NCT03434509 Suspended Ongoing Tai Chi Training for Children With ADHD N/A Interventional Due to COVID-19, we have suspended enrollment. Anticipated 50
NCT03458416 Terminated A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Patients With Prader-Willi Syndrome Phase 2 Interventional Insys Therapeutics filed Chapter 11 and terminated all studies. Actual 7
NCT03609450 Terminated Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 3) N/A Interventional COVID-19 Pandemic Actual 73
NCT03609749 Terminated Mindful Self-Regulation fMRI Study (MindfulPCfMRI) N/A Interventional COVID-19 pandemic Actual 21
NCT03705273 Terminated Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Phase 4 Interventional Dr. Arnold assisted in designing and initiating study for a pharmacology PhD candidate. The candidate left the institution and study enrollment was terminated. Actual 40
NCT03967093 Terminated A Study of BXQ-350 in Children and Young Adults With Relapsed Solid Tumors Phase 1 Interventional Bexion will not move forward with the Part 2 expansion portion of the trial in order to focus resources on the further development of BXQ-350 as an earlier treatment measure in the pediatric population. Actual 9
NCT04135326 Withdrawn Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy Early Phase 1 Interventional Per PI termination request, no patients enrolled Actual 0
NCT04158830 Withdrawn Aspirin (ASA) Therapy and Preeclampsia Prevention Phase 4 Interventional PI is no longer at this University. Actual 0
NCT04178525 Terminated Clinical Trial Evaluating the Safety and Efficacy of the Use of Chitosan Gel in Patients With Chronic Wounds N/A Interventional COVID-19 restrictions Actual 46
NCT04194983 Terminated The Effect of Fish Oils With Dairy or Plant Based Lipids on Mitochondrial and Physical, and Cognitive Function, in Elderly Humans N/A Interventional due to COVID-19 and lack of financial means to continue Actual 25
NCT04280588 Withdrawn Fingolimod in COVID-19 Phase 2 Interventional No participants enrolled Actual 0
NCT03685344 Terminated Safety and Antitumor Activity Study of Loncastuximab Tesirine and Durvalumab in Diffuse Large B-Cell, Mantle Cell, or Follicular Lymphoma Phase 1 Interventional In a limited number of patients, no additional activity was evident for the combination vs. Loncastuximab tesirine monotherapy. Actual 13
NCT04199442 Terminated Anxiety Assessment Before Regional Anesthesia. Observational Sanitary crisis du to Covid-19 Actual 200
NCT04209452 Terminated Improving Working Memory of Children With Autism N/A Interventional COVID-19 Actual 15
NCT04499352 Withdrawn A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have Advanced Anal Cancer Phase 2 Interventional Not due to safety reasons (sponsor decision). Actual 0
NCT04550234 Suspended A Study in Healthy Subjects to Assess Drug Availability of 2 Different Formulations of Verinurad and Allopurinol Phase 1 Interventional After internal evaluation of interim data, AZ team decided to postpone Study until Mid-2021 for further development of Phase 3 formulation. Anticipated 48
NCT04625231 Terminated Shared Decision-Making Tool for Opioid Prescribing After Ambulatory Hand Surgery in Veterans N/A Interventional Due to decreased case volume due to COVID-19 enrollment has stopped. Actual 45
NCT01363882 Terminated Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) N/A Interventional Insufficient enrollment & high rate of failure to complete protocol Actual 25
NCT02112643 Withdrawn Selenium in Mild Thyroid Eye Disease in North America N/A Interventional Lack of funding Actual 0
NCT02691455 Terminated The AGS Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study (ASSISTS) N/A Interventional Difficulty in recruiting participants Actual 43
NCT02492997 Terminated Clinical Evaluation of Venus Versa Octipolar Applicator for Reduction of Abdomen Circumference N/A Interventional Trial was terminated early due to slow enrollment. Actual 44
NCT03261479 Terminated Validation of Thermal Imaging to Detect Pneumonia Observational Research stopped after lab-based data using mouse model did not support use of technology. Actual 22
NCT03381196 Terminated A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications Phase 3 Interventional Based on interim Analysis outcome being futile for FLZ3001; decision was taken to stop (early terminate) both FLZ3001/3002. There was no safety concern. Actual 553
NCT03477526 Terminated Status and Develepment Mental Quality of Life COPD/IPF Inpatients Before and After Pulmonary Rehabilitation N/A Interventional PhD Student stopped working on this project Actual 1
NCT03810690 Withdrawn Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia Phase 1/Phase 2 Interventional Study was terminated before the start of dosing due to a business decision and not due to safety or efficacy reasons. Actual 0
NCT03893292 Withdrawn Preop Cooled Radiofrequency Ablation for Total Knee Replacement Observational Lack of participants Actual 0
NCT04030624 Withdrawn Remote Electronic Patient Monitoring in Gastrointestinal Cancer N/A Interventional Funding discontinued due to changes in corporate structures Actual 0
NCT04061317 Terminated SPOT-FRAILTY Assessment of Frailty in Patients Over the Age of 70 Undergoing a Cardiac Intervention Observational COVID Restrictions in a vulnerable population. Actual 82
NCT04225299 Withdrawn Evaluation of Efficacy of TOOKAD® (VTP) Versus Active Surveillance for Intermediate Risk Localized Prostate Cancer Phase 3 Interventional FDA didn't approve the design of the protocol so we didn't start the study Actual 0
NCT04356456 Withdrawn A Double-Blind, Randomized, Placebo-Controlled Study Evaluating the Nutritional Supplement Lumenato and Its Impact on Skin Parameters in Healthy Female Subjects N/A Interventional Covid-19 Actual 0
NCT01743976 Terminated Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain Phase 4 Interventional Failure to recruit subjects Actual 5
NCT01632202 Terminated Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Phase 4 Interventional No subjects were recruited at the Weill Cornell site. Actual 11
NCT03376256 Terminated Compuflo Instrument for Thoracic ES Identification N/A Interventional Difficulty in participant recruitment Actual 2
NCT02906124 Terminated Study to Evaluate the Safety of Repatha® in Pregnancy Observational Actual 4
NCT03041688 Suspended KRT-232 (AMG-232) and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia Phase 1 Interventional Other - to update dosing schedule Anticipated 58
NCT03578731 Terminated Efficacy of the "Consilium" Smartphone App for Detecting Symptoms and Treatment Side Effects in Cancer Patients Observational Mainly due to insufficient recruitment Actual 224
NCT03731728 Terminated Group CBT and Exercise in Management of Depression N/A Interventional COVID-19 Actual 70
NCT03913676 Terminated Disseminating a Waitlist Treatment for Anxiety With Velibra N/A Interventional The study was not feasible. Actual 11
NCT04020211 Terminated HF10 Treatment of Chronic Knee Pain Observational Limited Enrollment Actual 3
NCT04028960 Terminated IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase Phase 2 Interventional Funding was rescinded Actual 5
NCT04366232 Terminated Efficacy of Intravenous Anakinra and Ruxolitinib During COVID-19 Inflammation (JAKINCOV) Phase 2 Interventional investigator decision Actual 2
NCT04393727 Terminated Transfusion of Convalescent Plasma for the Early Treatment of Patients With COVID-19 Phase 2 Interventional Study was stopped because the Promoter was changed and a new study on convalescent plasma promoted by AIFA was started in Italy. Actual 1
NCT04493099 Withdrawn Alvocidib in Combination With Decitabine and Venetoclax in Patients With Relapsed or Refractory AML or as Frontline Therapy in Unfit Patients With AML Phase 1/Phase 2 Interventional The original sponsor was acquired by a new company and has elected to end funding for all Investigator Sponsored Trials (ISTs) Actual 0
NCT04628819 Terminated Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children N/A Interventional Not enough patients included Actual 61
NCT04629417 Suspended Measuring Adherence to Home Shoulder Physiotherapy With Artificial Intelligence N/A Interventional Due to COVID-19 all research activities including recruitment have been paused. Anticipated 120
NCT01848431 Withdrawn Randomized Study on the Effects of Moderate Anaemia in Free Microvascular Tissue Transfer Observational staff change and lack of ressources Actual 0
NCT04188574 Suspended A Trial Involving Treatment of BB2603 in Subjects With Distal Subungual Onychomycosis of the Toenail Phase 2 Interventional Study pause due to COVID-19 pandemic impacts. Anticipated 220
NCT01925378 Withdrawn A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia Phase 2 Interventional The study is going to open in a new site Actual 0
NCT02196311 Withdrawn Treatment Of Supracondylar Fractures Closed Reduction And Circular Ring External Fixation Versus Open Reduction and Internal Fixation Observational no patient recruited Actual 0
NCT02761928 Terminated Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients Observational Insufficient enrollment, lack of funding to continue Actual 31
NCT03655444 Terminated Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy Phase 1/Phase 2 Interventional Provider of drug decided to discontinue study. Actual 6
NCT02782403 Terminated Axitinib and Bosutinib in Treating Patients With Chronic, Accelerated, or Blastic Phase Chronic Myeloid Leukemia Phase 1/Phase 2 Interventional Terminated per PI's request at the time of CR Actual 6
NCT02842710 Withdrawn Staphylococcus Aureus Resistant to Methicillin (MRSA) Screening in Trauma N/A Interventional the study did not start due to a lack of staff Actual 0
NCT02850731 Withdrawn Motorized Platform and Autonomy Among the Frail and Pre-frail Older Adult (PLATAUTONOMIE) N/A Interventional Organisation problem Actual 0
NCT02897830 Terminated Ixazomib, Lenalidomide, Dexamethasone Induction and Extended Consolidation Plus Lenalidomide Maintenance in Multiple Myeloma Phase 2 Interventional negatives results Actual 46
NCT03100006 Terminated Phase Ib/IIa Trial to Evaluate Oregovomab and Nivolumab in Epithelial Cancer of Ovarian, Tubal or Peritoneal Origin Phase 1/Phase 2 Interventional The study had poor efficacy. Actual 13
NCT02077530 Withdrawn Metabolic Syndrome Cohort in Korea Observational [Patient Registry] Actual 0
NCT02642146 Terminated Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study Observational [Patient Registry] We decided to terminate recruit earlier because patient recruiting was not active as expected at the beginning of the study. Actual 71
NCT04183738 Withdrawn Inflammation and Co-Infections in D²EFT Phase 4 Interventional In the context of COVID-19 pandemic. Actual 0
NCT02444585 Withdrawn Longjohn Amgen Study - Effect of Denosumab... Phase 1 Interventional No participants enrolled in the trial Actual 0
NCT04214249 Suspended BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia Phase 2 Interventional Other - pending protocol updates Anticipated 124
NCT00948025 Terminated A Comparative Post-marketing Study of Commercially Available Peripheral Nerve Gap Repair Options N/A Interventional transitioning from 361 HCT/P Tissue to a Biologic (BLA) Actual 23
NCT02230527 Terminated Establishing the Microcirculatory Effects of Ticagrelor on Tissue Perfusion in Critical Limb Ischemia Phase 2/Phase 3 Interventional Lack of enrollment Actual 27
NCT03202108 Withdrawn Evaluation of Krio in Children and Adults With Epilepsy N/A Interventional Product manufacturing issues. Actual 0
NCT00330434 Withdrawn Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism N/A Interventional Study was a F32 Fellowship. Trial was proposed however Principle Investigator does not believe trial took place. Actual 0
NCT01197482 Terminated Inhaled Steroids and Control of Severe Asthma Observational 6 out of 20 patients were included. The trend towards the treatment of severe asthma has meanwhile developed in a different direction, so that there is no longer any intention to pursue the study objective mentioned here. Actual 6
NCT03143894 Terminated Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation N/A Interventional Poor accrual (inability to enroll participants) Actual 7
NCT03963869 Suspended Effectiveness of Malaria Camps as Part of the Odisha State Malaria Elimination Drive N/A Interventional The study has been suspended because of COVID-19. We will resume as soon as COVID-19 restrictions are lifted. Anticipated 2700
NCT04274907 Suspended A Safety Study of Oral Venetoclax in Combination With Intravenous Pembrolizumab in Adult Participants With Previously Untreated Non-Small Cell Lung Cancer (NSCLC) With High Programmed Cell Death Ligand-1 (PD-L1) Expression Phase 1 Interventional Company Decision Actual 2
NCT01998035 Terminated Romidepsin Plus Oral 5-Azacitidine in Relapsed/Refractory Lymphoid Malignancies Phase 1/Phase 2 Interventional PI left institution Actual 52
NCT02004353 Terminated Observation of Benefits for Patients Implanted With a Hearing Implant of the Company Cochlear Observational [Patient Registry] Original study purpose accomplished Actual 1518
NCT01745224 Terminated Revlite Laser System Compared to the Candela Alex TriVantage System Refractory Mixed Type Melasma N/A Interventional The study stopped because patient enrollment requirements were not met. Actual 10
NCT02790034 Terminated Evaluation of the Efficacy, Safety, and Tolerability of Sarizotan in Rett Syndrome With Respiratory Symptoms Phase 2/Phase 3 Interventional The study did not demonstrate evidence of efficacy on the primary or secondary efficacy variables Actual 129
NCT03105219 Withdrawn IvaBradinE to Treat MicroalbumiNuria in Patients With Type 2 Diabetes and Coronary Heart Disease Phase 3 Interventional Shortfall in funding Actual 0
NCT03275792 Withdrawn Shiga Toxin Producing Escherichia Coli (STEC) Volume Expansion Phase 1 Interventional Funding not obtained. Actual 0
NCT03702062 Withdrawn Dynamic Heart Failure Prediction With Real-time Functional Status Data in the Ambulatory Setting N/A Interventional Study never started Actual 0
NCT03857659 Suspended Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care N/A Interventional COVID related termination Actual 113
NCT03922711 Terminated A Study to Assess the Safety and Effectiveness of Pridopidine Compared to Placebo in the Treatment of Levodopa-Induced Dyskinesia in Patients With Parkinson's Disease Phase 2 Interventional COVID-19 Actual 23
NCT03949998 Withdrawn The Immediate Effects of Dry Needling on Post-concussion Syndrome N/A Interventional no participants Actual 0
NCT03962231 Suspended Exercise Program in Patients With Shoulder Pain and Rotator Cuff Tear N/A Interventional Coronavirus Anticipated 78
NCT04042077 Terminated Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections Phase 3 Interventional COVID-19 seriously affected the study execution as required by the protocol Actual 269
NCT04149769 Withdrawn Mobility and Therapeutic Benefits Resulting From Exoskeleton Use in a Home and Community Setting (SC140121 Study 3) N/A Interventional COVID Actual 0
NCT02867618 Terminated Carfilzomib and TGR-1202 in Treatment of R/R Lymphoma Phase 1/Phase 2 Interventional PI left institution Actual 11
NCT04352868 Withdrawn Customizing Myopia Control With Multifocal Toric Contact Lens N/A Interventional COVID-19 Actual 0
NCT04621955 Withdrawn Observational Study of Home Administration of Carfilzomib Observational Not possible to conduct study Actual 0
NCT03163277 Terminated Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X) Phase 4 Interventional Sloww accrual and COVID-19 related problems (impossible to perform LPs) Actual 38
NCT03424031 Terminated A Very Early Standing Study in Elderly Stroke N/A Interventional Many study exits (many deaths, aggravations) that we had anticipated (but not enough). The patients did not stay long enough in the department to complete the protocol (many study exits that we had not anticipated). Actual 45
NCT04339816 Terminated Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial Phase 3 Interventional Steering Committee decision in accordance with stopping rule 1: Emergence of new data Actual 3
NCT04356040 Suspended TactiFlex PAF IDE Trial N/A Interventional Enrollment suspended due to temporary device unavailability. Anticipated 355
NCT00537446 Terminated Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral Sclerosis N/A Interventional Insufficient enrollment Actual 8
NCT04197219 Withdrawn Pembrolizumab With Axitinib in Recurrent Endometrial Cancer Phase 2 Interventional PI is leaving institution Actual 0
NCT01857557 Terminated Evaluation of an Aerobic Exercise Program in Migraine Management N/A Interventional Challenges with participant recruitment as a result of COVID-19 pandemic Actual 39
NCT02775149 Suspended Dental Erosion in Patients With Gastro-oesophageal Reflux Observational No participants Anticipated 30
NCT03033316 Terminated A Evaluation of the Safety of Oncocort IV Pegylated Liposomal Dexamethasone Phosphate in Patients With Progressive Multiple Myeloma Phase 1/Phase 2 Interventional Patient enrolment issues Actual 7
NCT03537131 Suspended Dapagliflozin During Exercise for the PrevenTion of Hypoglycaemia Phase 2 Interventional Temporary halt due to COVID-19 pandemic Anticipated 34
NCT03587896 Terminated Implementation of Self Help Plus in Adult Syrian Refugees in Turkey (RE-DEFINE) N/A Interventional 12-month assessment process has been stopped prematurely due to logistic reasons. Actual 642
NCT03629821 Suspended Effect of Classic Ballet Practice on School Children's Postural Balance N/A Interventional The study has been suspended because COVID pandemic. Anticipated 50
NCT03637257 Withdrawn Carbon Dioxide (CO2) Measurement With a CO2/O2 Guedel Airway N/A Interventional due to other priorities Actual 0
NCT03684369 Withdrawn Improving Mobility and Reducing Fatigue in People With Multiple Sclerosis by Electrical Stimulation Therapy N/A Interventional The project was not funded. Actual 0
NCT03743571 Suspended Augmenting Exposure Therapy for Social Anxiety With Transcranial Direct Current Stimulation N/A Interventional recruitment suspended due to COVID-related social distancing requirements Anticipated 128
NCT03827902 Withdrawn Diabetic Foot Ulcer and Wound Infection Observational Unable to recruit participants Actual 0
NCT03884959 Withdrawn A Safety and Efficacy Study of Infusions of HepaStem in Urea Cycle Disorders Pediatric Patients Phase 2 Interventional Sponsor decided to stop enrollment Actual 0
NCT03892525 Suspended Study of Intratumoral Selicrelumab With Atezolizumab in Patients With Refractory or Relapsed B Cell Lymphoma Phase 1 Interventional End of drug development Actual 4
NCT03917433 Suspended Augmenting Virtual Reality Exposure Therapy for Acrophobia N/A Interventional temporarily suspended recruitment due to COVID-related social distancing requirements Anticipated 128
NCT03962829 Terminated Effect of mCPP on Cognitive Control, Appetite, and Neural Responses N/A Interventional due to the Covid 19 pandemic Actual 32
NCT04181957 Terminated Effects of LDX on Cognitive Processes and Appetite N/A Interventional COVID-19 Actual 22
NCT04340102 Withdrawn Development of a Scalable Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness N/A Interventional Study was not funded. Actual 0
NCT04364815 Withdrawn The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial Phase 3 Interventional Investigators opted to change the design of the study. Actual 0
NCT04399824 Withdrawn Focal Radiation Therapy for the Treatment of Low or Intermediate-Risk Prostate Cancer N/A Interventional Study did not open Actual 0
NCT03699033 Withdrawn Hypofractionated Radiotherapy With Carboplatin and Paclitaxel in Non-Small Cell Lung Cancer Phase 2 Interventional No patients available Actual 0
NCT03844152 Terminated RIGHTWHEY - Responders In Gut HealTh Markers Using Fermented WHEY N/A Interventional COVID-19 Actual 43
NCT03869008 Terminated Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena. N/A Interventional Funding no longer available Actual 7
NCT03941119 Terminated Evaluating the Impact of VR-therapy on BPSD and QoL of Individuals With Dementia Admitted to Hospital N/A Interventional All recruitment activities for this study (with acutely ill inpatients with dementia) stopped due to the COVID pandemic. Actual 77
NCT03974984 Withdrawn Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery Observational Not feasable due to logistics Actual 0
NCT04047966 Terminated Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect Growth Observational Due to the current pandemic situation, recruitment has been disrupted by the inability to recruit more patients Actual 42
NCT04094766 Withdrawn Safety and Efficacy of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy in R/R Acute B Lymphoblastic Leukemia Phase 1 Interventional Production plan adjustment Actual 0
NCT04154059 Suspended Strengthening Program for Foot-ankle Muscles in People With Knee Osteoarthritis N/A Interventional The recruitment of potential participants is suspended due to the covid-19 pandemic. Anticipated 76
NCT04160182 Withdrawn Feasibility and Effectiveness of an Internet-based Intervention to Manage Fatigue in Breast Cancer Survivors N/A Interventional Due to COVID this trial never got up and running. Actual 0
NCT04230330 Withdrawn Nivolumab in Combination With GDP/ L-asparaginase in NK/ T-cell Lymphoma Phase 1 Interventional PI has left the institution. Actual 0
NCT04232319 Withdrawn Feasibility and Effectiveness of a Sleep Hygiene Education Program for Sleep Issues in Breast Cancer Survivors N/A Interventional Due to COVID this study was never started. Actual 0
NCT04232501 Suspended Radial, Sequential Compression Device Deep Venous Thrombosis Detection Study N/A Interventional Due to COVID-19, Radial slowed their operations. Hence the investigational device is not available. Anticipated 200
NCT04295681 Suspended Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Cognitive Disorders Phase 3 Interventional Due to pandemic COVID-19 Anticipated 246
NCT01930838 Withdrawn Complications After Bariatric Surgery - a Clinical Trial Observational [Patient Registry] Actual 0
NCT02464280 Terminated Tomosynthesis of Pathologies of the Chest and Skeletal Structures in Comparison to CT Observational Actual 60
NCT02953366 Withdrawn Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis Phase 3 Interventional Sponsor decision Actual 0
NCT02953379 Withdrawn Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis Phase 3 Interventional Sponsor decision Actual 0
NCT01781611 Terminated Dipyridamole Assessment for Flare Reduction in Systemic Lupus Erythematosus (SLE) N/A Interventional Slow recruitment Actual 18
NCT04620421 Suspended Effect of Rhythm-based Multitask Training on Falls Among Older Adults N/A Interventional COVID-19 Anticipated 126
NCT03839472 Suspended Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors N/A Interventional Revision to improve cell recovery Anticipated 20
NCT00120731 Withdrawn Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones N/A Interventional Determined not feasible Actual 0
NCT00986440 Terminated Study of CS-7017 in Colorectal Cancer Patients Who Have Achieved Disease Control Following First-Line Chemotherapy Phase 2 Interventional Due to changes to the standard of care within the proposed market for CS-7017. Actual 84
NCT01068171 Withdrawn Developing a Diabetic Foot Ulcer Protocol N/A Interventional no patients who met enrollment criteria Actual 0
NCT01960764 Withdrawn Examination of Whether Host Preconditioning Modifies Short-term Transplant Survival Phase 1 Interventional This sub-study was not done because main study results reached significance. Actual 0
NCT02144142 Withdrawn Evaluation of the Kinetic Properties of an Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients Phase 2 Interventional This sub-study was not done because main study results reached significance. Actual 0
NCT02538887 Withdrawn Use of a Supplemental Radiofrequency Detection System Subsequent to Manual Counting of Vaginal Textiles Following Vaginal Birth Observational Sponsor dissolved before study started Actual 0
NCT02555384 Withdrawn AMblyopia Treatment Through PErceptual Training in Children (AMPEL) N/A Interventional Inclusion and Exclusion criteria too stringent, no patient coluld be recruited Actual 0
NCT02573519 Terminated Gastrointestinal Motility Among Diabetes Patients N/A Interventional Renewal of PET/CT scanners and slow recruitment Actual 40
NCT02942758 Terminated Low-dose AZA, Pioglitazone, ATRA Versus Standard-dose AZA in Patients >=60 Years With Refractory AML Phase 2 Interventional Due to financial reasons. Actual 10
NCT02973295 Withdrawn Silymarin in NAFLD Phase 4 Interventional Sponsor withdrawn their agreement Actual 0
NCT03043898 Terminated Mapping Sound Propagation Through the Human Lung for Better Diagnosis Observational COVID-19 Actual 62
NCT03065634 Terminated Return to Work and Living Healthy After Head and Neck Cancer N/A Interventional insufficient recruitment rate Actual 39
NCT03229850 Suspended Dynamics of Insulin Absorption in Subclinical Lipohypertrophy Using the Euglycemic Clamp Technique N/A Interventional Study was suspended due to current COVID 19 research curtailment Anticipated 10
NCT03246620 Terminated Oral Olanzapine Versus Haloperidol or Diazepam Phase 4 Interventional The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias. Actual 12
NCT02151903 Terminated Open-Label Extension Study of De-immunized DI-Leu16-IL2 Immunocytokine Administered in Participants With B-cell NHL Phase 1/Phase 2 Interventional Clinical benefit was noted before the scheduled completion of the trial and the extension study was terminated early. Actual 5
NCT02446509 Terminated A Psychoeducation Intervention for Caregivers of Patients With Bipolar Disorder N/A Interventional Actual 12
NCT03168490 Suspended In Vivo Effects of the Gluten Friendly Bread in Coeliac Disease N/A Interventional Anticipated 60
NCT00601848 Terminated Photodynamic Therapy in Treating Patients With Resectable Non-Small Cell Lung Cancer That Has Spread to the Pleura Phase 2 Interventional Poor accrual and change in standards of care Actual 9
NCT01874288 Terminated A Study of De-immunized DI-Leu16-IL2 Administered Subcutaneously in Participants With B-cell NHL Phase 1/Phase 2 Interventional Clinical benefit was noted in the earlier portion of the trial; hence, participants were not enrolled in 2 expansion cohorts and the study was terminated early. Actual 24
NCT02241343 Terminated Venous Occlusion and Limb Swelling N/A Interventional Safety concerns Actual 1
NCT04325165 Withdrawn DBS of PPN to Improve Walking in Chronic SCI Patients N/A Interventional Recruitment issues Actual 0
NCT00793013 Withdrawn Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation Phase 2 Interventional IRB approval lapsed. Actual 0
NCT01822275 Terminated Phase II Trial of Low-Dose Whole Brain Radiotherapy With Concurrent Temozolomide and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma Multiforme Phase 2 Interventional Poor accrual Actual 23
NCT01922895 Suspended Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis N/A Interventional Lack of funding Actual 53
NCT01925573 Terminated Optune(NOVOTTF-100A)+ Bevacizumab+ Hypofractionated Stereotactic Irradiation Bevacizumab-Naive Recurrent Glioblastoma (GCC 1344) N/A Interventional Poor accrual Actual 7
NCT02020707 Suspended Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Phase 1 Interventional pending resolution of budget issues. Anticipated 36
NCT02435446 Terminated Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS) N/A Interventional PROBLEM of inclusion Actual 31
NCT02490332 Terminated The Effects of Ventilation Tubes - The SIUTIT Trial N/A Interventional Failed to include the required number of participants Actual 31
NCT02717390 Terminated Bright by Three (BB3) Effectiveness Study N/A Interventional Lack of funding to recruit target sample size Actual 100
NCT02754466 Suspended Oral Health and Its Relation to Development and Well-being of Schoolchildren Before and After Restorative Treatments N/A Interventional Children could not be examined due to COVID-19 pandemic and schools closure. Actual 270
NCT02765425 Withdrawn Training the Brain With a Robotic Device for Balance Recovery N/A Interventional Loss of department staff and COVID Actual 0
NCT02765737 Terminated Dehydrated Human Amnion Chorion Membrane (dHACM) vs. Control in the Treatment of Partial Thickness Burns. N/A Interventional Slow enrollment, issues with inclusion/exclusion and choice of control Actual 23
NCT02992782 Suspended Decongestive Exercise and Compression for Breast Cancer Related Lymphedema Management N/A Interventional Covid-19 Anticipated 60
NCT03160157 Withdrawn Comparing the Outcomes of Laparoscopic Cholecystectomy vs. Robotic Cholecystectomy Observational No enrollment Actual 0
NCT02086331 Terminated Evaluation of Musculoskeletal Microcirculation With Ultrasound N/A Interventional Actual 5
NCT03503435 Withdrawn The Effect of Art Therapy on Total Laryngectomy Patients N/A Interventional Due to COVID-19 we are not able to recruit in the foreseeable future Actual 0
NCT03512483 Withdrawn VCH -- vAFC Phase 3 N/A Interventional COVID-19 Actual 0
NCT03546504 Terminated Program to Improve Dental Care: Children With ASD N/A Interventional ran out of money Actual 3
NCT03642990 Suspended NR in Chemo-induced Peripheral Neuropathy Phase 2 Interventional Evaluating safety data Anticipated 39
NCT03684278 Suspended Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind Multi-centre Trial (RAPID-I) Phase 2 Interventional COVID-19 Pandemic Anticipated 290
NCT03742375 Terminated Quantitative HPV Genotyping in Screening of Anal Intraepithelial Neoplasia in HIV-positive Patients N/A Interventional COVID-19 pandemic Actual 24
NCT03847324 Suspended Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty N/A Interventional COVID-19 Anticipated 60
NCT03889158 Terminated Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation Phase 4 Interventional COVID-19 Actual 34
NCT03924622 Terminated Pressure Injury Prevention in AE and PFC N/A Interventional Unable to continue to conduct study procedures due to pandemic Actual 54
NCT04010136 Suspended Identification of Elderly Patients in Need of Palliative Care by Family Physicians N/A Interventional We were not able to recruit participants to enrol the study. As it was not able, the investigation team decided not to proced. Anticipated 180
NCT04011098 Terminated Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour Phase 1 Interventional Unable to meet recruitment numbers, lack of participation Actual 5
NCT04072484 Terminated Effectiveness of Chest Compressions Under Mild Hypoxia N/A Interventional Research at the University of Chicago was halted in March 2020. Actual 19
NCT04081506 Withdrawn Targeting the Optimal Mean Arterial Pressure in Hypoxic Ischemic Brain Injury After Cardiac Arrest N/A Interventional COVID-19 pandemic Actual 0
NCT04087265 Withdrawn Accuracy of Trans-abdominal Ultrasound in Evaluating Bowel Preparation Adequacy Before Colonoscopy N/A Interventional The PI requested to terminate due to his schedule Actual 0
NCT04128462 Withdrawn MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function Phase 3 Interventional Study postponed before recruiting any participants - may start in 2nd or 3rd quarter 2021 Actual 0
NCT04138433 Suspended Mechanisms Underlying Spoken Language Production N/A Interventional Due to COVID-19 - recruitment suspended since March 2020 in line with guidance from the UCLH/UCL Joint Research Office Anticipated 60
NCT04141904 Suspended Tofacitinib in Depression (TIDE) Phase 1/Phase 2 Interventional Covid-19 pandemic Anticipated 50
NCT04279249 Suspended Home Air Filtration for Traffic-Related Air Pollution N/A Interventional Due to COVID-19 Anticipated 288
NCT04292392 Withdrawn Pain Levels and Opioid Usage in Three Nerve Block Cohorts in Primary TKA N/A Interventional Final protocol and ICF has not been approved by local IRB. No subjects have been enrolled. Study will not be pursued due to current COVID-19 pandemic. Actual 0
NCT04556032 Terminated Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women N/A Interventional Sponsor terminated study due to unforeseen recruitment circumstances amidst the COVID19 pandemic. Actual 4
NCT04573010 Withdrawn Reducing Intracranial atheroSclErosis With Repatha Phase 4 Interventional Duplicate entry Actual 0
NCT02483000 Terminated Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies Phase 1 Interventional Closed early due to lack of funding Actual 3
NCT02455024 Terminated An Observational Registry to Evaluate the Incidence of and Risk Factors for Vascular Occlusive Events Associated With ICLUSIG® Observational Business Decision; Insufficient Enrollment Actual 3
NCT03184584 Terminated Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome Phase 2/Phase 3 Interventional Terminated early due to redeployment of study site staff during Covid-19 pandemic Actual 10
NCT03523507 Terminated fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population N/A Interventional Study terminated due to COVID-19 restrictions Actual 10
NCT03879200 Terminated Group Antenatal Care for Somali Born Women N/A Interventional Limited time frame and financial resources. The anticipated increase of eligable migrant women did not occur during the period because of changes in migration policies. Actual 136
NCT04164758 Terminated Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine Phase 2 Interventional Study enrollment impacted by COVID-19 pandemic and Sponsor terminated for business reasons Actual 11
NCT04231409 Terminated Fast-Acting Subperception Study (FAST) N/A Interventional Study follow-up activities affected by COVID-19 Actual 41
NCT04269265 Suspended The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Vaccination Phase 1/Phase 2 Interventional Recruitment is suspended and expected to resume Spring 2021. Anticipated 46
NCT04560972 Withdrawn LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer Phase 1 Interventional Administrative isse. Study team notified me to withdraw the study. Actual 0
NCT04612985 Withdrawn Evaluation of the XACT Robotic System for Image-guided Percutaneous Lung Procedures N/A Interventional The IDE wasn't approved Actual 0
NCT02936037 Terminated Effect of MD1003 in Progressive Multiple Sclerosis (SPI2) Phase 3 Interventional Sponsor decision for business purposes Actual 642
NCT03334669 Suspended Family-centered Obesity Prevention: Communities for Healthy Living (CHL) N/A Interventional The primary trial was halted due to covid-19 in the last 6 months of the trial; as a result, the intervention was not fully implemented and the final outcomes were not measured. Outcomes will be assessed with the data available (BL, Y1, Y2). Actual 4280
NCT03762356 Withdrawn Questionnaire About Individual's Insight/Awareness of Risk of Violence Observational Study did not receive final approval however it was decided to not pursue. Actual 0
NCT04001998 Withdrawn Healthy Volunteer Study Comparing Tablet and Capsule Formulations Phase 1 Interventional On hold to determine chosen formulations Actual 0
NCT04610606 Terminated Pilot Prehabilitation Intervention in Lung Cancer N/A Interventional Covid-19 pandemic Actual 34
NCT01020864 Withdrawn Cetuximab in Combination With Chemotherapy for Patients With Head and Neck Cancer Phase 2 Interventional Actual 0
NCT01668277 Terminated Effects of Saline on Circulation in Children Phase 2 Interventional Actual 15
NCT01865630 Withdrawn Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage Phase 1 Interventional PI moved to another institution Actual 0
NCT03467633 Terminated Atrial Fibrillation Trial to Evade Recurrence: effectS of Hiit Before electrO-Cardioversion for 3-weeKs N/A Interventional Not enough participants recruited. Actual 12
NCT03948334 Terminated A Study to Assess the Safety and Efficacy of ZPL389 With TCS/TCI in Atopic Dermatitis Patients Phase 2 Interventional Coe terminated due to lack of efficacy Actual 123
NCT04001153 Withdrawn Occlusal Compensation After the Hall Technique Observational There will be no opportunity to recruit patients during the pandemic of COVID-19 and possibly even post-pandemic Actual 0
NCT04108143 Suspended Use of MonitorMe in COPD N/A Interventional COVID-19 (study will re-open for recruitment when possible) Anticipated 30
NCT04171089 Withdrawn Suicide Prevention in Prepubertal Children N/A Interventional Due to COVID-19 Pandemic Actual 0
NCT04340544 Terminated Hydroxychloroquine for the Treatment of Mild COVID-19 Disease Phase 2 Interventional It appeared to be impossible for the study centres to recruit the targeted number of patients, due to reduced incidence and reduced acceptance to IMP Actual 17
NCT04374552 Withdrawn Asymptomatic COVID-19 Trial Phase 2 Interventional The investigators have decided not to go forward with this protocol Actual 0
NCT04452643 Withdrawn Efficacy of BACMUNE (MV130) in the Prevention of Disease Due to COVID-19 Infection in Healthcare Personnel Phase 3 Interventional Not authorized by Cofepris (Mexico Competent Regulatory Authority) Actual 0
NCT04469491 Suspended Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study Phase 2 Interventional In anticipation for Data and Safety Monitoring Board Anticipated 60
NCT04610996 Withdrawn The Valid of GFR in Chronic Kidney Disease Patients Observational Actual 0
NCT03383198 Terminated Pectoralis (II) Block With Liposomal Bupivacaine vs Bupivacaine for Breast Surgery Phase 4 Interventional Early termination due to manufacturer discontinued supplying the product for the study. Actual 5
NCT04274933 Terminated A Study to Evaluate the Safety and Tolerability of Venetoclax Tablets in Combination With Capecitabine Tablets in Adult Participants With Hormone Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer Who Had Disease Progression During or After CDK4/6 Inhibitor Therapy Phase 1 Interventional Company Decision Actual 4
NCT02747238 Terminated Does Ultrasound Help Junior Anesthesia Residents With Placement of Labor Analgesia in Pregnant Patients N/A Interventional lack of enrollment Actual 32
NCT02757391 Terminated CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors Phase 1 Interventional Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention. Actual 1
NCT02981017 Withdrawn Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure N/A Interventional Decided to do a different clinical trial opportunity. Actual 0
NCT03493412 Withdrawn Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease Phase 4 Interventional discontinued due to change in operating plans prior to study initiation and enrollment Actual 0
NCT03744832 Suspended Point of Care Streptococcal Pharyngitis Testing N/A Interventional The study was stopped secondary to the research curtailment and reallocation of testing resources secondary to the COVID-19 pandemic. Actual 145
NCT03974152 Suspended Effects of Nicotine Salt Aerosol on Cigarette Smokers N/A Interventional COVID concerns Anticipated 15
NCT04257357 Withdrawn Supervised Exercise Following Pulmonary Embolism N/A Interventional Due to Covid-19 pandemia the study was never initiated Actual 0
NCT04581070 Terminated The COVID-IYON Study - Study Examining Data Pertaining to Clinical Outcomes and Organisational Responses to the 2020 SARS-CoV-2 Pandemic" Observational Study stopped due to low accrual Actual 4
NCT03340103 Withdrawn Early Administration of the Lutein/Zeaxanthin in Premature Newborns N/A Interventional Recruitment was not possible Actual 0
NCT04347889 Withdrawn Preventing COVID-19 in Healthcare Workers With HCQ: A RCT Phase 2 Interventional Evidence that HCQ ineffective, loss of HCW interest, Actual 0
NCT04140734 Suspended Spacer Graft Study N/A Interventional Study has expired with the IRB Anticipated 100
NCT04220632 Terminated A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease Phase 1/Phase 2 Interventional Adverse events of the first patient Actual 1
NCT04342897 Terminated A Study of LY3127804 in Participants With COVID-19 Phase 2 Interventional Trial terminated for futility. Actual 95
NCT04363866 Withdrawn Assessing Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19) Phase 2 Interventional discontinued in favor of more promising directions that may benefit patients Actual 0
NCT03598140 Terminated Sildenafil Treatment for Mild TBI Phase 2 Interventional PI, Dr. Josh Gaston, left the institution and the study has been stopped. Actual 22
NCT04613102 Withdrawn The Efficacy and Safety of 3% Cannabidiol (CBD) Cream in Patients With Epidermolysis Bullosa: A Phase II/III Trial Phase 2/Phase 3 Interventional The study protocol will be updated (major updates), following Health Canada request Actual 0
NCT00336154 Withdrawn Study to Evaluate the Efficacy of Tetracycline in Epidermolysis Bullosa Phase 4 Interventional Actual 0
NCT03731702 Withdrawn Optimization of Collection Methods for Studies of the Human Microbiota Observational Deemed not human subjects research Actual 0
NCT03937791 Terminated Immunotherapy With E7 T Cell Receptor T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions Phase 2 Interventional All analysis with identifiable specimens/data is complete or site has no identifiers linked to the specimens/data. The one enrolled pt has been taken off study Actual 1
NCT04606810 Terminated Measuring the Impact of an Innovative Educational Intervention in Inflammatory Arthritis N/A Interventional Difficulties at recruiting enough participants for this study Actual 112
NCT00895024 Terminated Caregiver Assessments of the Quality of Home Hospice Care Observational PRMS No Slow Accrual Actual 74
NCT03601247 Suspended Silicone Gel for Postsurgical Scars of the Eyelid N/A Interventional The principal investigator suspended the study temporarily because of the COVID pandemic. We do not want patients to attend their follow-up visits at this time unless absolutely necessary. Anticipated 100
NCT03605589 Suspended Pembro + Blina Combination in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Leukemia or Lymphoma Phase 1 Interventional Slow recruitment. Amendment pending Anticipated 24
NCT04030351 Terminated Effect of Dried Fruit Intake on Acid-base Balance N/A Interventional Institution shut down due to COVID-19 Actual 109
NCT04034381 Suspended Dietary Intake, Health and Micronutrient Status in Haiti Observational Study suspended due to civil unrest and corresponding safety concerns and logistical challenges. Anticipated 1290
NCT04127721 Withdrawn Itacitinib for the Prevention of Graft Versus Host Disease in Patients Undergoing Donor Stem Cell Transplantation Phase 2 Interventional 0 ACTUAL Enrollment must have Overall Recruitment Status Actual 0
NCT00206375 Terminated Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Phase 4 Interventional Actual 16
NCT02885051 Terminated Evaluation of Pain in Preterm Newborn N/A Interventional At the end of the inclusion period, the observed correlations were much lower than expected. Thus, it did not seem relevant to prolong the inclusions. Actual 91
NCT03054870 Terminated A Comparison of Technegas and Xenon-133 Planar Lung Imaging in Subjects Referred for Ventilation Scintigraphy Phase 3 Interventional Trial met primary efficacy endpoint target. No additional subjects necessary. Actual 226
NCT02730962 Terminated Interventional Bioremediation of Microbiota in Metabolic Syndrome Phase 2 Interventional Delays in IND approval caused a lack of funding to conduct the trial. Actual 12
NCT04138485 Withdrawn Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc) Phase 2 Interventional Due to business reasons, not safety issues Actual 0
NCT04364009 Suspended Anakinra for COVID-19 Respiratory Symptoms Phase 3 Interventional Efficiency and safety reasons Actual 71
NCT04603963 Terminated Inspiratory Muscle Training in Patients With COVID 19 N/A Interventional There was a change in the institutional flow reducing the cases of covid 19 Actual 55
NCT00506779 Terminated Gleevec/Taxol for Patients With Uterine Papillary Serous Carcinoma Phase 1/Phase 2 Interventional the study was terminated early due to poor enrollment Actual 17
NCT02208271 Suspended A Validated Necrosis Assay to Determine the Need for Revision Surgery in Metal-on-metal Total Hip Arthroplasty Observational The lab was acquired by another company and has put this study's samples on hold. Actual 174
NCT02530502 Terminated Radiation Therapy With Temozolomide and Pembrolizumab in Treating Patients With Newly Diagnosed Glioblastoma Phase 1 Interventional The protocol was amendment to be stopped after phase I (phase 2 removed from protocol) Actual 4
NCT03176498 Suspended Human Umbilical Cord Mesenchymal Stem Cell Therapy for Cerebral Infarction Patients in Convalescent Period. Phase 1/Phase 2 Interventional Others Anticipated 40
NCT03180450 Suspended The Study of Heart Failure With Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSC) Phase 1/Phase 2 Interventional Others Anticipated 60
NCT03180463 Suspended The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells Phase 1/Phase 2 Interventional Others Anticipated 30
NCT03184935 Suspended Research for Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Myelodysplastic Syndrome (MDS) Phase 1/Phase 2 Interventional Others Anticipated 40
NCT03186456 Suspended The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Acute Cerebral Infarction Phase 1 Interventional Others Anticipated 40
NCT03569150 Withdrawn Culturally-Adapting a Communication Intervention to Improve Palliative Care Literacy on Two Native American Reservations N/A Interventional Study not funded. Actual 0
NCT03619746 Terminated Point-of-Care Ultrasound Educational Initiative for Insect Bites N/A Interventional Lack of accrual. We were unable to enroll enough participants to have meaningful results. Actual 71
NCT03816852 Suspended The Safety and Efficiency Study of Mesenchymal Stem Cell in Premature Ovarian Insufficiency Phase 2 Interventional Others Anticipated 12
NCT04058977 Withdrawn Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness Phase 1/Phase 2 Interventional Withdrawn prior to participant enrollment due to funding status Actual 0
NCT04088903 Withdrawn Study of Daratumumab for Decreasing Circulating Antibodies in Sensitized Patients Awaiting Heart Transplantation Phase 1 Interventional Protocol changed to use subcutaneous rather than intravenous daratumumab. Actual 0
NCT04163913 Withdrawn Radial Medical - GAPS N/A Interventional Insufficient funding Actual 0
NCT04250740 Suspended The Morning Coffee Study N/A Interventional Due to COVID-19 this research needed to pause in March 2020. We plan to start the study again when we have approval to do so. Anticipated 30
NCT04315155 Withdrawn Evaluating Safety & Efficacy Belinostat Combo w Nivo Alone & w Ipi in Patients w Treated Metastatic/Advanced Carcinomas w ARID1A Lof Mutation Phase 1 Interventional study abandoned for funding issues Actual 0
NCT04360876 Withdrawn Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot Randomized Clinical Trial Phase 2 Interventional Funding not received Actual 0
NCT04610879 Terminated Changing Agendas on Sleep, Treatment and Learning in Epilepsy Phase 4 Interventional Following the internal pilot, the study did not meet prespecified stop/go criteria for continuation. Actual 5
NCT03621787 Terminated Assessing the Safety and Efficacy of a Novel Subcutaneous Implant Insertion Device on Healthy Adults N/A Interventional Expiration of study funds. Actual 9
NCT04344288 Terminated Corticosteroids During Covid-19 Viral Pneumonia Related to SARS-Cov-2 Infection Phase 2 Interventional Competent Authority's decision Actual 11
NCT04602884 Suspended Early Detection of COVID-19 Using Breath Analysis N/A Interventional no additional parcipitants could be recruited at site. Actual 50
NCT02243397 Suspended Molecular and Cellular Analysis of Breast Cancer Observational Safety Anticipated 500
NCT03084861 Terminated A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Phase 1/Phase 2 Interventional Low recruitment. No safety issue associated. Actual 9
NCT02790736 Suspended Brief Intervention to Reduce Fear of Public Speaking Phase 4 Interventional COVID-19 restrictions Actual 6
NCT03349476 Suspended Model Based Fast Anatomical Mapping N/A Interventional study to reopen with additional enrollment Anticipated 150
NCT03499353 Terminated Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer Phase 2 Interventional This study was terminated based on Pfizer's change in clinical development strategy not related to safety and efficacy. Actual 61
NCT03510208 Suspended Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery Phase 1/Phase 2 Interventional Regulatory Anticipated 23
NCT03630809 Suspended Immune Response and Potential Booster for Patients Who Have Received HER2-pulsed DC1 Phase 2 Interventional Suspended for protocol revisions Anticipated 40
NCT03861403 Terminated A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid Tumors Phase 1/Phase 2 Interventional Product development discontinued unrelated to safety. Actual 10
NCT04233814 Suspended Safety, Tolerability and Pharmacokinetic Study of LTI-03 in Healthy Adult Subjects Phase 1 Interventional pending clinical laboratory analyses Anticipated 56
NCT04371406 Withdrawn Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients Phase 3 Interventional Regulatory approvals have not been obtained Actual 0
NCT00058188 Terminated Zolendronate for the Prevention of Bone Loss in Men w/ Prostate CA on Long-Term Androgen Deprivation Phase 3 Interventional Closed by the research committee Actual 53
NCT02610335 Terminated Evaluation of Spinal Mobility Reeducation in Patients Treated for a Lumbar Spinal Stenosis After Epidural Infiltration N/A Interventional The recruitment of participants was very difficult despite a change in the organisation. The inclusion criteria did not result in the expected number of participants, and the credits ran out. Actual 23
NCT02689739 Withdrawn Validation of Ultrasound in Predicting a Low Lying Placenta Throughout Pregnancy Observational Actual 0
NCT03526536 Terminated Pilot: Insulin Sensitivity/Management in Hyperglycemic Patients in Perioperative Period ESRD/Non-ESRD Phase 4 Interventional The study required more participants than anticipated for statistical significance. Actual 40
NCT03647995 Terminated Probiotics in the Prevention of Antibiotic Induced Diarrhea and Clostridium Difficile Associated Diarrhea. N/A Interventional Were not able to enroll enough participants due to shortage of study staff Actual 25
NCT03923010 Terminated A Study of Itraconazole in the Management of Superficial Fungal Infections in India Phase 4 Interventional Further recruitment not possible due to COVID 19 impact. Hence a decision to close study was taken at the antifungal CDT in Aug 2020. Actual 40
NCT03975192 Withdrawn Neurostimulation for Opiate Withdrawal in the PICU N/A Interventional There was no enrollment. Actual 0
NCT04100083 Withdrawn Spironolactone for Hidradenitis Suppurativa Phase 4 Interventional Lack of funding Actual 0
NCT04231864 Withdrawn Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic Epstein-Barr Virus Positive Nasopharyngeal Cancer Phase 2 Interventional Feasibility Actual 0
NCT01897714 Terminated Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients Phase 1/Phase 2 Interventional The study was terminated at median 46-48 months long term follow-up and mature overall survival follow-up data. Actual 75
NCT02595918 Terminated Nivolumab in Treating Patients With High-Risk Kidney Cancer Before Surgery Phase 1 Interventional Inadequate accrual rate Actual 19
NCT04034927 Suspended Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer Phase 2 Interventional Scheduled Interim Monitoring Anticipated 170
NCT04567589 Withdrawn A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization Measures Among Healthcare Professionals in Canada Observational This study was cancelled before any data collection due to business reasons. Actual 0
NCT01801878 Withdrawn Pilot Study of Skin Quality Improvement After Adipose-drived Stem Cell Transfer in Irradiated Breasts N/A Interventional Difficulty in recruiting research subjects Actual 0
NCT01898377 Terminated Imatinib Mesylate and Mycophenolate Mofetil for Steroid-Refractory Sclerotic/Fibrotic cGVHD in Children Phase 2 Interventional New treatment option introduced for patients with the study indication Actual 9
NCT02982499 Terminated Biomechanics of Optic Neuropathy Observational Principal investigator's decision due to lack of resources Actual 10
NCT03089567 Withdrawn Comparison of the Salivary Levels of Streptococcus Mutans in Pediatric Patients With Early Childhood Caries After the Application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish Early Phase 1 Interventional Study was not conducted. No participants were enrolled Actual 0
NCT03458910 Terminated Heart Rate Variability and Emotion Regulation N/A Interventional COVID-19 increased risk of participation Actual 193
NCT03735095 Suspended Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer Early Phase 1 Interventional Analysis of Data Anticipated 6
NCT03748173 Terminated Infasurf®(Calfactant) Aerosol for Infants With Bronchiolitis-AERO-04 Phase 1 Interventional slowdown due to covid Actual 13
NCT03796403 Terminated Bupivacaine Plus Diclofenac Versus Bupivacaine Alone for Postoperative Pain Relief in Gynecologic Cancer Patients N/A Interventional Diclofenac is no longer recommend for intramuscular administration by the Medical Council of Thailand Actual 140
NCT03846583 Withdrawn Tucatinib + Abemaciclib + Herceptin for HER2+ MBC Phase 1 Interventional Study halted prematurely, prior to enrollment of first participant. Actual 0
NCT03902977 Terminated Effect of Quilting Sutures on Post-operative Drainage After Mastectomy and/or Axillary Lymph Node Dissection N/A Interventional insufficient recruitment Actual 10
NCT04060888 Withdrawn A Study of Ustekinumab in Chinese Participants With Active Systemic Lupus Erythematosus Phase 3 Interventional Pre-planned IA (global study) showed lack of efficacy in this indication. No new safety signals observed, findings consistent with known profile. Actual 0
NCT04503538 Withdrawn Telemedicine for Early Detection of Cytokine Release Syndrome and Neurotoxicity N/A Interventional Principal investigator decided not to pursue trial Actual 0
NCT04567095 Withdrawn A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization Measures Among Patients in Canada Observational This study was cancelled before any data collection due to business reasons. Actual 0
NCT02218567 Terminated Behavioural Problems in Huntington Disease : Analysis and Enhancement of Caregiver and Patient Experience N/A Interventional inclusion difficult Actual 12
NCT02403518 Terminated Clinical Outcomes of the Freedom Spinal Cord Stimulation (SCS) System for the Management of Chronic Back and Leg Pain N/A Interventional Lack of recruitment Anticipated 45
NCT02503280 Withdrawn The Transendocardial Autologous Cells (hMSC) or (hMSC) and (hCSC) in Ischemic Heart Failure Trial. Phase 1/Phase 2 Interventional Study has never enrolled any subjects Actual 0
NCT02537964 Terminated Effectiveness of Chlorhexidine Bathing in the Neonatal Intensive Care Unit N/A Interventional funding not available Actual 24
NCT02699723 Withdrawn Arsenic Trioxide and Itraconazole in Treating Patients With Advanced Basal Cell Cancer Early Phase 1 Interventional Logistics Actual 0
NCT00796107 Terminated A Study of R1507 in Combination With Letrozole in Postmenopausal Women With Advanced Breast Cancer Phase 2 Interventional Due to the discontinuation of compound development, this study has been terminated. Actual 6
NCT03177252 Withdrawn Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients Phase 1 Interventional Investigator decided not to go forward with the trial. Actual 0
NCT03603080 Suspended Efficacy of Pharmacotherapy to Enhance Weight Loss Following Sleeve Gastrectomy Phase 4 Interventional Difficulty with enrollment and then Covid pandemic Anticipated 110
NCT03675113 Withdrawn Effect of Upper Extremity Aerobic Exercise Training on Exercise Capacity Patients With Chronic Heart Failure N/A Interventional This study was a doctorate thesis and student changed the subject of her thesis. Actual 0
NCT03768115 Withdrawn Autologous Plasma Treatment for Severe Dry Eye Patients Early Phase 1 Interventional The inclusion criteria for plasmapheresis is too stringent to get any potential subjects. Actual 0
NCT03944733 Withdrawn Iron Status, Maternal Depressive Symptoms, and Mother-child Interactions N/A Interventional The study was never started as a result of change of personnel and funding Actual 0
NCT04014400 Terminated Suprathel Versus Xeroform for the Management of Skin Graft Donor Sites N/A Interventional We observed that using the Suprathel dressing required additional treatment of the wound and had a longer healing time than the standard of care Xeroform dressing; it did not dry the wound out properly to promote healing. Actual 10
NCT04113083 Suspended An Observational Study for Evaluation of for the Prevalence of Cerebrotendinous Xanthomatosis (CTX) Disease Observational Due to COVID 19 Pandemic Actual 22
NCT04158596 Withdrawn Safety and Efficacy of SDX-3101 for the Treatment of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) N/A Interventional Covid-19 Actual 0
NCT04341987 Withdrawn Treating Nightmares Among Domiciliary Patients N/A Interventional Covid-related Actual 0
NCT04467151 Withdrawn Administration of Anti-SARS-CoV-2 Convalescent Plasma in Hospitalized, Non-ICU Patients With COVID-19 Phase 2 Interventional Did not obtain funding to proceed with study Actual 0
NCT03436420 Terminated Gemcabene for the Treatment of Pediatric NAFLD Phase 2 Interventional Terminated due to lack of efficacy and safety concerns. Actual 6
NCT02022735 Terminated Deep Brain Stimulation Effects on Gait and Balance in Patients With Parkinson's Disease N/A Interventional funding not secured Actual 11
NCT02175082 Terminated Cycling in Parkinson's Disease N/A Interventional Terminated prior to enrollment goals due to difficulty with recruiting subjects Actual 12
NCT02522975 Terminated Biosimilar Erythropoietin in Anaemia Treatment (Correction Phase Study) Phase 4 Interventional Actual 16
NCT02755194 Terminated "Drugs in Lactation" Analysis Consortium Observational This infrastructure project has been taken over by another study. Actual 68
NCT03052361 Terminated Triage Administration of Ondansetron for Gastroenteritis in Children Phase 2/Phase 3 Interventional The recruitment was much slower than expected and the COVID pandemic added new barriers to recruitment. Actual 81
NCT03373877 Terminated Evaluation of Ruxolitinib in Combination With PU-H71 for Treatment of Myelofibrosis Phase 1 Interventional Samus is focusing all of their efforts in myelofibrosis on the new oral formulation of PU-H71. Actual 4
NCT03443622 Withdrawn Phase I Study of SC-43 Oral Solution in Subjects With Refractory Solid Tumors Phase 1 Interventional Another study has been started in other country. Actual 0
NCT03557684 Suspended Leucine for Depression Study (L-DEP) Early Phase 1 Interventional COVID-19 Anticipated 90
NCT03597503 Terminated Treatment of Impulsive Aggression (IA) in Adolescent With ADHD in Conjunction With Standard ADHD Treatment Phase 3 Interventional Financial decision Actual 186
NCT03779555 Terminated Lenalidomide Adherence in Older Adults Observational Principal Investigator left the university Actual 17
NCT04133480 Withdrawn Investigation of Cognitive Outcomes With Cannabidiol Oral Solution Phase 4 Interventional The decision to withdraw the study was based on pandemic-related concerns of conducting a Phase IV study requiring multiple clinic visits when medication is commercially available. The study was withdrawn before any participants were recruited. Actual 0
NCT04227626 Withdrawn Inpatient Closed Loop Glucose Control With the Gen 2 GlucoSTAT N/A Interventional The study has not started, the device is not ready so the study will be delayed Actual 0
NCT04290962 Withdrawn Web-Based Lifestyle Intervention for the Improvement of Health in African American Cancer Survivors N/A Interventional no accrual Actual 0
NCT04434040 Suspended Ipatasertib + Atezolizumab to Prevent Recurrence in TNBC Phase 2 Interventional Study team plans to revise one of the agents used in the treatment plan of the study. Anticipated 40
NCT04153422 Suspended IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS or FGFR-3 Antibodies Phase 2 Interventional Recruitment not started at Loyola, PI leaving Loyola, PI may resume at next affiliating instituation. Anticipated 20
NCT03197025 Terminated Immunotherapy With E6 T Cell Receptor (TCR) T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions Phase 1 Interventional The study was closed due to investigator discretion based on the lack of perceived clinical activity observed in the study. Actual 1
NCT04600648 Withdrawn Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children N/A Interventional poor enrollment Actual 0
NCT04270461 Withdrawn NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors Phase 1 Interventional Study is withdrawn because of administrative reasons Actual 0
NCT02660528 Terminated Tocilizumab Augmentation in Treatment-Refractory Major Depressive Disorder Phase 2 Interventional Study staff change. Actual 3
NCT02750254 Terminated Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation Phase 1 Interventional Toxicity. Only enrolled patients in phase I portion of trial. Actual 5
NCT02859428 Terminated Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31 Observational Investigator left NIH Actual 51
NCT02885987 Withdrawn Use of Accessory Device AmplifEYE During Average Risk Screening Colonoscopy to Increase Adenoma Detection Rate N/A Interventional decided not to go ahead with study at this time Actual 0
NCT02919553 Withdrawn Modified Wet Suction Versus Capillary Techniques for EUS Guided Fine Needle Aspiration and Biopsy of Solid Lesions N/A Interventional decided not to proceed with study at this time Actual 0
NCT02930122 Terminated IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions Phase 2 Interventional Lack of funding Actual 6
NCT03327987 Withdrawn Early Flu Shots in SOT Observational The study was on hold and later withdrawn due to shortage of staff Actual 0
NCT03487731 Withdrawn Allogeneic Human Mesenchymal Stem Cell Injection in PAtieNts With FaceTogenic Back Pain Phase 1/Phase 2 Interventional PI decided to not proceed with study Actual 0
NCT03508427 Suspended Toi Même: a Mobile System for Measuring Bipolar Illness N/A Interventional Suspended since april 2020 as the application is temporarily unavailable Anticipated 93
NCT02703311 Terminated REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System N/A Interventional Edwards acquired Valtech Cardio Ltd in 2017 and opted to replace this study with NCT03600688.11 patients were enrolled in REPAIR and follow-up is complete. Actual 11
NCT03741062 Terminated Effects of Laser Stimulation on Wound Healing of Human Palatal Tissue N/A Interventional COVID-19 Actual 11
NCT00769002 Terminated PET-CT Scans in Healthy Volunteers After Flu Vaccination N/A Interventional Actual 18
NCT03376321 Terminated A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection Phase 3 Interventional Study terminated early (date of study termination decision: 28 August 2020) as a result of the outcome of the pre-planned Interim Analysis. Actual 334
NCT02010567 Terminated Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer Phase 1/Phase 2 Interventional The study was halted prematurely at the funding partner's request. Actual 32
NCT02452359 Terminated Clinical Evaluation of Using Intense Pulsed Light for Improving the Appearance of Striae Distensae N/A Interventional Continuing the trial was considered to be superfluous. Actual 54
NCT02452398 Terminated Clinical Evaluation of Hair Removal and Permanent Hair Reduction for Skin Types VI Using Intense Pulsed Light N/A Interventional Study withdrawn as technology already proven with data no longer needed. Actual 79
NCT03259425 Terminated Neoadjuvant Trial of Nivolumab in Combination With HF10 Oncolytic Viral Therapy in Resectable Stage IIIB, IIIC, IVM1a Melanoma Phase 2 Interventional DSMC Recommendation Actual 7
NCT03819504 Withdrawn Stereotactic Non-invasive Ablation of Ventricular Tachycardia N/A Interventional Change in the design of the study Actual 0
NCT04589897 Suspended Manuka Honey Sinus Rinse Study N/A Interventional Paused for Covid-19 Anticipated 40
NCT04591288 Terminated FES to Improve Gait in CP N/A Interventional Closed by the sponsor for not fully meeting subject recruitment targets. Actual 2
NCT01938716 Terminated Gemcitabine Pharmacokinetics After Preoperative Chemoradiation Therapy N/A Interventional Early termination due to low accrual Actual 12
NCT00759083 Withdrawn Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Phase 4 Interventional The study was discontinued early due to inadequate patient enrollment. No patients were enrolled. Actual 0
NCT01003795 Withdrawn Promus - Registry Experience at the Washington Hospital Center, Drug-eluting Stent (DES) Observational Not Funded Actual 0
NCT01806064 Terminated Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell Carcinoma Phase 1/Phase 2 Interventional The study did not meet endpoint. Actual 173
NCT02100735 Withdrawn Evaluation of an Analgosedation Protocol in Mechanically Ventilated Patients N/A Interventional Difficulty in with enrollment of patient Actual 0
NCT02354144 Terminated Lubricant Investigation in Men to Inhibit Transmission of HPV Infection Phase 2/Phase 3 Interventional Mandated by DSMB because of lack of protective effect of carrageenan, higher proportion of adverse events in the carrageenan compared to placebo arm, and low probability that continued accrual would lead to a significant protective effect. Actual 258
NCT02607124 Terminated A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy Phase 1/Phase 2 Interventional A competing trial was opened for patient population with combination of ribociclib and everolimus. Actual 11
NCT02642939 Terminated Study of Oral Mifepristone as Salvage Therapy in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Phase 2 Interventional Lack of enrollment Actual 3
NCT03008772 Withdrawn REWARDS- In-stent Restenosis Observational [Patient Registry] Not funded Actual 0
NCT03037645 Terminated Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers Phase 1/Phase 2 Interventional Phase 1b portion completed. Sponsor decided not to proceed with P2 portion of study. Vecabrutinib was very well tolerated, there was insufficient evidence of activity at the doses tested in the Phase 1b to advance to Phase 2. Actual 39
NCT03273257 Terminated Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Phase 2 Interventional The study was stopped due to slower than expected recruitment and the additional limitations on clinical research imposed by the COVID-19 pandemic, both of which made study completion within a reasonable timeframe appear unlikely. Actual 14
NCT03682055 Terminated Phase 1/2a Study of VK-2019 in Patients With Epstein-Barr Virus (EBV)-Positive Nasopharyngeal Carcinoma (NPC) Phase 1/Phase 2 Interventional Lack of efficacy Actual 14
NCT03800420 Terminated Efficacy and Safety of BBT-401-1S in Ulcerative Colitis Phase 2 Interventional to carry out the rest of the study with new CRO and modified protocol as a multi-regional study. Actual 16
NCT03945331 Terminated Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans With Motor Complete Paraplegia N/A Interventional COVID-19 disrupted interventions irrecoverably. Actual 2
NCT04106050 Withdrawn Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy Phase 1 Interventional Sponsor Decision Actual 0
NCT04323969 Terminated Gait Modification for Knee Osteoarthritis N/A Interventional COVID-related laboratory shutdown. Actual 3
NCT00927108 Withdrawn Rajavtihi Neuronal Adult Stem Cells Project Phase 2 Interventional Actual 0
NCT01130324 Withdrawn VIBATIV Pregnancy Registry Observational [Patient Registry] Released by he FDA from this Post-Marketing Commitment Actual 0
NCT02363647 Suspended Personalized Cancer Therapy for Patients With Metastatic Medullary Thyroid or Metastatic Colon Cancer N/A Interventional No Current Funding Actual 10
NCT02595996 Terminated Propranolol Dose Escalation in Lymphedema in Patients Phase 2 Interventional Lack of funding Actual 1
NCT02965508 Terminated Home-based Primary Care for Homebound Seniors N/A Interventional The Data Safety Monitoring Board determined that the serious adverse event rate was higher among patients awaiting enrollment in the home-based primary care intervention compared to those who had initiated home-based primary care. Actual 230
NCT03110588 Withdrawn Phase I Trial of PACE for Metastatic Prostate Cancer Phase 1 Interventional PI left the institution Actual 0
NCT03264092 Terminated Comparison of Three Tissue Acquiring Techniques During EUS Guided Biopsies of Solid Tumors. N/A Interventional Preliminary analysis of the results showed no statistically significant difference Actual 54
NCT03625336 Withdrawn MR Imaging of Prostatic Calcifications Observational study on hold for an undetermined time Actual 0
NCT03945227 Withdrawn Clinical Trial for Evaluating Efficacy and Safety of PDR001 in Concurrent Plus Consolidation Versus Consolidation Only in Addition to Standard Chemoradiotherapy in Unresectable Stage III NSCLC Patients (PASTURE) Phase 2 Interventional Due to the delay in the study shceduled, due to the start of competitive study and the approval of Durvalumab from the Ministry of Food and Drug Safety, it was judged that it was difficult to enroll subjects. Actual 0
NCT04426344 Withdrawn Core Warming of COVID-19 Patients N/A Interventional Internal decision Actual 0
NCT02064959 Terminated To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients N/A Interventional interim analysis revealed it was futile, we would not reach an answer at N=60. Actual 32
NCT03567694 Suspended Single and Multiple Doses of HA115 and Food Effect in Healthy Adult Volunteers Phase 1 Interventional Business decision Anticipated 120
NCT00004026 Terminated CT-2584 in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Previous Therapy Phase 2 Interventional Anticipated 80
NCT00551239 Withdrawn Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma Phase 3 Interventional Actual 0
NCT02425878 Terminated Ulipristal Acetate 10 mg and Asisted Reproduction Phase 3 Interventional Lack of availibility of eligible subjects Actual 2
NCT03203993 Terminated China Ovarian Cancer BRCA Testing Study Observational Failure to obtain HGR approval. Actual 29
NCT02876094 Terminated Effect of Low-Dose Celecoxib on SMN2 in Patients With Spinal Muscular Atrophy Phase 2 Interventional Terminated: Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention Actual 1
NCT02946346 Terminated Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women N/A Interventional Difficulty to continue follow-up during the coronavirus epidemic Actual 190
NCT03449160 Withdrawn Postural Training Device (UPRIGHT) for Back Pain N/A Interventional COVID 19 which is preventing outpatient and elective procedures Actual 0
NCT03484962 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Liver Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT01118715 Terminated Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial N/A Interventional Impractical to enroll the #s needed for statistical significance; project manager relocated Actual 128
NCT03501056 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Lung Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03509298 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Pancreatic Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03524261 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Breast Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03524274 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT03540199 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Kidney Cancer Phase 2 Interventional No participant enrolled Actual 0
NCT03554395 Withdrawn Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Gastric Cancer Phase 2 Interventional No participants enrolled Actual 0
NCT04333628 Terminated Chloroquine for Mild Symptomatic and Asymptomatic COVID-19 Phase 2/Phase 3 Interventional Teminated due to changes in treatment guidelines . Actual 5
NCT03793686 Terminated A Study of Safety of PBCLN-003 Following Antibiotic Therapy in Subjects With C.Difficile-associated Diarrhea Phase 1 Interventional Unable to enroll subjects Actual 26
NCT03796416 Withdrawn Obesity Study to Assess Induction of Labor N/A Interventional in error Actual 0
NCT03871400 Suspended The NanoStrand Clinical Study N/A Interventional Study halted prematurely and will not resume; participants are no longer receiving intervention due to coronavirus pandemic and unexpected enrollment delays. Actual 18
NCT03963024 Terminated Treosulfan-TMI Conditioning and Rapamycin GvHD Prophylaxis Before Allo-HSCT Phase 1 Interventional low rate of enrolment Actual 9
NCT03973021 Withdrawn Very Small Embryonic-like Stem Cells for Erectile Dysfunction Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT03975101 Withdrawn Very Small Embryonic-like Stem Cells for Knee Osteoarthritis Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT03976206 Withdrawn Very Small Embryonic-like Stem Cells for Facial Skin Antiaging Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT03985462 Withdrawn Very Small Embryonic-like Stem Cells for Ovary Phase 1/Phase 2 Interventional Policy changes have contributed to the failure to carry out smoothly Actual 0
NCT04058301 Suspended Text-Enabled Ascertainment and Community Linkage for Health N/A Interventional COVID-19 Anticipated 200
NCT04165668 Terminated Wellbeing and Stress Among Mobile Phone Dispatched Lay Responders Observational Due to the COVID-19 Pandemic. Actual 460
NCT04234581 Terminated The Effect of Lysulin on Glycemic Control and Advanced Glycation N/A Interventional Sponsor decision Actual 59
NCT04388189 Withdrawn Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion Phase 4 Interventional No participants enrolled Actual 0
NCT04388202 Withdrawn Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram Phase 4 Interventional No participants enrolled Actual 0
NCT04516603 Withdrawn Influence of Fampridine on Working Memory in Healthy Subjects Phase 2 Interventional Changement of study design. Restart spring 2021. Actual 0
NCT01601496 Terminated Evaluation of FUSION™ Vascular Graft for Above Knee Targets N/A Interventional Slow Enrollment Actual 117
NCT02547376 Terminated Genetic and Telomere Characteristics of High of Grade Soft Tissue Sarcomas Observational Covid-19 Actual 77
NCT02812849 Withdrawn Somatostatin Receptor Imaging in Cardiac Sarcoidosis Observational Logistic reasons Actual 0
NCT02687815 Terminated Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma) Phase 2 Interventional Futility of vitamin D supplementation based on protocol threshold: <30% conditional power to detect pre-specified effect- 16% reduction in severe exacerbations. Actual 192
NCT02843568 Suspended Improving Pulmonary Function Following Radiation Therapy N/A Interventional Administrative suspension at the request of the Director, Office of Industry Engagement Anticipated 120
NCT02941016 Withdrawn Vascular Inflammation and Cholesterol Lowering Therapy Phase 4 Interventional Logistic reasons Actual 0
NCT03259308 Terminated Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 279
NCT03342859 Terminated Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned Phase 1 Interventional Due to findings in the preclinical carcinogenicity studies for vilaprisan (BAY1002670) Actual 10
NCT03697954 Withdrawn Direct Full-stage Implantation of Sacral Neuromodulation Observational Work has already been published by other groups Actual 0
NCT04085978 Terminated Effects of a Hypoglycemia Protocol With Glucose Gel on Neonatal Intensive Care Unit (NICU) Admission Observational The standard of care had changed during our wait for the Program Letter of Agreement between Phoenix Children's Hospital and Banner to administering IV glucose in the newborn nursery so we weren't able to meet our objective. Actual 400
NCT04246411 Withdrawn Ultrasound vs. Auscultation for Optimal Depth of the Cuffless RAE Tube N/A Interventional It was confirmed that cuffed RAE tubes with small diameter could be used, so there was no reason to use RAE cuffless tubes. Actual 0
NCT04335071 Terminated Tocilizumab in the Treatment of Coronavirus Induced Disease (COVID-19) Phase 2 Interventional 1.) Not possible to recruit the planned number of patients during the planned study period; 2.) "Dexamethason" was included in the standard of care for the study population during the course of the study and inclusion criteria could no longer be met. Actual 5
NCT04462757 Suspended SCIL-1Ra in COVID-19 Feasibility & PK/PD Phase 2 Interventional Lack of patients in the trial population from which to recruit and lack of funding Actual 5
NCT03122470 Withdrawn Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer N/A Interventional PI departure - study not conducted. Actual 0
NCT04519424 Withdrawn CSL324 in COVID-19 Phase 2 Interventional Due to business reasons, not safety issues. Actual 0
NCT04592380 Withdrawn Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF Phase 3 Interventional Product was divested to Chiesi USA, who decided to not move forward with study. Actual 0
NCT02611128 Suspended Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia Observational temporarily closed to enrollment due to COVID Anticipated 65
NCT02701322 Terminated Influence of Medical Clowning in Videofluoroscopic Examination of Pediatric Speech Disorder N/A Interventional machine malfunction and updated work rutines Actual 10
NCT03604523 Terminated Esophageal Dysmotility - Prospective Study Evaluating Methods for Esophageal Dilation N/A Interventional Slow enrollment Actual 10
NCT03763175 Terminated Efficacy and Safety of SYN-010 in IBS-C Phase 2 Interventional Interim Futility Analysis Actual 59
NCT04585022 Terminated Whole Blood Metal Ion Concentrations in Metal-on-metal Total Hip Arthroplasty and Hip Resurfacing N/A Interventional High early failure rates and adverse reactions in similar devices Actual 75
NCT01863498 Terminated Prospective Trial: Pain Management After Pectus Excavatum Repair, Epidural Versus PCA N/A Interventional Institution converted to an alternative strategy for pain control Actual 65
NCT03515941 Terminated Postoperative Chemoradiation or Chemotherapy After Preoperative Chemotherapy for Gastric Cancers Early Phase 1 Interventional The PI has decided to close the study due to the outdated study design. Actual 6
NCT04128020 Withdrawn Azacitidine Plus Nivolumab Following Reduced-intensity Allogeneic PBSC Transplantation for Patients With AML and High-risk Myelodysplasia Phase 1 Interventional Funder withdrew funding after not accruing any subjects after 1 year. Actual 0
NCT04460105 Withdrawn Lanadelumab in Participants Hospitalized With COVID-19 Pneumonia Phase 1 Interventional Study was withdrawn due to challenges in site recruitment and lack of patient enrollment Actual 0
NCT00538681 Terminated Study for Participants With Advanced, Not Amenable to Surgery, or Metastatic Lung Cancer Comparing Treatment With Pemetrexed + Cisplatin + Enzastaurin Versus Pemetrexed + Cisplatin + Placebo Phase 2 Interventional Terminated due to lack of efficacy demonstrated in relevant participant population in other clinical trials. Actual 35
NCT02824211 Withdrawn Demonstrating the Feasibility of a Novel Oxygen Delivery Device N/A Interventional Was unable to obtain funding Actual 0
NCT02907918 Terminated Neoadjuvant Study of Palbociclib in Combination With Letrozole and Trastuzumab in Stage II-III ER+ HER2+ Breast Cancer Phase 2 Interventional Futility Actual 26
NCT03013127 Terminated A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surgery Phase 2 Interventional Inclusion of patients was stopped because ≤2 patients had clinical benefit. Actual 12
NCT03056508 Terminated Lifestyle, Exercise and Diet: The LEAD Study N/A Interventional Due to COVID-19, recruitment and enrollment was suspended and never resumed. COVID-related changes have been made to the clinical program which houses our intervention, and we could not compare new participants with our previous cohort. Actual 14
NCT03636373 Suspended Pilot Study Evaluating The Efficacy Of Etanercept In Acute Gout Phase 4 Interventional Temporarily paused due to COVID 19 and expected to resume Anticipated 40
NCT03886493 Terminated Neoadjuvant Dupilumab in Men With Localized High-Risk Prostate Cancer Phase 2 Interventional Low accrual due to COVID-19 pandemic. Actual 7
NCT03947203 Withdrawn Oral Health Promotion: Youth as Agents Of Change N/A Interventional Unable to staff the project Actual 0
NCT03992716 Terminated Reaching Protein Target With SmofKabiven® Extra Nitrogen vs Olimel N9E During the Early Phase of Acute Critical Illness Phase 4 Interventional Study had to be put on hold after the outbreak of Covid-19 in the participating countries and was terminated in September 2020 since a date for re-starting was not foreseeable. Actual 7
NCT04129320 Withdrawn Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and Neck Phase 2/Phase 3 Interventional Change in study design Actual 0
NCT04212065 Withdrawn Long Acting Subcutaneous vs Short Acting Sublingual Buprenorphine in Pregnant and Lactating Women Phase 4 Interventional closed due to new safety concerns of subcutaneous buprenorphine in pregnant patients Actual 0
NCT03891641 Terminated Momentum-enabled Treadling Methodology to Improve Gait and Enhance Mobility N/A Interventional COVID-19 continues to prevent recruitment of people over the age of 65 years. Actual 17
NCT02152670 Terminated Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET N/A Interventional Study drug became unaffordable for the purposes of the research. Actual 1
NCT04322773 Terminated Anti-il6 Treatment of Serious COVID-19 Disease With Threatening Respiratory Failure Phase 2 Interventional The study has been terminated due to changed clinical conditions and too few patients available Actual 20
NCT01244191 Terminated Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Phase 3 Interventional Sponsor decision due to the protocol-defined stopping boundary for futility was met based on the interim OS data. Actual 1048
NCT04581564 Suspended Rhythm-based Intervention in Aphasia Early Phase 1 Interventional Due to COVID-19 Anticipated 20
NCT02438371 Terminated Nifedipine or Nifedipine Plus Indomethacin for Treatment of Acute Preterm Labor Phase 4 Interventional Study halted due to slow recruitment Actual 37
NCT02285283 Terminated Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps Phase 2/Phase 3 Interventional Recruitment failure. Actual 58
NCT02455817 Withdrawn REWARDS-Angina at Follow up Post Stenting Observational Actual 0
NCT02630355 Terminated Remote Ischaemic Preconditioning to Prevent Dialysis Induced Cardiac Injury Phase 2 Interventional The study was terminated prematurely after ad-interim analysis for the primary outcome. Actual 32
NCT03547206 Terminated Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Phase 2 Interventional Terminated by Sponsor Actual 165
NCT03786380 Terminated Diabetic Gastroparesis Study 05 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 202
NCT03850535 Terminated A Study Evaluating the Safety and Efficacy of Idasanutlin in Combination With Cytarabine and Daunorubicin in Patients Newly Diagnosed With Acute Myeloid Leukemia (AML) and the Safety and Efficacy of Idasanutlin in the Maintenance of First AML Complete Remission Phase 1/Phase 2 Interventional Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2. Actual 24
NCT03947814 Terminated A Study of Orally Administered Pimodivir in Adult Participants With Renal Impairment Phase 1 Interventional Strategic decision to stop pimodivir phase 1 studies Actual 29
NCT04264533 Terminated Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia Phase 2 Interventional the study was started in the second half of the outbreak, and the number of qualifying COVID-19 patients decreased with the control of the epidemic so that we had to stop our trial before reaching the predefined sample size. Actual 56
NCT04089761 Terminated Safety and Efficacy of Nerivio™ for the Acute Treatment of Migraine in Adolescents N/A Interventional Due to the outbreak of the COVID-19 pandemic in the USA on March 2020, all study sites stopped enrolling patients to the study Actual 60
NCT04280068 Terminated Targeting Non-virally Suppressed Adults With Alcohol Use Disorder in HIV Primary Care N/A Interventional Due to COVID-19 recruitment and enrollment of participants was halted Actual 3
NCT04311112 Suspended Safety and Efficacy of Zuretinol Acetate in Subjects With Inherited Retinal Disease Phase 2/Phase 3 Interventional Company dissolved Anticipated 45
NCT03027401 Withdrawn Clinical Sequencing of Cancer and Tissue Repository: OncoGenomics Observational closed by PI and FDA Actual 0
NCT03788486 Withdrawn Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device N/A Interventional Covid Actual 0
NCT03827564 Terminated Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease N/A Interventional Study discontinued due to business reasons. Actual 14
NCT04007926 Suspended Mechanisms of Insulin Resistance and Exercise in South Asians N/A Interventional COVID-19 Anticipated 66
NCT04010682 Suspended Late Pregnancy Sample Collection Study Observational sufficient volunteer recruited for the moment. Study may be re-opened at a later date Anticipated 40
NCT04088266 Withdrawn An Open-Label, Single-Center Study to Evaluate the Exposure-Response Relationship Between the Plasma Drug Concentrations and the Change From Baseline in QTc at Steady State Following Once-daily Administration of CASSIPA® in Opioid Dependent Subjects. Phase 4 Interventional Study delayed indefinetly Actual 0
NCT04464460 Withdrawn A Study to Evaluate the Safety, Pharmacokinetics (PK), and Efficacy of TAK-671 for the Treatment of Coronavirus Disease (COVID) 2019 in Adults Phase 1 Interventional Business Decision (no enrollment) Actual 0
NCT00785135 Terminated Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria N/A Interventional Unable to recruit - multiple reasons.- inclusion/exclusion criteria too strict was th emain reason. Actual 13
NCT02036502 Terminated A Study of Pembrolizumab (MK-3475) in Combination With Standard of Care Treatments in Participants With Multiple Myeloma (MK-3475-023/KEYNOTE-023) Phase 1 Interventional Business Reasons Actual 77
NCT02720341 Terminated VIT-ARMin Virtual, Intensified and Patient-tailored Robotic Arm Therapy With the Exoskeleton Robot ARMin N/A Interventional Doctoral students on project defended their thesis. Actual 222
NCT02880904 Terminated Vulvar Scarring Grading Scale for Lichen Sclerosus Observational Investigator is no longer at Northwestern University Actual 30
NCT02881229 Terminated Vulvar Mucosal Specialty Clinic Chart Review Observational Investigator is no longer at Northwestern University Actual 719
NCT03315143 Terminated Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk Phase 3 Interventional study terminated prematurely for financial reasons and Covid-19 pandemic Actual 10584
NCT03389893 Terminated Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis Phase 4 Interventional Due to inability to meet accrual goals within the funding period. Actual 72
NCT03497117 Terminated 19F MRI of Ventilation in Subjects With Cystic Fibrosis Undergoing Treatment for Pulmonary Exacerbation Early Phase 1 Interventional Enrollment barriers made study completion impossible Actual 5
NCT03521934 Terminated Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial) Phase 3 Interventional study terminated prematurely for financial reasons and Covid-19 pandemic Actual 1222
NCT03837418 Withdrawn DESIGNING A PROGRAMMING LANGUAGE FOR PATIENT-ORIENTED PRESCRIPTIONS (POP-PL) Observational Investigator is no longer at Northwestern University. Actual 0
NCT03921476 Withdrawn Acne and Mood: Impact of Treatment on Depression, Anxiety, and Sexual Function Observational Investigator left Northwestern University Actual 0
NCT03955471 Suspended Study to Evaluate the Efficacy and Safety of the Combination of Niraparib and Dostarlimab (TSR-042) in Participants With Platinum Resistant Ovarian Cancer Phase 2 Interventional This study has temporarily held recruitment activities to perform a pre-planned interim analysis. Other elements of this study are still ongoing. Anticipated 150
NCT04386668 Terminated Let It Out (LIO) and COVID19: Testing an Online Emotional Disclosure-based Intervention During the COVID19 Pandemic N/A Interventional Interim analysis indicated adaptations to intervention may be required. Actual 80
NCT00152308 Terminated Non-Polymer-Based, Rapamycin-Eluting Stents to Prevent Restenosis Phase 4 Interventional Slow enrolement Anticipated 333
NCT01289340 Withdrawn Wound Healing and Pain Management in Partial Thickness Burns Observational Actual 0
NCT01742273 Terminated Vitamin K1 to Slow Progression of Vascular Calcification in HD Patients Phase 3 Interventional Termination stopped due to low recruitment rates Actual 63
NCT01974726 Terminated Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction N/A Interventional End of funding Actual 95
NCT02204202 Terminated PET Assessment of Acute Lung Transplant Rejection Observational PI left institution Actual 28
NCT02402803 Terminated Dried Blood Spot- Statin Pilot Study Observational No recruitment Actual 20
NCT03012737 Terminated Palliation of Dyspnea With Mouth Piece Ventilation N/A Interventional Difficulty in finding suitable patients. Actual 22
NCT03025425 Terminated Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD N/A Interventional Difficulty in finding suitable patients Actual 20
NCT03383146 Terminated A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 451
NCT03420781 Terminated A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 03 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 467
NCT03441334 Terminated rTMS Combined With BWSTT in Stroke With Body Weight Supported Treadmill Training (BWSTT) After Stroke N/A Interventional The enrollment was not achieved within proposed timeframe. Actual 1
NCT03499587 Terminated Effects of Maternal Obesity on Offspring Brain Development Observational study population limited Actual 13
NCT03511716 Terminated Observational Study of the Heart Repair Technologies Mitral Bridge in Treating Mitral Valve Regurgitation Observational Could not enroll enough patients and ran out of $$ to manufacture more devices Actual 34
NCT03518996 Withdrawn Non-Invasive Brain Stimulation and Delirium N/A Interventional EEG data collection instrument unavailable Actual 0
NCT03529916 Suspended Endothelial Cell Gene Networks of CVD Observational No eligible participants were recruited Anticipated 20
NCT03575494 Withdrawn Relationship Between Oral Health Status and Unexplained Female Infertility in Turkish Population Observational this study does not need to get a clinicaltrials number Actual 0
NCT03630081 Withdrawn Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Phase 3 Interventional Change in business strategy Actual 0
NCT02220855 Suspended A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas Phase 2 Interventional Not stated by Pharmaceutical Company Actual 14
NCT03802422 Withdrawn Vitamin B12 for Carpal Tunnel Syndrome N/A Interventional It is hard to enroll patients due to Covid-19 pandemic. Actual 0
NCT03883607 Terminated Elafibranor, PK and Safety in Children and Adolescents 8 to 17 Years of Age With Non Alcoholic Steatohepatitis (NASH) Phase 2 Interventional Continuation of the trial cannot serve a scientific purpose, no safety concerns identified Actual 10
NCT03963492 Suspended Intermittent vs Continuous Walking in People With Multiple Sclerosis N/A Interventional COVID-19 Pandemic Anticipated 24
NCT04060693 Withdrawn Device Accuracy of Non-invasive Glucose Measurements in Ethnic Skin N/A Interventional Miscommunication with the CRO that was hired to help with the regulatory submission process Actual 0
NCT04076345 Terminated Interest of the Presepsin Assay as a Biomarker of Bacterial Infection, in the Management of Newborns and Infants Under 3 Months of Age Admitted for Fever in Pediatric Emergency Service (Presepsin) Observational investigator not available Actual 31
NCT04111861 Suspended Singing for Chronic Pain, a New Intervention for the Management of Chronic Pain N/A Interventional COVID-19 - unable to bring patients for intervention due to C-19 restrictions at present Anticipated 24
NCT04146779 Terminated Yoga Intervention in Head and Neck Cancer Patients Undergoing Concurrent Chemo-Radiation N/A Interventional COVID-19 Actual 19
NCT04258020 Suspended Postextubation Management in Patients at Risk for Extubation Failure N/A Interventional Study is on hold due to significant impact of COVID pandemic Actual 3
NCT04304365 Withdrawn Home Follow-up After Medication Abortion N/A Interventional Unable to implement the study due to delays from COVID-19 policies which postponed the start. Actual 0
NCT00515528 Terminated Vaccination Plus Ontak in Patients With Metastatic Melanoma Phase 2 Interventional The immune monitoring data failed to demonstrate an improvement in any biologic endpoint with denileukin diftitox. Actual 17
NCT03452267 Withdrawn Insulin Signaling in Skeletal Muscle Phase 2/Phase 3 Interventional Lack of funding Actual 0
NCT03758352 Withdrawn The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient N/A Interventional Large sample size Actual 0
NCT04000191 Withdrawn Ice as an Adjunct for Local Anesthesia During Anorectal Surgeries N/A Interventional Study was neer started and PI left the institution. Actual 0
NCT04015219 Terminated Management of Signs and Symptoms Associated With Dry Eye Disease N/A Interventional enrollment constraints Actual 3
NCT04081584 Suspended Trans-abdominal Fetal Pulse Oximetry: Tissue Light Scattering Observational COVID-19 Anticipated 30
NCT04081623 Suspended Trans-abdominal Fetal Pulse Oximetry: Signal Integrity Observational COVID-19 Anticipated 50
NCT04254172 Terminated A Low Interventional Study to Monitor Activity Using Wearable Sensors in Duchenne Muscular Dystrophy Observational This low-interventional study (involving no study drug) has been terminated early due to the COVID-19 pandemic, and not for any safety or efficacy reasons. Actual 2
NCT04342156 Withdrawn Safety And Efficacy Of Hydroxychloroquine For At Risk Population (SHARP) Against COVID-19 Phase 3 Interventional The number of patients with COVID-19 in Singapore was coming down for the community and the concerns about the potential side effects particularly when the baseline ECG and serum electrolytes was not proposed. Actual 0
NCT04359277 Terminated A Randomized Trial of Anticoagulation Strategies in COVID-19 Phase 3 Interventional the PROTECT study is being transitioned to ACTIV4 ACUTE anticoagulation inpatient study Actual 77
NCT04447729 Withdrawn A Study to Test if Fremanezumab Reduces Pain in Patients With Interstitial Cystitis-Bladder Pain Syndrome Phase 2 Interventional Withdrawn due to logistic reasons Actual 0
NCT01673386 Terminated A Subject Treatment Preference Study of Tivozanib Versus Sunitinib in Subjects With Metastatic RCC Phase 2 Interventional Sponsor Actual 58
NCT03161470 Terminated Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) N/A Interventional Physicians/audiologists preferred to manage patients with BPPV immediately rather than enrolling in study except for difficult to treat cases. Actual 13
NCT03725358 Withdrawn A Cluster-RCT to Increase the Uptake of LARCs Among Adolescent Females and Young Women in Cameroon. N/A Interventional Problems with the Performance-Based Financing System in Cameroon, combined with the restrictions on movement brought on by the Covid-19 pandemic. Actual 0
NCT04067362 Terminated Chicory Fiber Effect on Satiety and GI Tolerance N/A Interventional COVID-19 Actual 30
NCT04113135 Withdrawn The Utilization of Yoga as a Therapeutic Tool to Promote Physical Activity Behavior Change and Improved Postural Control in Individuals With Multiple Sclerosis N/A Interventional Unable to complete initial data collection due to tornado and then COVID-19 has limited in person data collection/intervention. Actual 0
NCT02433067 Terminated Physical Activity Intervention on Myocardial Function in Patients With HER2 + Breast Cancer N/A Interventional Actual 89
NCT04583397 Suspended Effects of WiFi Exposure on Sleep in Women N/A Interventional Corona Anticipated 34
NCT01811693 Terminated Field Administration of Stroke Therapy-Blood Pressure Lowering Phase 2 Interventional The funding period for the study has ended. Actual 4
NCT00001978 Terminated Determination of Kidney Function Observational All analysis with identifiable specimens/data is complete or site has no identifiers linked to the specimens/data Actual 456
NCT00896610 Terminated Natural History of Autoimmune Diabetes and Its Complications Observational All analysis with identifiable specimens/data is complete or site has no identifiers linked to the specimens/data Actual 356
NCT01907594 Withdrawn Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers Phase 2 Interventional Ran out of funding Actual 0
NCT02232477 Terminated Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in MPS I N/A Interventional Termination of study by investigator related to COVID pandemic. Actual 6
NCT02431663 Terminated Ketamine in Refractory Convulsive Status Epilepticus Phase 3 Interventional Futility Actual 57
NCT02558205 Withdrawn Correlation Between CT Perfusion and Post Y-90 TARE PET/CT Dosimetry Observational unable to rectuir Actual 0
NCT04265690 Withdrawn A Multi-Component Nutrition Program for Pregnant and Parenting Teens N/A Interventional The study never launched due to several COVID-19 related barriers. Actual 0
NCT03101592 Terminated INTERVAL: Varying Intervals of ART to Improve Outcomes in HIV N/A Interventional Enrollment completed. Outcomes measured after only 1 yr due to loss of funding. Actual 9118
NCT02463669 Terminated The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department Observational COVID pandemic Actual 200
NCT02822963 Withdrawn Impact of Anticoagulants and Antiplatelets in Patients on Transurethral Resection of the Prostate Observational No funding Actual 0
NCT03107325 Withdrawn Biokinetics Study for F-18 FDG in Pediatric Molecular Imaging Phase 4 Interventional No subjects who met the study criteria agreed to participate in two years prior to the COVID-19 crisis. Actual 0
NCT02387164 Terminated Prevention Trial: Immune-tolerance With Alum-GAD (Diamyd) and Vitamin D3 to Children With Multiple Islet Autoantibodies Phase 2 Interventional The study was interrupted early and terminated when only 26 out of 80 patients were enrolled due to new clinical study results indicating that the current study would not be informative. Actual 26
NCT00017069 Terminated Arsenic Trioxide and Dexamethasone in Treating Patients With Recurrent or Refractory Stage II or Stage III Multiple Myeloma Phase 2 Interventional 0
NCT00020969 Terminated Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes Phase 2 Interventional 0
NCT00054184 Terminated Polyglutamate Paclitaxel Compared With Docetaxel in Treating Patients With Progressive Non-Small Cell Lung Cancer Phase 3 Interventional Anticipated 350
NCT00054197 Terminated Polyglutamate Paclitaxel Compared With Gemcitabine or Vinorelbine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer Phase 3 Interventional 0
NCT00054210 Terminated Polyglutamate Paclitaxel Plus Carboplatin Compared With Paclitaxel Plus Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer Phase 3 Interventional 0
NCT00551733 Terminated Carboplatin With Either Paclitaxel Poliglumex or Paclitaxel in Treating Women With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer Phase 3 Interventional Anticipated 450
NCT00576225 Terminated CT-2103/Carboplatin vs Paclitaxel/Carboplatin for NSCLC in Women With Estradiol > 25 pg/mL Phase 3 Interventional Actual 43
NCT03745352 Suspended Pevonedistat With Azacitidine Versus Azacitidine Alone in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Phase 2 Interventional Other - Pending amendment to change study design Anticipated 72
NCT04575558 Withdrawn HOPE: A Trial of Hydroxichloroquine Plus Azithromycin in High Risk COVID-19 Phase 2 Interventional Withdrawn due to lack of study centers interested in participating. Actual 0
NCT00017433 Terminated Arsenic Trioxide in Treating Patients With Multiple Myeloma Phase 2 Interventional 0
NCT01849081 Withdrawn Evaluating the Efficacy of CPAP Therapy for the Treatment of Fatty Liver N/A Interventional Change in priorities, study closed prior to enrollment Actual 0
NCT04579796 Suspended The Accuracy of Ultrasound in the Detection of Placenta Site in the First Trimester. N/A Interventional lack of funding Anticipated 25
NCT03004001 Terminated Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome N/A Interventional Difficult recruitment Actual 3
NCT03265951 Terminated Ramelteon for Complex Insomnia in Veterans With PTSD Phase 4 Interventional Lack of response Actual 1
NCT04057014 Withdrawn Immediate Versus Delayed Treatment of Odontogenic Infections Phase 4 Interventional No funding available for the activity Actual 0
NCT01987596 Terminated Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Phase 3 Interventional Actual 23
NCT04293900 Withdrawn Diet, Physical Activity and Body Composition Changes During R-CHOP Observational Study never started due to COVID pandemic and lack of study funding. Actual 0
NCT04325893 Terminated Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease Phase 3 Interventional decrease in number of eligible patients Actual 259
NCT04349449 Withdrawn ENTYVIO in Bio-naive Patients With Moderate/Severe Crohn's Disease (CD) in Daily Practice Observational Business Decision (no enrollment) Actual 0
NCT04561817 Withdrawn To Evaluate the Safety and Efficacy of Ipatasertib (GDC-0068) in Combination With Paclitaxel in Platinum-resistant Recurrent Epithelial Ovarian Cancer Phase 2 Interventional Evolving data with Ipatasertib that changes the known risk / benefit background in pursuing future studies. Actual 0
NCT01636999 Withdrawn Comparing Sedara to Butorphanol in Early Labor N/A Interventional Actual 0
NCT02095210 Terminated HER2 PET Imaging in Breast Cancer Patients Using [68GA]ABY-025 Phase 1 Interventional slow recruitment Actual 2
NCT02137265 Withdrawn Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism N/A Interventional No funding obtained Actual 0
NCT02557945 Suspended Gabapentin in Patients at Clinical Risk for Psychosis Phase 1/Phase 2 Interventional This study is temporarily suspended due to COVID-19 Anticipated 48
NCT02758288 Withdrawn BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach Observational Actual 0
NCT02933073 Suspended Study of Oncoimmunome for the Treatment of Stage III/IV Ovarian Carcinoma Phase 1 Interventional Study recruitment is temporary on hold by the sponsor due to patient recruitment challenges and the ongoing review of the investigational adjuvant. Anticipated 15
NCT02975986 Withdrawn Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN) N/A Interventional Actual 0
NCT03234465 Terminated Efficacy, Safety and Tolerability of AG013 in Oral Mucositis Compared to Placebo When Administered Three Times Per Day Phase 2 Interventional No efficacy could be demonstrated, sponsor decided to prematurely end the study. Actual 200
NCT03286075 Terminated Impact of tDCS on Emotional Processing in Healthy Subjects. N/A Interventional The department in charge of this research is no longer able to follow this project. Only two inclusions this study is close Actual 2
NCT03656835 Suspended Nanochip Technology in Monitoring Treatment Response and Detecting Relapse in Participants With Diffuse Large B-Cell Lymphoma N/A Interventional Internal review to increase accruals Anticipated 40
NCT03744663 Suspended Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films Phase 2 Interventional Study team not ready to start enrolling and unsure of when this may happen. Anticipated 30
NCT03806023 Terminated EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals N/A Interventional Funding expired due to grant for new project (NCT03851302) Actual 8
NCT04113291 Withdrawn Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure N/A Interventional Insufficient funding Actual 0
NCT04206865 Withdrawn Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output Phase 4 Interventional New study initiated Actual 0
NCT04401631 Withdrawn Analytical Validation of the abioSCOPE Device With an IgE Test Panel: Point-of-Care Precision, Sample Type Comparison and Method Correlation Observational Sponsor financial has been stopped Actual 0
NCT04442932 Withdrawn abioSCOPE IgE Assay to Aid in the Diagnosis of Allergies Observational Sponsor financial has been stopped. Actual 0
NCT03219866 Terminated Nebulizer Versus Dry Powdered Inhalers for COPD Phase 4 Interventional Lower enrollment than Sponsor expected - Sponsor stopped study Actual 40
NCT03285308 Terminated A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis 01 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision. Actual 336
NCT03369184 Terminated Elective Percutaneous Coronary Intervention With or Without Supplemental OXYgen Phase 3 Interventional Slow recruitment Actual 65
NCT03421678 Withdrawn Ethnic/Racial Differences in Metabolism and DNA Adduct Formation Observational Study was completed at other sites Actual 0
NCT03426345 Terminated Study to Evaluate the Safety and Efficacy of Relamorelin in Patients With Diabetic Gastroparesis Study 02 Phase 3 Interventional The Relamorelin program is being terminated solely based on a business decision Actual 311
NCT03741803 Suspended Relationship Between Delayed Cord Clamping at Birth and Neonatal Bilirubin Levels in Parturients With a Prior Child Requiring Therapy for Neonatal Jaundice N/A Interventional Study paused due to COVID-19 Anticipated 100
NCT03801889 Withdrawn SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare Anemias Phase 2 Interventional Protocol suspended prior to patient enrollment Actual 0
NCT03984604 Terminated Investigation of the Efficacy and Safety of CHI-921 in Insomnia. Phase 2 Interventional COVID-19 Actual 21
NCT04048746 Terminated Evaluation of the Written Information Delivered by the General Practitioner of the Patients Presenting to the Emergency Room for an Aggravation of Asthma Observational The PI decided to stop. Actual 10
NCT04171648 Terminated Effect of Dry Roasted Peanuts and Boiled Peanuts on Glycemic Control N/A Interventional Covid-19 Pandemic halted my study due to exposure risks. Actual 24
NCT04201743 Withdrawn An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2mL Injection) in the Treatment of Osteoarthritis of the Knee Phase 4 Interventional Resources limited secondary to COVID-19 pandemic. Actual 0
NCT04379375 Terminated Nudges to Improve Health Behaviors That Limit COVID-19 Spread N/A Interventional Slow enrollment rate Actual 45
NCT02715765 Terminated The Use of Transcranial Electrical Stimulation for Hallucinations N/A Interventional PI left university, the grant could not be transferred, no data was collected Actual 3
NCT02416193 Terminated Can Vitamin D3 Improve Cognitive Function in Individuals With Type 2 Diabetes? (THINK-D) Phase 2 Interventional the study was halted prematurely due to slow recruitment and expiration of funding Actual 56
NCT01052896 Withdrawn Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition Phase 3 Interventional Unable to recruit subjects - unworkable Actual 0
NCT00969956 Suspended Time To Complications Occurs in Diabetes Observational Local regulations Anticipated 950
NCT00991315 Terminated Collecting and Storing Blood and Tumor Tissue Samples From Patients Undergoing Prostatectomy or Transurethral Resection of the Prostate Observational Specimens are now collected through the BRS protocol. Actual 126
NCT03189030 Terminated Study of Personalized Immunotherapy in Adults With Metastatic Colorectal Cancer Phase 1 Interventional Study terminated due to business realignment Actual 28
NCT03333694 Terminated Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis) Phase 1 Interventional The study fully enrolled and completed after last patient completed the study Actual 40
NCT03428763 Withdrawn ELECTOR Treat-to-target Via Home-based Disease Activity Monitoring of Patients With Rheumatoid Arthritis N/A Interventional Technical problems with POC Actual 0
NCT04230291 Terminated Hidradenitis Suppurativa Written Action Plan N/A Interventional Principal investigator is not longer at this institution Actual 8
NCT02240706 Terminated Phase I/II Trial to Investigate BI 836858 in Myelodysplastic Syndromes Phase 2 Interventional Actual 25
NCT02505087 Terminated Pharmacological Treatment of a Rare Genetic Disease: N-acetylcysteine in Myopathy Associated Selenoprotein N-related Myopathy (SEPN1-RM) Phase 2/Phase 3 Interventional Actual 7
NCT04574427 Suspended INtra-operative Evaluation of a Novel FLUorescENt C-mEt Tracer in Penile and Tongue Observational Tracer not available. Anticipated 20
NCT01803334 Terminated Impact of Marking Surgical Incision on Patient's Abdomen N/A Interventional Not enough participants could be enrolled and so the PI decided to close the study. No participants completed the study Actual 4
NCT02476955 Terminated Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole Phase 1 Interventional Actual 41
NCT02808806 Terminated A Reduction in Time With Electronic Monitoring In Stroke N/A Interventional technical difficulties Actual 80
NCT03277612 Terminated Effects of C-section Delivery on Infant Brain Development Observational Study halted prematurely and will not resume; participants are no longer being examined Actual 9
NCT03699904 Terminated Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial Phase 2 Interventional In light of the evolving Covid19 pandemic ongoing study recruitment was felt to pose an unacceptable risk to patient safety. Actual 85
NCT03838835 Terminated Equine Facilitated CBT Group Therapy for Youth Anxiety N/A Interventional COVID-19 Actual 59
NCT03981250 Suspended Effect of One Minute of Resistance Exercise Per Day on Muscular Strength (The ONE Study) N/A Interventional Covid-19 Anticipated 56
NCT04085393 Withdrawn Granisetron Extended Release Injection (GERSC) for the Prevention of Chemotherapy-induced Nausea and Vomiting Phase 2 Interventional sponsor withdrew study Actual 0
NCT04118374 Suspended A Pilot Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes N/A Interventional research-related activities have been impacted by the COVID-19 outbreak (participant recruitment/enrollment/on-site subject visits) Anticipated 10
NCT04379492 Withdrawn A Study of Hydroxycholoroquine Compared to Placebo as Treatment for People With COVID-19 Phase 2 Interventional Emerging evidence does not support the use of HCQ for treatment or prevention of SARS -CoV2 infection. No pts have been enrolled. Actual 0
NCT00843531 Terminated RAD001 and Erlotinib in Patients With Neuroendocrine Tumors Phase 2 Interventional Low Accrual Actual 17
NCT04019067 Withdrawn Magnetically Controlled Capsule Endoscopy First vs. Standard Algorithm in Patients With Melena N/A Interventional few patients met all the inclusion criteria Actual 0
NCT00213720 Terminated Treatment of Subclinical Hyperthyroidism Observational recruitment difficulties Actual 145
NCT01675154 Terminated Phase 2 Study of Orlistat and SLx-4090 for the Treatment of Type 1 Hyperlipoproteinemia Phase 2 Interventional Due to unavailability of the drug. Actual 5
NCT02283905 Terminated Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Phase 4 Interventional Poor enrollment numbers of patients Actual 2
NCT02764164 Terminated Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS) N/A Interventional Lack of funding Actual 1
NCT03843476 Withdrawn Personalized Spine Study Group Registry Observational [Patient Registry] Requested by surgeons to pursue new study Actual 0
NCT03953625 Suspended Interest of the Return to Primary Care of the "Low Back Pain Booklet" of Health Insurance in the Recovery of Common Acute Low Back Pain N/A Interventional The PI decided. Anticipated 100
NCT04130282 Terminated VAC077: Safety and Immunogenicity of the Pfs25-IMX313/Matrix-M Vaccine Phase 1 Interventional Delays caused by Covid-19 Actual 1
NCT04348890 Withdrawn Proof of Concept Trial of Vamorolone in Pediatric Ulcerative Colitis Phase 1/Phase 2 Interventional Programmatic decision Actual 0
NCT04365582 Suspended OUTpatient Treatment of COVID-19 in Patients With Risk Factor for Poor Outcome Phase 3 Interventional The PI decided. Anticipated 640
NCT04480879 Suspended Evaluation of AZD8154 Concentrations in Blood Phase 1 Interventional Need for evaluation of emerging pre-clinical toxicology findings Anticipated 15
NCT04571814 Suspended Targeting the ERN Computerized Intervention Targeting the Error-related Negativity in Young Children N/A Interventional COVID-19 Anticipated 175
NCT01831596 Terminated Evaluation of a Novel Post-Surgical Dressing N/A Interventional The study was terminated by Spiracur. Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 59
NCT03839277 Suspended Adenoma Detection Rate Using Endocuff Vision in China N/A Interventional One investigator is out-of-service due to carrying out another task. Anticipated 1200
NCT03888534 Withdrawn Intravenous Ixazomib in Pediatric Participants With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy) Phase 1 Interventional Business decision (no safety or efficacy concerns) Actual 0
NCT04042623 Terminated Study of Safety and Efficacy of AVB-S6-500 in Patients With IgA Nephropathy Phase 2 Interventional Business reasons Actual 1
NCT04233359 Terminated A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer. N/A Interventional To few patients recruited to allow for study completion within ph.d. project. Actual 4
NCT04275128 Terminated Cooled Versus Conventional Genicular Radiofrequency Ablation for Chronic Knee Pain Observational Insurance companies no longer cover this procedure Actual 1
NCT04358081 Terminated Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease Phase 3 Interventional low enrollment Actual 20
NCT04537143 Withdrawn Image Biomarkers for Progression of AMD Observational Funding for staff no longer available Actual 0
NCT04569214 Withdrawn The Efficacy and Safety of PAZ320 on PPG and Insulin Blood Levels in Type II Diabetic Patients Phase 2 Interventional Actual 0
NCT03925428 Withdrawn Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas Phase 1 Interventional Other - Protocol moved to Disapproved Actual 0
NCT04116359 Withdrawn Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma Phase 1/Phase 2 Interventional Other - Protocol moved to Disapproved Actual 0
NCT01930175 Terminated Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Phase 2 Interventional The study recruitment was terminated in Dec-2015 for strategic reasons related to the development of the compound. Actual 13
NCT02300961 Suspended Feasibility Neurocognitive Outcome After Transplant N/A Interventional Covid-19 Anticipated 35
NCT02563015 Terminated Can Correction of Low Vitamin D Status in Infancy Program for a Leaner Body Composition? N/A Interventional Covid19 pandemic prevented continuation of study visits Actual 132
NCT02858466 Terminated Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity N/A Interventional failure to recruit Actual 68
NCT02858479 Terminated Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic N/A Interventional failure to recruit Actual 41
NCT03151772 Terminated Bioavailability of Disulfiram and Metformin in Glioblastomas Early Phase 1 Interventional Problems with including patients Actual 3
NCT03435042 Suspended A Hypnosis-based Group Intervention to Improve Quality of Life in Children With Cancer and Their Parents. N/A Interventional Recruitment and organisational difficulties Anticipated 30
NCT00536939 Terminated Trial of Paclitaxel, Bevacizumab, and Enzastaurin Versus Paclitaxel, Bevacizumab and Placebo for Breast Cancer Phase 2 Interventional Study has been terminated due to slow enrollment Actual 2
NCT04563728 Suspended Use Surveillance Technology to Reduce Elder Abuse Recidivism N/A Interventional Covid-19 Anticipated 10
NCT03292835 Suspended Complex Cutaneous Leishmaniasis Healing Study in Algeria Observational [Patient Registry] Political Issues in Algeria and now Covod-19 lock-down Anticipated 100
NCT03391856 Terminated Prolonged Isolated Thrombocytopenia After Allo-SCT : N-acetyl-L-cysteine (NAC) Versus Supportive Therapy Phase 2/Phase 3 Interventional protocol changed Actual 15
NCT03698747 Terminated Myelin Imaging in Concussed High School Football Players Observational PI left organization Actual 13
NCT04153071 Withdrawn Unipolar Microplasma Radiofrequency Device: In-vivo Histologic Study N/A Interventional Per Investigator and sponsor decision Actual 0
NCT04236037 Terminated Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura N/A Interventional It is unrealistic to succeed with sufficient inclusion within the timeframe of the study, why it is terminated. Actual 5
NCT02331095 Terminated Statin Use in Patients With Acute VTE Early Phase 1 Interventional Low recruitment Actual 21
NCT04343690 Withdrawn COPING With COVID-19( CWC-19) N/A Interventional Study Ended May 1, 2020 with no enrollment Actual 0
NCT03409341 Withdrawn Personalizing Immune Checkpoint Inhibitor Therapy Observational No enrollment Actual 0
NCT03673566 Withdrawn Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - CHMCO N/A Interventional Business pivot caused termination of study before enrollment. Actual 0
NCT03673579 Withdrawn Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - MHSB N/A Interventional Business pivot caused termination of study before enrollment. Actual 0
NCT03791541 Withdrawn A Study Evaluating the Use of Potential Predictors of Readmission in Hospitalized Medicine Patients N/A Interventional Pilot study results not meaningful. Students researchers graduated. Actual 0
NCT04039568 Suspended Meditation Versus Education for Improving Depression in Chronic Pain, a Randomized Controlled Trial N/A Interventional COVID-19 Pandemic. Update in-process. Anticipated 160
NCT04202471 Withdrawn Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries N/A Interventional COVID-19 pandemic Actual 0
NCT03486002 Terminated EFFEXTS OF THE CLEANSWEEP SUCTION CATHETER N/A Interventional Access to the devices was halted by the sponsor Actual 8
NCT03626623 Terminated Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care N/A Interventional Sponsor Discretion Actual 15
NCT03712930 Terminated Treatment of Metastatic Castration-Resistant Prostate Cancer With Homologous Recombination Deficiency Phase 2 Interventional Sponsor's decision to revisit the development approach for prostate cancer. Actual 13
NCT03793712 Terminated Study With Lu AF11167 for the Treatment of Negative Symptoms in Patients With Schizophrenia Phase 2 Interventional Lack of efficacy based on interim analysis Actual 168
NCT03929497 Terminated Flexible-dose Long-term Extension Study of Lu AF11167 in Patients With Schizophrenia With Prominent Negative Symptoms Phase 2 Interventional Lack of efficacy based on the interim analysis in the 17972A study Actual 96
NCT03932656 Suspended Latent Toxoplasmosis in Females With Borderline Personality Disorder Observational Funding issues Anticipated 100
NCT04018508 Suspended Massage Therapy for Self-efficacy in LVAD Recipients N/A Interventional COVID19 pandemic closed in-person clinics temporarily Anticipated 74
NCT04293978 Suspended Virtual Reality Relaxation for Addiction Inpatients N/A Interventional Recruitment and intervention provision paused due to COVID-19 situation. Planned to resume. Anticipated 40
NCT02285179 Suspended Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside Tamoxifen Phase 1/Phase 2 Interventional Inclusion stopped due to COVID-19 Anticipated 290
NCT03689985 Terminated Functionality and Accuracy of the smART System in Real-Life ICU Settings N/A Interventional Due to the company's intent to conduct a new study under a different protocol with the smART+ System which is a more advanced version of the smART System Actual 2
NCT04044950 Withdrawn A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer Phase 2 Interventional The study was closed due to investigator discretion based on the lack of ability to recruit patients and research goals of the program. Actual 0
NCT04428918 Withdrawn Biospecimen Procurement for Immunological Landscape Studies Following Hematopoietic Cell Transplantation Observational The study was closed due to investigator discretion based on the lack of ability to recruit patients and research goals of the program. Actual 0
NCT01663766 Terminated Phase I Study of Milatuzumab for Graft Versus Host Disease Phase 1 Interventional PIs agreed no safety signals were shown, drug did not appear to lessen the risk of preventing GVHD no further patients would be enrolled Actual 12
NCT02161679 Withdrawn Phase II Study of IMMU-132 Alone or in Combination With Carboplatin in Patients With Triple-Negative Breast Cancer Phase 2 Interventional FDA asked to administratively split from IND115621- to open a new IND you need to file a protocol we only drafted it to get the IND open - never initiated Actual 0
NCT02548494 Terminated Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes N/A Interventional Project terminated due to insufficient resources for recruitment. Actual 17
NCT02826655 Terminated Adaptive Optics for Ophthalmic Technologies N/A Interventional lack of funding Actual 4
NCT02267772 Terminated IV Acetaminophen vs IV Morphine for Pain Control in Pregnant Women N/A Interventional Difficulties in recruitment Actual 163
NCT03121079 Withdrawn Interferon-α Prevents Leukemia Relapse of AML Patients After Transplantation N/A Interventional there was almost no patient would enroll in this study. Actual 0
NCT03304184 Suspended The Role of Biodentine in Class V Dental Lesions on Oral Health Related Quality of Life Phase 3 Interventional COVID Anticipated 40
NCT03379558 Terminated Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study Observational (due to change in the post-marketing requirement to assess alirocumab during pregnancy) Actual 37
NCT03362021 Terminated Comparison of Two Different Sedation Protocols During Transvaginal Oocyte Retrieval Observational Primary investigator transferred in another hospital; ongoing pandemic; Actual 80
NCT03171051 Terminated LED Device for Non-Invasive Lipolysis N/A Interventional device development placed on hold Actual 10
NCT03615508 Terminated Exploration of Pupil Dilation in Horner's Patients Taking Flomax Phase 4 Interventional incomplete enrollment Actual 1
NCT03726996 Terminated Desipramine in Infantile Neuroaxonal Dystrophy (INAD). Phase 4 Interventional Funding exhausted Actual 4
NCT03742973 Terminated A Study of Baricitinib (LY3009104) in Participants With Primary Biliary Cholangitis Who do Not Respond or Cannot Take UDCA Phase 2 Interventional Study was terminated due to enrollment futility. Actual 2
NCT03867708 Withdrawn Outcomes of Transcatheter ASD Closure Guided by 3D-TEE Observational No participants found Actual 0
NCT03960242 Suspended Evaluation of Clinical Progression in Patients With Motor Predominant Parkinson Disease. Observational Temporary halt of the trial due to COVID-19 crisis related delays Anticipated 30
NCT01007136 Terminated Transcranial Direct Current Stimulation (tDCS)-Enhanced Stroke Recovery N/A Interventional Funding limit reached due to slower then anticipated recruitment. Actual 62
NCT02301000 Terminated IMT for Primary Clostridium Difficile Infection Phase 2/Phase 3 Interventional Slow recruitment in pilot phase. A follow-up trial is launched (NCT03796650). Actual 21
NCT03021252 Terminated Respiratory Muscle Training in Stroke Swallowing Disorders N/A Interventional Because of the SARS-COV2 pandemic. Recruitment stopped at 48 patients Actual 50
NCT01239160 Terminated Two Pneumatic Compression Devices in the Treatment of Lower Extremity Lymphedema N/A Interventional Futility and underpowering of endpoint data Actual 238
NCT03059407 Suspended Impact of Therapy Dog Presence on Pediatric Echocardiogram N/A Interventional Due to COVID-19, the study has been put on hold. Anticipated 160
NCT03332355 Suspended Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 Phase 1 Interventional Business Reasons Anticipated 9
NCT03721796 Terminated Cancer Treatment Decision-making in the HIV Population: an Observational Study of Physician-patient Interactions Observational study design changed due to COVID-19 Actual 14
NCT03896334 Suspended Effect of Isometric Handgrip Training on Ambulatory Blood Pressure in Patients With Hypertension N/A Interventional The study is suspended because of the COVID-19 pandemic Anticipated 250
NCT04421664 Terminated Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada) Phase 3 Interventional Request of Health Canada after publication of https://doi.org/10.7326/M20-4207 Actual 70
NCT03447730 Terminated Safety, Tolerability and Pharmacodynamics of SYNB1020 Phase 1/Phase 2 Interventional Interim futility analyses identified a lack of SYNB1020 efficacy. Actual 23
NCT00894751 Terminated Two Anesthetic Techniques in Magnetic Resonance Imaging (MRI) Phase 1 Interventional low enrollment and high participant withdraw Actual 98
NCT01658852 Withdrawn Effects and Safety of Metronidazole in Patients With Gastrectomy Phase 3 Interventional Because of difficulties on recruiting participants Actual 0
NCT02920190 Withdrawn Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat Phase 4 Interventional Lack of funds to cover the costs of the study medications Actual 0
NCT04145193 Withdrawn Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC Phase 2 Interventional Study withdrawn prior to enrollment due to changing standard of care landscape. Actual 0
NCT02488278 Withdrawn GLUCOME USABILITY STUDY N/A Interventional Actual 0
NCT03384238 Suspended Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery Phase 1/Phase 2 Interventional Interim Analysis Anticipated 27
NCT03517696 Withdrawn Membrane Sweeping in Early Labor and Delivery Outcomes N/A Interventional Study IRB approval expired Actual 0
NCT03551535 Withdrawn Monitored Home Exercise in Pregnancy N/A Interventional Study IRB approval expired Actual 0
NCT03704285 Suspended Development of pk/pd Model of Propofol in Patients With Severe Burns Observational Outbreak COVID 19 Anticipated 30
NCT03705338 Suspended Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol Observational Outbreak COVID 19 Anticipated 20
NCT03855683 Suspended Stress, Anxiety, and Mood Group Therapy N/A Interventional Social distancing regulations related to COVID19. Anticipated 50
NCT04220476 Withdrawn CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer Phase 2 Interventional Initiating a new study with revised Statistics. Actual 0
NCT02844855 Terminated Memory for Action in Neurological Patients N/A Interventional failure to recruit 83/99 Actual 83
NCT03224975 Terminated Acute Pain Memory Among Former Burned: Exploration of fMRI. N/A Interventional failure to recruit Actual 24
NCT03604991 Suspended Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery Phase 2/Phase 3 Interventional Scheduled Interim Monitoring Anticipated 278
NCT00226746 Withdrawn Efficacy Study of Gemcitabine, Paclitaxel, and Irradiation in the Treatment of Pancreatic Cancer Phase 2 Interventional Actual 0
NCT04558892 Terminated Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome. Phase 2/Phase 3 Interventional The primary objectives were achieved. Actual 65
NCT02033278 Terminated Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure. Phase 2 Interventional Low recruitment rate, bibliographic evidence of lack of efficacy Actual 27
NCT02395237 Withdrawn COMPOUND (INN): HOE490O - GLIMEPIRIDE / METFORMIN HCl (Amaryl® M)0 (Glimepiride/Metformin Hydrochloride Immediate Release Combination Tablet) in Fed Conditions in Healthy Male and/or Female Subjects. Phase 1 Interventional Actual 0
NCT02972281 Terminated Systematic Search for Primary Immunodeficiency in Adults With Infections N/A Interventional deficient inclusions Actual 120
NCT03311568 Terminated Microcirculatory Alterations in Critical Disease: New Ultrasound Technology N/A Interventional Researcher has quit. Question still unanswered. A related study (observational, not to be registered) has started recently. Actual 30
NCT03559517 Terminated Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305) Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 30
NCT03860753 Terminated Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot) Phase 1/Phase 2 Interventional Halted enrollment due to COVID-19 Actual 4
NCT04532554 Withdrawn Growth Hormone in Obese Cases With Covid-19 Phase 4 Interventional No participants enrolled Actual 0
NCT02153684 Suspended Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform Observational Temporarily suspended due to COVID-19 Anticipated 120
NCT02925364 Terminated Functional and Anatomical MRI of the Spinal Cord and Peri-spinal Tissues Observational Slow recruitment Actual 30
NCT02952573 Terminated Testing JNJ-42756493 In Combination With Dexamethasone in Multiple Myeloma That Came Back After a Period of Improvement Phase 2 Interventional Low patient accrual Actual 20
NCT03017287 Terminated Safety and Efficacy of the GlucoMe APP in Patients With Uncontrolled Diabetes Treated With MDI N/A Interventional Actual 40
NCT03018756 Suspended Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea Phase 3 Interventional Temporarily suspended due to COVID-19 Actual 21
NCT03357692 Withdrawn All-on-Four Implants With Ultrasonic N/A Interventional no enough patients have been enrolled Actual 0
NCT03405090 Suspended Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators Phase 4 Interventional Temporarily suspended due to COVID-19 Anticipated 17
NCT03767829 Terminated A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease Phase 1/Phase 2 Interventional The sponsor decided not to proceed with Part B for business reasons. Actual 32
NCT03769961 Terminated Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect Observational Low enrollment Actual 6
NCT03786367 Suspended Dyspnea in Chronic Thromboembolic Pulmonary Hypertension Observational Temporarily suspended due to COVID-19 Anticipated 20
NCT03790774 Terminated Neurofeedback in Alzheimer's Disease N/A Interventional Due to COVID-19 concerns and restrictions in our at-risk population, interactions were halted. Actual 5
NCT03824535 Suspended 18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules Phase 2 Interventional Suspended Due to Covid-19 Anticipated 50
NCT03957096 Terminated A Safety Study of SGN-CD47M in Patients With Solid Tumors Phase 1 Interventional Sponsor decision based on portfolio prioritization Actual 16
NCT04077385 Withdrawn Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity N/A Interventional PI resigned from faculty position and K23 award was terminated early Actual 0
NCT04098016 Suspended Healthy Roots Digital Intervention N/A Interventional Aim 1 enrollment and study activities have been completed. Aim 2 start date is now anticipated for 01/11/2021. Anticipated 50
NCT04239222 Suspended Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot N/A Interventional Study suspended due to COVID 19 Anticipated 24
NCT04558580 Withdrawn Safety Study of Rufinamide Given as an add-on Therapy to Treat Patients With Seizures Phase 3 Interventional Actual 0
NCT02817113 Terminated Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer Phase 1 Interventional Strategy change Actual 4
NCT02923232 Terminated Ocular Adaptation and Visual Performance for Accommodative Contact Lens N/A Interventional Funding organization requested to stop the study Actual 32
NCT03567356 Suspended Treatment of Opioid Use: Medication Adherence Therapy N/A Interventional IRB temporarily suspended study due to COVID-19 Anticipated 50
NCT03858621 Suspended Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl N/A Interventional COVID 19 outbreak Anticipated 100
NCT04008602 Suspended Effectiveness of Quick Icing (QI) Technique on Strenght of Jump. N/A Interventional COVID-19 Anticipated 150
NCT04243031 Withdrawn QuantiFERON Access Clinical Performance Study Protocol Observational Business Decision Actual 0
NCT04306783 Withdrawn In-Home Sensor Monitoring of Older Adults With Cancer N/A Interventional Investigator is leaving the university Actual 0
NCT04360512 Terminated Dose-response of Talus Mobilizations N/A Interventional Suspended due to the covid-19 pandemic. Actual 42
NCT02787902 Suspended Weight Management in Mothers and Adult Daughters N/A Interventional Trial suspended due to COVID-19. Anticipated 168
NCT03212963 Terminated Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05% Phase 4 Interventional Sponsor's Decision Actual 16
NCT03045705 Withdrawn Evaluation of the Effect the Medical Team in the Delivery Room Has on Pain Management During Labor. N/A Interventional Problem with patient recruitment Actual 0
NCT03046654 Terminated Cervical Cerclage Position Throughout the Pregnancy. N/A Interventional Difficulty in patient recruitment Actual 7
NCT03930290 Terminated Physiologic Elasticity Changes During Pregnancy and After Labor. Observational Difficulty in patient recruiting Actual 12
NCT00751101 Terminated Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer Phase 2 Interventional Low Accrual Actual 24
NCT02522273 Withdrawn Evaluation of the 'SensPoint' Lactate Meter in the Estimation of Foetal Scalp Blood and Umbilical Cord Blood Lactate Observational Actual 0
NCT04274452 Withdrawn A Study to Assess the Efficacy and Safety of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP) Phase 3 Interventional The ARGX-113-1908 study will be replaced by a similar design with a subcutaneous formulation (ARGX-113-2004) Actual 0
NCT04548622 Terminated Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Results N/A Interventional Dr. Ralph Hoffman unexpectedly passed away. Actual 15
NCT02648932 Terminated The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients Phase 2 Interventional Poor accrual Actual 9
NCT02822196 Withdrawn Serratus Anterior Muscle Plane Block vsThoracic Paravertebral Block For Unilateral Mastectomies Phase 4 Interventional Critical study personnel left the institution Actual 0
NCT02936206 Terminated Examination of Breast Cancer Cells of Pre-menopausal and Post-menopausal Women Before and After Exposure to Tamoxifen or Fulvestrant. Phase 1 Interventional low accrual rate Actual 4
NCT03348826 Withdrawn Study of Sodium Bicarbonate in Restoring Blocked Catheters Phase 2 Interventional No participants were enrolled Actual 0
NCT03566823 Terminated Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 306) Phase 3 Interventional Sponsor decision to discontinue the SHP647 (ontamalimab) clinical trial development program for inflammatory bowel diseases (IBD) early. Actual 34
NCT04098887 Withdrawn Lattice Stereotactic Body Radiation Therapy (Lattice SBRT) for Localized Unresectable or Metastatic Conventional Type Chondrosarcoma N/A Interventional Investigator decided to not go forward with the study. Actual 0
NCT04256655 Withdrawn Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of CDX 6114 in PKU Patients Phase 1 Interventional study product composition to move from liquid to solid Actual 0
NCT04401527 Withdrawn Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite Phase 2 Interventional No recruitment Actual 0
NCT03760250 Suspended Imiquimod for Preventing Keloid Recurrence Phase 2 Interventional Investigator decision Actual 5
NCT01495247 Terminated Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer Phase 1/Phase 2 Interventional Study did not meet Phase Ib primary objective to establish the maximum tolerated dose/recommended dose for Phase II Actual 18
NCT02027012 Terminated Treatment of Resistant Hypertension by Renal Denervation in China N/A Interventional company strategic change Actual 1
NCT02252094 Terminated Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS N/A Interventional Device no longer available in Singapore Actual 8
NCT03179605 Terminated Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Phase 2 Interventional Difficulty in enrollment Actual 22
NCT03192995 Terminated Treatment With Lorcaserin for Cocaine Use: The TLC Study Phase 2 Interventional FDA alert regarding study drug safety Actual 22
NCT03328741 Suspended Evaluation of a Web-based Platform for Osteoarthritis Treatment N/A Interventional COVID-19 Anticipated 270
NCT03438760 Terminated Improving STEM Outcomes for Young Children With Language Learning Disabilities N/A Interventional with 2/3 of the data collected, we had to terminate the study because of COVID19. Actual 36
NCT03537716 Withdrawn Fat Reduction Induced by Magnetic Device - Ultrasonographic Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03545633 Withdrawn Changes in Abdominal Tissues Induced by Magnetic Device - MRI Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03545646 Withdrawn Changes in Abdominal Tissues Induced by Magnetic Device - CT Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03547934 Withdrawn Fat Reduction Induced by Magnetic Device - Waist Circumference Evaluation N/A Interventional It wasn't possible to recruit the desired number of patients. Actual 0
NCT03728855 Terminated Effects of Self-administration of Medication During Hospitalization on Medication Safety, Adherence, and Patient Satisfaction in Dutch Hospitals N/A Interventional Difficult recruitment, despite several interventions. Actual 193
NCT04008459 Terminated Walking and Balance Related to Sagittal Spinal Posture Alignment Observational Recruitment no longer viable as spinal classes were stopped due to the COVID-19 situation. Actual 41
NCT04044326 Withdrawn The Safety and Efficacy of Spherical Microwave Ablation for the Treatment of Malignant Liver Tumors N/A Interventional Machine cannot provide Actual 0
NCT04062383 Suspended Positive Emotions After Acute Coronary Events at Northwestern University N/A Interventional In-person recruitment suspended due to COVID Anticipated 10
NCT04361916 Terminated Home Care for Patients With COVID-19: Active Monitoring in Two Italian Health Units (Casale Monferrato and Torino) N/A Interventional interrupted early due to the drastic reduction in the number of cases Actual 37
NCT04394286 Suspended A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects Phase 1/Phase 2 Interventional Reevaluation of development strategy Anticipated 21
NCT04402580 Terminated Efficacy of Anti-CD20 Antibodies (Rituximab Biosimilar) in the Treatment of Childhood Steroid-dependent Nephrotic Syndrome Phase 2 Interventional due to unexpectedly high rate of relapse in the active comparator arm. Actual 30
NCT04440488 Withdrawn ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study Phase 4 Interventional Reevaluation of development strategy Actual 0
NCT02253992 Terminated An Investigational Immuno-therapy Study to Determine the Safety of Urelumab Given in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkin's Lymphoma Phase 1/Phase 2 Interventional Actual 232
NCT03342326 Terminated Lexical Priming by Music in Alzheimer's Disease and Healthy Aging N/A Interventional failure to recruit Actual 58
NCT03399227 Withdrawn Liver Transplantation: Skeletal Effects Observational no funding Actual 0
NCT03560232 Terminated Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Phase 4 Interventional Unable to recruit patients in a timely fashion and unable to recruit sufficient patients Actual 17
NCT03624777 Suspended Efficacy of the Stroll Safe Outdoor Fall Prevention Program N/A Interventional Currently on hold due to COVID-19 restrictions in community program sites Anticipated 105
NCT03730064 Suspended Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression Early Phase 1 Interventional Due to COVID-19 pandemic Anticipated 3
NCT03808935 Terminated Cannabis Extract in Refractory Epilepsy Study Phase 3 Interventional Participants are no longer being examined or receiving intervention. Actual 17
NCT03811951 Terminated Neuro Biomarkers of Smoking Behavior Phase 2 Interventional Different study initiation Actual 4
NCT03908203 Withdrawn Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction N/A Interventional The Study will be conducted in another research center. The Sponsor has changed. Actual 0
NCT03919214 Suspended Hypertension Management in Cancer Patients N/A Interventional Suspended due to Covid-19 Anticipated 40
NCT03959852 Terminated Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain Phase 4 Interventional Residency completed. Actual 6
NCT04054687 Suspended Intranasal TXA for Anterior Epistaxis in the Emergency Department Phase 2 Interventional Due to coronavirus pandemic Anticipated 86
NCT04137809 Withdrawn TREAT Foot Drop After Stroke With Ankle Robot N/A Interventional Study withdrawn due to logistical and safety concerns relating to Covid-19. Actual 0
NCT04141917 Suspended Test-and-treat for Influenza in Homeless Shelters Phase 4 Interventional Enrollments on hold until fall flu season. Anticipated 3200
NCT04269317 Suspended Clinical Study to Evaluate the Safety and Effectiveness of the Treatment With Tixel C on Acne Scars N/A Interventional Corona Virus delayed opening Anticipated 44
NCT04408846 Withdrawn Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis N/A Interventional The Study will be conducted in another research center. The Sponsor has changed. Actual 0
NCT02664077 Terminated A Study Evaluating Regorafenib Following Completion of Standard Chemotherapy for Patients With Colon Cancer Phase 3 Interventional Due to the significantly lower than expected accrual it was impossible to evaluate the endpoint in a timely fashion. Actual 34
NCT04091594 Suspended Investigating the Effects of Sensory Input Orthotics in Disorders of Posture and Movement N/A Interventional PI seeking alternative funding for the study Anticipated 50
NCT02353780 Terminated Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept Phase 4 Interventional Low enrollment Actual 10
NCT01030471 Withdrawn Supporting Treatment Adherence Needs in Diabetes N/A Interventional Actual 0
NCT01703338 Terminated Clinical and Biomechanics Research in Core Muscles After Lumbar Fusion Surgery Observational Actual 100
NCT02499627 Terminated Bendamustine Plus Brentuximab Vedotin in HL and CD30+ PTCL in First Salvage Setting Phase 2 Interventional expected accrual not reached Actual 43
NCT02932319 Terminated Outpatient Foley Catheter for Induction of Labor in Nulliparous for Prolonged Pregnancy N/A Interventional Deficient Inclusions Actual 43
NCT02949661 Withdrawn Local Wound Infiltration for Tracheal Reconstruction N/A Interventional Loss of interest in the subject Actual 0
NCT03718455 Terminated Evaluation of Magseed as Localization Device for Biopsy Proven Metastatic Axillary Lymph Nodes N/A Interventional Limited operating room availability Actual 1
NCT01948297 Terminated Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations Phase 1 Interventional Actual 77
NCT02336373 Terminated Treatment of Hemoglobin SC Disease With Hydroxyurea Phase 2 Interventional low enrollment Actual 32
NCT04204109 Terminated Interprofessional Versus Monoprofessional Case-based Learning in Childhood Cancer N/A Interventional Covid 19 and subsequent cancellation of all meeting activity Actual 49
NCT00592306 Withdrawn Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation Phase 3 Interventional lack of enrollment Actual 0
NCT02113280 Withdrawn DEMAND - DEgenerative Meniscal Tears - Arthroscopy vs. Dedicated Exercise N/A Interventional Failed funding application. Actual 0
NCT03306693 Terminated Educational Intervention to Increase the Emotional Competence of Patients With Oesogastric and Bronchopulmonary Cancers N/A Interventional insufficient inclusions Actual 23
NCT03580798 Terminated Ridge Preservation Comparing Simultaneous vs. Delayed Grafting N/A Interventional Not enough patients available Actual 7
NCT03607708 Suspended Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety N/A Interventional COVID-19 Anticipated 30
NCT03612167 Suspended Constructing A Model of Health Promotion and Active Aging for Community-Dwelling Older Adults N/A Interventional no funding Anticipated 150
NCT03721315 Terminated Health Literacy Activation RCT Among the COPD Patients and Designated Support Dyad N/A Interventional SARS-CoV2 pandemic Actual 6
NCT03778606 Suspended Oligosaccharide for Cdiff(+) Heme-onc Patients N/A Interventional Temporarily paused due to COVID-19 and expected to resume. Anticipated 12
NCT03950648 Withdrawn Spatial Cognitive Training for Chronic Vestibular Disorders N/A Interventional COVID-19 Actual 0
NCT03956251 Suspended Ridge Preservation With Putty Allografts N/A Interventional COVID Anticipated 30
NCT03979066 Terminated Study Evaluating NEOadjuvant Immunotherapy in Resectable PANCreatic Ductal Adenocarcinoma Phase 2 Interventional Loss of funding Actual 1
NCT03988842 Suspended Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism Phase 4 Interventional COVID-19 pandemic Actual 4
NCT04155268 Withdrawn Flotation-REST for Chronic Pain, Stress, and Sleep N/A Interventional Unable to conduct the study due to Covid-19. Actual 0
NCT04162964 Suspended Chair Yoga for Stress in Dementia N/A Interventional COVID-19 Anticipated 40
NCT02790996 Terminated Neonatal Vancomycin Trial Phase 2 Interventional Planned interim analysis yielded different event rate affecting sample size and ability to recruit sufficient numbers within remaining trial time frame Actual 242
NCT03088735 Terminated Transfer Strategy in an Oocyte Donation Programme N/A Interventional Due to the clinically and statistically significant inferior results for the D3 group following evaluation by the institutional review board. Actual 134
NCT02591394 Terminated STEPs to Blood Pressure Reduction. N/A Interventional Funding period ended and slow enrollment Actual 115
NCT02928887 Suspended Light Therapy in Cardiopulmonary Bypass Surgery N/A Interventional Cardiac surgeon collaborator has left the institution Anticipated 30
NCT02711059 Withdrawn Insulin Resistance in Primary Hyperparathyroidism N/A Interventional studien skjuts på framtiden Actual 0
NCT03357133 Terminated Tirofiban for Patients Treated With Alteplase Phase 2/Phase 3 Interventional The number and speed of enrollment were significantly less than expected. Actual 30
NCT04148300 Suspended The Impact of Oral Health Literacy on Dental Anxiety and Utilization of Oral Health Services Observational Due to COVID-19 and lock-down of the university Actual 550
NCT04546802 Withdrawn HepATocellular Cancer Hcv Therapy Study Phase 3 Interventional Recruitment will be too difficult due to available PBS funded treatment and recent Australian clinical guidelines will conflict with the premise of the study. Actual 0
NCT03073850 Terminated Antithrombotic Treatment in Patients With Effectively Maintained Sinus Rhythm After Atrial Fibrillation Ablation Phase 4 Interventional Majority of enrolled patients have withdrawn. Actual 48
NCT03204149 Terminated Evaluation of Safety of Low Level Laser Device Treatment in Chronic Wounds N/A Interventional Project termination Actual 5
NCT03377751 Terminated Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation? N/A Interventional Majority of enrolled patients have withdrawn. Actual 20
NCT03983070 Suspended The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size. N/A Interventional Covid-19. No in-person study procedures are currently allowable by the overseeing IRB. Anticipated 30
NCT00891917 Withdrawn Liq-NOL Efficacy in Pediatric Patients With Down Syndrome Phase 2 Interventional no funding Actual 0
NCT02434874 Withdrawn Sacral Nerve Stimulation to Treat Urgency Urinary Incontinence With Wireless Neuromodulation N/A Interventional Study will no longer take place. Actual 0
NCT03151408 Terminated An Efficacy and Safety Study Of Pracinostat In Combination With Azacitidine In Adults With Acute Myeloid Leukemia Phase 3 Interventional The IDMC recommended to stop the study prematurely due to a lack of efficacy. Actual 406
NCT03203837 Terminated Biomarker Analyses in Hepatocellular Carcinoma (HCC) Patients Treated With TheraSphere® Observational Funding Discontinued due to low accrual rate Actual 4
NCT03506139 Withdrawn Biologically-based Target Volumes to Treat Newly Diagnosed Glioblastoma Phase 2 Interventional Not funded Actual 0
NCT03742180 Withdrawn Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy N/A Interventional Unavailable drug in Egypt. Actual 0
NCT03896451 Withdrawn Comparison Between Two Total Knee Prosthesis Medacta GMK Sphere and Medacta GMK PS N/A Interventional Medacta GMK PS is not in use anymore Actual 0
NCT04097496 Terminated Effects of ACT OUT! Social Issue Theater on Youth and Adolescents N/A Interventional COVID-19 pandemic and related school policies. Actual 1537
NCT04122183 Suspended Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening N/A Interventional Subject contact has been suspended until it is safe to screen hearing and participants feel safe seeing clinicians. Anticipated 40
NCT03213665 Suspended Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Phase 2 Interventional Scheduled Interim Monitoring Anticipated 49
NCT04136561 Withdrawn Novel Strategy to Encourage Early Removal of Central Venous Catheters N/A Interventional No participants enrolled. Unable to enroll Actual 0
NCT02943447 Terminated Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis Phase 2 Interventional The study was terminated because of the availability of alternate therapies for primary biliary cholangitis (PBC). Actual 71
NCT00894361 Terminated Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs Phase 4 Interventional PI/study coordinator retired due to personal family health matters; study sponsor withdrew funding. Study terminated and no data collected or analyzed Actual 400
NCT00979147 Terminated Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty N/A Interventional PI/study coordinator retired due to personal family health matters; study sponsor withdrew funding. Study terminated and no data collected or analyzed Actual 400
NCT01113658 Withdrawn Clinical Evaluation of the SNaP Wound Care System N/A Interventional The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01349894 Withdrawn SNaP Wound Care System Over Skin Cancer Excision Sites and Split Thickness Skin Grafts (STSGs) Observational The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01417208 Withdrawn Clinical Evaluation of the SNaP Wound Care System in Promoting Healing in Chronic Wounds Observational The study was terminated by Spiraur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT01623882 Withdrawn Clinical Evaluation of the Combined Use of Apligraf® and the SNaP® Pressure Wound Therapy System Observational The study was terminated by Spiracur (original sponsor). Efforts were made to contact the PI/study team members, but were unsuccessful. Actual 0
NCT02051764 Terminated Imaging Characteristics of a Follow-up 18F-AV-1451 Scan Phase 2 Interventional Lower than expected enrollment Actual 44
NCT02192359 Suspended Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas Phase 1 Interventional Drug not available. Anticipated 53
NCT03088930 Withdrawn Evaluating Crizotinib in the Neoadjuvant Setting in Patients With Non-small Cell Lung Cancer Phase 2 Interventional Low Accrual Actual 0
NCT03120793 Terminated ARDS Esophageal Balloon Pressure Changes With Positioning Study Observational Failure to recruit/enroll Actual 2
NCT03133897 Terminated Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study Phase 3 Interventional it was felt by the sponsoring institution that the current standard of oversight expected by the Health Canada regulations, would not be possible to achieve Actual 20
NCT02772809 Terminated Usability Testing of Affordable Haptic Robots for Stroke Therapy N/A Interventional The robot was no longer available to the study. Actual 23
NCT03615924 Terminated Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease Phase 3 Interventional Recommendation from an independent data monitoring committee (DMC) and accepted by AstraZeneca. Actual 193
NCT03657095 Terminated A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension Phase 3 Interventional The pivotal study, BPS-314d-MR-PAH-302 (NCT01908699), failed to demonstrate efficacy. Actual 112
NCT03711786 Suspended The Sub-Saharan Africa Regional Partnership for Mental Health Capacity Building N/A Interventional COVID-19 - pause in in-person enrollment; follow-up by phone continuing Anticipated 1160
NCT03750656 Terminated Use of Hyoscyamine Versus Tamsulosin for Management of Ureteral Stent Irritation Phase 4 Interventional Not accruing patients quickly enough Actual 6
NCT03862027 Terminated Evaluating Safety of Transpulmonary Pressure Guided PEEP Management in Neurocritical Care Patients N/A Interventional Failure to enroll/recruit Actual 2
NCT03985215 Withdrawn The Value of Follow-Up After Childhood Acute Lymphoblastic Leukaemia in Denmark - Family Perspectives Observational Overlapping with another danish questionnaire study Actual 0
NCT04013763 Terminated Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care N/A Interventional 1. Limit number of patients during COVID-19 situation 2. Too small number of wheat allergic patients who are using wheat containing soap Actual 7
NCT04048057 Suspended The Effect of Different Exercise Programs in Coronary Artery Patients: A Randomized Controlled Study N/A Interventional Because of Covid-19 pandemia, The cardiac rehabilitation unit in the hospital conducting the study has been closed for a while. Anticipated 60
NCT04058145 Withdrawn AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma Phase 2 Interventional Funding Withdrawn Actual 0
NCT04073407 Terminated Study of the Safety and Tolerability of AXA1957 in Adolescent Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD) N/A Interventional Sponsor has determined that information it would have collected would not inform future development of a therapy with AXA 1957 for NAFLD Actual 9
NCT04106843 Withdrawn Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or Unresectable Rare Endocrine Cancers Phase 2 Interventional No Participants Registered Actual 0
NCT03423537 Terminated Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART Phase 3 Interventional Inability for further recruitment, change of position of the principal investigator, COVID-19 pandemic Actual 80
NCT03535584 Suspended Exercise to Treat Frailty and Decreased Physical Function in Transplant Candidates N/A Interventional Due to Covid19 pandemic at this time we are on pause Anticipated 50
NCT03636048 Terminated Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) N/A Interventional not enough participants Actual 20
NCT03691038 Terminated Comparison of Conventional Dose Regimen and New Dose Regimen of Pregabalin N/A Interventional Participants couldn't be enrolled due to complain of frequent visit. Actual 10
NCT03768726 Terminated Extension Study Evaluating The Safety And Tolerability Of Flexible Doses Of Oral Ziprasidone In Children And Adolescents With Bipolar I Disorder Phase 3 Interventional Pfizer has decided to perform the pre-specified final analysis at the current enrollment using a re-estimation of the sample size. Actual 23
NCT04084574 Suspended Diet and Hypertension Management in African Americans With Chronic Kidney Disease N/A Interventional Aim 1 enrollment and study activities have been completed. Aim 2 anticipated start date is 3/2021. Anticipated 50
NCT04175717 Terminated Feasibility of a Physiotherapy-led Follow-up Programme in Adult Critical Illness Survivors N/A Interventional Due to COVID pandemic Actual 3
NCT04249713 Withdrawn An Alternative Dose Interval Study in Participants With Hidradenitis Suppurativa Receiving Brodalumab Early Phase 1 Interventional Biomarker Samples Not Collected Actual 0
NCT04249947 Suspended P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Phase 1 Interventional FDA Clinical Hold Anticipated 40
NCT04254666 Suspended New Skills - No Scores Research Study N/A Interventional The COVID-19 pandemic required that we discontinue the study. Anticipated 30
NCT04377165 Terminated Innovative Tool to Limit Spread of SARS-CoV-2 in Residential Aged Care Facilities N/A Interventional Engagement issues, poor recruitment to study Actual 34
NCT04392128 Withdrawn Study Evaluating the Efficacy of Hydroxychloroquine and Azithromycine in Patients With COVID-19 and Hematological Malignancies (HYACINTHE) Phase 2 Interventional competent authority decision Actual 0
NCT04541719 Withdrawn Patient Controlled Remifentanil Analgesia for Normal Labour Phase 2 Interventional no participants enrolled Actual 0
NCT03008616 Terminated Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia Phase 2/Phase 3 Interventional Following a recommendation from the Data and Safety Monitoring Board (DSMB), the study was stopped early for futility. There were no safety concerns raised. Actual 59
NCT03473665 Terminated Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis Phase 4 Interventional Slow recruitment Actual 9
NCT01571791 Suspended Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Phase 2 Interventional No enough recruited cases Anticipated 90
NCT01718756 Suspended Continuous Lornoxicam Infusion for Orthopaedic Surgery Phase 1/Phase 2 Interventional No enough fund or cases Anticipated 96
NCT01861561 Terminated Low-dose VS High-dose IV Cyclophosphamide for Proliferative LN in Children Phase 4 Interventional The duration of the study is longer than 5 years and we can not recruit the participants to the target number. Actual 43
NCT01937884 Terminated Supplemental Parenteral Nutrition in Pediatric Respiratory Failure Phase 2 Interventional Unable to enroll patients Actual 18
NCT01945229 Terminated Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE) Observational Preliminary analyses of data indicated study should be terminated for futility Actual 110
NCT02420652 Terminated Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy Phase 2 Interventional Slow accrual Actual 27
NCT02432378 Suspended Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines Phase 1/Phase 2 Interventional Anticipated 25
NCT02607488 Suspended Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Bariatric Surgery Phase 1/Phase 2 Interventional No fund no enough recruiting centers Anticipated 180
NCT01799889 Terminated Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies Phase 2 Interventional Sponsor's decision to discontinue development of entospletinib. Actual 326
NCT03523091 Terminated OnabotulinumtoxinA Bladder Injection Study Phase 4 Interventional Lack of enrollment Actual 1
NCT02757976 Terminated Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial N/A Interventional Consensus RAFT-LVendo Steering Committee to terminate. Actual 8
NCT03909867 Suspended Emission Patterns of Respiratory Syncytial Virus Observational The emergence of SARS-CoV-2 required a temporary hold of recruitment Anticipated 29
NCT03015051 Terminated High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Phase 4 Interventional Difficulty in recruiting subjects who meet the inclusion/exclusion criteria Actual 30
NCT03106597 Terminated Manidipine Versus Amlodipine in Patients With Hypertension Phase 4 Interventional Difficulty in enrolling subjects Actual 46
NCT03221166 Terminated Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors Phase 3 Interventional Difficulty in recruiting subjects who meet the inclusion/exclusion criteria Actual 9
NCT04097093 Withdrawn Long-term Surival of GIST Patients ≥ 10 Years on Imatinib Observational [Patient Registry] Lack of feasibility Actual 0
NCT02219334 Terminated Comparing Nasal Suction Devices in Children With Bronchiolitis: A Pilot Study N/A Interventional The study was stopped due to low enrollment. Actual 55
NCT02429934 Terminated Abatacept for SLE Arthritis (IM101-330) Phase 1/Phase 2 Interventional Response rate in placebo group for primary outcome was 100% on interim analysis. Actual 28
NCT02507986 Suspended Mobile Phones in Cryptogenic Stroke Patients Bringing Single Lead ECGs to Detect Atrial Fibrillation N/A Interventional no personnel for recruitment Anticipated 200
NCT02577367 Terminated Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding Phase 4 Interventional Hospital has a new protocol holding off feeding 2 hours for LT4 administration. Actual 4
NCT02774551 Suspended Physical Activity Intervention Trial to Mitigate Muscle Loss and Increase Muscle Strength N/A Interventional Suspended since March 2020 due to the ongoing covid-19 situation Anticipated 160
NCT02964481 Terminated Malignant Hyperthermia Registry and Genetic Testing Observational Lack of funding to enroll additional participants Actual 64
NCT03060954 Terminated Non-Inferiority Study Comparing MINI WELL READY® and FineVision® in Patients With Cataract Surgery N/A Interventional The clinical study is closed to further enrolment based on the lack of perceived need to compare the study device with the control device. Actual 8
NCT03589755 Withdrawn The Impact of Mindfulness Meditation in Veterans With Epilepsy N/A Interventional unable to recruit enough candidates Actual 0
NCT03597282 Terminated A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma Phase 1 Interventional Closed due to historically slow enrollment compounded by the COVID-19 pandemic. Actual 22
NCT03682367 Terminated Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery Phase 3 Interventional Poor Recruitment Actual 10
NCT03821649 Suspended SOONER Feasibility Study Protocol N/A Interventional Suspended due to non-essential research prohibitions at the study's recruitment and outcome assessment sites in the context of COVID-19. Anticipated 80
NCT03907202 Terminated A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM Phase 1 Interventional The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects. Actual 25
NCT03978884 Withdrawn Phase 4 Study of the Efficacy of Losartan Based Therapy in Hypertensives With and Without Diabetes Phase 4 Interventional Unable to effective arrange trial logistics Actual 0
NCT04093115 Withdrawn Study of CX1106 in Patients With Advanced Head and Neck Squamous Cell Carcinoma Phase 2 Interventional The study was terminated voluntarily by the sponsor due to changes in clinical development strategy. Actual 0
NCT04130906 Suspended Theta Burst Stimulation in Binge Eating Disorder: A Single Session RCT N/A Interventional The study includes adults vulnerable to COVID-19 and procedures cannot accommodate social distancing. Anticipated 66
NCT04138602 Withdrawn BTL Emsella Chair Versus Sham for the Treatment of Fecal Incontinence N/A Interventional Lack of enrollment Actual 0
NCT04143490 Suspended Effects of Exercise in Patients With Ulcerative Colitis N/A Interventional Due to Covid-19 Anticipated 24
NCT04206800 Terminated Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients N/A Interventional Difficulty in enrolling participants Actual 5
NCT04228549 Suspended MyPADMGT Support of Out-Patients With Peripheral Arterial Disease N/A Interventional Outpatient clinic site suspended temporarily due to COVID 19 virus Anticipated 210
NCT04244825 Suspended Safety, Pharmacodynamics, and Pharmacokinetics of Orally Administered BLD-2660 in Subjects With IPF Phase 2 Interventional Suspended due to concerns for patient safety during COVID-19 crisis Anticipated 32
NCT04291508 Suspended Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Phase 2 Interventional Study put on hold due to CIV-19 pandemic and NHLBI directive for PETAL network to redirect efforts to COVI-19 specific treatment trials. Anticipated 900
NCT04300335 Suspended The Feasibility and Effects of Exercise on Patients Suffering From Multiple Myeloma N/A Interventional Due to COVID-19 and the fact that the study participants are part of the "high-risk" population, the start of the recruiting process has been delayed at will. Anticipated 45
NCT04377425 Withdrawn COVID-19 Prevalence and Cognitive Deficits in Neurological Patients Observational No acute neurological patients presented with concomitant COVID-19 Actual 0
NCT04430010 Suspended Multi-level Determinants of Implementation and Sustainment in the Education Sector N/A Interventional Schools opening remotely has prevented recruitment Anticipated 588
NCT02608944 Withdrawn Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging N/A Interventional MRI perfusion techniques development took years than expected. Actual 0
NCT02929394 Terminated Trabectedin Maintenance Post 1st-line in STS Phase 3 Interventional Poor accrual Actual 13
NCT03124628 Withdrawn Effects of Flywheel Exercise on Muscle and Walking Function in Teenagers and Young Adults With Cerebral Palsy N/A Interventional Lack of funding Actual 0
NCT03497598 Terminated Preventing Recurrent Urinary Tract Infections With α-D-mannose Phase 4 Interventional not enough patients Actual 15
NCT04540952 Terminated Randomized Trial Comparing Fluid Capture Efficiency of Total Capture Drape Versus Standard Drape for Hysteroscopy. N/A Interventional COVID-19 Actual 68
NCT03554356 Suspended Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE) N/A Interventional Device modifications required prior to trial proceeding. Anticipated 70
NCT03638596 Suspended Leveraging Transdermal Alcohol Monitoring to Reduce Drinking Among DWI Defendants N/A Interventional Suspended enrollment due to pandemic, follow-up visits still ongoing. Anticipated 440
NCT03648619 Suspended Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging N/A Interventional Insufficient recruitment Anticipated 50
NCT03698838 Terminated Myelin Imaging Changes In Patients With Neurosurgical Diseases Observational Principal Investigator left Institution Actual 20
NCT03829618 Terminated Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound Phase 3 Interventional COVID lack of cases/recruitment Actual 29
NCT02132598 Terminated Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases Phase 2 Interventional Trial stopped due to slow patient accrual. Actual 5
NCT03833596 Terminated Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD) Phase 4 Interventional Low recruitment Actual 3
NCT03883321 Terminated EssaiClinique_CBSM Observational few patient feedback and principal investigator disponibility Actual 25
NCT04037306 Terminated Measurements From Stool to Support Dietary Change N/A Interventional Weight loss center programming suspended due to COVID-19 pandemic Actual 7
NCT04059666 Suspended Gastrointestinal Tract Microbiome in Healthy Term Infants Receiving Mother'S-own Breast Milk or Cow's Milk-based Infant Formulas N/A Interventional COVID-19 Anticipated 111
NCT04170868 Withdrawn Psychoeducational Video Series - Proof of Concept N/A Interventional COVID Actual 0
NCT04220788 Withdrawn Pharmacist Enhanced Service for Cardiovascular Risk Reduction N/A Interventional No enrollment due to difficulty in recruitment of study sites Actual 0
NCT04325061 Suspended Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Phase 4 Interventional Lack of enrollment Anticipated 200
NCT04326075 Suspended Early CPAP in COVID-19 Patients With Respiratory Failure. N/A Interventional the insurance contract hasn't been drafted yet Anticipated 900
NCT04350086 Withdrawn Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection Phase 4 Interventional unfavorable opinion of the ethics committee Actual 0
NCT04360135 Suspended Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy Phase 2/Phase 3 Interventional PI has decided to put this study on hold at this time. Actual 208
NCT03613831 Withdrawn Multi-center Complex Atrial Tachycardia High-Resolution Mapping Registry (MATH) Observational The sponsor has decided to stop the study Actual 0
NCT00603941 Terminated A Phase 1/2 Study of CS7017, an Oral PPARγ Agonist, in Combination With Paclitaxel Phase 1/Phase 2 Interventional Due to low enrollment, no participant had a dose limiting toxicity, therefore a maximum tolerated dose could not be established Actual 19
NCT03953352 Withdrawn Evaluation of the Automatic Deformable Recontouring on the Daily MVCT for Head and Neck Cancer Adaptive Radiotherapy N/A Interventional Study cancelled Actual 0
NCT00182455 Terminated Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP) Phase 4 Interventional loss of funding Anticipated 12
NCT00936234 Withdrawn Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM). Phase 2/Phase 3 Interventional insufficient recruitment Actual 0
NCT00975468 Suspended Pressure-Controlled vs Volume-Controlled Ventilation During One Lung Ventilation N/A Interventional Financial shortages due to lack of funderx Anticipated 40
NCT01232153 Withdrawn Preoxygenation Before Prehospital Tracheal Intubation With NIV Versus Balloon N/A Interventional departure without replacement of the principal investigator Actual 0
NCT01539395 Withdrawn A Cross-Sectional Study of MSDx Complex 1 as a Marker for Active Disease in Multiple Sclerosis Observational Actual 0
NCT02859844 Terminated Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction N/A Interventional Termination after a few pilot participants due to further protocol development Actual 9
NCT03522480 Withdrawn The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 2 N/A Interventional Change of Research Objectives for Grant Funded Study Actual 0
NCT03527550 Suspended Cognitive Control Training for Urgency in a Naturalistic Clinical Setting N/A Interventional Recruitment paused due to COVID-19 Anticipated 90
NCT03530605 Withdrawn Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma N/A Interventional Study never initiated, PI left institution Actual 0
NCT03547349 Suspended The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 3 N/A Interventional COVID-19 Anticipated 169
NCT03047213 Suspended Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations Phase 2 Interventional Other - TSC1/TSC2 testing issues and futility analysis Anticipated 209
NCT03836482 Suspended Selective Cytopheretic Device (SCD) Trial N/A Interventional Study halted temporarily to obtain protocol amendment approval but potentially will resume. Anticipated 10
NCT04101006 Terminated Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function Observational recruitment difficulties, high postoperative drop-out rate Actual 78
NCT04538196 Withdrawn Coding Improvement Project: Resident Education on Documentation N/A Interventional Study staffing constraints Actual 0
NCT02640690 Suspended Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma N/A Interventional Recruitment has been suspended because of COVID related restrictions and limitations imposed on data collection Anticipated 210
NCT02949843 Terminated Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations Phase 2 Interventional Slow accrual, closed by IRB Actual 19
NCT03106571 Terminated Study of Pomaglumetad and Methamphetamine Phase 1 Interventional Deemed unable to enroll targeted participants in part due to COVID-19 shut downs Actual 19
NCT03515200 Terminated Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia Phase 1 Interventional Due to departure of PI from St. Jude Actual 12
NCT03648047 Terminated Digital Biofeedback System Versus Conventional Rehabilitation After Rotator Cuff Repair N/A Interventional COVID-19 pandemic imposed restrictions to normal study conduct Actual 50
NCT04163224 Withdrawn Minimal Invasive Approach for Surgical Repair of Rib Fractures With a Novel Intrathoracic Device Observational Sponsor strategy change Actual 0
NCT01784861 Terminated VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors Phase 1/Phase 2 Interventional Pharmaceutical company decision Actual 23
NCT02154984 Terminated Time Restricted Diet in Obese or Overweight Pre or Postmenopausal Participants N/A Interventional Study closed due to funding before accrual was met Actual 45
NCT02349633 Terminated Study For Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M) Phase 2 Interventional The study was ended for strategic reasons and changes in the external environment. The safety profile and risk benefit ratio for PF-0674775 remained unchanged. Actual 65
NCT02820077 Terminated Hemostatic Powder Versus Clinical Management for the Treatment of Upper Gastrointestinal Bleeding From Tumor Lesions N/A Interventional Global recall of Hemospray Actual 62
NCT03362593 Terminated A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses Phase 1 Interventional The program is canceled due to company strategic reasons. Actual 186
NCT03780205 Terminated Bilateral and Unilateral Amblyopia Treatment Study Observational Unable to recruit sufficient number of subjects Actual 1
NCT03877250 Withdrawn Analysis of Biopsy Specimens to Study Responses to PD-1 or PD-L1 Therapies Observational The primary objectives have not been met due to no patient enrollment therefore, the PI is requesting to close the study at this time. Actual 0
NCT03953456 Terminated Study to Evaluate the Effect of Elafibranor on Hepatic Lipid Composition in Subjects With Nonalcoholic Fatty Liver (NAFL) Phase 2 Interventional Continuation of the trial cannot serve a scientific purpose Actual 17
NCT04075071 Terminated A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start N/A Interventional Intervention and and final data collection point was not completed due to coronavirus school closures in March 2020. Actual 70
NCT00586209 Terminated L-Glutamine Therapy for Sickle Cell Anemia Phase 2 Interventional Due to inadequate supplies of study drug & internal business decisions. Actual 15
NCT02975336 Terminated A Phase II Study of M2951 in Systemic Lupus Erythematosus (SLE) Phase 2 Interventional Study is completed; primary analysis completed. Actual 480
NCT03237754 Terminated Neurostimulation in Chronic and Episodic Migraine N/A Interventional Recruitment problems (especially for chronic migraine patients) Actual 41
NCT03540368 Suspended Tranexamic Acid for The Treatment of Gastrointestinal Bleeding N/A Interventional increased number of patients death Anticipated 336
NCT03607500 Suspended Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation N/A Interventional Lack of funding Anticipated 30
NCT03752242 Suspended Evaluation of Topical Application of BMX-010 in Subjects With Acne Vulgaris. Phase 2 Interventional Enrollment stopped for chemistry work on investigational product. Actual 2
NCT03825913 Terminated 3-month Aerobic and Resistance Exercise Intervention for Individuals Diagnosed With Melanoma N/A Interventional two key faculty members are no longer part of the study and institution Actual 1
NCT03889873 Suspended Evaluating Change in Drinking Identity as a Mechanism for Reducing Hazardous Drinking - Study 2 N/A Interventional Paused enrollment due to COVID-19 pandemic; will resume Fall 2020 Anticipated 328
NCT04118569 Suspended Personalized Experiences to Inform Improved Communication for Patients With Life Limiting Illness N/A Interventional On hold due to COVID-19 pandemic. Anticipated 80
NCT04349228 Withdrawn Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals Phase 3 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT04351919 Withdrawn Assessment of Efficacy and Safety of HCQ and Antibiotics Administrated to Patients COVID19(+) Phase 4 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT03249272 Terminated Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Phase 4 Interventional Sponsor withdrew funding Actual 31
NCT04386434 Withdrawn Active for Life Assisted Living Feasibility and Acceptability Study N/A Interventional Pandemic, researchers no longer have access to residents of assisted living. Actual 0
NCT03871569 Terminated Medico-economical Evaluation on Buccodental Teleexpertise in Nursing Home N/A Interventional Difficulty recruiting and follow-up due to the epidemic context of COVID19 Actual 171
NCT04528927 Withdrawn Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia Phase 3 Interventional - Interest in the use of HCQ is controversial. Actual 0
NCT00860379 Terminated The Effect of Selenium Supplementation Among Pediatric Patients With Burns Phase 4 Interventional Due to a shift in primary responsibilities, the PI was not longer able to enroll subjects. Actual 14
NCT02429505 Withdrawn Treatment of Leishmaniasis With Impavido® (Miltefosine): Higher-Weight Patient Registry Observational [Patient Registry] This study was COMPLETED, but no patients were enrolled. Actual 0
NCT01334489 Terminated The Trial of Pessary After Laser for TTTS N/A Interventional Interim analysis unfavorable to continue the study Actual 352
NCT01535157 Terminated Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer Phase 1/Phase 2 Interventional drug combination not providing any efficacy. Will use this data in opening new trial Actual 12
NCT02090868 Withdrawn An Oral Intake Screening Tool for Patients Receiving Non-Invasive Ventilation Observational No patients recruited due to decreased levels of patients requiring non-invasive ventilation during the study. Actual 0
NCT02759120 Terminated CleanUP IPF for the Pulmonary Trials Cooperative Phase 3 Interventional Terminated for futility after review of first planned interim analysis. Actual 509
NCT02810236 Suspended Focal Breast Pain: Does a Normal Ultrasound Provide Reassurance? N/A Interventional The study is suspended due to the pandemic Anticipated 160
NCT02874820 Terminated I2PETPG - Imidazoline2 Binding Sites in a Group of Participants Diagnosed With AD Early Phase 1 Interventional Patient recruitment issues. Actual 2
NCT02927470 Withdrawn TMS of Visual Working Memory N/A Interventional Investigators are no longer at NYU Langone Health Actual 0
NCT03036891 Withdrawn Naloxegol for Opioid-Related Gastroparesis Phase 2 Interventional Actual 0
NCT03556930 Withdrawn Simulated Radiotherapy Treatment Assisted With Pediatric Radiation Oncology With Movie Induced Sedation Effect Technique Early Phase 1 Interventional Project was never initiated. Actual 0
NCT03693274 Terminated Mindfulness to Improve Functional Outcomes in Patients With Fibromyalgia or Central Sensitization N/A Interventional Principal investigator leaving institution. Actual 16
NCT04374474 Withdrawn Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19) Phase 4 Interventional Study withdrawn before any enrollment (site's research goals adjustments). Actual 0
NCT04384614 Withdrawn Covid-19 In Tunisia: An Observational Cross-Sectional Registry Study Observational [Patient Registry] The sponsor decided to withdraw the study for funding reasons. Actual 0
NCT04527796 Terminated Influence of a Residential Rehabilitation Program on Body Composition in Patients With Cystic Fibrosis N/A Interventional number included Actual 39
NCT02315625 Terminated Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery Phase 2 Interventional Study closed due to poor accrual. Actual 16
NCT03992079 Terminated A Multimodal Enhanced Recovery Program in Anorectal Surgery N/A Interventional PI is no longer at institution Actual 60
NCT04282681 Withdrawn XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU) Observational Sponsor decision due to clinical strategy changes Actual 0
NCT04332341 Suspended Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation Early Phase 1 Interventional COVID-19 hold Anticipated 20
NCT02638506 Terminated RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches Phase 4 Interventional Covid restrictions Actual 60
NCT02743169 Withdrawn Improvement of Ambulance Response Times in Karachi, Pakistan Observational Could not acquire data Actual 0
NCT03232632 Terminated Assessment of Cardiac Fixation During PET Using a New Drug Within Amyloid Cardiac Injuries. Early Phase 1 Interventional intervention programming Actual 7
NCT03251872 Terminated Olaparib for PAH: a Pilot Study Early Phase 1 Interventional OPTION pilot trial merged with the new NCT03782818 - OPTION multicenter trial Actual 6
NCT03289624 Withdrawn SHARE for Persons With Chronic Conditions and Their Family Caregivers N/A Interventional Lost Funding Actual 0
NCT03312127 Terminated Evaluation of Peri-surgical Results at Short and Mean Terms of the GORE ® Excluder Iliac Branch Endoprosthesis N/A Interventional End of inclusion period Actual 3
NCT03348111 Withdrawn Establishing a New Protocol for Early Mucositis and Peri-implantitis Treatment Using an Air-polishing Device N/A Interventional No participant enrolled Actual 0
NCT03738124 Withdrawn Evaluation of the Valiant Mona LSA Thoracic Stent Graft System in Thoracic Aortic Aneurysms and Chronic Dissections N/A Interventional Production of the medical device was stopped Actual 0
NCT04053543 Terminated CXA-10 Study in Subjects With Pulmonary Arterial Hypertension Phase 2 Interventional LOE Actual 33
NCT04066088 Withdrawn Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior Associated With Prader-Willi Syndrome Phase 4 Interventional PI departure from institution Actual 0
NCT04227938 Terminated Study of ALPN-101 in Steroid-resistant or Steroid-refractory Acute GVHD Versus Host Disease Phase 1 Interventional Change in sponsor strategy Actual 1
NCT04317924 Withdrawn Pneumostasis With Use of Bio-absorbable Mesh and Fibrin Sealant in Lung Resection N/A Interventional Resources not available to conduct the research. Actual 0
NCT03522805 Terminated Impact of Non-invasive Ventilation in Hypercapnic COPD N/A Interventional Failure to accrue subjects. All activity has stopped & no analysis will be done on what has been collected. Actual 6
NCT04142554 Withdrawn Parsaclisib in Newly Diagnosed Stage I-IIIC Triple Negative or HER2+ Breast Cancer Phase 1 Interventional Funding withdrawn from funding source. Actual 0
NCT04528758 Suspended F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow Early Phase 1 Interventional re-evaluation of radiotracer Anticipated 15
NCT04438551 Suspended Software Application for Low-Sodium Diet Trial (SALT) N/A Interventional Study is on hold until pilot study is completed. Anticipated 80
NCT04403685 Terminated Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers Phase 3 Interventional Safety Actual 129
NCT01096290 Terminated Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications Phase 4 Interventional Number of needed participants could not be obtained Actual 23
NCT02026726 Terminated Do Oral Steroid Dose Packs Predict How Well Epidural Steroid Injections Will Work? Observational could not recruit Actual 10
NCT02673151 Suspended 68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment Phase 2/Phase 3 Interventional logistics Anticipated 200
NCT02775422 Terminated Comparison of Serological Test s for the Virus Chicken Pox Virus (VZV) and Correlation With the Patient's Memory of the Infection or Vaccination N/A Interventional Low inclusion rate. Actual 308
NCT03202498 Terminated Safety and Tolerability of Yaq-001 in Patients With Cirrhosis N/A Interventional COVID-19 pandemic prevents patients from making in-hospital visits, which are mandatory to assessment of safety in this study Actual 31
NCT03665636 Suspended Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I Early Phase 1 Interventional due to COVID-19 Anticipated 5
NCT03821766 Withdrawn Haemodynamic Abnormalities Recorded With Cardiac Catheterization Along With Body's Surface Micro-accelerometers (KT-KCG) Observational Technical failure Actual 0
NCT03834584 Terminated A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma Phase 1 Interventional Terminated due to sponsor decision. Actual 11
NCT04100681 Terminated Intermittent Negative Pressure; Impact on Peripheral Artery Disease and Intermittent Claudication N/A Interventional The study was terminated early due to slow recruitment and inability to recruit patients during the Covid-19 situation. Actual 16
NCT04222985 Suspended Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2 Phase 1/Phase 2 Interventional (Enrollment suspended for 1 site due to Covid-19; For the other sites, enrollment completed in Part A and planned to be restarted for Part B at the end of 2022) Anticipated 381
NCT04358835 Withdrawn Keto-diet for Intubated Critical Care COVID-19 N/A Interventional Study did not begin enrollment, multiple competing studies at same institution Actual 0
NCT04526236 Suspended Influence of Aging on Perioperative Methadone Dosing Phase 4 Interventional pandemia of covid 19 Anticipated 60
NCT01508598 Terminated Validation of Circulating Endothelial Cells and Microparticles in Youth Observational Not enough subjects enrolled to be able to analyze data. Actual 390
NCT01977027 Terminated Strategies for Recovery of Dexterity Post Stroke N/A Interventional PI left insitution Actual 91
NCT02589314 Terminated Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2 Observational We could not achieve the number of participants necessary to continue with the study and limited money to continue with the study Actual 90
NCT01055067 Terminated ARQ 197 for Participants With Relapsed or Refractory Germ Cell Tumors Phase 2 Interventional The study was terminated early for futility according to the stopping rule of the Simon 2-stage design. Actual 27
NCT02558023 Terminated The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Phase 3 Interventional no candidats Actual 14
NCT02716701 Terminated Exercise in Multiple Sclerosis N/A Interventional lack of funding Anticipated 40
NCT02737930 Terminated Fluoxetine for Visual Recovery After Ischemic Stroke Phase 2 Interventional Slow recruitment and lack of funding to expand to other sites. Actual 17
NCT03330561 Suspended PRS-343 in HER2-Positive Solid Tumors Phase 1 Interventional Partial clinical hold Anticipated 110
NCT03370302 Terminated A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of TAK-228 as Single Agent in Adult East Asian Participants With Advanced Nonhematological Malignancies Phase 1 Interventional More favorable safety profile was observed in QD schedule, therefore further enrollment in QW schedule was terminated. Actual 28
NCT04525170 Withdrawn Clinical Evaluation of HPT Treated Rigid Contact Lenses Made From Hexafocon A N/A Interventional It was decided by the sponsor to not proceed. Actual 0
NCT01864018 Suspended Ixazomib Citrate, Cyclophosphamide, and Dexamethasone in Treating Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis Phase 1/Phase 2 Interventional Actual 71
NCT02373540 Terminated Algovita Post-Market Clinical Study: Spinal Cord Stimulation to Treat Chronic Pain Observational Actual 91
NCT04522466 Terminated Evaluation of the Pharmacokinetics and Pharmacodynamics of Hydroxychloroquine in COVID-19 Intensive Care Unit Patients Phase 3 Interventional Stop of the study by competent authority (ANSM) Actual 7
NCT02266147 Terminated Study of SD-101 in Combination With Localized Low-dose Radiation in Patients With Untreated Low-grade B-cell Lymphoma Phase 1/Phase 2 Interventional The sponsor terminated the trial early because there was sufficient data to make a decision about SD-101 in the lymphoma development program. Actual 29
NCT01951378 Terminated Comparison of Nebulizers in ED in Pediatric Asthma Patients Phase 4 Interventional No data are available for this study as the PI has left the institution. Actual 40
NCT04275011 Suspended Bone Response to Exercise in Women on Antiresorptive Medications N/A Interventional The study has been suspended until further notice due to COVID-19. Anticipated 46
NCT04493697 Withdrawn Using Neuromodulation to Improve Parkinson's Disease N/A Interventional Device provider has requested withdrawal citing modifications needed for study integrity. Actual 0
NCT03538015 Terminated Carvedilol in Treating Hypoglycemia Unawareness Phase 2 Interventional Sponsor was impacted by COVID-19 and did not have sufficient funds to continue. Actual 1
NCT04520620 Withdrawn Concentration-effect Relationship of Enoxaparin for Thromboembolic Prevention Phase 4 Interventional End of the COVID 19 epidemic in the region and decision to participate in a national study on the same subject (COVI-DOSE). Actual 0
NCT00031174 Terminated Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers Observational Due to technical and logistical constraints and a change in the study team's focus of research Actual 151
NCT00756834 Terminated Case Collection Study for Collecting Images for the Development and Validation of Computer Aided Detection Software Observational No longer pursuing FDA submission/approval. Actual 135
NCT01213563 Terminated Management of Type 2 Diabetes After Gastric Bypass Surgery N/A Interventional Data were published that superseded this study. Actual 50
NCT01391520 Withdrawn Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent Phase 3 Inte